المؤلفون: Williams, Ashley S., Crown, Scott B., Lyons, Scott P., Koves, Timothy R., Wilson, Rebecca J., Johnson, Jordan M., Slentz, Dorothy H., Kelly, Daniel P., Grimsrud, Paul A., Zhang, Guo-Fang, Muoio, Deborah M.

المصدر: Cell Metabolism ; volume 36, issue 2, page 422-437.e8 ; ISSN 1550-4131

مصطلحات موضوعية: Cell Biology, Molecular Biology, Physiology

الإتاحة: https://doi.org/10.1016Test/j.cmet.2024.01.007
https://api.elsevier.com/content/article/PII:S155041312400007X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S155041312400007X?httpAccept=text/plainTest

المؤلفون: Drake, Joshua C., Wilson, Rebecca J., Laker, Rhianna C., Guan, Yuntian, Spaulding, Hannah R., Nichenko, Anna S., Shen, Wenqing, Shang, Huayu, Dorn, Maya V., Huang, Kian, Zhang, Mei, Bandara, Aloka B., Brisendine, Matthew H., Kashatus, Jennifer A., Sharma, Poonam R., Young, Alexander, Gautam, Jitendra, Cao, Ruofan, Wallrabe, Horst, Chang, Paul A., Wong, Michael, Desjardins, Eric M., Hawley, Simon A., Christ, George J., Kashatus, David F., Miller, Clint L., Wolf, Matthew J., Periasamy, Ammasi, Steinberg, Gregory R., Hardie, D. Grahame, Yan, Zhen

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2021 Sep . 118(37), 1-10.

الوصول الحر: https://www.jstor.org/stable/27075775Test

المؤلفون: Wilson, Rebecca J.

المساهمون: Stafford, M., Kuh, D.

مصطلحات موضوعية: 614.4

الوصف: As the UK population expands and adverse health increases with the ageing population, health care services are under pressure to meet demands. Thus, it is necessary to understand how individuals manage their health at different stages in adulthood and identify the health and social factors across life associated with different approaches to health management. Data from the MRC National Survey of Health and Development, a British birth cohort study following 5362 individuals from birth to 68 years, were used to measure health management across adult life. Measures of health professional consultation at age 43, women’s management of symptoms and general health in midlife and health check attendance at age 68 were developed from the rich data archive. Associations were tested between health and social factors from childhood and adulthood (socioeconomic position, health, health care utilisation, lifestyle, personality and family support) and health management outcomes using multivariable regression models and structural equation modelling. Associations between measures of health management from earlier, mid and later adulthood were tested to explore patterns of health management across adult life. Childhood serious illness was associated with higher consultation at age 43 and with lower self-management in midlife and lower health check attendance in later life in women, although these associations largely operated through adult factors. Worse health in adulthood and more health care utilisation were associated with a higher likelihood of proactive health management approaches. Higher social class across life was associated with lower consultation, higher self-management and attending more health checks. Positive health behaviours were associated with higher levels of self-management and higher health check attendance. The correlates of health management differed between health challenges and life course stage. Proactive management of one health challenge was sometimes associated with the proactive management of another at a later stage in the life course. This suggests that whilst some individuals may have a greater propensity to proactively manage their health throughout adulthood by various means, other individuals may take little or no action when responding to health challenges; this group should be encouraged to better engage with proactive health management.

الوصول الحر: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.746831Test

المؤلفون: Wilson, Rebecca J., de Siqueira, Alexandre Fioravante, Brooks, Stephen J., Price, Benjamin W., Simon, Lea M., van der Walt, Stéfan J., Fenberg, Phillip B.

المساهمون: Alfred P. Sloan Foundation, Gordon and Betty Moore Foundation

المصدر: Methods in Ecology and Evolution ; volume 14, issue 2, page 372-384 ; ISSN 2041-210X 2041-210X

الوصف: Natural history collections are invaluable resources for understanding biotic response to global change. Museums around the world are currently imaging specimens, capturing specimen data and making them freely available online. In parallel to the digitisation effort, there have been great advancements in computer vision: the computer trained automated recognition/detection, and measurement of features in digital images. Applying computer vision to digitised natural history collections has the potential to greatly accelerate the use of these collections for biotic response to global change research. In this paper, we apply computer vision to a very large, digitised collection to test hypotheses in an established area of biotic response to climate change research: temperature‐size responses. We develop a computer vision pipeline (Mothra) and apply it to the NHM collection of British butterflies (>180,000 imaged specimens). Mothra automatically detects the specimen and other objects in the image, sets the scale, measures wing features (e.g. forewing length), determines the orientation of the specimen (pinned ventrally or dorsally) and identifies the sex. We pair these measurements and specimen collection data with temperature records for 17,726 specimens across a subset of 24 species to test how adult size varies with temperature during the immature stages of species. We also assess patterns of sexual size dimorphism across species and families for 32 species trained for automated sex ID. Mothra accurately measures the forewing lengths of butterfly specimens compared to manual measurements and accurately determines the sex of specimens, with females as the larger sex in most species. An increase in adult body size with warmer monthly temperatures during the late larval stages is the most common temperature‐size response. These results confirm suspected patterns and support hypotheses based on recent studies using a smaller dataset of manually measured specimens. We show that computer vision can be a ...

الإتاحة: https://doi.org/10.1111/2041-210x.13844Test

المؤلفون: Lyons, Scott P., Wilson, Rebecca J., Muoio, Deborah M., Grimsrud, Paul A.

المصدر: Data in Brief ; volume 42, page 108051 ; ISSN 2352-3409

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1016Test/j.dib.2022.108051
https://api.elsevier.com/content/article/PII:S2352340922002621?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2352340922002621?httpAccept=text/plainTest

المؤلفون: Wilson, Rebecca J., Lyons, Scott P., Koves, Timothy R., Bryson, Victoria G., Zhang, Hengtao, Li, TianYu, Crown, Scott B., Ding, Jin-Dong, Grimsrud, Paul A., Rosenberg, Paul B., Muoio, Deborah M.

المساهمون: NHLBI, NIDDKD

المصدر: Molecular Metabolism ; volume 57, page 101429 ; ISSN 2212-8778

مصطلحات موضوعية: Cell Biology, Molecular Biology

الإتاحة: https://doi.org/10.1016Test/j.molmet.2021.101429
https://api.elsevier.com/content/article/PII:S2212877821002878?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2212877821002878?httpAccept=text/plainTest

المؤلفون: Wilson, Rebecca J.

مصطلحات موضوعية: African Americans Paleopathology Paleopathology Paleopathology Health and race

الوصف: Thesis (M.A.) -- University of Tennessee, Knoxville, 2005.
Title from title page screen (viewed on Jul. 7, 2005). Thesis advisor: Lee Meadows Jantz. Document formatted into pages (xviii, 218 p. : ill.(chiefly col.), maps). Vita. Includes bibliographical references (p. 136-148).

الإتاحة: http://etd.utk.edu/2005/WilsonRebecca.pdfTest

المؤلفون: Jones, Thomas C., Wilson, Rebecca J., Moore, Darrell

المصدر: The Journal of Arachnology, 2018 Jan 01. 46(1), 26-30.

الوصول الحر: https://www.jstor.org/stable/26549277Test

المؤلفون: Zhao, Henan, Lewellen, Bevan M., Wilson, Rebecca J., Cui, Di, Drake, Joshua C., Zhang, Mei, Yan, Zhen

المصدر: Scientific Reports ; volume 11, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1038/s41598-021-96112-1Test
https://www.nature.com/articles/s41598-021-96112-1.pdfTest
https://www.nature.com/articles/s41598-021-96112-1Test

المؤلفون: Drake, Joshua C., Wilson, Rebecca J., Cui, Di, Guan, Yuntian, Kundu, Mondira, Zhang, Mei, Yan, Zhen

المساهمون: National Institutes of Health, American Diabetes Association, American Heart Association

المصدر: Frontiers in Physiology ; volume 12 ; ISSN 1664-042X

مصطلحات موضوعية: Physiology (medical), Physiology

الوصف: Unc51 like autophagy activating kinase 1 (Ulk1), the primary autophagy regulator, has been linked to metabolic adaptation in skeletal muscle to exercise training. Here we compared the roles of Ulk1 and homologous Ulk2 in skeletal muscle insulin action following exercise training to gain more mechanistic insights. Inducible, skeletal muscle-specific Ulk1 knock-out (Ulk1-iMKO) mice and global Ulk2 knock-out (Ulk2 –/– ) mice were subjected to voluntary wheel running for 6 weeks followed by assessment of exercise capacity, glucose tolerance, and insulin signaling in skeletal muscle after a bolus injection of insulin. Both Ulk1-iMKO and Ulk2 –/– mice had improved endurance exercise capacity post-exercise. Ulk1-iMKO did not improve glucose clearance during glucose tolerance test, while Ulk2 –/– had only marginal improvement. However, exercise training-induced improvement of insulin action in skeletal muscle, indicated by Akt-S473 phosphorylation, was only impaired in Ulk1-iMKO. These data suggest that Ulk1, but not Ulk2, is required for exercise training-induced improvement of insulin action in skeletal muscle, implicating crosstalk between catabolic and anabolic signaling as integral to metabolic adaptation to energetic stress.

الإتاحة: https://doi.org/10.3389/fphys.2021.732308Test