المؤلفون: Alonso, Guy Todd, Ebekozien, Osagie, Gallagher, Mary Pat, Rompicherla, Saketh, Lyons, Sarah K, Choudhary, Abha, Majidi, Shideh, Pinnaro, Catherina T, Balachandar, Sadana, Gangat, Mariam, Curda Roberts, Alissa Jeanne, Marks, Brynn E, Creo, Ana, Sanchez, Janine, Seeherunvong, Tossaporn, Jimenez-Vega, Jose, Patel, Neha S, Wood, Jamie R, Gabriel, Liana, Sumpter, Kathryn M, Wilkes, Meredith, Rapaport, Robert, Cymbaluk, Anna, Wong, Jenise C, Sanda, Srinath, Albanese-O'neill, Anastasia

المصدر: Journal of diabetes. 13(8)

مصطلحات موضوعية: Humans, Diabetic Ketoacidosis, Diabetes Mellitus, Type 1, Disease Progression, Hospitalization, Registries, Risk Assessment, Risk Factors, Cross-Sectional Studies, Age Factors, Up-Regulation, Adolescent, Child, Child, Preschool, Infant, Infant, Newborn, United States, Female, Male, Biomarkers, COVID-19, Glycated Hemoglobin, 1型糖尿病, DKA, pediatric, type 1 diabetes, 儿科, 新型冠状病毒肺炎, Diabetes, Pediatric, Prevention, Metabolic and endocrine, Clinical Sciences, Public Health and Health Services

الوصف: BackgroundDiabetes is a risk factor for poor COVID-19 outcomes, but pediatric patients with type 1 diabetes are poorly represented in current studies.MethodsT1D Exchange coordinated a US type 1 diabetes COVID-19 registry. Forty-six diabetes centers submitted pediatric cases for patients with laboratory confirmed COVID-19. Associations between clinical factors and hospitalization were tested with Fisher's Exact Test. Logistic regression was used to calculate odds ratios for hospitalization.ResultsData from 266 patients with previously established type 1 diabetes aged

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/43q896t1Test

المؤلفون: Lee, Joyce M., Ospelt, Emma, Noor, Nudrat, Mungmode, Ann, Ebekozien, Osagie, Gupta, Meenal, Malik, Faisal S., Fogel, Naomi R., Accacha, Siham, Hsieh, Susan, Wilkes, Meredith, Neyman, Anna, Vendrame, Francesco, T1D Exchange Quality Improvement Collaborative

المساهمون: Pediatrics, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Telemedicine, Coronavirus disease 2019, Type 1 diabetes care, Institutional barriers

الوصف: The aim of this study was to describe rates of telemedicine use 18 months after the start of the coronavirus disease 2019 pandemic and to assess the institutional barriers to its implementation for type 1 diabetes care across centers of the T1D Exchange Quality Improvement Collaborative. Observational electronic health record data capturing telemedicine rates from 15 U.S. centers between September 2020 and September 2021 and a survey of 33 centers capturing telemedicine rates and key components of telemedicine were analyzed. A capacity score was developed and summed to a total capacity score and compared with overall telemedicine rates across centers. Telemedicine visits decreased by 17.4% from September 2020 to September 2021. Generally, it was observed that the lower the average telemedicine capacity score, the lower the rate of telemedicine visits. Despite a decline in the utilization of telemedicine 18 months after the start of the pandemic, visit rates were still 20% higher than in the pre-pandemic period. However, there is a need to improve structural components to ensure telemedicine capacity and robust telemedicine utilization.

وصف الملف: application/pdf

العلاقة: Clinical Diabetes; Lee JM, Ospelt E, Noor N, et al. Institutional Barriers to the Successful Implementation of Telemedicine for Type 1 Diabetes Care. Clin Diabetes. 2024;42(1):34-39. doi:10.2337/cd23-0056; https://hdl.handle.net/1805/40970Test

الإتاحة: https://doi.org/10.2337/cd23-0056Test
https://hdl.handle.net/1805/40970Test

المؤلفون: Wu, Vickie, Choleva, Lauryn, Wilkes, Meredith

المصدر: Endocrinology and Metabolism Clinics of North America ; volume 53, issue 1, page 27-38 ; ISSN 0889-8529

مصطلحات موضوعية: Endocrinology, Endocrinology, Diabetes and Metabolism

الإتاحة: https://doi.org/10.1016/j.ecl.2023.09.002Test
https://api.elsevier.com/content/article/PII:S0889852923000610?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0889852923000610?httpAccept=text/plainTest

المؤلفون: Choleva, Lauryn¹ (AUTHOR) lauryn.choleva@mountsinai.org, Wilkes, Meredith¹ (AUTHOR)

المصدر: JCEM Case Reports. Nov2023, Vol. 1 Issue 6, p1-4. 4p.

مصطلحات موضوعية: *CHILD patients, *PAPILLARY carcinoma, *THYROID cancer, *ENDOCRINE glands, *TEENAGE girls, *HEMOLYTIC anemia

مستخلص: β-Thalassemia is characterized by the abnormal synthesis of β-hemoglobin chains resulting in hemolytic anemia. Treatment involves frequent blood transfusions, which leads to deposition of iron in many organs, including endocrine glands. To date, several cases of papillary thyroid cancer (PTC) in patients with β-thalassemia have been reported in the adult literature, but there have been none in pediatrics. Here we report on an female adolescent with β-thalassemia who initially presented for evaluation of secondary amenorrhea. On examination, her thyroid gland was asymmetric, firm in consistency, with palpable lymph nodes along the right anterior cervical chain. A thyroid ultrasound revealed an enlarged right lobe containing 3 focal hypoechoic masses with calcific foci. Biopsy was consistent with PTC. She underwent total thyroidectomy and histological examination confirmed the diagnosis. Her postoperative course was uncomplicated and she was started on replacement therapy with levothyroxine. This is the first reported case of PTC in a pediatric patient with β-thalassemia. The incidence of thyroid cancer in patients with β-thalassemia is currently unknown; however, there may be utility in routine surveillance of this patient population. [ABSTRACT FROM AUTHOR]

المؤلفون: Beliard, Kara, Wilkes, Meredith, Yau, Mabel, Aluf, Anna, Rapaport, Robert

المصدر: Journal of Diabetes ; volume 13, issue 6, page 523-524 ; ISSN 1753-0393 1753-0407

الإتاحة: https://doi.org/10.1111/1753-0407.13173Test

المؤلفون: Gujral, Jasmine, Costin, Gertrude, Khurana, Divya, Yau, Mabel, Wallach, Elizabeth, Romero, Christopher J., Wilkes, Meredith, Sethuram, Swathi, Rapaport, Robert

المصدر: International Journal of Pediatric Endocrinology ; volume 2020, issue 1 ; ISSN 1687-9856

الوصف: Background Antifungals act on fungal sterols structurally similar to human cholesterol. Ketoconazole reversibly suppresses steroidogenesis by inhibiting cytochrome P450 enzymes and interferes with dihydrotestosterone (DHT) activity by binding to the androgen receptor. Hypospadias was reported in infants exposed to nystatin in utero. Case presentation A male infant exposed to antepartum nystatin presented with severe under-undervirilization and transient adrenal corticosteroid abnormalities. He was born in USA at 31 weeks gestation to a mother treated with vaginal Polygynax capsules (nystatin-100,000 international units, neomycin sulphate-35,000 international units and polymyxin B-35,000 international units) for vaginal discharge in the Ivory Coast. She used approximately 60 capsules between the first trimester until delivery. The infant was born with micropenis, chordee, perineo-scrotal hypospadias and bifid scrotum with bilaterally palpable gonads. The karyotype was 46,XY. No Mullerian structures were seen on ultrasound. Serum 17-hydroxyprogesterone (17 OHP) on newborn screening was high (304 ng/ml, normal < 35). Cortisol response to cosyntropin on the 3rd day of life (DOL) was 10 mcg/ml; the subnormal cortisol response may have resulted from prematurity and the predelivery treatment with betamethasone. The elevation of several adrenal corticosteroids was not consistent with any specific enzymatic defect. Hydrocortisone and fludrocortisone were initiated at another hospital for suspected mild glucocorticoid and mineralocorticoid deficiencies. Genetic screening for adrenal and gonadal developmental defects performed when transferred to our care were normal. All medications were gradually discontinued over 5–8 months. Adrenal and testicular responses to cosyntropin and human chorionic gonadotropin (hCG) were normal at 8 months. Conclusions We report severe undervirilization in a 46,XY infant born to a mother treated with prolonged and high dose nystatin during pregnancy. This presentation suggests ...

الإتاحة: https://doi.org/10.1186/s13633-020-00087-1Test

المؤلفون: Marks, Brynn E., Mungmode, Ann, Neyman, Anna, Levin, Laura, Rioles, Nicole, Eng, Donna, Lee, Joyce M., Basina, Marina, Hawah-Jones, Nana, Mann, Elizabeth, O’Malley, Grenye, Wilkes, Meredith, Steenkamp, Devin, Aleppo, Grazia, Accacha, Siham, Ebekozien, Osagie

المساهمون: Pediatrics, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Type 1 diabetes, Learning health systems, Data-sharing, Peer collaboration

الوصف: This article describes the evolution of the Type 1 Diabetes Exchange Quality Improvement Collaborative (T1DX-QI) and provides insight into the development and growth of a successful type 1 diabetes quality improvement (QI) program. Since its inception 8 years ago, the collaborative has expanded to include centers across the United States with varying levels of QI experience, while simultaneously achieving many tangible improvements in type 1 diabetes care. These successes underscore the importance of learning health systems, data-sharing, benchmarking, and peer collaboration as drivers for continuous QI. Future efforts will include recruiting additional small- to medium-sized centers focused on adult care and underserved communities to further the goal of improving care and outcomes for all people living with type 1 diabetes.

وصف الملف: application/pdf

العلاقة: Clinical Diabetes; Marks BE, Mungmode A, Neyman A, et al. Baseline Quality Improvement Capacity of 33 Endocrinology Centers Participating in the T1D Exchange Quality Improvement Collaborative. Clin Diabetes. 2022;41(1):35-44. doi:10.2337/cd22-0071; https://hdl.handle.net/1805/36527Test

الإتاحة: https://doi.org/10.2337/cd22-0071Test
https://hdl.handle.net/1805/36527Test

المؤلفون: Gallagher, Mary Pat, Rompicherla, Saketh, Ebekozien, Osagie, Wilkes, Meredith, Antal, Zoltan, Feuer, Alexis Jamie, Rioles, Nicole, Noor, Nudrat, Gabriel, Liana, O’Malley, Grenye, Golden, Lauren, Alonso, G. Todd, Ospelt, Emma, Odugbesan, Ori, Lyons, Sarah K., Mungmode, Ann, Prahalad, Priya, Clements, Mark, Neyman, Anna, Demeterco-Berggren, Carla, Rapaport, Robert

المساهمون: Pediatrics, School of Medicine

المصدر: Author

مصطلحات موضوعية: COVID-19, type 1 diabetes, SARS-CoV-2

الوصف: Background Outcomes of the novel coronavirus SARS-CoV-2 (COVID-19) have improved throughout the pandemic. However, whether outcomes of COVID-19 in the type 1 diabetes (T1D) population improved over time is unknown. Therefore, we aim to investigate differences in COVID-19 outcomes for patients with T1D in the US. Method We analyzed data collected via a registry of patients with T1D and COVID-19 from 56 sites between April 2020 and January 2021. First, we grouped cases into First Surge (04/09/2020 - 07/31/2020, n=188) and Late Surge (08/01/2020 - 01/31/2021, n=410). Then, we compared outcomes between both groups using descriptive statistics and logistic regression models. Results Adverse outcomes were more frequent during the first surge including Diabetic Ketoacidosis (32% versus 15%, p<0.001), severe hypoglycemia (4% versus 1%, p=0.04) and hospitalization (52% versus 22%, p<0.001). The First surge cases were older (28 +/- 18.8 years versus 18.8 +/- 11.1 years, p<0.001), had higher hemoglobin A1c (HbA1c) levels (Median (IQR): 9.3 (4.0) versus 8.4(2.8), <0.001) and use public insurance (n(%): 107 (57) versus 154 (38), p <0.001). There were five times increased odds of hospitalization for adults (OR 5.01 (2.11,12.63) in the first surge compared to the late surge. Conclusion COVID-19 cases among patients with T1D reported during the first surge had a higher proportion of adverse outcomes than those presented in a later surge.

وصف الملف: application/pdf

العلاقة: Journal of Clinical Outcomes Management; Gallagher MP., et al. (2022). Differences in COVID-19 Outcomes Among Patients With Type 1 Diabetes: First vs Later Surges. Journal of Clinical Outcomes Management, 29(1). https://doi.org/10.12788/jcom.0084Test; https://hdl.handle.net/1805/32031Test

الإتاحة: https://doi.org/10.12788/jcom.0084Test
https://hdl.handle.net/1805/32031Test

المؤلفون: Marks, Brynn E., Mungmode, Ann, Neyman, Anna, Levin, Laura, Rioles, Nicole, Eng, Donna, Lee, Joyce M., Basina, Marina, Hawah-Jones, Nana, Mann, Elizabeth, O'Malley, Grenye, Wilkes, Meredith, Steenkamp, Devin, Aleppo, Grazia, Accacha, Siham, Ebekozien, Osagie

المصدر: Clinical Diabetes; Winter2023, Vol. 41 Issue 1, p35-44, 10p

مصطلحات موضوعية: ENDOCRINOLOGY, TYPE 1 diabetes, DATABASE management, BENCHMARKING (Management), QUALITY assurance, INTERPROFESSIONAL relations, ORGANIZATIONAL effectiveness, HEALTH promotion, EVALUATION

مصطلحات جغرافية: UNITED States

مستخلص: This article describes the evolution of the Type 1 Diabetes Exchange Quality Improvement Collaborative (T1DX-QI) and provides insight into the development and growth of a successful type 1 diabetes quality improvement (QI) program. Since its inception 8 years ago, the collaborative has expanded to include centers across the United States with varying levels of QI experience, while simultaneously achieving many tangible improvements in type 1 diabetes care. These successes underscore the importance of learning health systems, data-sharing, benchmarking, and peer collaboration as drivers for continuous QI. Future efforts will include recruiting additional small- to medium-sized centers focused on adult care and underserved communities to further the goal of improving care and outcomes for all people living with type 1 diabetes. [ABSTRACT FROM AUTHOR]

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المؤلفون: Wilkes, Meredith, Graber, Evan, Rapaport, Robert

المصدر: Journal of Diabetes ; volume 13, issue 6, page 525-526 ; ISSN 1753-0393 1753-0407

الإتاحة: https://doi.org/10.1111/1753-0407.13177Test