المؤلفون: Tian Xie, Xiaoqiao Mo, Yun Liu, Wenhua Jing, Jing Xun, Jiayuan Tu, Xiangda Zhang, Xueshun Chen

المصدر: Expert Review of Respiratory Medicine
article-version (VoR) Version of Record

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), corticosteroids, law.invention, Standard care, Randomized controlled trial, Adrenal Cortex Hormones, law, Internal medicine, medicine, Humans, Immunology and Allergy, Adverse effect, Randomized Controlled Trials as Topic, SARS-CoV-2, business.industry, dose, Public Health, Environmental and Occupational Health, COVID-19, mortality, Respiration, Artificial, adverse events, Corticosteroid therapy, Meta-analysis, Other, business, Meta-Analysis

الوصف: Background To assess the efficacy and safety of corticosteroids in COVID-19 patients compared with standard care or placebo. Methods Electronic databases were searched to identify relevant studies. The mortality, adverse events, and other data from studies were pooled for statistical analysis. Results Ten randomized clinical trials were eligible for inclusion. Corticosteroid treatment in COVID-19 patients did not significantly reduce the risk of death (RR: 0.93; CI: 0.82, 1.05) and the need for mechanical ventilation (RR: 0.82; CI: 0.62, 1.08). No mortality reduction was also observed in the subgroup of patients requiring mechanical ventilation (RR: 0.90; CI: 0.79–1.03). The use of corticosteroids increased mortality in the subgroup of patients not requiring oxygen support (RR: 1.24; CI: 1.00–1.55). The survival benefit was observed in a low dosage of corticosteroids (RR: 0.90; CI: 0.84–0.97) and dexamethasone (RR: 0.90; 95% CI: 0.79–1.04). There was no difference in the rates of adverse events (RR: 1.13; CI: 0.58, 2.20) and secondary infections (RR: 0.87; CI: 0.66, 1.15). Conclusion Corticosteroid treatment did not convincingly improve survival in severe COVID-19 patients. Low-dose dexamethasone could be considered as a drug for the treatment of COVID-19 patients. More high-quality trials are needed to further verify this conclusion. Expert Opinion: The effect of corticosteroids on patient survival highly depended on the selection of the right dosage and type and in a specific subgroup of patients. This meta-analysis, which included more RCTs, evaluated the safety and efficacy in severe COVID-19 patients and analyzed the effects of different types of corticosteroid treatments. Corticosteroid treatment did not convincingly improve survival in severe COVID-19 patients. But the low dose dexamethasone appear to have a role in the management of severe COVID-19 patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8025a1bdf973927577b1bbe3df6a3d57Test
https://doi.org/10.1080/17476348.2021.1983429Test

المؤلفون: Wenhua Jing, Sinan Du, Zexin Zhang

المصدر: Polymers; Volume 10; Issue 4; Pages: 458

مصطلحات موضوعية: concave particle, seeded emulsion polymerization, good solvent, buckling, self-assembly, depletion interaction

الوصف: Shape is an essential property of polymeric particles. Herein, we propose a simple method to synthesize polymeric particles with a well-controlled concave shape. Our method takes advantage of the powerful seeded emulsion polymerization strategy with the well-known principle of “like dissolves like” in solvent chemistry. We first prepared polystyrene (PS) particles with a single dimple by seeded emulsion polymerization. Then the dimpled PS particles were dispersed in a dimethylformamide (DMF) and water mixture. Consequently, the non-crosslinked polymer chains inside the particle were dissolved by DMF, a good solvent for PS, and the PS chains migrated out of the particle, causing buckling of the dimple and enlargement of the concave. By systematic change of the fraction of DMF in the solvent mixture, we changed the amount of the dissolved PS chains, and achieved polymeric particles with precisely tuned degree of concaveness. These concave particles were found to readily self-assemble, driven by polymer-induced depletion interaction. The concave PS particles reported here provide potential building blocks for self-assembled polymeric materials, and new model systems for condensed matter research.

وصف الملف: application/pdf

العلاقة: https://dx.doi.org/10.3390/polym10040458Test

الإتاحة: https://doi.org/10.3390/polym10040458Test

المؤلفون: Wenhua Jing, Fei Xu, Gaojian Chen, Zexin Zhang

المصدر: ACS macro letters. 10(1)

مصطلحات موضوعية: chemistry.chemical_classification, Materials science, Polymers and Plastics, Polymers, digestive, oral, and skin physiology, Organic Chemistry, Composite number, Microcarrier, Polymer, equipment and supplies, complex mixtures, Polymerization, Inorganic Chemistry, Magnetics, chemistry, Colloidal particle, Materials Chemistry, Composite material, Shear flow, human activities

الوصف: We report a simple and effective method to synthesize composite bowl-shaped colloidal particles composed of a magnetic bottom and polymer wall. The bowl-shape is determined by the stirring and the resulting centrifugal force acting on the components during the synthesis. By systematically varying the stirring speed, we have found the lower and upper bounds for the bowl formation. Moreover, the size and thickness of the bowl can be tuned by changing the amount of the TPM monomer during synthesis. Functional groups can be easily introduced in the solidifying step through the polymerization of TPM by adding initiators and functional monomers. For example, by copolymerization of glycomonomer with TPM, bowl-shaped particles with biological activity can be obtained. In addition, such composite particles can be further modified to produce micromotors with well-controlled motions.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89c1923a83e0a063617bbf4ae3d2ad9Test
https://pubmed.ncbi.nlm.nih.gov/35548979Test

المؤلفون: Wenhua, Jing, Dandan, Guo, Zunxi, Ning, Ye, Yang, Ting, Liu, Miao, Wang, Huiyuan, Gao

المصدر: Bioorganic Chemistry. 129:106193

مصطلحات موضوعية: Methicillin-Resistant Staphylococcus aureus, Caesalpinia, Organic Chemistry, Drug Discovery, Glycosides, Microbial Sensitivity Tests, Molecular Biology, Biochemistry, Anti-Bacterial Agents

الوصف: Anti-virulence strategy represents an emerging alternative strategy in the war against increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) due to its milder selection pressure on bacterial resistance. Sortase A (SrtA), as an important virulence factor, is a membrane-localized cysteine transpeptidase which anchors cell surface proteins to the cell wall. Natural products in medicinal plants are the source of targeting bacterial virulence factors. Here, we found polyphenolic glycosides (1-15), including thirteen new derivatives isolated from the stems of Caesalpinia cucullata, exhibited weak to moderate SrtA inhibitory activity without affecting the growth of MRSA, and compound 7 (53.7 % inhibition at 100 μM) was superior to the positive control curcumin. Meanwhile, compounds 2, 4 and 8 could effectively reduce the dose of ceftiofur in combination in vitro with fractional inhibitory concentration index (FICI) ranging from 0.188 to 0.375, which meant polyphenolic glycosides have got antibacterial activity with different ways. Here, we reported all new compounds structures determined by spectroscopy methods and their antibacterial activities, together, the relationship between structures with the inhibitory efficiency. The results indicated that polyphenolic glycosides could be used as promising therapeutic agents to prevent resistance development for S. aureus infections.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ac28e5fa67625afa7446b8073d361bTest
https://doi.org/10.1016/j.bioorg.2022.106193Test

المؤلفون: Huiyuan Gao, Xinxin Zhang, Liping Long, Hongxia Zhou, Ying Wang, Wenhua Jing, Maoqiang Yang

المصدر: Fitoterapia. 134:226-249

مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Caesalpinia, biology, 010405 organic chemistry, Chemistry, Stereochemistry, Phytochemicals, General Medicine, biology.organism_classification, 01 natural sciences, Biosynthetic Pathways, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Broad spectrum, Biosynthesis, Biological property, Drug Discovery, Diterpenes, Pharmacophore, Lactone, Tricyclic

الوصف: Natural products, especially diterpenoids, are enriched with numerous compounds with a broad spectrum of therapeutic indications, suggesting that functional moieties serve as a core pharmacophore. Cassane diterpenoids (CAs), as the main and characteristic constituents of medical plants in the Caesalpinia genus, have been widely studied due to their bioactivities, and >450 compounds have been reported since the 1960s, including 283 compounds that have been reported in the past decade. There are five main types of structures for these compounds: tricyclic cassane diterpenoids with a fused furan ring (I) or butanolide lactone (II), tricyclic cassane diterpenoids (III), norcassane diterpenoids (IV), and other types (V). CAs derivatives have a wide range of biological properties, including anti-inflammatory, antimalarial, antitumour, antiviral, antimicrobial, antinociceptive, and antioxidant effects. This review highlights the role of the biosynthetic pathway, including those with abnormal skeletons, as well as advances in structure, pharmacological activities and primarily mechanisms of CAs obtained from the Caesalpinia genus. The findings herein provide new insights into the development of this kind of natural diterpenoids.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c761a55821efe025d582264a69c8edTest
https://doi.org/10.1016/j.fitote.2019.02.023Test

المؤلفون: Yiren Yang, Huiyuan Gao, Shizhou Qi, Shen Xueying, Ting Liu, Miao Wang, Ying Wang, Wenhua Jing, X. Li

المصدر: Bioorganic chemistry. 96

مصطلحات موضوعية: Circular dichroism, Stereochemistry, Phosphodiesterase Inhibitors, Anti-Inflammatory Agents, 01 natural sciences, Biochemistry, Drug Discovery, Molecular Biology, Caesalpinia, biology, Molecular Structure, 010405 organic chemistry, Chemistry, Spectrum Analysis, Organic Chemistry, NF-kappa B, Phosphodiesterase, Carbon-13 NMR, biology.organism_classification, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Caesalpinia bonduc, Docking (molecular), Proton NMR, Target protein, Diterpenes, Two-dimensional nuclear magnetic resonance spectroscopy

الوصف: In this paper, chemical investigation on the chloroform soluble fraction of seed kernels of Caesalpinia bonduc resulted in the isolation of five new cassane diterpenoids: norcaesalpinin O (1), norcaesalpinin P (2), caesalpinin MQ (3), caesall O/P (4/5) and seven known compounds (6–12). Compounds structures were elucidated by 1H NMR, 13C NMR, 2D NMR, HR-MS and ECD (electronic circular dichroism) spectral analysis. The characters for new compounds with the presence of an aromatized C ring or demethyl group at C-17 position in the structures were found. By means of bioactive screenings, the inhibitory effect on type-4 phosphodiesterase (PDE4, the target protein of asthma disease) and nuclear factor-kappa B (NF-κB) expression were valued. Compound 1 was found to exhibit moderate inhibitory activity on PDE4 and much better binding affinity than other structures by docking studies for interaction analyzing. Compounds 6, 10 and 11 displayed considerable inhibitory strength against NF-κB expression with inhibitory ratio 48.6%, 42.9% and 37.1% at 10 µM, respectively. The isolation of cassane-type diterpenoids with anti-inflammation activity from C. bonduc implied that this plant might be a good source for anti-inflammation agents finding.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8685efd178c32ff77fb857b397fb9fTest
https://pubmed.ncbi.nlm.nih.gov/31962203Test

المؤلفون: Miao Wang, Wenhua Jing, Xinxin Zhang, Liping Long, Yue Jin, Ting Liu, Kai-Ru Song, Yiren Yang, Huiyuan Gao, Shizhou Qi

المصدر: Bioorganic Chemistry. 107:104628

مصطلحات موضوعية: Leptopus, Magnetic Resonance Spectroscopy, Cell Survival, Propanols, Malpighiales, Molecular Conformation, 01 natural sciences, Biochemistry, HeLa, Structure-Activity Relationship, Genus, Cell Line, Tumor, Drug Discovery, Humans, Medicinal plants, Cytotoxicity, Molecular Biology, Plants, Medicinal, biology, Traditional medicine, Phenylpropanoid, Plant Extracts, 010405 organic chemistry, Chemistry, Organic Chemistry, Euphorbiaceae, food and beverages, biology.organism_classification, Antineoplastic Agents, Phytogenic, Triterpenes, 0104 chemical sciences, Plant Leaves, 010404 medicinal & biomolecular chemistry, Phytochemical, Drug Screening Assays, Antitumor

الوصف: Most of Euphorbiaceae plants are considered as folk medicinal plants because of their various pharmacological effects. However, there are eight Leptopus genus plants which belong to Euphorbiaceae have never be investigated. Thus, four Leptopus genus plants were collected to study their chemical constituents and pharmacological activities. In the present work, the cytotoxicities of the extracts of four Leptopus genus plants were evaluated before phytochemical experiments. And nine new phenylpropanoid-conjugated pentacyclic triterpenoids, along with twenty-two known compounds were isolated from the whole plants of Leptopus lolonum. The structures of these new compounds were unequivocally elucidated by HRESIMS and 1D/2D NMR data. All triterpenoids were screened for their cytotoxicities against four cancer cell lines including HepG2, MCF-7, A549 and HeLa. Among these isolates, the triterpenoid with a phenylpropanoid unit showed increasing cytotoxicity on cancer cells, which suggested the importance of the phenylpropanoid moiety.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0493412ae402b74364737ff175c7f4Test
https://doi.org/10.1016/j.bioorg.2021.104628Test

المؤلفون: Ying Wang, Baichun Hu, Yusheng Peng, Xin Xiong, Wenhua Jing, Jian Wang, Huiyuan Gao

المصدر: Journal of Chemical Information & Modeling; May2019, Vol. 59 Issue 5, p2309-2323, 15p