المؤلفون: Michael S. Lawrence, Kwok-Kin Wong, D. R. Mani, Xiaohong Zhang, Heidi Greulich, Tzu-Hsiu Chen, Bethany Kaplan, Gad Getz, Alice H. Berger, Michael J. Eck, Se-Hoon Lee, Jacob D. Jaffe, Lauren Ambrogio, David A. Frank, Philipp Mertins, Wendy Winckler, Shantanu Banerji, Steven A. Carr, Jinghui Zhang, Matthew Meyerson, Nam Pho, Marcin Imielinski, William C. Hahn, Cai-Hong Yun, Sarah R. Walker, Jeonghee Cho, Kumiko E. Tanaka, Rachel G. Liao

المصدر: Proceedings of the National Academy of Sciences. 109:14476-14481

مصطلحات موضوعية: Lung Neoplasms, Receptor, ErbB-2, Immunoblotting, Adenocarcinoma of Lung, Adenocarcinoma, SH2 domain, Tropomyosin receptor kinase C, Receptor tyrosine kinase, Mice, chemistry.chemical_compound, Cell Movement, Tandem Mass Spectrometry, Animals, Cloning, Molecular, Phosphorylation, Alleles, DNA Primers, Multidisciplinary, biology, Tyrosine phosphorylation, Biological Sciences, Molecular biology, Protein Structure, Tertiary, Retroviridae, chemistry, Mutation, ROR1, NIH 3T3 Cells, biology.protein, Dimerization, Tyrosine kinase, Platelet-derived growth factor receptor, Proto-oncogene tyrosine-protein kinase Src

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c515f2e4b7375040a3b03368ee396169Test
https://doi.org/10.1073/pnas.1203201109Test

المؤلفون: Kathy Stirrups, Inga Prokopenko, Jeanette Erdmann, Jun Ding, Serena Sanna, Patricia B. Munroe, Ramaiah Nagaraja, Antonella Mulas, Christian Fuchsberger, Cameron D. Palmer, Simon C. Potter, Ruth J. F. Loos, Nicole Soranzo, Tuomas O. Kilpeläinen, Michael Boehnke, Sekar Kathiresan, Francesco Cucca, David Altshuler, Hyun Min Kang, Melissa Parkin, Neil Robertson, Heribert Schunkert, Timothy M. Frayling, Gonçalo R. Abecasis, Arne Pfeufer, Toby Johnson, Joshua C. Randall, Mark I. McCarthy, Joel N. Hirschhorn, Nilesh J. Samani, Anne U. Jackson, Tanya M. Teslovich, Eleanor Wheeler, Benjamin F. Voight, Yun Li, Carlo Sidore, Panagiotis Deloukas, N P Burtt, Nigel W. Rayner, Richa Saxena, Peter S. Chines, Jared Maguire, Wendy Winckler, Cecilia M. Lindgren, Andrew P. Morris, Iris M. Heid, Christopher Newton-Cheh, Inês Barroso, Elizabeth K. Speliotes

المصدر: PLoS Genet. 8:e1002793 (2012)
PLoS Genetics, Vol 8, Iss 8, p e1002793 (2012)
PLoS Genetics

مصطلحات موضوعية: Cancer Research, Genotyping Techniques, Genome-wide association study, 030204 cardiovascular system & hematology, QH426-470, Cardiovascular, 0302 clinical medicine, Endocrinology, Gene Frequency, Genetics (clinical), Oligonucleotide Array Sequence Analysis, 2. Zero hunger, Genetics, 0303 health sciences, Anthropometry, Statistics, 3. Good health, Phenotype, Cardiovascular Diseases, Medicine, Research Article, Genotype, Quantitative Trait Loci, Genomics, Single-nucleotide polymorphism, Quantitative trait locus, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, SNP, Humans, Metabolomics, Molecular Biology, Genotyping, Ecology, Evolution, Behavior and Systematics, Alleles, 030304 developmental biology, Genetic association, Diabetic Endocrinology, 0604 Genetics, Genome, Human, Human Genetics, Diabetes Mellitus Type 2, Diabetes Mellitus, Type 2, Metabolic Disorders, Mathematics, Genome-Wide Association Study, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b37c5626e6089342d54f61300353c4Test
https://ora.ox.ac.uk/objects/uuid:00d09741-e53b-4d8b-9852-aae6b9fc0ab7Test

المؤلفون: Carleton Goold, Nadia Solovieff, William B. Dobyns, Richard A. Gibbs, Elisa Rahikkala, Jonathan D. Biag, Colleen F. Macmurdo, Eric Boerwinkle, Sonya A. Gunter, Sandra L. Poliachik, Brian H.Y. Chung, Christine D. Wilson, Evan A. Boyle, Scott Mahan, Robert F. Hevner, Russell P. Saneto, Katta M. Girisha, Rebecca Leary, Wendy Winckler, Molly Weaver, Sharon S. McDaniel, Jay Shendure, Laura A. Jansen, Shanming Liu, Shalini N. Jhangiani, Andrew E. Timms, William R. Sellers, Gisele Ishak, Michael Morrissey, Michael O. Dorschner, Donna M. Muzny, Catarina D. Campbell, Jeffrey G. Ojemann, Beth Martin, Edward J. Novotny, Renzo Guerrini, Ghayda M. Mirzaa, Leon Murphy, Valerio Conti, Jonathan A. Bernstein, James R. Lupski, Sarah Collins, Suchithra Menon, Carissa Olds, Kit San Yeung

المصدر: JAMA neurology. 73(7)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Hemimegalencephaly, Pathology, medicine.medical_specialty, Adolescent, Developmental Disabilities, Neurogenetics, Nerve Tissue Proteins, Biology, Mechanistic Target of Rapamycin Complex 1, medicine.disease_cause, 03 medical and health sciences, Epilepsy, Young Adult, 0302 clinical medicine, medicine, Animals, Humans, Megalencephaly, Amino Acids, Child, Exome sequencing, Cells, Cultured, Genetic Association Studies, Retrospective Studies, Cerebral Cortex, Neurons, Mutation, Mosaicism, TOR Serine-Threonine Kinases, Macrocephaly, Cortical dysplasia, medicine.disease, Embryo, Mammalian, Rats, Malformations of Cortical Development, 030104 developmental biology, Gene Expression Regulation, Child, Preschool, Multiprotein Complexes, Intercellular Signaling Peptides and Proteins, Female, Neurology (clinical), medicine.symptom, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7d0a49983a07e254d5281c050e787fTest
https://pubmed.ncbi.nlm.nih.gov/27158974Test

المؤلفون: Nicolas Stransky, Guo Chen, Jeffrey E. Gershenwald, Daniel Auclair, Gad Getz, Andrey Sivachenko, Michael S. Noble, Daniel DiCara, Katherine Stemke-Hale, Eran Hodis, Eric S. Lander, Robert C. Onofrio, Dirk Schadendorf, Kristin G. Ardlie, Nikhil Wagle, Gregory V. Kryukov, Liren Li, Donald L. Morton, Stefan T. Arold, Douglas Voet, Kristian Cibulskis, Alex H. Ramos, Elizabeth Nickerson, Levi A. Garraway, Lynda Chin, Michael A. Davies, Wendy Winckler, Ian R. Watson, Kelly Chong, John E. Ladbury, Matthew Meyerson, Stacey Gabriel, Stephan N. Wagner, Jean Philippe Theurillat, Dave S.B. Hoon, Marcin Imielinski, Michael S. Lawrence, Jennifer A. Wargo, Chelsea S. Place, Gordon Saksena

المصدر: Cell. 150:251-263

مصطلحات موضوعية: Models, Molecular, Proto-Oncogene Proteins B-raf, rac1 GTP-Binding Protein, Neuroblastoma RAS viral oncogene homolog, Ultraviolet Rays, Molecular Sequence Data, Medizin, Mutagenesis (molecular biology technique), RAC1, Genome-wide association study, Biology, medicine.disease_cause, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Exome, Amino Acid Sequence, Melanoma, Gene, Cells, Cultured, 030304 developmental biology, Genetics, 0303 health sciences, Mutation, Biochemistry, Genetics and Molecular Biology(all), medicine.disease, Mutagenesis, 030220 oncology & carcinogenesis, Melanocytes, Sequence Alignment, Genome-Wide Association Study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e12ca56ac7b344bbb6df731bb7e992Test
https://doi.org/10.1016/j.cell.2012.06.024Test

المؤلفون: Joseph Thibault, Michael F. Berger, Markus Warmuth, Adam A. Margolin, Laura E. MacConaill, Scott Mahan, Vivien W. Chan, Levi A. Garraway, Vic E. Myer, Christine D. Wilson, Stacey Gabriel, Jill P. Mesirov, Dmitriy Sonkin, Eva Bric-Furlong, Aaron Shipway, Wendy Winckler, Anupama Reddy, Adam Korejwa, Carrie Sougnez, Felipa A. Mapa, Judit Jané-Valbuena, Gad Getz, John Monahan, Peter Aspesi, Kristin G. Ardlie, Barbara L. Weber, Jianjun Yu, Nicolas Stransky, Michael R. Reich, Ted Liefeld, Emanuele Palescandolo, Michael D. Jones, Charlie Hatton, William R. Sellers, Lauren Murray, Melanie de Silva, Paula Morais, Michael Morrissey, Robert Schlegel, Jordi Barretina, Joseph Lehar, Jeffrey A. Porter, Supriya Gupta, Nanxin Li, Robert C. Onofrio, Gregory V. Kryukov, Pichai Raman, Matthew Meyerson, Jennifer L. Harris, Guoying K. Yu, Jill Cheng, Kavitha Venkatesan, Kalpana Jagtap, Jodi Meltzer, Peter Finan, Sungjoon Kim, Li Wang, Ingo H. Engels, Giordano Caponigro, Todd R. Golub, Manway Liu

المصدر: Nature

مصطلحات موضوعية: Encyclopedias as Topic, Databases, Factual, Topoisomerase Inhibitors, medicine.drug_class, Plasma Cells, Antineoplastic Agents, Genomics, Computational biology, Biology, Bioinformatics, Models, Biological, Article, Receptor, IGF Type 1, Cell Line, Tumor, Neoplasms, medicine, Chromosomes, Human, Humans, Cell Lineage, Precision Medicine, Mitogen-Activated Protein Kinase Kinases, Clinical Trials as Topic, Multidisciplinary, Massive parallel sequencing, Genome, Human, Drug discovery, business.industry, Gene Expression Profiling, Cancer, Sequence Analysis, DNA, medicine.disease, Human genetics, Gene Expression Regulation, Neoplastic, Gene expression profiling, Genes, ras, Receptors, Aryl Hydrocarbon, Pharmacogenetics, Personalized medicine, Drug Screening Assays, Antitumor, business, Topoisomerase inhibitor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea2b343d8b7c92d22e0d943912cb141Test
http://europepmc.org/articles/PMC3320027Test

المؤلفون: Elisabeth Brambilla, Holger Moch, Robert C. Onofrio, Juergen Wolf, Roman K. Thomas, Hannie Sietsma, Nathanael S. Gray, Odd Terje Brustugun, Åslaug Helland, Ming-Sound Tsao, Erich Stoelben, Xianming Deng, Bruce E. Johnson, Jianming Zhang, Jeffrey R. Simard, Joachim H. Clement, Daniel Rauh, Adam J. Bass, Christian Brambilla, Helga B. Salvesen, Wenjun Zhou, Alex Soltermann, Kwok-Kin Wong, Pasi A. Jänne, Michael J. Eck, Brittany Woods, Sascha Ansén, Jeonghee Cho, Johannes M. Heuckmann, Harry J.M. Groen, Mirjam Koker, Wenchu Lin, Amit Dutt, Iver Petersen, Heidi Greulich, Chunxiao Xu, Silvia Querings, Eric B. Haura, Martin L. Sos, Stefanie Heynck, Wendy Winckler, Peter S. Hammerman, Philippe Lorimier, Matthew Meyerson, Franziska Gabler, Megan Hanna, Lear E. Brace, Alex H. Ramos, Thomas Zander, Sang Min Lim, Charlie Hatton, Michael S. Lawrence, Martin Peifer, Danila Seidel, Frauke Leenders, Wim Timens, David G. Beer

المساهمون: University of Zurich, Meyerson, M, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Research Institute for Asthma and COPD (GRIAC)

المصدر: Cancer discovery, 1(1), 78-89. AMER ASSOC CANCER RESEARCH

مصطلحات موضوعية: Lung Neoplasms, Mice, Nude, DISCOIDIN DOMAIN RECEPTORS, 610 Medicine & health, Biology, IMATINIB, GEFITINIB, ACTIVATION, Erlotinib Hydrochloride, Mice, Gefitinib, Carcinoma, Non-Small-Cell Lung, 10049 Institute of Pathology and Molecular Pathology, hemic and lymphatic diseases, medicine, Animals, Humans, Phosphorylation, Protein Kinase Inhibitors, DASATINIB, IDENTIFICATION, PROLIFERATION, Receptor Protein-Tyrosine Kinases, INHIBITOR, Cancer, Imatinib, medicine.disease, COLLAGEN, Dasatinib, Thiazoles, stomatognathic diseases, Cell Transformation, Neoplastic, Pyrimidines, src-Family Kinases, Oncology, Receptors, Mitogen, Mutation, NIH 3T3 Cells, Quinazolines, Cancer research, Adenocarcinoma, 2730 Oncology, Erlotinib, SRC, medicine.drug, Proto-oncogene tyrosine-protein kinase Src

وصف الملف: Hammerman_CancDisc_2011.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb428483e6dd644a6ad34119a1ad051Test
https://doi.org/10.1158/2159-8274.cd-11-0005Test

المؤلفون: Olufunmilayo I. Olopade, Jason J. Pitt, Dezheng Huo, Wendy Winckler, Markus Riester, Yonglan Zheng, Dominic Fitzgerald, Kevin P. White, John Obafunwa, Abiodun Popoola, Ayodele Sanni, Toshio F. Yoshimatsu, Nasiru Ibrahim, Adeyinka G. Falusi, Shengfeng Wang, Temidayo O. Ogundiran, Olayiwola Oluwasola, Oladosu Ojengbede, Guimin Gao, Jordi Barretina, Chinedum P. Babalola

المصدر: Cancer Research. 78:287-287

مصطلحات موضوعية: APOBEC, Genetics, Cancer Research, Single-nucleotide polymorphism, Heritability, Biology, medicine.disease, medicine.disease_cause, Germline, Breast cancer, Germline mutation, Oncology, medicine, Carcinogenesis, SNP array

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::bf50baffaf017ea4ae359062b9a9a3a0Test
https://doi.org/10.1158/1538-7445.am2018-287Test

المؤلفون: Megan Hanna, Whei F. Moriarty, Craig H. Mermel, Levi A. Garraway, Jürgen Wolf, Adi F. Gazdar, Mirjam Koker, Heidi Greulich, John D. Minna, Tzu Hsiu Chen, Rameen Beroukhim, Jörg Rahnenführer, Takeshi Shimamura, Wendy Winckler, Martin L. Sos, Martin Peifer, Peter Frommolt, Isabel Stückrath, Derek Y. Chiang, Kathrin Michel, Stefanie Heynck, Roland T. Ullrich, Gad Getz, Matthew Meyerson, Stefanie Fischer, Roman K. Thomas, Florian Fischer, Daniel Rauh, Laura Tolosi, William M. Lin, Martin Hellmich, Luc Girard, Danan Li, Barbara A. Weir, Roeland Verhaak, Jordi Barretina, Kinjal Shah, Jonathan Weiss, Michael Peyton, Kwok-Kin Wong, Thomas Zander, Geoffrey I. Shapiro, Thomas LaFramboise

المصدر: Journal of Clinical Investigation. 119:1727-1740

مصطلحات موضوعية: Models, Molecular, Drug Evaluation, Preclinical, Viral Oncogene, Antineoplastic Agents, Biology, medicine.disease_cause, Substrate Specificity, Hsp90 inhibitor, Mice, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, medicine, Animals, Humans, Mutation, ABL, Oncogene, Gene Expression Profiling, Cancer, General Medicine, medicine.disease, Magnetic Resonance Imaging, Protein Structure, Tertiary, ErbB Receptors, Dasatinib, Phenotype, Technical Advance, Cancer research, KRAS, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53549a9be5b265c7dcba9a3ab5bb3fffTest
https://doi.org/10.1172/jci37127Test

المؤلفون: Wendy Winckler, Roman K. Thomas, Thomas LaFramboise

المصدر: Bioinformatics. 25:722-728

مصطلحات موضوعية: Statistics and Probability, Gene Dosage, Copy number analysis, Computational biology, Biology, Biochemistry, Genome, Neoplasms, Humans, Sensitivity (control systems), Autistic Disorder, Statistical theory, Molecular Biology, Oligonucleotide Array Sequence Analysis, Genetics, Hybridization probe, Rank (computer programming), Nonparametric statistics, Computational Biology, Genetic Variation, DNA, Original Papers, Computer Science Applications, Computational Mathematics, Computational Theory and Mathematics, Comparative genomic hybridization

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119e9a0ae2181e53119e10030a11b536Test
https://doi.org/10.1093/bioinformatics/btp063Test

المؤلفون: Evgeny Sviridov, Vadim Ustyansky, Damir Dosymbekov, Tatiana Serebryiskaya, Laura E. MacConaill, Laura Mulvey, Valery Kaznacheev, Zoltan Dezso, Jun Yao, Tatiana Nikolskaya, Kornelia Polyak, Yuri Nikolsky, Wendy Winckler

المصدر: Cancer Research. 68:9532-9540

مصطلحات موضوعية: Genetics, Cancer Research, Mutation, Proteome, Estrogen Receptor alpha, Gene Amplification, Breast Neoplasms, Single-nucleotide polymorphism, Biology, Amplicon, medicine.disease_cause, Genome, Phenotype, Gene Expression Regulation, Neoplastic, Genes, jun, Oncology, Cell Line, Tumor, Gene duplication, medicine, Humans, Female, Transcription factor, Gene

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c8c61964eb28da4c158326935a0d40Test
https://doi.org/10.1158/0008-5472.can-08-3082Test