المؤلفون: Potok, Weronika, van der Groen, Onno, Sivachelvam, Sahana, Bächinger, Marc, Fröhlich, Flavio, Kish, Laszlo B., Wenderoth, Nicole

المصدر: Journal of Neurophysiology 130, 458-473, 2023

مصطلحات موضوعية: Electrical Engineering and Systems Science - Signal Processing, Quantitative Biology - Neurons and Cognition

الوصف: Stochastic Resonance (SR) describes a phenomenon where an additive noise (stochastic carrier-wave) enhances the signal transmission in a nonlinear system. In the nervous system, nonlinear properties are present from the level of single ion channels all the way to perception and appear to support the emergence of SR. For example, SR has been repeatedly demonstrated for visual detection tasks, also by adding noise directly to cortical areas via transcranial random noise stimulation (tRNS). When dealing with nonlinear physical systems, it has been suggested that resonance can be induced not only by adding stochastic signals (i.e., noise) but also by adding a large class of signals that are not stochastic in nature which cause "deterministic amplitude resonance" (DAR). Here we mathematically show that high-frequency, deterministic, periodic signals can yield resonance-like effects with linear transfer and infinite signal-to-noise ratio at the output. We tested this prediction empirically and investigated whether non-random, high-frequency, transcranial alternating current stimulation applied to visual cortex could induce resonance-like effects and enhance performance of a visual detection task. We demonstrated in 28 participants that applying 80 Hz triangular-waves or sine-waves with tACS reduced visual contrast detection threshold for optimal brain stimulation intensities. The influence of tACS on contrast sensitivity was equally effective to tRNS-induced modulation, demonstrating that both tACS and tRNS can reduce contrast detection thresholds. Our findings suggest that a resonance-like mechanism can also emerge when deterministic electrical waveforms are applied via tACS.
Comment: accepted for publication in J. Neurophysiology

الوصول الحر: http://arxiv.org/abs/2310.03763Test

المؤلفون: Heimhofer, Caroline, Koblitz, Susanne, Bächinger, Marc, Wenderoth, Nicole

المصدر: Current Issues in Sport Science (CISS); Bd. 9 Nr. 2 (2024): 15th Annual Conference of the Swiss Society of Sports Sciences, February 7 and 8, 2024, at ETH Zurich: Approaches in Sports Sciences: Today and Tomorrow. Book of Abstracts; 048 ; Current Issues in Sport Science (CISS); Vol. 9 No. 2 (2024): 15th Annual Conference of the Swiss Society of Sports Sciences, February 7 and 8, 2024, at ETH Zurich: Approaches in Sports Sciences: Today and Tomorrow. Book of Abstracts; 048 ; 2414-6641

مصطلحات موضوعية: motor fatigability, functional MRI

الوصف: Introduction Motor fatigability is a limiting factor in any kind of setting, in which physical performance is required. Motor fatigability can be quantified through the decrease in movement speed, when low-force movements are performed repeatedly with maximal speed. In this study, we measure motor fatigability in healthy participants through fast finger tapping for 30s. Previous research has shown that the decrease in movement speed, also called motor slowing, is associated with a rise in brain activity, a reduction in surround inhibition in the primary sensorimotor cortex (SM1), and an increase in co-activation of antagonistic muscle groups involved in the movement (Bächinger et al., 2019). However, it remains an open question of whether motor slowing and the associated release of inhibition causes a reduction of signal-to-noise ratio for movement-specific information. Here, we aim to answer this question by assessing finger representations using representational similarity analysis (RSA) when participants perform fatiguing tapping with either the index or middle finger. We hypothesized that a reduction of movement-specific information would be associated with the index and middle finger representations in SM1 getting “blurred” over time due to a gradual break-down of surround inhibition. Thus, if the signal-to-noise ratio of movement-specific information decreases in parallel with motor slowing, we would expect finger representations to become more overlapping. Vice-versa, if the signal-to-noise ratio of movement-specific information increases despite motor slowing, we would expect sharper finger representation. Methods 26 healthy young participants performed a motor slowing task during functional MRI. The participants performed 30s of maximal speed finger tapping with the index and the middle finger, alternating between trials. To quantify motor slowing from the behaviour, we performed a linear regression analysis. For the first-level general linear model of the fMRI data, the fingers were regressed ...

العلاقة: https://ciss-journal.org/article/view/10888Test

الإتاحة: https://doi.org/10.36950/2024.2ciss048Test
https://ciss-journal.org/article/view/10888Test

المؤلفون: Huwiler, Stephanie, Carro-Domínguez, Manuel, Stich, Fabia, Sala, Rossella, Aziri, Florent, Trippel, Anna, Ryf, Tabea, Markendorf, Susanne, Niederseer, David, Bohm, Philipp, Stoll, Gloria, Laubscher, Lily, Thevan, Jeivicaa, Spengler, Christina M., Gawinecka, Joanna, Osto, Elena, Huber, Reto, Wenderoth, Nicole, Schmied, Christian, Lustenberger, Caroline

المصدر: Current Issues in Sport Science (CISS); Bd. 9 Nr. 2 (2024): 15th Annual Conference of the Swiss Society of Sports Sciences, February 7 and 8, 2024, at ETH Zurich: Approaches in Sports Sciences: Today and Tomorrow. Book of Abstracts; 004 ; Current Issues in Sport Science (CISS); Vol. 9 No. 2 (2024): 15th Annual Conference of the Swiss Society of Sports Sciences, February 7 and 8, 2024, at ETH Zurich: Approaches in Sports Sciences: Today and Tomorrow. Book of Abstracts; 004 ; 2414-6641

مصطلحات موضوعية: sleep, left-ventricular function, slow waves, auditory stimulation

الوصف: Introduction The role of sleep in cardiovascular health, particularly the impact of deep non-rapid eye movement (NREM) sleep, is gaining interest in the prevention of cardiovascular diseases (Grandner et al., 2016). Essentially slow waves, prominent brain oscillations during deep sleep, seem to represent an important cardiovascular recovery process for the human body. However, to date, the specific mechanisms through which sleep affects cardiovascular function and whether slow waves accelerate recovery remain elusive. Methods Here, we explored the role of slow waves in promoting cardiovascular function. In this randomized, cross-over trial involving 18 healthy male participants (Huwiler et al., 2023), we investigated how experimentally enhancing slow waves via auditory stimulation (Huwiler et al., 2022) impacts cardiovascular dynamics during sleep and next-day cardiac function, assessed via an echocardiography. All participants underwent three experimental nights including two conditions for slow wave enhancement and one SHAM control condition while brain oscillatory, blood pressure, and cardiac dynamics were continuously measured during sleep. Results Using a linear mixed-effect model approach, we found auditory stimulation to significantly increase slow wave activity (F(2, 33.095) = 11.397, p < 0.001) during times of stimulation. This slow wave enhancement coincided with a dynamic cardiovascular activation, indicated through short increases in blood pressure and a biphasic heart rate response. After sleep, we found a significant increase in general longitudinal strain (F(2, 34) = 81.17, p < 0.001), an increase in left-ventricular ejection fraction (F(2, 34) = 4.55, p = 0.018), and a decrease in E/e’ ratio (F(2, 34) = 3.38, p = 0.046) for both slow wave stimulation conditions compared to SHAM. Discussion/Conclusion We show that slow wave stimulation induces a cardiovascular activation response possibly related to increasing cardiovascular stability during sleep (De Zambotti et al., 2016). Moreover, we ...

العلاقة: https://ciss-journal.org/article/view/10820Test

الإتاحة: https://doi.org/10.36950/2024.2ciss004Test
https://ciss-journal.org/article/view/10820Test

المؤلفون: Meissner, Sarah Nadine, Bächinger, Marc, Kikkert, Sanne, Imhof, Jenny, Missura, Silvia, id_orcid:0 000-0001-7698-0875, Dominguez, Manuel Carro, Wenderoth, Nicole

المصدر: Nature Human Behaviour, 8 (1)

الوصف: The brain's arousal state is controlled by several neuromodulatory nuclei known to substantially influence cognition and mental well-being. Here we investigate whether human participants can gain volitional control of their arousal state using a pupil-based biofeedback approach. Our approach inverts a mechanism suggested by previous literature that links activity of the locus coeruleus, one of the key regulators of central arousal and pupil dynamics. We show that pupil-based biofeedback enables participants to acquire volitional control of pupil size. Applying pupil self-regulation systematically modulates activity of the locus coeruleus and other brainstem structures involved in arousal control. Furthermore, it modulates cardiovascular measures such as heart rate, and behavioural and psychophysiological responses during an oddball task. We provide evidence that pupil-based biofeedback makes the brain's arousal system accessible to volitional control, a finding that has tremendous potential for translation to behavioural and clinical applications across various domains, including stress-related and anxiety disorders. ; ISSN:2397-3374

وصف الملف: application/application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/wos/001098428400004; info:eu-repo/grantAgreement/SNF/Spark/190836; info:eu-repo/grantAgreement/SNF/Projekte Lebenswissenschaften/207719; info:eu-repo/grantAgreement/SNF/Bridge - Discovery/203606; http://hdl.handle.net/20.500.11850/644577Test

الإتاحة: https://doi.org/20.500.11850/644577Test
https://doi.org/10.3929/ethz-b-000644577Test
https://doi.org/10.1038/s41562-023-01729-zTest
https://hdl.handle.net/20.500.11850/644577Test

المؤلفون: Lin, Hao-Ping, Xu, Yang, Zhang, Xue, Woolley, Daniel, Zhao, Lina, Liang, Weidi, Huang, Mengdi, Cheng, Hsiao-ju, Zhang, Lixin, Wenderoth, Nicole

المصدر: Journal of NeuroEngineering and Rehabilitation, 21 (1)

مصطلحات موضوعية: EMG, Stroke, Neurofeedback, Mobile

الوصف: Background: Effective stroke rehabilitation requires high-dose, repetitive-task training, especially during the early recovery phase. However, the usability of upper-limb rehabilitation technology in acute and subacute stroke survivors remains relatively unexplored. In this study, we introduce subacute stroke survivors to MyoGuide, a mobile training platform that employs surface electromyography (sEMG)-guided neurofeedback training that specifically targets wrist extension. Notably, the study emphasizes evaluating the platform’s usability within clinical contexts. Methods: Seven subacute post-stroke patients (1 female, mean age 53.7 years, mean time post-stroke 58.9 days, mean duration per training session 48.9 min) and three therapists (one for eligibility screening, two for conducting training) participated in the study. Participants underwent ten days of supervised one-on-one wrist extension training with MyoGuide, which encompassed calibration, stability assessment, and dynamic tasks. All training records including the Level of Difficulty (LoD) and Stability Assessment Scores were recorded within the application. Usability was assessed through the System Usability Scale (SUS) and participants’ willingness to continue home-based training was gauged through a self-developed survey post-training. Therapists also documented the daily performance of participants and the extent of support required. Results: The usability analysis yielded positive results, with a median SUS score of 82.5. Compared to the first session, participants significantly improved their performance at the final session as indicated by both the Stability Assessment Scores (p = 0.010, mean = 229.43, CI = [25.74–433.11]) and the LoD (p < 0.001; mean: 45.43, CI: [25.56–65.29]). The rate of progression differed based on the initial impairment levels of the patient. After training, participants expressed a keen interest in continuing home-based training. However, they also acknowledged challenges related to independently using the Myo armband ...

وصف الملف: application/application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/wos/001190567000001; http://hdl.handle.net/20.500.11850/666880Test

الإتاحة: https://doi.org/20.500.11850/666880Test
https://doi.org/10.3929/ethz-b-000666880Test
https://doi.org/10.1186/s12984-024-01334-9Test
https://hdl.handle.net/20.500.11850/666880Test

المؤلفون: Huwiler, Stephanie, Carro-Domínguez, Manuel, Stich, Fabia M, Sala, Rossella, Aziri, Florent, Trippel, Anna, Ryf, Tabea, Markendorf, Susanne, Niederseer, David, Bohm, Philipp, Stoll, Gloria, Laubscher, Lily, Thevan, Jeivicaa, Spengler, Christina M, Gawinecka, Joanna, Osto, Elena, Huber, Reto, Wenderoth, Nicole, Schmied, Christian, Lustenberger, Caroline

المصدر: Huwiler, Stephanie; Carro-Domínguez, Manuel; Stich, Fabia M; Sala, Rossella; Aziri, Florent; Trippel, Anna; Ryf, Tabea; Markendorf, Susanne; Niederseer, David; Bohm, Philipp; Stoll, Gloria; Laubscher, Lily; Thevan, Jeivicaa; Spengler, Christina M; Gawinecka, Joanna; Osto, Elena; Huber, Reto; Wenderoth, Nicole; Schmied, Christian; Lustenberger, Caroline (2023). Auditory stimulation of sleep slow waves enhances left ventricular function in humans. European Heart Journal, 44(40):4288-4291.

مصطلحات موضوعية: Institute of Clinical Chemistry, Medical Clinic, Department of Child and Adolescent Psychiatry, 540 Chemistry, 610 Medicine & health, Cardiology and Cardiovascular Medicine, Auditory stimulation, Blood pressure, Echocardiography, Left ventricular function, Sleep slow waves, Strain imaging

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/252294/1/ZORA_ehad630.pdfTest; info:pmid/37794725; urn:issn:0195-668X

الإتاحة: https://doi.org/10.5167/uzh-25229410.1093/eurheartj/ehad630Test
https://www.zora.uzh.ch/id/eprint/252294Test/
https://www.zora.uzh.ch/id/eprint/252294/1/ZORA_ehad630.pdfTest

المؤلفون: Kikkert, Sanne, Sonar, Harshal A, Freund, Patrick, Paik, Jamie, Wenderoth, Nicole

المصدر: Kikkert, Sanne; Sonar, Harshal A; Freund, Patrick; Paik, Jamie; Wenderoth, Nicole (2023). Hand and face somatotopy shown using MRI-safe vibrotactile stimulation with a novel soft pneumatic actuator (SPA)-skin interface. NeuroImage, 269:119932.

مصطلحات موضوعية: Balgrist University Hospital, Swiss Spinal Cord Injury Center, 610 Medicine & health

الوصف: The exact somatotopy of the human facial representation in the primary somatosensory cortex (S1) remains debated. One reason that progress has been hampered is due to the methodological challenge of how to apply automated vibrotactile stimuli to face areas in a manner that is: (1) reliable despite differences in the curvatures of face locations; and (2) MR-compatible and free of MR-interference artefacts when applied in the MR head-coil. Here we overcome this challenge by using soft pneumatic actuator (SPA) technology. SPAs are made of a soft silicon material and can be in- or deflated by means of airflow, have a small diameter, and are flexible in structure, enabling good skin contact even on curved body surfaces (as on the face). To validate our approach, we first mapped the well-characterised S1 finger layout using this novel device and confirmed that tactile stimulation of the fingers elicited characteristic somatotopic finger activations in S1. We then used the device to automatically and systematically deliver somatosensory stimulation to different face locations. We found that the forehead representation was least distant from the representation of the hand. Within the face representation, we found that the lip representation is most distant from the forehead representation, with the chin represented in between. Together, our results demonstrate that this novel MR compatible device produces robust and clear somatotopic representational patterns using vibrotactile stimulation through SPA-technology.

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/231925/1/Hand_and_face_somatotopy.pdfTest; info:pmid/36750151; urn:issn:1053-8119

الإتاحة: https://doi.org/10.5167/uzh-23192510.1016/j.neuroimage.2023.119932Test
https://www.zora.uzh.ch/id/eprint/231925Test/
https://www.zora.uzh.ch/id/eprint/231925/1/Hand_and_face_somatotopy.pdfTest

المؤلفون: Cheng, Hsiao-Ju, Chin, Lay Fong, Kanzler, Christoph M., Lehner, Rea, Kuah, Christopher Wee Keong, Kager, Simone, Josse, Eva, Samkharadze, Tengiz, Sidarta, Ananda, Gonzalez, Pablo Cruz, Lie, Eloise, Zbytniewska-Mégret, Monika, Wee, Seng Kwee, Liang, Phyllis, Gassert, Roger, Chua, Karen, Lambercy, Olivier, Wenderoth, Nicole

المساهمون: Lee Kong Chian School of Medicine (LKCMedicine), Singapore-ETH Centre, Tan Tock Seng Hospital, Singapore Institute of Technology (SIT), Rehabilitation Research Institute of Singapore (RRIS)

مصطلحات موضوعية: Medicine, Health and Life Sciences, Stroke, Neurorehabilitation

الوصف: Stroke is a leading cause of lifelong disability worldwide, partially driven by a reduced ability to use the upper limb in daily life causing increased dependence on caregivers. However, post-stroke functional impairments have only been investigated using limited clinical scores, during short-term longitudinal studies in relatively small patient cohorts. With the addition of technology-based assessments, we propose to complement clinical assessments with more sensitive and objective measures that could more holistically inform on upper limb impairment recovery after stroke, its impact on upper limb use in daily life, and on overall quality of life. This paper describes a pragmatic, longitudinal, observational study protocol aiming to gather a uniquely rich multimodal database to comprehensively describe the time course of upper limb recovery in a representative cohort of 400 Asian adults after stroke. Particularly, we will characterize the longitudinal relationship between upper limb recovery, common post-stroke impairments, functional independence and quality of life. ; National Research Foundation (NRF) ; Published version ; This research is supported by the National Research Foundation Singapore (NRF) under its Campus for Research Excellence and Technological Enterprise (CREATE) programme. Open access funding by ETH Zurich.

وصف الملف: application/pdf

العلاقة: Frontiers in Neurology; Cheng, H., Chin, L. F., Kanzler, C. M., Lehner, R., Kuah, C. W. K., Kager, S., Josse, E., Samkharadze, T., Sidarta, A., Gonzalez, P. C., Lie, E., Zbytniewska-Mégret, M., Wee, S. K., Liang, P., Gassert, R., Chua, K., Lambercy, O. & Wenderoth, N. (2023). Upper limb sensorimotor recovery in Asian stroke survivors: a study protocol for the development and implementation of a technology-assisted digitaL biomarker (TAILOR) platform. Frontiers in Neurology, 14, 1246888-. https://dx.doi.org/10.3389/fneur.2023.1246888Test; https://hdl.handle.net/10356/173973Test; 2-s2.0-85179966363; 14; 1246888

الإتاحة: https://doi.org/10.3389/fneur.2023.1246888Test
https://hdl.handle.net/10356/173973Test

المؤلفون: Markicevic, Marija, Sturman, Oliver, Bohacek, Johannes, id_orcid:0 000-0002-8442-653X, Rudin, Markus, Zerbi, Valerio, Fulcher, Ben D., Wenderoth, Nicole

المصدر: eLife, 12

الوصف: Understanding how the brain’s macroscale dynamics are shaped by underlying microscale mechanisms is a key problem in neuroscience. In animal models, we can now investigate this relationship in unprecedented detail by directly manipulating cellular-level properties while measuring the whole-brain response using resting-state fMRI. Here, we focused on understanding how blood-oxygen-level-dependent (BOLD) dynamics, measured within a structurally well-defined striato-thalamo-cortical circuit in mice, are shaped by chemogenetically exciting or inhibiting D1 medium spiny neurons (MSNs) of the right dorsomedial caudate putamen (CPdm). We characterize changes in both the BOLD dynamics of individual cortical and subcortical brain areas, and patterns of inter-regional coupling (functional connectivity) between pairs of areas. Using a classification approach based on a large and diverse set of time-series properties, we found that CPdm neuromodulation alters BOLD dynamics within thalamic subregions that project back to dorsomedial striatum. In the cortex, changes in local dynamics were strongest in unimodal regions (which process information from a single sensory modality) and weakened along a hierarchical gradient towards transmodal regions. In contrast, a decrease in functional connectivity was observed only for corticostriatal connections after D1 excitation. Our results show that targeted cellular-level manipulations affect local BOLD dynamics at the macroscale, such as by making BOLD dynamics more predictable over time by increasing its self-correlation structure. This contributes to ongoing attempts to understand the influence of structure–function relationships in shaping inter-regional communication at subcortical and cortical levels. ; ISSN:2050-084X

وصف الملف: application/application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/wos/001134835400001; info:eu-repo/grantAgreement/ETHZ/ETH Grants/ETH-38 16-2; http://hdl.handle.net/20.500.11850/650255Test

الإتاحة: https://doi.org/20.500.11850/650255Test
https://doi.org/10.3929/ethz-b-000650255Test
https://doi.org/10.7554/elife.78620Test
https://hdl.handle.net/20.500.11850/650255Test

المؤلفون: Altermatt, Miriam, Thomas, Felix Alexander, Wenderoth, Nicole

المصدر: Frontiers in Human Neuroscience, 17

مصطلحات موضوعية: predictability, sensory feedback, short afferent inhibition, TMS, SEP = somatosensory evoked potential, co-activation, sensory gating, sensory attenuation

الوصف: Introduction: An important factor for optimal sensorimotor control is how well we are able to predict sensory feedback from internal and external sources during movement. If predictability decreases due to external disturbances, the brain is able to adjust muscle activation and the filtering of incoming sensory inputs. However, little is known about sensorimotor adjustments when predictability is increased by availability of additional internal feedback. In the present study we investigated how modifications of internal and external sensory feedback influence the control of muscle activation and gating of sensory input. Methods: Co-activation of forearm muscles, somatosensory evoked potentials (SEP) and short afferent inhibition (SAI) were assessed during three object manipulation tasks designed to differ in the predictability of sensory feedback. These included manipulation of a shared object with both hands (predictable coupling), manipulation of two independent objects without (uncoupled) and with external interference on one of the objects (unpredictable coupling). Results: We found a task-specific reduction in co-activation during the predictable coupling compared to the other tasks. Less sensory gating, reflected in larger subcortical SEP amplitudes, was observed in the unpredictable coupling task. SAI behavior was closely linked to the subcortical SEP component indicating an important function of subcortical sites in predictability related SEP gating and their direct influence on M1 inhibition. Discussion: Together, these findings suggest that the unpredictable coupling task cannot only rely on predictive forward control and is compensated by enhancing co-activation and increasing the saliency for external stimuli by reducing sensory gating at subcortical level. This behavior might serve as a preparatory step to compensate for external disturbances and to enhance processing and integration of all incoming external stimuli to update the current sensorimotor state. In contrast, predictive forward control is ...

وصف الملف: application/application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/wos/001112633300001; http://hdl.handle.net/20.500.11850/647528Test

الإتاحة: https://doi.org/20.500.11850/647528Test
https://doi.org/10.3929/ethz-b-000647528Test
https://doi.org/10.3389/fnhum.2023.1237407Test
https://hdl.handle.net/20.500.11850/647528Test