المؤلفون: Yu-Han Wu, Jia-Cheng Luo, Jing Zhang, Zi-Cheng He, Yu Lan, Gui-Fang Huang, Wangyu Hu, Wei-Qing Huang

المصدر: Results in Physics, Vol 54, Iss , Pp 107047- (2023)

مصطلحات موضوعية: Schottky barrier, Metal–semiconductor contact, van der Waals heterostructure, Electric field, First-principles calculations, Physics, QC1-999

الوصف: Two-dimensional (2D) transition metal carbides, nitrides, or carbonitrides (MXenes) have emerged as promising ultrathin materials for nanoelectronics and optoelectronics. However, the contact barrier at metal–semiconductor (MS) junctions still significantly limits the device's performance. Here, we propose a novel strategy—functionalizing accompanied with external electric fields—to tune the MS contact nature in MXene-based van der Waals (vdW) heterostructures, taking 2D Ti2C as an example, by means of first-principles calculations. Different Ti2CO2/Ti2CX2 (X = OH or S) vdW heterostructures are designed via functionalizing Ti2C metals to contact with 2D Ti2CO2. We reveal that OH functionalized vdW MS heterostructure (Ti2CO2/Ti2C(OH)2) can be tuned to the Ohmic contact owing to the strong interlayer interaction inducing a large number of interlayer transferred electrons; while for the sulfurized vdW MS heterostructure (Ti2CO2/Ti2CS2), its Schottky barrier height and contact type can be effectively tuned by external electric field due to the rather weak interlayer interaction. Our work paves a new way for the construction of 2D MXene-based vdW MS heterostructures and demonstrates the great potential of 2D MXenes in future nanoelectronics and optoelectronics.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2211379723008409Test; https://doaj.org/toc/2211-3797Test

الوصول الحر: https://doaj.org/article/bfdd83bd517049e3a79271de38071d06Test

المؤلفون: Yu‐Han Wang, Lei Li, Jinghui Shi, Meng‐Yuan Xie, Jianhang Nie, Gui‐Fang Huang, Bo Li, Wangyu Hu, Anlian Pan, Wei‐Qing Huang

المصدر: Advanced Science, Vol 10, Iss 32, Pp n/a-n/a (2023)

مصطلحات موضوعية: oxygen defects, adsorbate evolution mechanisms, lattice oxygen mechanisms, transition metal‐based (oxy)hydroxides, oxygen evolution reactions, Science

الوصف: Abstract The oxygen evolution reaction (OER) activity of transition metal (TM)‐based (oxy)hydroxide is dominated by the number and nature of surface active sites, which are generally considered to be TM atoms occupying less than half of surface sites, with most being inactive oxygen atoms. Herein, based on an in situ competing growth strategy of bimetallic ions and OH− ions, a facile one‐step method is proposed to modulate oxygen defects in NiFe‐layered double hydroxide (NiFe‐LDH)/FeOOH heterostructure, which may trigger the single lattice oxygen mechanism (sLOM). Interestingly, by only varying the addition of H2O2, one can simultaneously regulate the concentration of oxygen defects, the valence of metal sites, and the ratio of components. The proper oxygen defects promote synergy between the adsorbate evolution mechanism (AEM, metal redox chemistry) and sLOM (oxygen redox chemistry) of OER in NiFe‐based (oxy)hydroxide, practically maximizing the use of surface TM and oxygen atoms as active sites. Consequently, the optimal NiFe‐LDH/FeOOH heterostructure outperforms the reported non‐noble OER catalysts in electrocatalytic activity, with an overpotential of 177 mV to deliver a current density of 20 mA cm−2 and high stability. The novel strategy exemplifies a facile and versatile approach to designing highly active TM‐LDH‐based OER electrocatalysts for energy and environmental applications.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2198-3844Test

الوصول الحر: https://doaj.org/article/9c29b8f036734c3aa23632185f5bed4dTest

المؤلفون: Can Leng, Zhuo Tang, Yi-Ge Zhou, Zean Tian, Wei-Qing Huang, Jie Liu, Keqin Li, Kenli Li

المصدر: Engineering, Vol 24, Iss , Pp 126-137 (2023)

مصطلحات موضوعية: Catalytic materials, Fifth paradigm, Intelligence-driven, Machine learning, Synergy of interdisciplinary experts, Engineering (General). Civil engineering (General), TA1-2040

الوصف: Science is entering a new era—the fifth paradigm—that is being heralded as the main character of knowledge integrating into different fields to intelligence-driven work in the computational community based on the omnipresence of machine learning systems. Here, we vividly illuminate the nature of the fifth paradigm by a typical platform case specifically designed for catalytic materials constructed on the Tianhe-1 supercomputer system, aiming to promote the cultivation of the fifth paradigm in other fields. This fifth paradigm platform mainly encompasses automatic model construction (raw data extraction), automatic fingerprint construction (neural network feature selection), and repeated iterations concatenated by the interdisciplinary knowledge (“volcano plot”). Along with the dissection is the performance evaluation of the architecture implemented in iterations. Through the discussion, the intelligence-driven platform of the fifth paradigm can greatly simplify and improve the extremely cumbersome and challenging work in the research, and realize the mutual feedback between numerical calculations and machine learning by compensating for the lack of samples in machine learning and replacing some numerical calculations caused by insufficient computing resources to accelerate the exploration process. It remains a challenging of the synergy of interdisciplinary experts and the dramatic rise in demand for on-the-fly data in data-driven disciplines. We believe that a glimpse of the fifth paradigm platform can pave the way for its application in other fields.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2095809923001479Test; https://doaj.org/toc/2095-8099Test

الوصول الحر: https://doaj.org/article/a8e06a3ca9d747d4aeb83ee539230d76Test

المؤلفون: Hui Wu, Jiang-Long Guo, Jing-Jiong Yao, Jia-Jun Yu, Run-Yu Xia, Wei-Qing Huang, Xuan Tang, Guang-Ming He

المصدر: Frontiers in Nutrition, Vol 10 (2023)

مصطلحات موضوعية: vitamin C, Mendelian randomization, NHANES, NAFLD, cross-sectional study, Nutrition. Foods and food supply, TX341-641

الوصف: Background and aimsVitamin C, as an antioxidant, may play a role in the treatment of NAFLD. This research aimed to investigate the association of serum vitamin C levels with the risk of NAFLD and to further examine the causal relationship by Mendelian randomization (MR) method.MethodsThe cross-sectional study selected 5,578 participants of the National Health and Nutrition Examination Survey (NHANES), 2005–2006 and 2017–2018. The association of serum vitamin C levels with NAFLD risk was evaluated under a multivariable logistic regression model. A two-sample MR study, using genetic data from large-scale genome-wide association studies (GWAS) of serum vitamin C levels (52,014 individuals) and NAFLD (primary analysis: 1,483 cases /17,781 controls; secondary analysis: 1,908 cases/340,591 controls), was conducted to infer causality between them. The inverse-variance-weighted (IVW) was applied as the main method of MR analysis. A series of sensitivity analyzes were used to evaluate the pleiotropy.ResultsIn the cross-sectional study, results showed that Tertile 3 group (Tertile 3: ≥1.06 mg/dl) had a significantly lower risk (OR = 0.59, 95% CI: 0.48 ~ 0.74, p

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fnut.2023.1162031/fullTest; https://doaj.org/toc/2296-861XTest

الوصول الحر: https://doaj.org/article/4ba7799945f940d3910f67cf50f36f0bTest

المؤلفون: Xiong‐Hui Wu, Si‐Jun Zhao, Wei‐Qing Huang, Li‐Hua Huang, Xin‐You Luo, Song‐Liang Long

المصدر: Kaohsiung Journal of Medical Sciences, Vol 38, Iss 10, Pp 971-980 (2022)

مصطلحات موضوعية: allergic rhinitis, GATA binding protein 3, long non‐coding RNA MALAT1, microRNA‐135b‐5p, T‐helper 2 differentiation, Medicine (General), R5-920

الوصف: Abstract Allergic rhinitis (AR) threatens patient survival. CD4+ T cells play key roles in AR progression. Long non‐coding RNAs (lncRNAs) are key regulators of cell differentiation. Therefore, we investigated the molecular mechanism of the lncRNA metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) in AR. Expression levels of MALAT1, microRNA (miR)‐135b‐5p, interleukin‐4 (IL‐4), and GATA‐binding protein 3 (GATA‐3) in the nasal mucosa of AR patients were quantified. CD4+ T cells were isolated from the peripheral blood of healthy volunteers and treated with ovalbumin (OVA) and Th2 inducers. After MALAT1 and miR‐135b‐5p levels changed in CD4+ T cells, the proportion of IL‐4‐expressing cells and the levels of IL‐4 and GATA‐3 in OVA‐induced CD4+ T cells were determined. Binding relationships among MALAT1, miR‐135b‐5p, and GATA‐3 were predicted and verified. Rescue experiments were performed to confirm the role of the MALAT1/miR‐135b‐5p/GATA‐3 axis in Th2 differentiation of CD4+ T cells. MALAT1, IL‐4, and GATA‐3 expression was upregulated, whereas miR‐135b‐5p expression was downregulated, in patients with AR. MALAT1 knockdown or miR‐135b‐5p overexpression in CD4+ T cells notably decreased the proportion of IL‐4‐expressing cells and downregulated GATA‐3 and IL‐4 expression in OVA‐induced CD4+ T cells. MALAT1 and GATA‐3 exhibited competitive binding toward miR‐135b‐5p. MALAT1 facilitated CD4+ T cell Th2 differentiation via the miR‐135b‐5p/GATA‐3 axis. MALAT1 facilitated AR development by facilitating CD4+ T cell Th2 differentiation via the miR‐135b‐5p/GATA‐3 axis. This study may provide guidance for clinical treatment of AR.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1607-551XTest; https://doaj.org/toc/2410-8650Test

الوصول الحر: https://doaj.org/article/6ab69cce069c46858982c4a283a7770fTest

المؤلفون: Can Leng, Kenli Li, Zean Tian, Yubing Si, Huang Huang, Junfeng Li, Jie Liu, Wei-Qing Huang, Keqin Li

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract Derived from the most abundant natural polymer, cellulose nanocrystal materials have attracted attention in recent decades due to their chemical and mechanical properties. However, still unclear is the influence of different exposed facets of the cellulose nanocrystals on the physicochemical properties. Herein, we first designed cellulose II nanocrystals with different exposed facets, the hydroxymethyl conformations distribution, hydrogen bond (HB) analysis, as well as the relative structural stability of these models (including crystal facets {A, B, O} and Type-A models vary in size) are theoretically investigated. The results reveal that the HB network of terminal anhydroglucose depends on the adjacent chain’s contact sites in nanocrystals exposed with different facets. Compared to nanocrystals exposed with inclined facet, these exposed with flat facet tend to be the most stable. Therefore, the strategy of tuning exposed crystal facets will guide the design of novel cellulose nanocrystals with various physicochemical properties.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/0616859b6ce349de84fc38cffd29d6b2Test

المؤلفون: Can Leng, Kenli Li, Zean Tian, Yubing Si, Huang Huang, Junfeng Li, Jie Liu, Wei‑Qing Huang, Keqin Li

المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/445664c0c72d40f5b78b7944532f7427Test

المؤلفون: Jia-Li Liang, Fan Zhang, Jian-Hui Zhang, Wei-Qing Huang, Yu-Xin Wen, Bo-Chuan Chen

المصدر: Applied Sciences, Vol 13, Iss 4, p 2572 (2023)

مصطلحات موضوعية: atomization, electrolytic polishing, laser processing, piezoelectric, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999

الوصف: Piezoelectric atomization, which breaks liquid into tiny droplets, is widely used in aerospace, medicine, and health. Most research in piezoelectric atomizers has increased the atomization amount by improving mechanical structure and optimizing the vibration characteristics. However, as the core component of the atomizer is to realize atomization using the dynamic conical angle effect, the micro-tapered hole on the atomizing sheet has not been deeply studied. To eliminate the negative influence of the uneven burr caused by the hole machining process on the atomizing sheet, electrolytic polishing processing is proposed in this study to improve the quality of the micro-tapered holes. First, a theoretical model of the atomization amount and the conical angle is established. Second, the hole diameter and burr height are measured using a microscope, and the effectiveness of polishing on the burr removal of holes is verified. Lastly, the relationship between the conical angle and atomization amount is determined through an atomization amount experiment, which guides the revision of the theoretical model. The experimental results show that when the conical angle is 48,267° (the polishing time is 5 min), the atomization amount reaches a maximum of 5.202 mL/min, which is 3.93 times larger than that of the untreated one. This study demonstrates that polishing can effectively remove burr in the process of hole machining, which provides theoretical guidance for improving the quality of atomization sheets, and will further improve the atomization number of atomizers.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2076-3417/13/4/2572Test; https://doaj.org/toc/2076-3417Test

الوصول الحر: https://doaj.org/article/305f5a0e513e4c0285159a25c4609a43Test

المؤلفون: Rong Zhang, Yan Zhuang, Zheng-hui Xiao, Cai-yun Li, Fan Zhang, Wei-qing Huang, Min Zhang, Xiao-Ming Peng, Chao Liu

المصدر: Frontiers in Microbiology, Vol 13 (2022)

مصطلحات موضوعية: neonatal infections, metagenomic next-generation sequencing, Mycobacterium tuberculosis, Legionella pneumophila, Bacillus cereus, Microbiology, QR1-502

الوصف: Microbial infections cause significant morbidity and mortality in neonates. Metagenomic next-generation sequencing is a hypothesis-free and culture-free test that enables broad identification of pathogens and antimicrobial resistance genes directly from clinical samples within 24 h. In this study, we used mNGS for etiological diagnosis and monitoring the efficacy of antibiotic treatment in a cohort of neonatal patients with severe infections. The median age was 19.5 (3–52) days, median gestational age was 37.96 (31–40+3) weeks, and the median birth weight was 3,261 (1,300–4,300) g. The types of infectious diseases included pneumonia, sepsis, and meningitis. mNGS reported microbial findings in all cases, which led to changes in antibiotic treatment. These included cases of Mycobacterium tuberculosis, Legionella pneumophila, and Bacillus cereus. Eight of ten infants recovered after antibiotic adjustment and showed normal development during follow-up. On the other hand, neurological retardation was seen in two infants with meningitis. mNGS enabled etiological diagnosis and guided antibiotic therapy when all conventional methods failed to discover the culprit. It has the potential to cut down the overall cost and burden of disease management in neonatal infections.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmicb.2022.855988/fullTest; https://doaj.org/toc/1664-302XTest

الوصول الحر: https://doaj.org/article/22e98bb2ea4c4a9cb233295bcf43d945Test

المؤلفون: Yu Lan, Li-Xin Xia, Tao Huang, Weiping Xu, Gui-Fang Huang, Wangyu Hu, Wei-Qing Huang

المصدر: Nanoscale Research Letters, Vol 15, Iss 1, Pp 1-9 (2020)

مصطلحات موضوعية: Schottky barrier, Graphene-MoTe2 heterostructure, External electric field, Strain, First-principles calculations, Materials of engineering and construction. Mechanics of materials, TA401-492

الوصف: Abstract Two-dimensional (2D) transition metal dichalcogenides with intrinsically passivated surfaces are promising candidates for ultrathin optoelectronic devices that their performance is strongly affected by the contact with the metallic electrodes. Herein, first-principle calculations are used to construct and investigate the electronic and interfacial properties of 2D MoTe2 in contact with a graphene electrode by taking full advantage of them. The obtained results reveal that the electronic properties of graphene and MoTe2 layers are well preserved in heterostructures due to the weak van der Waals interlayer interaction, and the Fermi level moves toward the conduction band minimum of MoTe2 layer thus forming an n type Schottky contact at the interface. More interestingly, the Schottky barrier height and contact types in the graphene-MoTe2 heterostructure can be effectively tuned by biaxial strain and external electric field, which can transform the heterostructure from an n type Schottky contact to a p type one or to Ohmic contact. This work provides a deeper insight look for tuning the contact types and effective strategies to design high performance MoTe2-based Schottky electronic nanodevices.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s11671-020-03409-7Test; https://doaj.org/toc/1556-276XTest

الوصول الحر: https://doaj.org/article/547fa936044049018ff06c6b81a093d7Test