المؤلفون: Cai, Sidong, Chang, Junlei, Su, Mengqi, Wei, Yinxia, Sun, Haoran, Chen, Cong, Yiu, Kai-Hang

المساهمون: Basic and Applied Basic Research Foundation of Guangdong Province, National Natural Science Foundation of China, Program of the Shenzhen Municipal Science and Technology Commission, Sanming Project of Medicine in Shenzhen, HKU-SZH Fund for Shenzhen Key Medical Discipline

المصدر: Cellular and Molecular Life Sciences ; volume 80, issue 12 ; ISSN 1420-682X 1420-9071

مصطلحات موضوعية: Cell Biology, Cellular and Molecular Neuroscience, Pharmacology, Molecular Biology, Molecular Medicine

الوصف: Pathological cardiac remodeling plays an essential role in the progression of cardiovascular diseases, and numerous microRNAs have been reported to participate in pathological cardiac remodeling. However, the potential role of microRNA-455-5p (miR-455-5p) in this process remains to be elucidated. In the present study, we focused on clarifying the function and searching the direct target of miR-455-5p, as well as exploring its underlying mechanisms in pathological cardiac remodeling. We found that overexpression of miR-455-5p by transfection of miR-455-5p mimic in vitro or tail vain injection of miR-455-5p agomir in vivo provoked cardiac remodeling, whereas genetic knockdown of miR-455-5p attenuated the isoprenaline-induced cardiac remodeling. Besides, miR-455-5p directly targeted to 3’-untranslated region of protein arginine methyltransferase 1 (PRMT1) and subsequently downregulated PRMT1 level. Furthermore, we found that PRMT1 protected against cardiac hypertrophy and fibrosis in vitro. Mechanistically, miR-455-5p induced cardiac remodeling by downregulating PRMT1-induced asymmetric di-methylation on R1748, R1750, R1751 and R1752 of Notch1, resulting in suppression of recruitment of Presenilin, Notch1 cleavage, NICD releasing and Notch signaling pathway. Finally, circulating miR-455-5p was positively correlated with parameters of left ventricular wall thickening. Taken together, miR-455-5p plays a provocative role in cardiac remodeling via inactivation of the PRMT1-mediated Notch signaling pathway, suggesting miR-455-5p/PRMT1/Notch1 signaling axis as potential therapeutic targets for pathological cardiac remodeling.

الإتاحة: https://doi.org/10.1007/s00018-023-04987-2Test

المؤلفون: Cai, Sidong, Huang, Fangmei, Wang, Run, Wu, Min, Liu, Mingya, Peng, Yufen, Cao, Gaozhen, Li, Yapin, Liu, Shuhong, Lu, Jiena, Su, Mengqi, Wei, Yinxia, Yiu, Kai-Hang, Chen, Cong

المساهمون: Sanming Project of Medicine in Shenzhen

المصدر: Frontiers in Cardiovascular Medicine ; volume 10 ; ISSN 2297-055X

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Purpose This study evaluates the association between habitual physical activity (HPA) and the outcomes of patients with myocardial infarction (MI). Methods Patients newly diagnosed with MI were divided into two groups based on whether they engaged in HPA, defined as an aerobic activity with a duration of no less than 150 min/week, before the index admission. The primary outcomes included major adverse cardiovascular events (MACEs), cardiovascular (CV) mortality, and cardiac readmission rate 1 year following the index date of admission. A binary logistic regression model was applied to analyze whether HPA was independently associated with 1-year MACEs, 1-year CV mortality, and 1-year cardiac readmission rate. Results Among the 1,266 patients (mean age 63.4 years, 72% male), 571 (45%) engaged in HPA, and 695 (55%) did not engage in HPA before MI. Patients who participated in HPA were independently associated with a lower Killip class upon admission (OR = 0.48: 95% CI, 0.32–0.71, p < 0.001) and a lower prevalence of 1-year MACEs (OR = 0.74: 95% CI, 0.56–0.98, p = 0.038) and 1-year CV mortality (OR = 0.50: 95% CI, 0.28–0.88, p = 0.017) than those who did not participate in HPA. HPA was not associated with cardiac-related readmission (OR = 0.87: 95% CI, 0.64–1.17, p = 0.35). Conclusions HPA before MI was independently associated with a lower Killip class upon admission, 1-year MACEs, and 1-year CV mortality rate.

الإتاحة: https://doi.org/10.3389/fcvm.2023.1174466Test

المؤلفون: Su, Mengqi, Hou, Yilin, Cai, Sidong, Li, Wenpeng, Wei, Yinxia, Wang, Run, Wu, Min, Liu, Mingya, Chang, Junlei, Yang, Kelaier, Yiu, Kaihang, Chen, Cong

المصدر: Diabetologia; May2024, Vol. 67 Issue 5, p850-863, 14p

مستخلص: Aims/hypothesis: Type 2 diabetes mellitus is known to contribute to the development of heart failure with preserved ejection fraction (HFpEF). However, identifying HFpEF in individuals with type 2 diabetes early on is often challenging due to a limited array of biomarkers. This study aims to investigate specific biomarkers associated with the progression of HFpEF in individuals with type 2 diabetes, for the purpose of enabling early detection and more effective management strategies. Methods: Blood samples were collected from individuals with type 2 diabetes, both with and without HFpEF, for proteomic analysis. Plasma integrin α1 (ITGA1) levels were measured and compared between the two groups. Participants were further categorised based on ITGA1 levels and underwent detailed transthoracic echocardiography at baseline and during a median follow-up period of 30 months. Multivariable linear and Cox regression analyses were conducted separately to assess the associations between plasma ITGA1 levels and changes in echocardiography indicators and re-hospitalisation risk. Additionally, proteomic data for the individuals' left ventricles, from ProteomeXchange database, were analysed to uncover mechanisms underlying the change in ITGA1 levels in HFpEF. Results: Individuals with type 2 diabetes and HFpEF showed significantly higher plasma ITGA1 levels than the individuals with type 2 diabetes without HFpEF. These elevated ITGA1 levels were associated with left ventricular remodelling and impaired diastolic function. Furthermore, during a median follow-up of 30 months, multivariable analysis revealed that elevated ITGA1 levels independently correlated with deterioration of both diastolic and systolic cardiac functions. Additionally, higher baseline plasma ITGA1 levels independently predicted re-hospitalisation risk (HR 2.331 [95% CI 1.387, 3.917], p=0.001). Proteomic analysis of left ventricular myocardial tissue provided insights into the impact of increased ITGA1 levels on cardiac fibrosis-related pathways and the contribution made by these changes to the development and progression of HFpEF. Conclusions/interpretation: ITGA1 serves as a biomarker for monitoring cardiac structural and functional damage, can be used to accurately diagnose the presence of HFpEF, and can be used to predict potential deterioration in cardiac structure and function as well as re-hospitalisation for individuals with type 2 diabetes. Its measurement holds promise for facilitating risk stratification and early intervention to mitigate the adverse cardiovascular effects associated with diabetes. Data availability: The proteomic data of left ventricular myocardial tissue from individuals with type 2 diabetes, encompassing both those with and without HFpEF, is available from the ProteomeXchange database at http://proteomecentral.proteomexchange.orgTest. [ABSTRACT FROM AUTHOR]

: Copyright of Diabetologia is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Liao, Jiaxian, Wei, Dongyan, Sun, Chenghui, Yang, Yuqi, Wei, Yinxia, Liu, Xinhui

المساهمون: Hechi Science and Technology Plan Project

المصدر: BMC Nephrology ; volume 23, issue 1 ; ISSN 1471-2369

مصطلحات موضوعية: Nephrology

الوصف: Background Hemodialysis (HD) is the most important renal replacement therapy for patients with end-stage kidney disease (ESKD). Systemic inflammation is a risk factor of mortality in HD patients. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) are new inflammatory markers. However, previous studies have inconsistent conclusions about the predictive value of NLR, MLR and PLR on mortality of HD patients. The aim of this study was to establish an inflammation scoring system by including NLR, MLR and PLR, and evaluate the association between the inflammation score and all-cause and cardiovascular mortality in HD patients. Methods In this single center retrospective cohort study, 213 incident HD patients from January 1, 2015 to December 31, 2020 were included. Baseline demographic and clinical data and laboratory measurements were collected. According to the optimal cut-off values, NLR, MLR and PLR were assigned 0 or 1 point, respectively. Then, the inflammation score was obtained by adding the NLR, MLR and PLR scores. All patients were followed until July 31, 2021. The associations of the inflammation score with all-cause and cardiovascular mortality were assessed by multivariable-adjusted Cox models. Results Of 213 patients, the mean (± SD) age was 56.8 ± 14.4 years, 66.2% were men, and 32.9% with diabetes. The primary cause of ESKD was mainly chronic glomerulonephritis (46.5%) and diabetic nephropathy (28.6%). The median inflammation score was 2 (interquartile range = 1–3). During a median 30 months (interquartile range = 17–50 months) follow-up period, 53 patients had died, of which 33 deaths were caused by cardiovascular disease. After adjusting for demographics, primary diseases and other confounders in multivariable model, the inflammation score = 3 was associated with a hazard ratio for all-cause mortality of 4.562 (95% confidence interval, 1.342–15.504, P = 0.015) and a hazard ratio for cardiovascular mortality of 4.027 (95% confidence ...

الإتاحة: https://doi.org/10.1186/s12882-022-03020-1Test

المؤلفون: Shi, Lin, Wei, Yinxia

المصدر: Southern African Linguistics and Applied Language Studies; Vol. 41 No. 2 (2023); 224–226

الوصف: No abstract

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=78975075580c::1b876eecc342963b4d86c99669973316Test
https://www.ajol.info/index.php/salas/article/view/249858Test

المؤلفون: Wei, Yinxia

المصدر: Proceedings of the 2016 International Conference on Arts, Design and Contemporary Education

الإتاحة: https://doi.org/10.2991/icadce-16.2016.282Test

المؤلفون: Li, Lu, Wei, Yinxia

المصدر: Social Semiotics ; page 1-4 ; ISSN 1035-0330 1470-1219

الإتاحة: https://doi.org/10.1080/10350330.2021.1989295Test

المؤلفون: Wei Yinxia, Peng Ying

المصدر: Proceedings of the 2015 3d International Conference on Advanced Information and Communication Technology for Education.

مصطلحات موضوعية: media_common.quotation_subject, Teaching method, Subject (philosophy), ComputingMilieux_LEGALASPECTSOFCOMPUTING, Training (civil), Engineering management, Engineering education, Political science, ComputingMilieux_COMPUTERSANDEDUCATION, Production (economics), Quality (business), Engineering ethics, Disconnection, China, media_common

الوصف: Even though our country has the world’s most abundant engineering students and a huge demand for talents, the problem on the disconnection between higher engineering education and industry still exists, which exerts a passive influence on the quality of talent training. The reform of higher engineering education should learn the engineering education experiences from abroad, and formulate the scientific and rational talent training mode in accordance with national conditions. Complying to the tides of international engineering education reform, this paper puts forward the important strategies and choices of China’s engineering education reform, namely, educational concepts transfer from engineering science to engineering practice, teaching methods transfer from academy-oriented to project-oriented, the subject of talent training transfers from institutions of higher learning to the cooperation between production and learning.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::40259210f43ef48a0c7af7b7b3deabdcTest
https://doi.org/10.2991/icaicte-15.2015.29Test

المؤلفون: Peng, Ying, Wei, Yinxia

المصدر: Lecture Notes in Electrical Engineering ; Engineering Education and Management ; page 523-529 ; ISSN 1876-1100 1876-1119 ; ISBN 9783642248221 9783642248238

الإتاحة: https://doi.org/10.1007/978-3-642-24823-8_83Test

المؤلفون: Peng, Ying, Wei, Yinxia

المصدر: Engineering Education & Management; 2012, p523-529, 7p