المؤلفون: Wadkar, Ganesh H^{1, 1}, Kane, Sandeep R.¹, Mali, Dipak P.¹, Mohite, Shrinivas K.¹, Mathapati, Sunil S.², Deshpande, Sunil V.³

المصدر: Research Journal of Pharmacy and Technology 3(4):1224-1226. 2010

المؤلفون: Mali, Dipak P, Kamble, Snehal P, Gaikwad, Dinanath T, Wadkar, Ganesh H, Bhutkar, Mangesh A, Tamboli, Firoj A, Pawar, Vijaykumar T

المصدر: INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE; Vol 14 No 01 (2023): International Journal of Pharmaceutical Quality Assurance; 7-11 ; 0975-9506

الوصف: The need for herbal medicines is rising day by day tremendously all over the world. Many pharma industries are nowadays directing their studies on herbal material for their probable therapeutic values. In various scientifi c journals, a growing volume of research publications relied upon plant-based drugs and formulations. Hypertension is an important chronic disorder in economically developed as well as developing countries. According to WHO guidelines, it is necessary to standardize the herbal products that reach patients. Hence, standardizing the herbal antihypertensive formulations is necessary to give safe and eff ective medicines to the patients and society. The herbal antihypertensive formulation was standardized according to Ayurvedic Pharmacopeia and WHO guidelines. Various parameters such as botanical, physicochemical, pharmacological and toxicological were studied. A pharmacological study was carried to screen the selected marketed formulations for hemolytic and antihypertensive activity. The study showed that all formulations pass most of the standardization parameters and can be recommended for human beings. The outcome of present study will support the process of regulatory agencies and help in maintaining the quality of herbal medicines.

العلاقة: https://myresearchjournals.com/index.php/IJPQA/article/view/12435Test

الإتاحة: https://doi.org/10.25258/ijpqa.14.1.02Test
https://myresearchjournals.com/index.php/IJPQA/article/view/12435Test

المؤلفون: Gaikwad, Dinanath T., Bansode, Suraj P., Mali, Dipak P., Wadkar, Ganesh H., Pawar, Vijaykumar T., Tamboli, Firoj A.

المصدر: INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY; Vol 12 No 03 (2022): International Journal of Drug Delivery and Technology; 1020-1024 ; 0975-4415

الوصف: The aim of this work was to discover alpha amylase inhibitors from selected phytoconstituents of Terminalia arjuna by utilizing computational and in-silico methodology. Identified 37 phytoconstituents of T. arjuna were docked as test molecules. The complex structure of alpha-amylase in associated with Acarviostatin I03 was retrieved from protein data bank. Molecular screening by GA-based was performed to generate the cavity-enabled complex prototype using VLife MDS 4.4 software. Docking was used to identify the potent alpha-amylase inhibitor. Ligand-enzyme poses of the selected T. arjuna phytoconstituents identified seven potential biomolecules: baicalein, quercetin, gallic acid, kaempferol, pelargonidin, pyrocatechol and epicatechin with prominent interactions and showed better results than standard Acarviostatin I03 to the residues of alpha-amylase targets. interestingly, gallic acid showed multiple interactions as hydrogen bond, pi stacking and charge to the alpha-amylase target. This study reveals that phytoconstituents of T. arjuna possess promising antidiabetic potential. However, this research gives an appropriate platform for detecting newer inhibitors from plant sources for diabetic disease.

العلاقة: https://myresearchjournals.com/index.php/IJDDT/article/view/11300Test

الإتاحة: https://doi.org/10.25258/ijddt.12.3.17Test
https://myresearchjournals.com/index.php/IJDDT/article/view/11300Test

المؤلفون: Bhinge, Somnath D., Bhutkar, Mangesh A., Randive, Dheeraj S., Wadkar, Ganesh H., Todkar, Sachin S., Savali, Anil S., Chittapurkar, Hariprassanna R.

المصدر: Heliyon ; volume 7, issue 4, page e06903 ; ISSN 2405-8440

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1016/j.heliyon.2021.e06903Test
https://api.elsevier.com/content/article/PII:S2405844021010069?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2405844021010069?httpAccept=text/plainTest

المؤلفون: Randive, Dheeraj S., Bhutkar, Mangesh A., Bhinge, Somnath D., Wadkar, Ganesh H., Pattekari, Suraj N.

المصدر: Nanomaterial-Based Drug Delivery Systems ; page 209-238 ; ISBN 9783031305283 9783031305290

الإتاحة: https://doi.org/10.1007/978-3-031-30529-0_7Test

المؤلفون: Shejawal, Kiran P., Randive, Dheeraj S., Bhinge, Somnath D., Bhutkar, Mangesh A., Wadkar, Ganesh H., Jadhav, Namdeo R.

المصدر: Journal of Genetic Engineering and Biotechnology ; volume 18, issue 1, page 43 ; ISSN 1687-157X

مصطلحات موضوعية: Genetics, Biotechnology

الإتاحة: https://doi.org/10.1186/s43141-020-00058-2Test
https://api.elsevier.com/content/article/PII:S1687157X23005565?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1687157X23005565?httpAccept=text/plainTest

المؤلفون: Bhutkar, Mangesh A, Bhinge, Somnath Devidas, Randive, Dheeraj S, Wadkar, Ganesh H, Todkar, Sachin S

مصطلحات موضوعية: Hypoglycemic, Glucose diffusion, M. koenigii, C. roseus, Difusión de glucosa, Hipoglucemiantes

الوصف: Objective: The study aimed to verify the hypoglycemic effect of Murraya koenigii (M. koenigii) and Catharanthus roseus (C. roseus) by using various in-vitro techniques. Method: The extracts were studied for their effects on glucose adsorption capacity, in-vitro glucose diffusion, in-vitro amylolysis kinetics and glucose transport across the yeast cells. Results: It was observed that the extracts of M. koenigii and C. roseus adsorbed glucose and the adsorption of glucose increased remarkably with an increase in glucose concentration. There were no significant (p≤0.05) differences between their adsorption capacities. In the amylolysis kinetic experimental model the rate of glucose diffusion was found to be increased with time from 30 to 180 min and both the plant extracts exhibited significant inhibitory effects on the movement of glucose into external solution across the dialysis membrane as compared to control. The extracts also promoted glucose uptake by the yeast cells and the enhancement of glucose uptake was dependent on both the sample and glucose concentration. The extract of M. koenigii exhibited significantly higher (p≤0.05) activity than the extract of C. roseus at all concentrations used in the study. Our report suggests the mechanism(s) for the hypoglycemic effect of M. koenigii and C. roseus. Conclusion: The said effect was observed to be mediated by inhibiting alpha amylase, inhibiting glucose diffusion by adsorbing glucose and by increasing glucose transport across the cell membranes as revealed by in-vitro model of yeast cells. However, these effects need to be affirmed by using different in vivo models and clinical trials. ; Objetivo: El estudio tuvo como objetivo verificar el efecto hipoglucémico de Murraya koenigii (M. koenigii) y Catharanthus roseus (C. roseus) mediante el uso de diversas técnicas in vitro. Método: Los extractos se estudiaron por sus efectos sobre la capacidad de adsorción de glucosa, la difusión de glucosa in vitro, la cinética de amilolisis in vitro y el transporte de ...

وصف الملف: application/pdf

العلاقة: Mangesh A Bhutkar et al. Screening of in-vitro hypoglycemic activity of Murraya koenigii and Catharanthus roseus. Ars Pharm. 2018; 59(3): 1-7. [http://dx.doi.org/10.30827/ars.v59i3.7413Test]; http://hdl.handle.net/10481/57269Test; dx.doi.org/10.30827/ars.v59i3.7413

الإتاحة: https://doi.org/10.30827/ars.v59i3.7413Test
http://hdl.handle.net/10481/57269Test

المؤلفون: Bhutkar, Mangesh A., Randive, Dheeraj S., Bhinge, Somnath D., Wadkar, Ganesh H., Todkar, Sachin S., Shejawal, Kiran P.

المساهمون: Shivaji university kolhapur MS India

المصدر: Gold Bulletin ; volume 55, issue 1, page 93-103 ; ISSN 2364-821X 2190-7579

مصطلحات موضوعية: Inorganic Chemistry, General Materials Science

الإتاحة: https://doi.org/10.1007/s13404-022-00309-9Test

المؤلفون: Shejawal, Kiran P., Randive, Dheeraj S., Bhinge, Somnath D., Bhutkar, Mangesh A., Wadkar, Ganesh H., Todkar, Sachin S., Mohite, Shriniwas K.

المساهمون: shivaji university kolhapur bcud mh india

المصدر: Journal of Materials Research ; volume 36, issue 24, page 4894-4907 ; ISSN 0884-2914 2044-5326

مصطلحات موضوعية: Mechanical Engineering, Mechanics of Materials, Condensed Matter Physics, General Materials Science

الإتاحة: https://doi.org/10.1557/s43578-021-00431-yTest

المؤلفون: Chavan, Rohankumar R., Bhinge, Somnath D., Bhutkar, Mangesh A., Randive, Dheeraj S., Wadkar, Ganesh H., Todkar, Sachin S.

المصدر: Journal of Cosmetic Dermatology ; volume 20, issue 4, page 1283-1297 ; ISSN 1473-2130 1473-2165

الوصف: Background Blumea eriantha DC is the Indian medicinal remedy, mainly distributed in the States of India. It possesses wide array of medicinal properties. Aim To execute green synthesis approach for the preparation of silver and iron nanoparticles by using alcoholic Blumea Eriantha DC extract and to verify the biological potential of the prepared nanoparticles as a hair growth promoter. Patients/Method Extract was mixed with silver nitrate and ferric chloride for synthesis of silver and iron nanoparticles, respectively. Prepared nanoparticles were confirmed by UV, FT‐IR, SEM, X‐ray diffraction, and TEM. The qualitative and quantitative analysis was performed namely hair growth initiation, hair growth completion, hair length, hair weight, histopathological studies, skin thickness, and length of the hair follicle. Results The prepared nanoparticles were observed as a blend of spherical and irregular shape with an average particle size of 35nm. The transition of anagen hair follicles was observed in approximately 63.43 % of animals treated with Minoxidil, whereas 2% and 5% Blumea eriantha silver nanoparticles treated animal group exhibited 33.02% and 60.93%, respectively. The animal groups treated with 2% and 5% iron nanoparticles of Blumea Eriantha showed 44.09 and 38.89% in anagen induction, respectively, which suggest the hair growth‐promoting potential of the extract of Blumea eriantha DC. Conclusion Thus, it can be concluded that silver nanoparticles of Blumea Eriantha exhibit promising hair growth promoting activity.

الإتاحة: https://doi.org/10.1111/jocd.13713Test