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1دورية أكاديمية
المؤلفون: Radlović Nedeljko, Leković Zoran, Mladenović Marija, Vuletić Biljana, Radlović Jelena, Dučić Siniša, Nikolić Dejan
المصدر: Srpski Arhiv za Celokupno Lekarstvo, Vol 151, Iss 11-12, Pp 719-724 (2023)
مصطلحات موضوعية: celiac disease, pathogenesis, clinical forms, diagnostics, Medicine
الوصف: Celiac disease is a multisystemic autoimmune disease induced by gluten in wheat, rye, and barley. It is characterized by polygenic predisposition, prevailing prevalence in members of the white population (1%), especially in close relatives (5–15%), very heterogeneous expression and frequent association with other autoimmune diseases (3–10%), as well as selective deficiency of IgA and Down, Turner, and Williams syndromes. The basis of the disease and the key finding in its diagnostics is gluten-sensitive enteropathy, i.e., non-specific inflammation of the small intestinal mucosa which resolves by gluten-free diet. In addition to enteropathy, whether symptomatic or asymptomatic, the disease is also characterized by various extraintestinal manifestations, and even very serious complications. Therapy is based on a lifelong glutenfree diet, so that the disorder, if diagnosed in time and treated consistently, has an excellent prognosis.
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Leković Zoran, Radlović Vladimir, Mladenović Marija, Dučić Siniša, Đuričić Goran, Predojević-Samardžić Jelica, Vuletić Biljana, Rosić Petar, Janković Srđa, Radlović Nedeljko
المصدر: Srpski Arhiv za Celokupno Lekarstvo, Vol 151, Iss 7-8, Pp 423-426 (2023)
مصطلحات موضوعية: celiac disease, children, siblings, prevalence, Medicine
الوصف: Introduction/Objective. Celiac disease (CD) is the result of a polygenic predisposition and gluten-containing diet. The aim of this study was to determine the prevalence and clinical forms of CD in siblings of children with verified disease. Methods. The study included 83 siblings, aged 1.5–27 (11.77 ± 6.2) years, of 64 children with CD diagnosed according to ESPGHAN criteria (1990/2012). In addition to a detailed history and clinical examination, serum levels of IgA and antibodies to tissue transglutaminase (AtTG) IgA and IgG classes were determined in all subjects. All with elevated AtTG levels underwent multiple duodenal enterobiopsy. The diagnosis of CD was confirmed by the finding of characteristic histological changes. Results. The diagnosis of CB was made in 13 of 83 subjects (15.67%). Nine of them had an asymptomatic form of the disease, while in the others the disease was clinically manifested – in three the form was classical, in one it was accompanied by severe malnutrition (-26.80%), and in one the manifestation was nonclassical (only short stature). Except for sideropenia and hypoferritinemia in four patients, of which two with hemoglobin below the reference value, standard laboratory findings were within normal limits. Conclusion. Our research shows that the prevalence of CD in siblings of children with verified disease is 15.67%. It is mostly detected in its asymptomatic form. In accordance with this, routine application of serological screening for CD in this population group is necessary for its timely diagnosis and treatment.
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Prokić Dragan, Đuričić Slaviša, Kitić Ivana, Kocić Marija, Pašić Srđan, Vuletić Biljana
المصدر: Srpski Arhiv za Celokupno Lekarstvo, Vol 151, Iss 7-8, Pp 427-432 (2023)
مصطلحات موضوعية: celiac disease, tissue transglutaminase antibodies, hla-dq2/dq8 typing, non-invasive, Medicine
الوصف: Introduction/Objective. The objective of the paper is to assess the applicability of serum anti-tissue transglutaminase (tTG) antibodies IgA and IgG concentration and HLA-DQ2/DQ8 typing as a non-invasive alternative to duodenal biopsy in diagnosing celiac disease (CD) in pediatric population. Methods. A prospective cohort study included a total of 179 pediatric patients aged 1–18 years. Determination of tTG IgA and tTG IgG antibodies and human leukocyte antigen (HLA) DQ2/DQ8 typing was performed for all patients. Histology of duodenal biopsies was interpreted by the modified Marsh scoring system. Results. The diagnosis of CD was confirmed in 101 (56%) patients of the studied population. In cases of CD, HLA-DQ2/DQ8 was positive in 100 patients (99%). The tTG IgA antibodies in concentration higher than 100 U/ml were detected in 77 (76.2%) of the CD patients and in significantly smaller number for tTG IgG [29 (28.7%)] (p < 0.001). Statistically highly significant association of duodenal lesions Marsh grade 3 with concentration of tTG IgA 10-fold higher than the upper level of normal (ULN) was established (p < 0.001) Conclusion. Concentration of tTG IgA 10-fold higher than ULN is significantly positively correlated with Marsh grade 3 histopathology findings. Specific antibodies determination in combination with HLA-DQ2/ DQ8 typing proves to be sufficient for a diagnosis of CD, supporting the fact that duodenal biopsy may be avoided in a significant majority of patients – 75%.
وصف الملف: electronic resource
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4دورية أكاديمية
المؤلفون: Vuletić Biljana, Kočović Aleksandar, Mladenović Marija, Leković Zoran, Radlović Vladimir, Stojanović Biljana, Đonović Nela, Radlović Nedeljko
المصدر: Srpski Arhiv za Celokupno Lekarstvo, Vol 150, Iss 1-2, Pp 108-112 (2022)
مصطلحات موضوعية: celiac disease, wheat allergy, non-celiac gluten sensitivity, gluten ataxia, dermatitis herpetiformis, Medicine
الوصف: Gluten-related disorders are a heterogeneous group of clinical entities caused by intolerance to wheat, rye, and barley flour components. They occur in 3–5% of genetically predisposed persons and, based on pathogenic and clinical features, are classified into celiac disease, non-celiac gluten sensitivity, and wheat allergy. There are also specific entities such as dermatitis herpetiformis or gluten ataxia, which can occur either within the celiac disease or independently. This article based on the current knowledge shows the basic details of the pathogenesis, clinical expression, diagnosis, and treatment of these disorders.
وصف الملف: electronic resource
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5دورية أكاديمية
المؤلفون: Radlović Nedeljko, Leković Zoran, Radlović Vladimir, Mandić Jelena, Mladenović Marija, Radlović Jelena, Vuletić Biljana, Dučić Siniša, Bukva Bojan, Dašić Ivana
المصدر: Srpski Arhiv za Celokupno Lekarstvo, Vol 149, Iss 1-2, Pp 48-52 (2021)
مصطلحات موضوعية: nonclassical celiac disease, children and adolescents, symptoms and signs, Medicine
الوصف: Introduction/Objective. Nonclassical celiac disease (CD) is characterized by a very heterogeneous and non-specific clinical presentation. The aim of this study was to determine the basic symptoms and clinical signs of this CD subtype in children and adolescents Methods. The study was based on a sample of 58 children and adolescent, 38 female and 20 male, ages 1.75 to 17.75 (10.01±4.62) years with a nonclassical CD diagnosed according to the European Society for Pediatric Gastroenterology, Hepatology and Nutrition criteria from 1990 and 2012. Results. Except four patients who were between the ages of 1.75 to 2.50 years, all others were older than three years. The main clinical symptoms and signs suggestive of non-classical CD were anemia caused by iron deficiency (48.28%), short stature (34.48%), and intermittent abdominal pain (18.97%), anorexia with stagnation or weight loss (13.79%), and chronic constipation (6.9%). Thirty patients had one symptom or sign of the disease, 15 had two and 13 had three. In addition, 12 patients had dental enamel hypoplasia, 18 sideropenia without anemia and five mild isolated hypertransaminasemia. A gluten-free diet, apart from the dental enamel hypoplasia, has resulted in the withdrawal of all indicators of the disease. Conclusion. The main symptoms and clinical signs of nonclassical CD in children and adolescents were iron deficiency anemia, short stature and intermittent abdominal pain, and less frequently anorexia with stagnation or weight loss and chronic constipation. Excluding dental enamel hypoplasia, a gluten-free diet leads to a complete recovery of the patient.
وصف الملف: electronic resource
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6دورية أكاديمية
المؤلفون: Stojanović Biljana, Janković Sveta, Đonović Nela, Radlović Vladimir, Jovanović Stevan, Vuletić Biljana
المصدر: Vojnosanitetski Pregled, Vol 78, Iss 3, Pp 370-375 (2021)
مصطلحات موضوعية: biopsy, celiac disease, diagnosis, history of medicine, therapeutics, Medicine (General), R5-920
الوصف: nema
وصف الملف: electronic resource
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7دورية أكاديمية
المصدر: Sestrinska reč, Vol 24, Iss 82, Pp 14-17 (2021)
مصطلحات موضوعية: celiac disease, children, gluten free nutrition, gluten information, Nursing, RT1-120
الوصف: Introduction: Celiac disease is an autoimmune disease caused by an inadequate immune response in contact with gluten in genetically predisposed individuals. Barriers to maintaining a strict gluten-free diet arise due to several factors, the most common of which are: inadequate information, insufficient education about the disease, food contamination. Aim of the research: To determine the ways of informing parents about the celiac disease that has been diagnosed in their children, as well as to learn about the necessary procedures to improve information about gluten-free diet. Subjects and method: The study included a sample of 116 parents whose children are diagnosed with celiac disease and who are on a gluten-free diet. The place of research is the Institute for Maternal and Child Health of Serbia "Dr Vukan Cupic" in New Belgrade and the University Children's Clinic in Belgrade. The research instrument used is the Questionnaire on Parents' Awareness of Celiac Disease, which was created for the purposes of this research. Results with discussion: The results of the study show that 47.14% of parents of children with celiac disease ask for information about the proper nutrition of their children and gluten-free foods from the doctor of the institution where the child was diagnosed with the disease. In order to better understand the diagnosis of celiac disease in their child, 53.01% of parents most often chose to talk to the doctor who treats the child. Conclusion: Information on proper nutrition of children and gluten-free foods, as well as specific information on celiac disease, is requested from the doctor of the institution where the disease was diagnosed in the child and where they go for check-ups. Many complications caused by unrecognized celiac disease could be prevented by timely diagnosis and proper posture of the child, which contributes to good and adequate information.
وصف الملف: electronic resource
العلاقة: https://scindeks-clanci.ceon.rs/data/pdf/0354-8422/2021/0354-84222182014S.pdfTest; https://doaj.org/toc/0354-8422Test; https://doaj.org/toc/2466-5126Test
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8دورية أكاديمية
المؤلفون: Radlović Nedeljko, Leković Zoran, Mladenović Marija, Radlović Vladimir, Vuletić Biljana, Dučić Siniša, Golubović Zoran, Mahmutović Meho, Petrović-Tepić Snežana
المصدر: Srpski Arhiv za Celokupno Lekarstvo, Vol 147, Iss 7-8, Pp 450-454 (2019)
مصطلحات موضوعية: isolated hypertransaminasemia, classical celiac disease, children up to 2 years, Medicine
الوصف: Introduction/Objective Isolated hypertransaminasemia (IHTS) is a common, benign, and transient appearance in patients with celiac disease (CD). The aim of this study is to determine the frequency of IHTS in children up to two years old with clinically classical CD, as well as its connection with the onset of the first symptoms of the disease, the age of diagnosis, the clinical and laboratory nutritional parameters, and the degree of damage of small intestinal mucosa. Methods The study was based on a sample of 82 children, 55 female and 27 male, ages 7–24 (14.28 ± 4.41) months. The diagnosis of CD was based on the revised ESPGHAN criteria and the activity of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) by standard laboratory methods. Results IHTS was found in 39 (47.56%) patients, 27 of whom (69.23%) had elevated levels of both transaminases and 12 of only one – eight of AST and four of ALT. The increase in relation to the aforementioned reference value for ALT was 1.1–10.08 (1.67 ± 1.73), and for AST it was 1.08–7.91 (1.56 ± 1.29) times. In patients with IHTS compared to those with normal transaminasemia, the age of onset of CD was significantly lower (9.83 ± 3.69 vs. 12.95 ± 4.43 months, p = 0.001), as well as the age of diagnosis (12.97 ± 3.88 vs. 15.47 ± 4.56 months; p = 0.01), while the differences in the other observed parameters were not significant. Conclusions IHTS occurs in almost half of children up to two years old with classical CD. Hypertransaminasemia is in most cases mild and significantly more frequent in patients with earlier clinical expression of the CD.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/0370-8179Test
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9دورية أكاديمية
المؤلفون: Mladenović Marija, Radlović Nedeljko, Leković Zoran, Vuletić Biljana, Radlović Vladimir, Dučić Siniša, Golubović Zoran, Radlović Jelena, Mahmutović Meho, Petrović Jasna
المصدر: Srpski Arhiv za Celokupno Lekarstvo, Vol 147, Iss 11-12, Pp 683-687 (2019)
مصطلحات موضوعية: classic celiac disease, children up to 2 years, breastfeeding, age of gluten introduction, Medicine
الوصف: Introduction/Objective. The classic type of celiac disease (CD) is most common in children under two years of age. The aim of this study was to investigate whether breastfeeding, particularly breastfeeding during gluten introduction, and timing of gluten introduction, influence the onset of CD at this age. Methods. We retrospectively analyzed medical records of 93 children, 40 in the first and 53 in the second year, with a classic CD diagnosed at the University Children’s Hospital, Belgrade between 2000 and 2010. The diagnosis of CD was based on the criteria of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) from 1989. Results. Duration of breastfeeding reduced the onset of the CD in the first year p = 0.039 (OR = 1.43 95% CI 1.019–1.899). Also, breastfeeding at the time of gluten introduction significantly delayed the age at diagnosis (F = 1.671, t = 2.39, p = 0.029). The timing of gluten introduction did not affect the age of occurrence of CD in these group of children. Conclusion. Longer breastfeeding, and breastfeeding at the time of gluten introduction, postponed the onset of classic CD in patients up to two years. The association between the occurrence of CD and the time of introduction of gluten in this age group of patients has not been established.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/0370-8179Test
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10دورية أكاديمية
المؤلفون: Radlović Nedeljko, Leković Zoran, Mladenović Marija, Radlović Vladimir, Vuletić Biljana, Dučić Siniša, Golubović Zoran, Nikolić Dejan, Mahmutović Meho, Petrović-Tepić Snežana
المصدر: Srpski Arhiv za Celokupno Lekarstvo, Vol 147, Iss 3-4, Pp 189-192 (2019)
مصطلحات موضوعية: classical celiac disease, children, anemia, Medicine
الوصف: Introduction/Objective. Anemia is the most common extraintestinal manifestation of celiac disease (CD) in children. The aim of this study was to determine the frequency, severity and type of anemia in children with a classical CD, as well as the differences between anemic and non-anemic patients in their age, duration of illness, percentile body length or height, percentage of body weight (BW) deviation compared to ideal, and the degree of damage to the small intestine mucosa. Methods. The study was based on a sample of 90 children, 56 females and 34 males, ages 7–90 (18.23 Ѓ} 12.7) months with classical CD. The diagnosis of CD is based on the ESPGHAN criteria from 1990 and 2012, and of anemia on the 2011 WHO reference values. Results. Anemia was found in 47 (52.22%) patients, of which it was mild in 23 cases [hemoglobin (Hb) 100–109 g/L] and moderately severe in 24 (Hb 70–99 g/L), in 34 (72.34%) it was microcytic [mean cell volume (MCV) < 70 fl] and normocytic (MCV 70–87 fl) in 13 patients. Low serum iron levels (< 10.7 μmol/L) were found in 68 (75.56%), and hypoferritinemia (< 16 ng/ml) in 77 (85.56%) patients. Except for a greater deficit of BW in patients with anemia compared to those without anemia (-14.64 ± 9.60 vs. -8.56 ± 11.87%, p < 0.01), differences in other defined features were not significant. Conclusion. Mild or moderate iron deficiency anemia occurs in slightly more than half of children with a classical type CD. In anemic compared to non-anemic patients, there is a significantly higher BW deficit, while differences in other characteristics typical for this type of disease are not significant.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/0370-8179Test
