المؤلفون: Snellman, A, Lantero-Rodriguez, J, Emersic, A, Vrillon, A, Karikari, TK, Ashton, NJ, Kramberger, MG, Cucnik, S, Paquet, C, Rot, U, Zetterberg, H, Blennow, K

المصدر: Brain : a journal of neurology. 145(8):2834-2848

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:150361088Test

المؤلفون: Agathe Vrillon, Olivier Bousiges, Karl Götze, Catherine Demuynck, Candice Muller, Alix Ravier, Benoît Schorr, Nathalie Philippi, Claire Hourregue, Emmanuel Cognat, Julien Dumurgier, Matthieu Lilamand, Benjamin Cretin, Frédéric Blanc, Claire Paquet

المصدر: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)

مصطلحات موضوعية: Dementia with Lewy bodies, Alzheimer’s disease, Plasma biomarkers, Amyloid pathology, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

الوصف: Abstract Background Increasing evidence supports the use of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation for diagnosis of dementia. However, their performance for positive and differential diagnosis of dementia with Lewy bodies (DLB) in clinical settings is still uncertain. Methods We conducted a retrospective biomarker study in two tertiary memory centers, Paris Lariboisière and CM2RR Strasbourg, France, enrolling patients with DLB (n = 104), Alzheimer’s disease (AD, n = 76), and neurological controls (NC, n = 27). Measured biomarkers included plasma Aβ40/Aβ42 ratio, p-tau181, NfL, and GFAP using SIMOA and plasma YKL-40 and sTREM2 using ELISA. DLB patients with available CSF analysis (n = 90) were stratified according to their CSF Aβ profile. Results DLB patients displayed modified plasma Aβ ratio, p-tau181, and GFAP levels compared with NC and modified plasma Aβ ratio, p-tau181, GFAP, NfL, and sTREM2 levels compared with AD patients. Plasma p-tau181 best differentiated DLB from AD patients (ROC analysis, area under the curve [AUC] = 0.80) and NC (AUC = 0.78), and combining biomarkers did not improve diagnosis performance. Plasma p-tau181 was the best standalone biomarker to differentiate amyloid-positive from amyloid-negative DLB cases (AUC = 0.75) and was associated with cognitive status in the DLB group. Combining plasma Aβ ratio, p-tau181 and NfL increased performance to identify amyloid copathology (AUC = 0.79). Principal component analysis identified different segregation patterns of biomarkers in the DLB and AD groups. Conclusions Amyloid, tau, neurodegeneration and neuroinflammation plasma biomarkers are modified in DLB, albeit with moderate diagnosis performance. Plasma p-tau181 can contribute to identify Aβ copathology in DLB.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1758-9193Test

الوصول الحر: https://doaj.org/article/238f9ff7a6ad4b788865819ae0efee6eTest

المؤلفون: Thomas Quinaux, Zead Tubail, Isabelle Vrillon, Hervé Sartelet, Benjamin Savenkoff

المصدر: Case Reports in Nephrology and Dialysis, Vol 13, Iss 1, Pp 113-119 (2023)

مصطلحات موضوعية: atypical hemolytic uremic syndrome, campylobacter, complement system, alternate pathway, Diseases of the genitourinary system. Urology, RC870-923

الوصف: We present the case of a 17-year-old Caucasian male whose condition featured acute renal failure, anemia, and deep thrombocytopenia after five consecutive days of diarrhea. Campylobacter coli was identified in stool cultures and, although the direct role of this germ in the pathogenesis of hemolytic uremic syndrome (HUS) remains uncertain to this day, initial presentation was considered broadly consistent with typical HUS. However, the patient showed no signs of spontaneous recovery over time. While secondary investigations showed no abnormalities in ADAMTS13 activity or in the alternate pathway of complement, patient’s condition deteriorated. Worsening kidney failure required emergency renal replacement therapy and was followed by cardiac involvement in the form of acute heart failure. Given this unfavorable development, blood samples were drawn to look for mutations in the alternate complement pathway, and eculizumab therapy was initiated without further delay, allowing prompt improvement of cardiac function and recovery of diuresis. Upon discharge, the patient still had to undergo intermittent dialysis, which would later be withdrawn. Genetic analysis ultimately confirmed the presence of a complement factor H mutation associated with a high risk of disease recurrence, indicating long-term continuation of eculizumab therapy.

وصف الملف: electronic resource

العلاقة: https://beta.karger.com/Article/FullText/529941Test; https://doaj.org/toc/2296-9705Test

الوصول الحر: https://doaj.org/article/6b0cbb5ec4074b65b4947389a1ae29a9Test

المؤلفون: Dominique Gouilly, Agathe Vrillon, Elsa Bertrand, Marie Goubeaud, Hélène Catala, Johanne Germain, Nadéra Ainaoui, Marie Rafiq, Leonor Nogueira, François Mouton-Liger, Mélanie Planton, Anne-Sophie Salabert, Anne Hitzel, Déborah Méligne, Laurence Jasse, Benjamine Sarton, Stein Silva, Béatrice Lemesle, Patrice Péran, Pierre Payoux, Claire Thalamas, Claire Paquet, Jérémie Pariente

المصدر: NeuroImage: Clinical, Vol 43, Iss , Pp 103626- (2024)

مصطلحات موضوعية: TSPO, Neuro-inflammation, Rs6971, Cerebrospinal fluid, Alzheimer’s disease, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

الوصف: Background: PET imaging of the translocator protein (TSPO) is used to assess in vivo brain inflammation. One of the main methodological issues with this method is the allelic dependence of the radiotracer affinity. In Alzheimer’s disease (AD), previous studies have shown similar clinical and patho-biological profiles between TSPO genetic subgroups. However, there is no evidence regarding the effect of the TSPO genotype on cerebrospinal-fluid biomarkers of glial activation, and synaptic and axonal damage. Method: We performed a trans-sectional study in early AD to compare cerebrospinal-fluid levels of GFAP, YKL-40, sTREM2, IL-6, IL-10, NfL and neurogranin between TSPO genetic subgroups. Results: We recruited 33 patients with early AD including 16 (48%) high affinity binders, 13 (39%) mixed affinity binders, and 4/33 (12%) low affinity binders. No difference was observed in terms of demographics, and cerebrospinal fluid levels of each biomarker for the different subgroups. Conclusion: TSPO genotype is not associated with a change in glial activation, synaptic and axonal damage in early AD. Further studies with larger numbers of participants will be needed to confirm that the inclusion of specific TSPO genetic subgroups does not introduce selection bias in studies and trials of AD that combine TSPO imaging with cerebrospinal fluid biomarkers.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2213158224000652Test; https://doaj.org/toc/2213-1582Test

الوصول الحر: https://doaj.org/article/3f98282c7a774b81abd90595d8a333d4Test

المؤلفون: Emeršič, Andreja, Ashton, Nicholas J., Vrillon, Agathe, Lantero‐Rodriguez, Juan, Mlakar, Jernej, Gregorič Kramberger, Milica, Gonzalez‐Ortiz, Fernando, Kac, Przemysław R., Dulewicz, Maciej, Hanrieder, Jörg, Vanmechelen, Eugeen, Rot, Uroš, Zetterberg, Henrik, Karikari, Thomas K., Čučnik, Saša, Blennow, Kaj

المساهمون: BrightFocus Foundation, Hjärnfonden, Gun och Bertil Stohnes Stiftelse, Vetenskapsrådet, Alzheimer's Association, Familjen Erling-Perssons Stiftelse, Stiftelsen för Gamla Tjänarinnor, UK Dementia Research Institute

المصدر: Alzheimer's & Dementia ; ISSN 1552-5260 1552-5279

الوصف: INTRODUCTION The established cerebrospinal fluid (CSF) phosphorylated tau181 (p‐tau181) may not reliably reflect concomitant Alzheimer's disease (AD) and primary age‐related tauopathy (PART) found in Creutzfeldt–Jakob disease (CJD) at autopsy. METHODS We investigated CSF N‐terminal p‐tau181, p‐tau217, and p‐tau231 with in‐house Simoa assays in definite CJD ( n = 29), AD dementia ( n = 75), mild cognitive impairment (MCI) due to AD ( n = 65), and subjective cognitive decline (SCD, n = 28). Post‐mortem examination performed in patients with CJD 1.3 (0.3–14.3) months after CSF collection revealed no co‐pathology in 10, concomitant AD in 8, PART in 8, and other co‐pathologies in 3 patients. RESULTS N‐terminal p‐tau was increased in CJD versus SCD ( p < 0.0001) and correlated with total tau (t‐tau) in the presence of AD and PART co‐pathology (rho = 0.758–0.952, p ≤ 001). Concentrations in CJD +AD were indistinguishable from AD dementia, with the largest fold‐change in p‐tau217 (11.6), followed by p‐tau231 and p‐tau181 (3.2–4.5). DISCUSSION Variable fold‐changes and correlation with t‐tau suggest that p‐tau closely associates with neurodegeneration and concomitant AD in CJD. Highlights N‐terminal phosphorylated tau (p‐tau) biomarkers are increased in Creutzfeldt–Jakob disease (CJD) with and without concomitant AD. P‐tau217, p‐tau231, and p‐tau181 correlate with total tau (t‐tau) and increase in the presence of amyloid beta (Aβ) co‐pathology. N‐terminal p‐tau181 and p‐tau231 in Aβ‐negative CJD show variation among PRNP genotypes. Compared to mid‐region–targeting p‐tau181, cerebrospinal fluid (CSF) N‐terminal p‐tau has greater potential to reflect post‐mortem neuropathology in the CJD brain.

الإتاحة: https://doi.org/10.1002/alz.13907Test

المؤلفون: Grosyeux, Chloé, Alla, Asma, Barbé, Françoise, Dubourg, Laurence Derain, Chardon, Laurence, Guéant, Jean‐Louis, Frimat, Luc, Oussalah, Abderrahim, Vrillon, Isabelle

المساهمون: Department of Molecular Medicine, University of Pavia

المصدر: Nephrology ; ISSN 1320-5358 1440-1797

الوصف: Aim This study evaluated the bias and accuracy of the CKD‐EPI/CKiD and EKFC equations compared with the reference exogenous tracer‐based assessment of glomerular filtration rate (GFR) in adult and pediatric patients according to their renal transplant status. Methods We assessed the bias and P 30 accuracy of the CKD‐EPI/CKiD and EKFC equations compared with iohexol‐based GFR measurement. Results In the overall population ( n = 59), the median age was 29 years (IQR, 16.0–46.0) and the median measured GFR was 73.9 mL/min/1.73m 2 (IQR, 57.3–84.6). Among non‐kidney transplant patients, the median was 77.7 mL/min/1.73m 2 (IQR, 59.3–86.5), while among kidney transplant patients, it was 60.5 mL/min/1.73m 2 (IQR, 54.2–66.8). The bias associated with the EKFC and CKD‐EPI/CKiD equations was significantly higher among kidney transplant patients than among non‐kidney transplant patients, with a difference between medians (Hodges–Lehmann) of +10.4 mL/min/1.73m 2 (95% CI, 2.2–18.9; p = .02) for the EKFC and +12.1 mL/min/1.73m 2 (95% CI, 4.2–21.4; p = .006) for the CKD‐EPI/CKiD equations. In multivariable analysis, kidney transplant status emerged as an independent factor associated with a bias of >3.4 mL/min/1.73m 2 (odds ratio, 7.7; 95% CI, 1.4–43.3; p = .02) for the EKFC equation and a bias of >13.4 mL/min/1.73m 2 (odds ratio, 15.0; 95% CI, 2.6–85.7; p = .002) for the CKD‐EPI/CKiD equations. Conclusion In our study, which included adolescent and young adult kidney transplant patients, both the CKD‐EPI/CKiD and EKFC equations tended to overestimate the measured glomerular filtration rate, with the EKFC equation exhibiting less bias. Renal transplant status significantly influenced the degree of estimation bias. image

الإتاحة: https://doi.org/10.1111/nep.14328Test

المؤلفون: Belmonte, Richard, Silva‐Rodriguez, Maël, Barbé, Françoise, Bensenane, Mouni, Haghenejad, Vincent, Vrillon, Isabelle, Alla, Asma, Flahault, Adrien, Kormann, Raphael, Corbel, Alice, Aitdjafer, Zakia, Quilliot, Didier, Derain‐Dubourg, Laurence, Namour, Farès, Guéant, Jean‐Louis, Bronowicki, Jean‐Pierre, Oussalah, Abderrahim

المصدر: Hepatology Research ; ISSN 1386-6346 1872-034X

الوصف: Aim Renal dysfunction is a common complication of cirrhosis, occurring either as part of multiorgan involvement in acute illness or secondary to advanced liver disease. To date, no study has comprehensively assessed multiple renal function parameters in hospitalized patients with cirrhosis through a multiparametric analysis of renal biochemistry markers. Methods We conducted a retrospective, observational study including all consecutive patients hospitalized with cirrhosis who underwent a 43‐multiparametric renal function assessment between January 1, 2021, and June 30, 2023. Results All patients showed at least one of the following renal abnormalities: Kidney Disease: Improving Global Outcomes stage G2 or higher, sodium and/or chloride excretion fraction <1%, electrolyte‐free water clearance <0.4 mL/min, or tubular maximum phosphate reabsorption capacity <0.8 mmol/L. The estimated glomerular filtration rate equations significantly overestimated the measured creatinine clearance with median differences of +14 mL/min/1.73 m 2 (95% CI 6–29) and +9 mL/min/1.73 m 2 (95% CI 2–15) for European Kidney Function Consortium equations, respectively. Notably, 54% and 39% of patients demonstrated estimated glomerular filtration rates exceeding 30% of the measured creatinine clearance when the Chronic Kidney Disease ‐ Epidemiology Collaboration and European Kidney Function Consortium formulas were employed, respectively. Substantial discrepancies in Kidney Disease: Improving Global Outcomes stage assignments were observed between the estimated glomerular filtration rate‐ and measured creatinine clearance‐based assessments. Conclusions This study underscores the value of a multiparametric renal function assessment as a routine tool for evaluating renal function in patients with cirrhosis. A high prevalence of medically actionable renal abnormalities spanning multiple renal function modules, including alterations in glomerular function, salt and solute‐free water excretion, and proximal tubule phosphate ...

الإتاحة: https://doi.org/10.1111/hepr.14050Test

المؤلفون: Lantero-Rodriguez, Juan, Montoliu-Gaya, Laia, Benedet, Andrea L., Vrillon, Agathe, Dumurgier, Julien, Cognat, Emmanuel, Brum, Wagner S., Rahmouni, Nesrine, Stevenson, Jenna, Servaes, Stijn, Therriault, Joseph, Becker, Bruno, Brinkmalm, Gunnar, Snellman, Anniina, Huber, Hanna, Kvartsberg, Hlin, Ashton, Nicholas J., Zetterberg, Henrik, Paquet, Claire, Rosa-Neto, Pedro, Blennow, Kaj

المصدر: Acta Neuropathologica ; volume 147, issue 1 ; ISSN 0001-6322 1432-0533

مصطلحات موضوعية: Cellular and Molecular Neuroscience, Neurology (clinical), Pathology and Forensic Medicine

الوصف: Post-mortem staging of Alzheimer’s disease (AD) neurofibrillary pathology is commonly performed by immunohistochemistry using AT8 antibody for phosphorylated tau (p-tau) at positions 202/205. Thus, quantification of p-tau205 and p-tau202 in cerebrospinal fluid (CSF) should be more reflective of neurofibrillary tangles in AD than other p-tau epitopes. We developed two novel Simoa immunoassays for CSF p-tau205 and p-tau202 and measured these phosphorylations in three independent cohorts encompassing the AD continuum , non-AD cases and cognitively unimpaired participants: a discovery cohort ( n = 47), an unselected clinical cohort ( n = 212) and a research cohort well-characterized by fluid and imaging biomarkers ( n = 262). CSF p-tau205 increased progressively across the AD continuum, while CSF p-tau202 was increased only in AD and amyloid (Aβ) and tau pathology positive (A+T+) cases ( P < 0.01). In A+ cases, CSF p-tau205 and p-tau202 showed stronger associations with tau-PET ( r Sp205 = 0.67, r Sp202 = 0.45) than Aβ-PET ( r Sp205 = 0.40, r Sp202 = 0.09). CSF p-tau205 increased gradually across tau-PET Braak stages ( P < 0.01), whereas p-tau202 only increased in Braak V–VI ( P < 0.0001). Both showed stronger regional associations with tau-PET than with Aβ-PET, and CSF p-tau205 was significantly associated with Braak V–VI tau-PET regions. When assessing the contribution of Aβ and tau pathologies (indexed by PET) to CSF p-tau205 and p-tau202 variance, tau pathology was found to be the most prominent contributor in both cases (CSF p-tau205: R 2 = 69.7%; CSF p-tau202: R 2 = 85.6%) Both biomarkers associated with brain atrophy measurements globally ( r Sp205 = − 0.36, r Sp202 = − 0.33) and regionally, and correlated with cognition ( r Sp205 = − 0.38/− 0.40, r Sp202 = − 0.20/− 0.29). In conclusion, we report the first high-throughput CSF p-tau205 immunoassay for the in vivo quantification of tau pathology in AD, and a potentially cost-effective alternative to tau-PET in clinical settings and clinical ...

الإتاحة: https://doi.org/10.1007/s00401-023-02659-wTest

المؤلفون: Sindzingre, Louise, Bouaziz-Amar, Elodie, Mouton-Liger, François, Cognat, Emmanuel, Dumurgier, Julien, Vrillon, Agathe, Paquet, Claire, Lilamand, Matthieu

المصدر: The Journal of nutrition, health and aging ; volume 28, issue 3, page 100166 ; ISSN 1279-7707

مصطلحات موضوعية: Geriatrics and Gerontology, Nutrition and Dietetics, Medicine (miscellaneous)

الإتاحة: https://doi.org/10.1016/j.jnha.2024.100166Test
https://api.elsevier.com/content/article/PII:S1279770724002409?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1279770724002409?httpAccept=text/plainTest

المؤلفون: Éléonore Vrillon

المساهمون: Hermès, Laboratoire d'informatique de l'Université du Maine

المصدر: Sciences et Technologies de l'Information et de la Communication pour l'Éducation et la Formation 24(2):87-111

الوصف: The growth of Massive Open Online Courses (MOOC) phenomenon is pursuing all around the world, but behind a general term MOOC are multifaceted. Because of this heterogeneity, the comparison of MOOC research results is particularly difficult, just as the understanding of this object and its issues. This article examines MOOC characteristics of the French national platform FUN from October, 2013 till May, 2016. A set of information has been systematically identified in order to create an exhaustive and well-reasoned database. Multiple correspondence analysis (MCA) shows a typology of eight MOOC. This result enables a contextualization of MOOC specificities studied in research.
Alors que le nombre de MOOC dans le monde ne cesse de croître, la réalité qu’ils recouvrent est loin d’être uniforme. Cette hétérogénéité rend difficile une comparaison des recherches entre elles, tout comme une appréhension générale de cet objet d’étude et des enjeux qu’il soulève. Cet article présente une étude des caractéristiques des MOOC de la plateforme nationale française FUN d’octobre 2013 à mai 2016. Pour 195 MOOC, un ensemble d’informations a été systématiquement répertorié jusqu’à la constitution d’une base de données exhaustive et raisonnée. La réalisation d’une analyse des correspondances multiples (ACM) met au jour huit formes typiques de MOOC. Ce résultat rend possible un travail de contextualisation des MOOC étudiés, l’identification de leurs spécificités, tout en représentant un point d''appui méthodologique à la mise en place d'enquêtes de terrain.

الوصول الحر: https://www.persee.fr/doc/stice_1764-7223_2017_num_24_2_1741Test