المؤلفون: Dimitrios Papadopoulos, Vlasios Skopas, Nikolaos Trakas, Eleni Papaefstathiou, Nikolaos Tzogas, Demosthenes Makris, Zoe Daniil, Konstantinos Gourgoulianis

المصدر: Monaldi Archives for Chest Disease (2023)

مصطلحات موضوعية: Lactate dehydrogenase, LDH isoenzymes, COPD acute exacerbation, COPD outcomes, Medicine

الوصف: We aimed to test the association between serum lactate dehydrogenase (LDH) and its isoenzymes and treatment outcomes during hospitalization for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Thirty-eight AECOPD patients were recruited from a tertiary hospital from December 2017 to June 2018. Serum LDH and LDH isoenzymes were measured on venous blood collected at admission. Treatment outcomes included duration of hospital stay, initiation of non-invasive (NIV) or mechanical ventilation, initiation of antipseudomonal antibiotics, change in empirical antibiotic treatment, need for intravenous corticosteroids or methylxanthines, and percentage of change in C-reactive protein from admission to the third day. Multivariate linear and binary logistic regression analyses were used to test the study’s objectives. We found that, after adjusting for age, gender, comorbidities, COPD severity, level of hypoxemia, and inflammation markers, each 10 U/L increase in serum LDH was associated with prolongation of the hospital stay by 0.25 (0.03, 0.46) days, 42% higher odds (odds ratio [OR] 1.42 [1.00, 2.03]) for need of NIV, and 25% higher odds (OR 1.25 [1.04, 1.49]) for initiation of antipseudomonal treatment. LDH1 and LDH2 were the LDH isoenzymes that mainly drove these relationships. LDH release in the context of an AECOPD could originate from lung, muscle, or heart tissue damage due to airway inflammation, respiratory muscle recruitment, and myocardial stress. Myocardial injury and aerobic adaptation in respiratory muscles may explain the predominance of LDH1 and LDH2 isoenzymes in these associations.

وصف الملف: electronic resource

العلاقة: https://www.monaldi-archives.org/index.php/macd/article/view/2543Test; https://doaj.org/toc/1122-0643Test; https://doaj.org/toc/2532-5264Test

الوصول الحر: https://doaj.org/article/ea73e7e7b18f48558cc7b0c0ba66830dTest

المؤلفون: Dimitrios Papadopoulos, Panagiotis Misthos, Maria Chorti, Vlasios Skopas, Alexandra Nakou, Napoleon Karagianidis, Achilleas Lioulias, Vasiliki Filaditaki

المصدر: Monaldi Archives for Chest Disease, Vol 88, Iss 1 (2018)

مصطلحات موضوعية: Pulmonary hypoplasia, Computed tomography, Pneumonectomy, Medicine

الوصف: Pulmonary hypoplasia (PH) is a developmental anomaly of the lung parenchyma, characterized by a decrease in the number and size of airways, alveoli and vessels. We present a case of a 31-year-old patient with a history of chronic productive cough and frequent respiratory infections, who was referred for investigation of abnormal chest x-ray. The combination of chest computed tomography (CT) and bronchoscopy set the diagnosis of left pulmonary hypoplasia and the patient was treated surgically with a left pneumonectomy. PH is usually diagnosed immediately after birth, causing severe respiratory failure with high mortality. The less severe, unilateral forms can possibly survive by causing compensatory hyperinflation of the other lung and remain undiagnosed until adulthood, presenting either asymptomatic or with symptoms of chronic bronchitis and recurrent respiratory infections. Chest CT is considered the imaging technique of choice for the diagnosis and for the differential diagnosis from other congenital or acquired conditions. The treatment is usually conservative, although surgical resection is indicated in cases of severe cystic changes and intense symptomatology.

وصف الملف: electronic resource

العلاقة: https://www.monaldi-archives.org/index.php/macd/article/view/829Test; https://doaj.org/toc/1122-0643Test; https://doaj.org/toc/2532-5264Test

الوصول الحر: https://doaj.org/article/10ce393f149c40ab96cc9733cfbc93d9Test

المؤلفون: Vlasios Skopas, Nikolaos Koulouris, Stylianos A. Michaelides, Avgerinos-Romanos Michailidis, Nikolaos Trakas, George Bablekos

المصدر: Clinical Problems.

مصطلحات موضوعية: medicine.medical_specialty, COPD, Copd patients, business.industry, medicine.disease, Gastroenterology, Group A, Elevated blood, pCO2, Group B, Internal medicine, medicine, medicine.symptom, business, Confusion, Asterixis

الوصف: Given that signs of mental confusion (MC) and asterixis (AS) are usually encounterd in patients with liver failure (LF) we investigated the relation between presence of MC & AS in hypercapnic COPD patients and their blood levels of ammonia (BLA). We studied 44 patients with hypercapnic respiratory failure due to COPD (31 male and 13 female) aged 67.3±4.3 yrs. (mean±SD) with a mean PCO2 of 59.4±6.2 mmHg (range 48.2 - 71.8) by recording the presence of MC & AS on admission while simulataneously measuring their BLA by Conway9s microdiffusion method (CMM). Since CMM has fluctuating results we performed several measurements for each patient and used their mean values for statistical evaluation. From all patients 29 (Group A) presented MC and or AS while the rest 15 (Group B) did not. BLA in Group A were 76.5± 15.7 μg/dl while in Group B were 37,6 ± 9.2 μg/dl. Group A exhibited an increased BLA than Group B by 38,9 μg (almost double the value of Group B) and this difference was statistically signifigant (Student9s t-test, p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c5b47d9484d1f3bcceca3e351a12905cTest
https://doi.org/10.1183/13993003.congress-2018.pa4059Test

المؤلفون: Demosthenes Makris, Zoe Daniil, Charalampos Koufopoulos, Eleni Papaefstathiou, Vlasios Skopas, Konstantinos I. Gourgoulianis, Dimitrios Papadopoulos, Nikolaos Trakas

المصدر: Respiratory Physiology & Neurobiology. 283:103562

مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Acute exacerbation of chronic obstructive pulmonary disease, Cross-sectional study, Physiology, Pilot Projects, Sensitivity and Specificity, Gastroenterology, Hypoxemia, Diagnosis, Differential, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Lower respiratory tract infection, medicine, Humans, Respiratory system, Respiratory Tract Infections, Aged, Aged, 80 and over, COPD, L-Lactate Dehydrogenase, Respiratory tract infections, business.industry, General Neuroscience, Middle Aged, Symptom Flare Up, medicine.disease, Confidence interval, Isoenzymes, Cross-Sectional Studies, 030228 respiratory system, Acute Disease, Arterial blood, Female, medicine.symptom, business, Biomarkers, 030217 neurology & neurosurgery

الوصف: We aimed to evaluate differences in serum lactate dehydrogenase (LDH) isoenzymes between patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and other lower respiratory tract infections (LRTIs). Based on self-reported COPD diagnosis, 71 participants were divided into AECOPD (n = 38, 29 males, mean age 70.5 years) and LRTI (n = 33, 12 males, mean age 70.4 years) groups. Information on demographics, comorbidities, and COPD severity markers, as well as arterial blood gases and laboratory data were collected, while serum LDH electrophoresis was performed to examine the LDH isoenzymes. Adjusting for sex, age, comorbidities, degree of hypoxemia, inflammation markers, muscle and myocardial enzymes, and total serum LDH, the mean differences (95 % confidence intervals) in the ratios of serum LDH isoenzymes to total serum LDH between groups (LDHxAECOPD - LDHxLRTI) were statistically significant for LDH1 [4.9 (1.4 to 8.3)], LDH2 [3.0 (0.1 to 5.8)], LDH3 [-4.3 (-6.3 to -2.3)], and LDH4 [-3.2 (-4.9 to -1.5)]. A sum of LDH3 and LDH4 ratios below 29 % had the highest discriminative ability to classify a subject in the AECOPD group (AUC 0.841, sensitivity 76 %, specificity 87 %). Aerobic metabolic adaptive mechanisms in respiratory muscles during AECOPD could explain the above differences.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19e6a4aa80eb7d0e9307dfdfee88ec7Test
https://doi.org/10.1016/j.resp.2020.103562Test

المؤلفون: Panagiotis Misthos, Vlasios Skopas, Dimitrios Papadopoulos, Achilleas Lioulias, Alexandra Nakou, Maria Chorti, Napoleon Karagianidis, Vasiliki Filaditaki

المصدر: Monaldi Archives for Chest Disease, Vol 88, Iss 1 (2018)

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Adult, Lung Diseases, Chronic bronchitis, medicine.medical_specialty, medicine.medical_treatment, lcsh:Medicine, Asymptomatic, Pneumonectomy, Pulmonary hypoplasia, Bronchoscopy, Medicine, Humans, Abnormalities, Multiple, Lung, Respiratory Tract Infections, Computed tomography, medicine.diagnostic_test, business.industry, lcsh:R, medicine.disease, Anti-Bacterial Agents, medicine.anatomical_structure, Treatment Outcome, Respiratory failure, Thoracotomy, Albania, Female, Radiology, Differential diagnosis, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Tomography, X-Ray Computed

الوصف: Pulmonary hypoplasia (PH) is a developmental anomaly of the lung parenchyma, characterized by a decrease in the number and size of airways, alveoli and vessels. We present a case of a 31-year-old patient with a history of chronic productive cough and frequent respiratory infections, who was referred for investigation of abnormal chest x-ray. The combination of chest computed tomography (CT) and bronchoscopy set the diagnosis of left pulmonary hypoplasia and the patient was treated surgically with a left pneumonectomy. PH is usually diagnosed immediately after birth, causing severe respiratory failure with high mortality. The less severe, unilateral forms can possibly survive by causing compensatory hyperinflation of the other lung and remain undiagnosed until adulthood, presenting either asymptomatic or with symptoms of chronic bronchitis and recurrent respiratory infections. Chest CT is considered the imaging technique of choice for the diagnosis and for the differential diagnosis from other congenital or acquired conditions. The treatment is usually conservative, although surgical resection is indicated in cases of severe cystic changes and intense symptomatology.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa766157779ffa32457a0b4b2d203bdTest
https://www.monaldi-archives.org/index.php/macd/article/view/829Test

المؤلفون: Konstantinos I. Gourgoulianis, Vlasios Skopas, Dimitrios Papadopoulos, Eleni Papaefstathiou, V. Panoutsou, S. Michailidis, Nikolaos Trakas

المصدر: Clinica Chimica Acta. 493:S260-S261

مصطلحات موضوعية: COPD, medicine.medical_specialty, Exacerbation, business.industry, Biochemistry (medical), Clinical Biochemistry, Pulmonary disease, General Medicine, Ldh isoenzymes, medicine.disease, Biochemistry, Internal medicine, medicine, Hospital patients, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ca63f037472df64a419271ce366cac7dTest
https://doi.org/10.1016/j.cca.2019.03.537Test