المؤلفون: Pompili E., Baldassarre M., Zaccherini G., Tufoni M., Iannone G., Pratelli D., Palmese F., Vizioli L., Faggiano C., Bedogni G., Domenicali M., Caraceni P.

المساهمون: Pompili E., Baldassarre M., Zaccherini G., Tufoni M., Iannone G., Pratelli D., Palmese F., Vizioli L., Faggiano C., Bedogni G., Domenicali M., Caraceni P.

مصطلحات موضوعية: Anaemia, Early readmission, Haemoglobin, Hospitalisation, Liver cirrhosi, MELD score, Systemic inflammation

الوصف: Background & Aims: Patients with decompensated cirrhosis present frequent hospitalisations with a relevant clinical and socio-economic impact. This study aims to characterise unscheduled readmissions up to 1-year follow-up and identify predictors of 30-day readmission after an index hospitalisation for acute decompensation (AD). Methods: We performed a secondary analysis of a prospectively collected cohort of patients admitted for AD. Laboratory and clinical data at admission and at discharge were collected. Timing and causes of unscheduled readmissions and mortality were recorded up to 1 year. Results: A total of 329 patients with AD were included in the analysis. Acute-on-chronic liver failure was diagnosed in 19% of patients at admission or developed in an additional 9% of patients during the index hospitalisation. During the 1-year follow-up, 182 patients (55%) were rehospitalised and 98 (30%) more than once. The most frequent causes of readmission were hepatic encephalopathy (36%), ascites (22%), and infection (21%). Cumulative incidence of readmission was 20% at 30 days, 39% at 90 days, and 63% at 1 year. Fifty-four patients were readmitted for emergent liver-related causes within 30 days. Early readmission was associated with a higher 1-year mortality (47 vs. 32%, p = 0.037). Multivariable Cox regression analysis showed that haemoglobin (Hb) ≤8.7 g/dl (hazard ratio 2.63 [95% CI 1.38–5.02], p = 0.003) and model for end-stage liver disease-sodium score (MELD-Na) >16 at discharge (hazard ratio 2.23 [95% CI 1.27–3.93], p = 0.005), were independent predictors of early readmission. In patients with MELD-Na >16 at discharge, the presence of Hb ≤8.7 g/dl doubles the risk of early rehospitalisation (44% vs. 22%, p = 0.02). Conclusion: Besides MELD-Na, a low Hb level (Hb ≤8.7 g/dl) at discharge emerged as a new risk factor for early readmission, contributing to identification of patients who require closer surveillance after discharge. Impact and Implications: Patients with decompensated cirrhosis face ...

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37025944; info:eu-repo/semantics/altIdentifier/wos/WOS:001043951300001; volume:5; issue:5; firstpage:1; lastpage:9; numberofpages:9; journal:JHEP REPORTS; https://hdl.handle.net/11585/931395Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85151857468; https://www.sciencedirect.com/science/article/pii/S2589555923000290Test

الإتاحة: https://doi.org/10.1016/j.jhepr.2023.100698Test
https://hdl.handle.net/11585/931395Test
https://www.sciencedirect.com/science/article/pii/S2589555923000290Test

المؤلفون: Turco, L., Taru, M.G., Vitale, G., Mirici Cappa, F., Berardi, S., Baldan, A., Donato, R. Di, Pianta, P., Vero, V., Vizioli, L., Morelli, M.C., Piscaglia, F.

المصدر: Digestive and Liver Disease ; volume 56, page S2 ; ISSN 1590-8658

مصطلحات موضوعية: Gastroenterology, Hepatology

الإتاحة: https://doi.org/10.1016/j.dld.2024.01.004Test
https://api.elsevier.com/content/article/PII:S1590865824000057?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1590865824000057?httpAccept=text/plainTest

المؤلفون: D'Angelo R., Boschetti E., Amore G., Costa R., Pugliese A., Caporali L., Gramegna L. L., Papa V., Vizioli L., Capristo M., Contin M., Mohamed S., Cenacchi G., Lodi R., Morelli M. C., Fasano L., Pisani L., Cescon M., Tonon C., Pinna A. D., Dotti M. T., Sicurelli F., Scarpelli M., Filosto M., Casali C., Pironi L., Carelli V., De Giorgio R., Rinaldi R.

المساهمون: D'Angelo, R., Boschetti, E., Amore, G., Costa, R., Pugliese, A., Caporali, L., Gramegna, L. L., Papa, V., Vizioli, L., Capristo, M., Contin, M., Mohamed, S., Cenacchi, G., Lodi, R., Morelli, M. C., Fasano, L., Pisani, L., Cescon, M., Tonon, C., Pinna, A. D., Dotti, M. T., Sicurelli, F., Scarpelli, M., Filosto, M., Casali, C., Pironi, L., Carelli, V., De Giorgio, R., Rinaldi, R.

مصطلحات موضوعية: Allogenic hematopoietic stem cell transplantation, Liver transplantation, Mitochondrial neurogastrointestinal encephalomyopathy, Thymidine phosphorylase

الوصف: We report the longest follow-up of clinical and biochemical features of two previously reported adult mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) patients treated with liver transplantation (LT), adding information on a third, recently transplanted, patient. All three patients overcame the early post-operative period and tolerated immunosuppressive therapy. Plasma nucleoside levels dramatically decreased, with evidence of clinical improvement of ambulation and neuropathy. Conversely, other features of MNGIE, as gastrointestinal dysmotility, low weight, ophthalmoparesis, and leukoencephalopathy were essentially unchanged. A similar picture characterized two patients treated with allogenic hematopoietic stem cell transplantation (AHSCT). In conclusion, LT promptly and stably normalizes nucleoside imbalance in MNGIE, stabilizing or improving some clinical parameters with marginal periprocedural mortality rate as compared to AHSCT. Nevertheless, restoring thymidine phosphorylase (TP) activity, achieved by both LT and AHSCT, does not allow a full clinical recovery, probably due to consolidated cellular damage and/or incomplete enzymatic tissue replacement.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32683607; info:eu-repo/semantics/altIdentifier/wos/WOS:000549793600001; journal:JOURNAL OF NEUROLOGY; http://hdl.handle.net/11379/533439Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85088097701

الإتاحة: https://doi.org/10.1007/s00415-020-10051-xTest
http://hdl.handle.net/11379/533439Test

المؤلفون: Siniscalchi A., Vitale G., Morelli M. C., Ravaioli M., Laici C., Bianchini A., Del Gaudio M., Conti F., Vizioli L., Cescon M.

المساهمون: Siniscalchi A., Vitale G., Morelli M.C., Ravaioli M., Laici C., Bianchini A., Del Gaudio M., Conti F., Vizioli L., Cescon M.

مصطلحات موضوعية: Donor, Healthcare personnel, Intensive care unit, Liver transplant, Recipient, Adult, COVID-19, Coronavirus Infection, Critical Care, Crowding, End Stage Liver Disease, Female, Human, Italy, Liver Transplantation, Male, Middle Aged, Pandemic, Pneumonia, Viral

الوصف: Transplant programs have been severely disrupted by the COVID-19 pandemic. Italy was one of the first countries with the highest number of deaths in the world due to SARS-CoV-2. Here we propose a management model for the reorganization of liver transplant (LT) activities and policies in a local intensive care unit (ICU) assigned to liver transplantation affected by restrictions on mobility and availability of donors and recipients as well as health personnel and beds. We describe the solutions implemented to continue transplantation activities throughout a given pandemic: management of donors and recipients’ LT program, ICU rearrangement, healthcare personnel training and monitoring to minimize mortality rates of patients on the waiting list. Transplantation activities from February 22, 2020, the data of first known COVID-19 case in Italy’s Emilia Romagna region to June 30, 2020, were compared with the corresponding period in 2019. During the 2020 study period, 38 LTs were performed, whereas 41 were performed in 2019. Patients transplanted during the COVID-19 pandemic had higher MELD and MELD-Na scores, cold ischaemia times, and hospitalization rates (p < 0.05); accordingly, they spent fewer days on the waitlist and had a lower prevalence of hepatocellular carcinoma (p < 0.05). No differences were found in the provenance area, additional MELD scores, age of donors and recipients, BMI, re-transplant rates, and post-transplant mortality. No transplanted patients contracted COVID-19, although five healthcare workers did. Ultimately, our policy allowed us to continue the ICU’s operations by prioritizing patients hospitalized with higher MELD without any case of transplant infection due to COVID-19.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32979193; info:eu-repo/semantics/altIdentifier/wos/WOS:000572837700001; volume:15; issue:8; firstpage:1507; lastpage:1515; numberofpages:9; journal:INTERNAL AND EMERGENCY MEDICINE; http://hdl.handle.net/11585/806752Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85091507164

الإتاحة: https://doi.org/10.1007/s11739-020-02511-zTest
http://hdl.handle.net/11585/806752Test

المؤلفون: Muckli, L., de Martino, F., Vizioli, L., Petro, L.S., Smith, F.W., Ugurbil, K., Goebel, R., Yacoub, E.

المصدر: Muckli , L , de Martino , F , Vizioli , L , Petro , L S , Smith , F W , Ugurbil , K , Goebel , R & Yacoub , E 2015 , ' Contextual feedback to superficial layers of V1 ' , Current Biology , vol. 25 , no. 20 , pp. 2690-2695 . https://doi.org/10.1016/j.cub.2015.08.057Test

مصطلحات موضوعية: COMPUTATIONAL ARCHITECTURE, NEOCORTEX, RESPONSES, NETWORK, CORTEX, FMRI

الوصف: Neuronal cortical circuitry comprises feedforward, lateral, and feedback projections, each of which terminates in distinct cortical layers [1-3]. In sensory systems, feedforward processing transmits signals from the external world into the cortex, whereas feedback pathways signal the brain's inference of the world [4-11]. However, the integration of feedforward, lateral, and feedback inputs within each cortical area impedes the investigation of feedback, and to date, no technique has isolated the feedback of visual scene information in distinct layers of healthy human cortex. We masked feedforward input to a region of V1 cortex and studied the remaining internal processing. Using high-resolution functional brain imaging (0.8 mm(3)) and multivoxel pattern information techniques, we demonstrate that during normal visual stimulation scene information peaks in mid-layers. Conversely, we found that contextual feedback information peaks in outer, superficial layers. Further, we found that shifting the position of the visual scene surrounding the mask parametrically modulates feedback in superficial layers of V1. Our results reveal the layered cortical organization of external versus internal visual processing streams during perception in healthy human subjects. We provide empirical support for theoretical feedback models such as predictive coding [10, 12] and coherent infomax [13] and reveal the potential of high-resolution fMRI to access internal processing in sub-millimeter human cortex.

الإتاحة: https://doi.org/10.1016/j.cub.2015.08.057Test
https://cris.maastrichtuniversity.nl/en/publications/8897bc15-133b-4e2b-919e-248783f5e4a0Test

المؤلفون: Frasci, G., D'Aiuto, G., Comella, P., D'Aiuto, M., Di Bonito, M., Ruffolo, P., Iodice, G., Petrillo, A., Lastoria, S., Oliviero, P., Capasso, I., Montella, M., Siani, C., Santangelo, M., Vizioli, L., Comella, G., for the Southern Italy Cooperative Oncology Group (SICOG) Italy

مصطلحات موضوعية: breast cancer

الوصف: Background: The present article reports the updated survival outcome of the 200 patients enrolled in the Southern Italy Cooperative Oncology Group 9908 trial, which compared 12 weekly cycles of cisplatin–epirubicin–paclitaxel (PET) with 4 triweekly (once every 3 weeks) cycles of epirubicin–paclitaxel (ET) in patients with locally advanced breast cancer (LABC). Methods: The effects of treatment, pathologically documented response (pathological response), pre- and post-treatment biomarkers on relapse-free survival (RFS), distant metastasis-free survival (DMFS), and overall survival (OS) are analysed. Results: At a median follow-up of 74 (range 48–105 months) months, the 5-year RFS, DMFS, and OS were 64 % versus 53% ( P = 0.11), 73% versus 55% ( P = 0.04), and 82% versus 69% ( P = 0.07) in PET and ET, respectively. At multivariate analysis, after adjusting treatment effect for pretreatment biomarkers, PET independently predicted better DMFS ( P = 0.018) and OS ( P = 0.03), whereas the impact on RFS was of borderline significance (0.057). PET treatment was significantly better than ET treatment only in high-grade or highly proliferating tumours. The better outcome in PET arm was the results of both the higher rate of patients with optimal pathological response and the lower rate of patients with biologically aggressive residual tumour. Conclusions: The PET weekly regimen significantly improves both DMFS and OS in LABC patients, compared with the triweekly ET combination. The therapeutic advantage is limited to patients with highly aggressive tumours.

وصف الملف: text/html

العلاقة: http://annonc.oxfordjournals.org/cgi/content/short/21/4/707Test; http://dx.doi.org/10.1093/annonc/mdp356Test

الإتاحة: https://doi.org/10.1093/annonc/mdp356Test
http://annonc.oxfordjournals.org/cgi/content/short/21/4/707Test

المؤلفون: Frasci, G., D'Aiuto, G., Comella, P., D'Aiuto, M., Di Bonito, M., Ruffolo, P., Iodice, G., Petrillo, A., Lastoria, S., Oliviero, P., Capasso, I., Montella, M., Siani, C., Santangelo, M., Vizioli, L., Comella, G., for the Southern Italy Cooperative Oncology Group (SICOG) Italy

مصطلحات موضوعية: original article

الوصف: Background: The present article reports the updated survival outcome of the 200 patients enrolled in the Southern Italy Cooperative Oncology Group 9908 trial, which compared 12 weekly cycles of cisplatin–epirubicin–paclitaxel (PET) with 4 triweekly (once every 3 weeks) cycles of epirubicin–paclitaxel (ET) in patients with locally advanced breast cancer (LABC). Methods: The effects of treatment, pathologically documented response (pathological response), pre- and post-treatment biomarkers on relapse-free survival (RFS), distant metastasis-free survival (DMFS), and overall survival (OS) are analysed. Results: At a median follow-up of 74 (range 48–105 months) months, the 5-year RFS, DMFS, and OS were 64 % versus 53% ( P = 0.11), 73% versus 55% ( P = 0.04), and 82% versus 69% ( P = 0.07) in PET and ET, respectively. At multivariate analysis, after adjusting treatment effect for pretreatment biomarkers, PET independently predicted better DMFS ( P = 0.018) and OS ( P = 0.03), whereas the impact on RFS was of borderline significance (0.057). PET treatment was significantly better than ET treatment only in high-grade or highly proliferating tumours. The better outcome in PET arm was the results of both the higher rate of patients with optimal pathological response and the lower rate of patients with biologically aggressive residual tumour. Conclusions: The PET weekly regimen significantly improves both DMFS and OS in LABC patients, compared with the triweekly ET combination. The therapeutic advantage is limited to patients with highly aggressive tumours.

وصف الملف: text/html

العلاقة: http://annonc.oxfordjournals.org/cgi/content/short/mdp356v1Test; http://dx.doi.org/10.1093/annonc/mdp356Test

الإتاحة: https://doi.org/10.1093/annonc/mdp356Test
http://annonc.oxfordjournals.org/cgi/content/short/mdp356v1Test

المؤلفون: Ravaioli, F., Tamè, M.R., Marasco, G., Vizioli, L., Morelli, M.C., Pinna, A.D., Conti, F., Andreone, P., Colecchia, A., Festi, D.

المصدر: Digestive and Liver Disease ; volume 49, issue 1, page e39 ; ISSN 1590-8658

مصطلحات موضوعية: Gastroenterology, Hepatology

الإتاحة: https://doi.org/10.1016/j.dld.2017.01.082Test
https://api.elsevier.com/content/article/PII:S1590865817300865?httpAccept=text/plainTest
https://api.elsevier.com/content/article/PII:S1590865817300865?httpAccept=text/xmlTest

المؤلفون: Ravaioli, F., Tamè, M.R., Marasco, G., Vizioli, L., Morelli, M.C., Pinna, A.D., Conti, F., Andreone, P., Colecchia, A., Festi, D.

المصدر: Journal of Hepatology ; volume 66, issue 1, page S239 ; ISSN 0168-8278

مصطلحات موضوعية: Hepatology

الإتاحة: https://doi.org/10.1016/s0168-8278Test(17)30783-3
https://api.elsevier.com/content/article/PII:S0168827817307833?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0168827817307833?httpAccept=text/plainTest

المؤلفون: Ciccarese F., Chiesa A.M., FELETTI F, Vizioli L., Pasquali M., Forti P., Zoli M., Zompatori M.

المساهمون: Ciccarese, F., Chiesa, A. M., Feletti, F, Vizioli, L., Pasquali, M., Forti, P., Zoli, M., Zompatori, M.

مصطلحات موضوعية: Aging lung, Ultrasonography, Chest computed tomography

الوصف: Background: Age-associated changes in the pulmonary system could be detected with imaging techniques. Widespread use of lung ultrasonography (US) requires characterization of a normal pattern. Objectives: To compare US and computed tomography (CT) findings in healthy subjects undergoing both techniques (with CT as the gold standard). Methods: We prospectively selected 59 subjects undergoing chest CT and US on the same day, without a history of smoking, respiratory symptoms, or known pulmonary pathologies. There were 44 patients in group 1 (age ≥60 years - elderly) and 15 patients in group 2 (age ≤50 years - young). Lung US was performed with a convex and a linear probe, and 10 chest areas per patient were analyzed. Convex and linear probe agreement was evaluated by means of the Cohen κ statistic; Fisher's exact test was used to compare categorical variables between groups. Results: Isolated B-lines were frequent in both group 1 (54.5%) and group 2 (40.0%); the number of chest areas positive for B-lines increased with age (16.1% in group 1 vs. 5.3% in group 2, p = 0.0028). In group 2, we found that 37.5% of subjects with B-lines had at least 1 chest area with multiple B-lines, but only 2 subjects had 2 or more. Moreover, in group 1 the chest CT documented a reticular pattern (2.3%), areas of increased density (9.1%), ground glass (6.8%), cysts (2.3%), bronchiectasis (22.7%), and bronchial thickening (6.8%); in group 2, only cysts (6.7%) and bronchiectasis (6.7%) were found. Conclusions: The senile lung is characterized by mild changes on CT and US. Chest areas positive for B-lines increase with age, and focal multiple B-lines can be found. However, diffuse patterns, especially in symptomatic subjects, suggest a different diagnosis.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/26044398; info:eu-repo/semantics/altIdentifier/wos/WOS:000358442900007; volume:90; issue:1; firstpage:56; lastpage:62; numberofpages:7; journal:RESPIRATION; https://hdl.handle.net/11392/2546333Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84937976808

الإتاحة: https://doi.org/10.1159/000430994Test
https://hdl.handle.net/11392/2546333Test