المؤلفون: Staropoli, Alessia, Guastaferro, Valentino Maria, Vinale, Francesco, Turrà, David, Di Costanzo, Luigi, Vitale, Stefania

مصطلحات موضوعية: Biochemistry, Microbiology, FOS Biological sciences, Genetics, Molecular Biology, Neuroscience, Pharmacology, Chemical Sciences not elsewhere classified, Ecology, Infectious Diseases, FOS Health sciences, Plant Biology

الوصف: Fusaric acid (FA), a picolinic acid derivative, is a natural substance produced by a wide variety of fungal plant pathogens belonging to the Fusarium genus. As a metabolite, fusaric acid exerts several biological activities including metal chelation, electrolyte leakage, repression of ATP synthesis, and direct toxicity on plants, animals and bacteria. Prior studies on the structure of fusaric acid revealed a co-crystal dimeric adduct between FA and 9,10-dehydrofusaric acid. During an ongoing search for signaling genes differentially regulating FA production in the fungal pathogen Fusarium oxysporum ( Fo ), we found that mutants lacking pheromone expression have an increased production of FA compared to the wild type strain. Noteworthy, crystallographic analysis of FA extracted from Fo culture supernatants showed that crystals are formed by a dimeric form of two FA molecules (1:1 molar stoichiometry). Overall, our results suggest that pheromone signaling in Fo is required to regulate the synthesis of fusaric ...

العلاقة: https://dx.doi.org/10.6084/m9.figshare.23617706Test; https://dx.doi.org/10.1080/14786419.2023.2227992Test

الإتاحة: https://doi.org/10.6084/m9.figshare.23617706.v210.6084/m9.figshare.2361770610.1080/14786419.2023.2227992Test
https://tandf.figshare.com/articles/journal_contribution/Repression_of_autocrine_pheromone_signaling_leads_to_fusaric_acid_over-production/23617706/2Test

المؤلفون: Wang, Can, Cusin, Luca, Ma, Chun, Unsal, Elif, A, Wang, Hanlin, Consolaro, Valentina, Girelli, Montes‐garcía, Verónica, Han, Bin, Vitale, Stefania, Dianat, Arezoo, Croy, Alexander, Zhang, Haiming, Gutierrez, Rafael, Cuniberti, Gianaurelio, Liu, Zhaoyang, Chi, Lifeng, Ciesielski, Artur, Samorì, Paolo

المساهمون: Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010)

المصدر: ISSN: 0935-9648.

مصطلحات موضوعية: 2D covalent organic frameworks, transition metal dichalcogenides, van der Waals heterostructures, interface engineering, charge transport, [CHIM]Chemical Sciences

الوصف: International audience

العلاقة: hal-04240357; https://hal.science/hal-04240357Test; https://hal.science/hal-04240357v2/documentTest; https://hal.science/hal-04240357v2/file/Advanced%20Materials%20-%202023%20-%20Wang%20-%20Enhancing%20the%20Carrier%20Transport%20in%20Monolayer%20MoS2%20through%20Interlayer%20Coupling%20with%202D.pdfTest

الإتاحة: https://doi.org/10.1002/adma.202305882Test
https://hal.science/hal-04240357Test
https://hal.science/hal-04240357v2/documentTest
https://hal.science/hal-04240357v2/file/Advanced%20Materials%20-%202023%20-%20Wang%20-%20Enhancing%20the%20Carrier%20Transport%20in%20Monolayer%20MoS2%20through%20Interlayer%20Coupling%20with%202D.pdfTest

المؤلفون: Vitale, Stefania, Puozzo, Hugo, Saiev, Shamil, Bonnaud, Leïla, Ricciardulli, Antonio Gaetano, Ciesielski, Artur, Beljonne, David, Samorì, Paolo

المساهمون: Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-19-GRF1-0005,prospect,PatteRned cOatings based on 2D materials benzoxazine reSin hybrids for broad range Pressure detection(2019), European Project: 881603,H2020,H2020-SGA-FET-GRAPHENE-2019, GrapheneCore3(2020), European Project: 833707,SUPRA2DMAT

المصدر: ISSN: 0897-4756.

مصطلحات موضوعية: [CHIM.MATE]Chemical Sciences/Material chemistry

الوصف: International audience ; Flexible piezoresistive pressure sensors are key components in wearable technologies for health monitoring, digital healthcare, human–machine interfaces, and robotics. Among active materials for pressure sensing, graphene-based materials are extremely promising because of their outstanding physical characteristics. Currently, a key challenge in pressure sensing is the sensitivity enhancement through the fine tuning of the active material’s electro-mechanical properties. Here, we describe a novel versatile approach to modulating the sensitivity of graphene-based piezoresistive pressure sensors by combining chemically reduced graphene oxide (rGO) with a thermally responsive material, namely, a novel trifunctional polybenzoxazine thermoset precursor based on tris(3-aminopropyl)amine and phenol reagents (PtPA). The integration of rGO in a polybenzoxazine thermoresist matrix results in an electrically conductive nanocomposite where the thermally triggered resist’s polymerization modulates the active material rigidity and consequently the piezoresistive response to pressure. Pressure sensors comprising the rGO-PtPA blend exhibit sensitivities ranging from 10e–2 to 1 kPa–1, which can be modulated by controlling the rGO:PtPA ratio or the curing temperature. Our rGO-PtPA blend represents a proof-of-concept graphene-based nanocomposite with on-demand piezoresistive behavior. Combined with solution processability and a thermal curing process compatible with large-area coatings technologies on flexible supports, this method holds great potential for applications in pressure sensing for health monitoring.

العلاقة: info:eu-repo/grantAgreement//881603/EU/Graphene Flagship Core Project 3/ GrapheneCore3; info:eu-repo/grantAgreement//833707/EU/Supramolecular engineering of multifunctional systems and devices: the molecular approach to 2D materials/SUPRA2DMAT; hal-04205527; https://hal.science/hal-04205527Test; https://hal.science/hal-04205527/documentTest; https://hal.science/hal-04205527/file/islandora_166626.pdfTest

الإتاحة: https://doi.org/10.1021/acs.chemmater.3c01191Test
https://hal.science/hal-04205527Test
https://hal.science/hal-04205527/documentTest
https://hal.science/hal-04205527/file/islandora_166626.pdfTest

المؤلفون: Aprile Anna Maria, Coppola Mariangela, Turra David, Vitale Stefania, Cascone Pasquale, Diretto Gianfranco, Fiore Alessia, Castaldi Valeria, Romanelli Alessandra, Avitabile Concetta, Guerrieri Emilio, Woo Sheridan Lois, Rao Rosa

المساهمون: Aprile, ANNA MARIA, Coppola, Mariangela, Turra, David, Vitale, Stefania, Cascone, Pasquale, Diretto, Gianfranco, Fiore, Alessia, Castaldi, Valeria, Romanelli, Alessandra, Avitabile, Concetta, Guerrieri, Emilio, Woo, SHERIDAN LOIS, Rao, Rosa

مصطلحات موضوعية: bioactive molecule, Botrytis cinerea, Fusarium oxysporum, plant induced defense, Tomato protection, Tuta absoluta

الوصف: Trichoderma spp. are among the most widely used plant beneficial fungi in agriculture. Its interaction with the plant triggers resistance responses by the activation of Induced Systemic Resistance mediated by Jasmonic acid and Ethylene and/or Systemic Acquired Resistance, which involves Salicylic acid, with the consequent control of a wide range of plant parasites. However, the benefit they can confer to plants may be reduced or nullified by environmental conditions or fungal ecological fitness. A novel approach to enhance their effectiveness in plant defense is to combine them with bioactive molecules including plant-derived compounds. Here, we show that plant treatment with Trichoderma afroharzianum (strain T22) and Systemin, a tomato peptide active in triggering plant defense, confers protection against the fungal pathogens Fusarium oxysporum, Botrytis cinerea and the insect pest Tuta absoluta. The observed defensive response was associated with an increase of Jasmonic acid and related metabolites and a decrease of Salicili acid.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000796252100001; volume:17; issue:1; firstpage:569; lastpage:579; numberofpages:11; journal:JOURNAL OF PLANT INTERACTIONS; https://hdl.handle.net/11588/908215Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85130398130

الإتاحة: https://doi.org/10.1080/17429145.2022.2072528Test
https://hdl.handle.net/11588/908215Test

المؤلفون: Falanga, Annarita, Maione, Angela, La Pietra, Alessandra, de Alteriis, Elisabetta, Vitale, Stefania, Bellavita, Rosa, Carotenuto, Rosa, Turrà, David, Galdiero, Stefania, Galdiero, Emilia, Guida, Marco

المساهمون: Falanga, Annarita, Maione, Angela, La Pietra, Alessandra, de Alteriis, Elisabetta, Vitale, Stefania, Bellavita, Rosa, Carotenuto, Rosa, Turrà, David, Galdiero, Stefania, Galdiero, Emilia, Guida, Marco

مصطلحات موضوعية: Fusarium oxysporum, Candida albican, polymicrobial biofilm, WMR, Galleria mellonella

الوصف: During an infection, a single or multispecies biofilm can develop. Infections caused by non-dermatophyte molds, such as Fusarium spp. and yeasts, such as Candida spp., are particularly difficult to treat due to the formation of a mixed biofilm of the two species. Fusarium oxysporum is responsible for approximately 20% of human fusariosis, while Candida albicans is responsible for superficial mucosal and dermal infections and for disseminated bloodstream infections with a mortality rate above 40%. This study aims to investigate the interactions between C. albicans and F. oxysporum dual-species biofilm, considering variable formation conditions. Further, the ability of the WMR peptide, a modified version of myxinidin, to eradicate the mixed biofilm when used alone or in combination with fluconazole (FLC) was tested, and the efficacy of the combination of WMR and FLC at low doses was assessed, as well as its effect on the expression of some biofilm-related adhesin and hyphal regulatory genes. Finally, in order to confirm our findings in vivo and explore the synergistic effect of the two drugs, we utilized the Galleria mellonella infection model. We concluded that C. albicans negatively affects F. oxysporum growth in mixed biofilms. Combinatorial treatment by WMR and FLC significantly reduced the biomass and viability of both species in mature mixed biofilms, and these effects coincided with the reduced expression of biofilm-related genes in both fungi. Our results were confirmed in vivo since the synergistic antifungal activity of WMR and FLC increased the survival of infected larvae and reduced tissue invasion. These findings highlight the importance of drug combinations as an alternative treatment for C. albicans and F. oxysporum mixed biofilms.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000818520200001; volume:14; issue:6; firstpage:1167; lastpage:1181; numberofpages:15; journal:PHARMACEUTICS; http://hdl.handle.net/11588/888827Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85132243277

الإتاحة: https://doi.org/10.3390/pharmaceutics14061167Test
http://hdl.handle.net/11588/888827Test

المؤلفون: Vitale, Stefania, Rampazzo, Enrico, Hiebner, Dishon, Devlin, Henry, Quinn, Laura, Prodi, Luca, Casey, Eoin

المساهمون: Vitale, Stefania, Rampazzo, Enrico, Hiebner, Dishon, Devlin, Henry, Quinn, Laura, Prodi, Luca, Casey, Eoin

مصطلحات موضوعية: Pseudomonas putida, bacterial biofilm, bio-nano interaction, fluorescent silica nanoparticle, surface chemistry, Biofilm, Poloxamer, Silicon Dioxide, Extracellular Polymeric Substance Matrix, Nanoparticles

الوصف: Nanoparticles (NPs) are considered a promising tool in the context of biofilm control. Many studies have shown that different types of NPs can interfere with the bacterial metabolism and cellular membranes, thus making them potential antibacterial agents; however, fundamental understanding is still lacking on the exact mechanisms involved in these actions. The development of NP-based approaches for effective biofilm control also requires a thorough understanding of how the chosen nanoparticles will interact with the biofilm itself, and in particular with the biofilm self-produced extracellular polymeric matrix (EPS). This work aims to provide advances in the understanding of the interaction between engineered fluorescent pluronic silica (PluS) nanoparticles and bacterial biofilms, with a main focus on the role of the EPS matrix in the accumulation and diffusion of the particles in the biofilm. It is demonstrated that particle surface chemistry has a key role in the different lateral distribution and specific affinity to the biofilm matrix components. The results presented in this study contribute to our understanding of biofilm-NP interactions and promote the principle of the rational design of smart nanoparticles as an important tool for antibiofilm technology.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35830504; info:eu-repo/semantics/altIdentifier/wos/WOS:000829313700001; volume:14; issue:30; firstpage:34502; lastpage:34512; numberofpages:11; journal:ACS APPLIED MATERIALS & INTERFACES; https://hdl.handle.net/11585/904554Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85135196874; https://doi.org/10.1021/acsami.2c10347Test

الإتاحة: https://doi.org/10.1021/acsami.2c10347Test
https://hdl.handle.net/11585/904554Test

المؤلفون: Gámez-Arjona, Francisco, Vitale, Stefania, Voxeur, Aline, Dora, Susanne, Müller, Sascha, Sancho-Andrés, Gloria, Montesinos, Juan Carlos, Di Pietro, Antonio, Sánchez-Rodríguez, Clara

المساهمون: Department of Biology ETH Zürich (D-BIOL), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology Zürich (ETH Zürich), Universidad de Córdoba = University of Córdoba Córdoba, Institut Jean-Pierre Bourgin (IJPB), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Swiss National Science Foundation (SNSF)SNF 310030_184769Vontobel FoundationInstituto de Salud Carlos IIISpanish GovernmentMICINN PID2019-108045RB-I00European Union (EU)FP7-PEOPLE-ITN-607963National Research Institute for Agriculture, Food and Environment tenure track grant

المصدر: ISSN: 2375-2548 ; Science Advances ; https://hal.inrae.fr/hal-03752595Test ; Science Advances , 2022, 8 (16), pp.eabl9734. ⟨10.1126/sciadv.abl9734⟩.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio], [SDV.BV]Life Sciences [q-bio]/Vegetal Biology

الوصف: International audience ; Fungal pathogens grow in the apoplastic space, in constant contact with the plant cell wall (CW) that hinders microbe progression while representing a source of nutrients. Although numerous fungal CW modifying proteins have been identified, their role during host colonization remains underexplored. Here, we show that the root-infecting plant pathogen Fusarium oxysporum (Fo) does not require its complete arsenal of cellulases to infect the host plant. Quite the opposite: Fo mutants impaired in cellulose degradation become hypervirulent by enhancing the secretion of virulence factors. On the other hand, the reduction in cellulase activity had a severe negative effect on saprophytic growth and microconidia production during the final stages of the Fo infection cycle. These findings enhance our understanding of the function of plant CW degradation on the outcome of host-microbe interactions and reveal an unexpected role of cellulose degradation in a pathogen’s reproductive success.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35442735; hal-03752595; https://hal.inrae.fr/hal-03752595Test; https://hal.inrae.fr/hal-03752595/documentTest; https://hal.inrae.fr/hal-03752595/file/sciadv.abl9734.pdfTest; PUBMED: 35442735; PUBMEDCENTRAL: PMC9020665; WOS: 000786214100019

الإتاحة: https://doi.org/10.1126/sciadv.abl9734Test
https://hal.inrae.fr/hal-03752595Test
https://hal.inrae.fr/hal-03752595/documentTest
https://hal.inrae.fr/hal-03752595/file/sciadv.abl9734.pdfTest

المؤلفون: Yao, Yifan, Chen, Yusheng, Wang, Kuidong, Turetta, Nicholas, Vitale, Stefania, Han, Bin, Wang, Hanlin, Zhang, Lei, Samorì, Paolo

المساهمون: Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), ANR-10-LABX-0026,CSC,Center of Chemistry of Complex System(2010)

المصدر: ISSN: 2375-2548 ; Science Advances ; https://hal.science/hal-03616809Test ; Science Advances , 2022, 8 (10), ⟨10.1126/sciadv.abn2225⟩.

مصطلحات موضوعية: [CHIM.MATE]Chemical Sciences/Material chemistry

الوصف: International audience ; Organic light-emitting devices are key components for emerging opto- and nanoelectronics applications including health monitoring and smart displays. Here, we report a foldable inverted polymer light-emitting diode (iPLED) based on a self-suspended asymmetrical vertical nanoscaffold replacing the conventional sandwich-like structured LEDs. Our empty vertical-yet-open nanoscaffold exhibits excellent mechanical robustness, proven by unaltered leakage current when applying 1000 cycles of 40-kilopascal pressure loading/unloading, sonication, and folding, with the corresponding iPLEDs displaying a brightness as high as 2300 candela per square meter. By using photolithography and brush painting, arbitrary emitting patterns can be generated via a noninvasive and mask-free process with individual pixel resolution of 10 μm. Our vertical nanoscaffold iPLED can be supported on flexible polyimide foils and be recycled multiple times by washing and refilling with a different conjugated polymer capable of emitting light of different color. This technology combines the traits required for the next generation of high-resolution flexible displays and multifunctional optoelectronics.

العلاقة: hal-03616809; https://hal.science/hal-03616809Test; https://hal.science/hal-03616809/documentTest; https://hal.science/hal-03616809/file/islandora_147765.pdfTest

الإتاحة: https://doi.org/10.1126/sciadv.abn2225Test
https://hal.science/hal-03616809Test
https://hal.science/hal-03616809/documentTest
https://hal.science/hal-03616809/file/islandora_147765.pdfTest

المؤلفون: Staropoli, Alessia, Guastaferro, Valentino Maria, Vinale, Francesco, Turra, David, Di Costanzo, Luigi, Vitale, Stefania

مصطلحات موضوعية: Biochemistry, Microbiology, FOS Biological sciences, Genetics, Molecular Biology, Neuroscience, Pharmacology, Chemical Sciences not elsewhere classified, Ecology, Infectious Diseases, FOS Health sciences, Plant Biology

الوصف: Fusaric acid (FA), a picolinic acid derivative, is a natural substance produced by a wide variety of fungal plant pathogens belonging to the Fusarium genus. As a metabolite, fusaric acid exerts several biological activities including metal chelation, electrolyte leakage, repression of ATP synthesis, and direct toxicity on plants, animals and bacteria. Prior studies on the structure of fusaric acid revealed a co-crystal dimeric adduct between FA and 9,10-dehydrofusaric acid. During an ongoing search for signaling genes differentially regulating FA production in the fungal pathogen Fusarium oxysporum ( Fo ), we found that mutants lacking pheromone expression have an increased production of FA compared to the wild type strain. Noteworthy, crystallographic analysis of FA extracted from Fo culture supernatants showed that crystals are formed by a dimeric form of two FA molecules (1:1 molar stoichiometry). Overall, our results suggest that pheromone signaling in Fo is required to regulate the synthesis of fusaric ...

العلاقة: https://dx.doi.org/10.6084/m9.figshare.23617706Test; https://dx.doi.org/10.1080/14786419.2023.2227992Test

الإتاحة: https://doi.org/10.6084/m9.figshare.23617706.v110.6084/m9.figshare.2361770610.1080/14786419.2023.2227992Test
https://tandf.figshare.com/articles/journal_contribution/Repression_of_autocrine_pheromone_signaling_leads_to_fusaric_acid_over-production/23617706/1Test

المؤلفون: Wang, Can, Cusin, Luca, Ma, Chun, Unsal, Elif, Wang, Hanlin, Consolaro, Valentina Girelli, Montes‐García, Verónica, Han, Bin, Vitale, Stefania, Dianat, Arezoo, Croy, Alexander, Zhang, Haiming, Gutierrez, Rafael, Cuniberti, Gianaurelio, Liu, Zhaoyang, Chi, Lifeng, Ciesielski, Artur, Samorì, Paolo

المصدر: Advanced Materials; 1/4/2024, Vol. 36 Issue 1, p1-11, 11p