المؤلفون: Vila Pueyo, Marta

المساهمون: University/Department: Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia

مرشدي الرسالة: Macaya Ruiz, Alfons, Pozo Rosich, Patricia, Giraldo Arjonilla, Jesús

المصدر: TDX (Tesis Doctorals en Xarxa)

مصطلحات موضوعية: Migranya, Migraña, Migraine, Paroxisme, Paroxismo, Paroxysmal, Genètica, Genética, Genetics, Ciències de la Salut

الوصف: Aquesta tesi es centra en l’anàlisi genètica dels següents trastorns neurològics paroxístics pediàtrics: el torticoli paroxístic benigne del lactant (TPBL), l’hemiplegia alternant de la infància (HAI), la discinèsia paroxística cinesigènica (DPC) i el síndrome de la deficiència del transportador de glucosa GLUT1 (GLUT1DS); i en l’anàlisi genètica i epigenètica de la migranya, un trastorn neurològic paroxístic majoritàriament de l’adult. Els trastorns neurològics paroxístics pediàtrics analitzats són trastorns rars, poc estudiats, en els quals la simptomatologia i el patró d’herència han portat a sospitar-ne una base monogènica i un vincle amb el grup de les canalopaties neuronals. La dificultat en el seu estudi deriva, majoritàriament, de la manca de sèries importants de pacients de les quals se’n puguin obtenir conclusions extrapolables. L’interès d’aprofundir en el seu coneixement, a banda del propi interès científic, rau en trobar les causes que els originen i, així, poder trobar un tractament contra aquests trastorns, millorar la qualitat de vida dels pacients que els sofreixen i/o poder oferir consell genètic als familiars dels individus afectes. - El cribratge mutacional en 2 pacients afectes de TPBL ha identificat la mutació p.Glu533Lys en el gen CACNA1A com a causant de la malaltia, junt amb els estudis funcionals que indiquen que aquesta mutació provoca una pèrdua de funció de la proteïna codificada. - El cribratge mutacional en una cohort de 10 pacients d’HAI ha identificat 3 mutacions en el gen ATP1A3 (p.Asp801Asn, p.Glu815Lys i p.Gly947Arg) en 5 dels pacients, remarcant l’existència d’una heterogeneïtat genètica major de l’esperada en aquest trastorn. - El cribratge mutacional en la DPC ha identificat 3 mutacions diferents en el gen PRRT2 en 8 dels 10 pacients (c.649dupC, c.649delC i c.219_220delGA) descrivint per primera vegada tant la mutació c.219_220delGA com la presència de la c.649dupC i la c.649delC en un mateix pacient. - El cribratge mutacional en la GLUT1DS va permetre trobar mutacions de novo en el gen SLC2A1 en 3 dels 5 pacients analitzats: la c.667C>T, la c.710_711delGA i una deleció de tot l’exó 1; remarcant l’interès en cercar delecions GLUT1DS. La migranya és un trastorn neurològic primari molt prevalent que es manifesta amb crisis episòdiques i recurrents de mal de cap incapacitant. Els criteris de la International Headache Society subclassifiquen la malaltia en diferents subtipus, incloent la migranya sense aura (MO), la migranya amb aura (MA) i la migranya hemiplègica (MH). - El cribratge mutacional de la MH va permetre identificar 4 mutacions en el gen CACNA1A (p.Ser218Leu, p.Thr501Met, p.Arg583Gln i p.Thr666Met), 2 mutacions en el gen ATP1A2 (p.Ala606Thr i p.Glu825Lys) i la mutació p.Phe1661Leu en el gen SCN1A. - L’estudi d’associació genètica a nivell genòmic (GWAS) de la MO va permetre la identificació de 2 SNPs associats a MO, un localitzat en el gen MEF2D i l’altre proper al gen TGFBR2. També es van trobar SNPs que suggerien una tendència a la replicació en el gens PHACTR1 i ASTN2. A més a més, es van replicar els resultats obtinguts en un GWAS anterior, trobant novament associats a migranya els gens TRPM8 i LRP1. Aquest estudi va permetre identificar el primer loci d’associació a susceptibilitat a patir MO. - L’estudi epigenètic en un model de MA va permetre trobar diferències de metilació de l’ADN degudes al tractament amb àcid valproic o topiramat o a l’efecte de la depressió cortical propagant (DCP), el fenomen subjacent de l’aura, en gens que podrien estar relacionats amb la susceptibilitat a patir migranya. Els resultats podrien indicar que ambdós tractaments protegeixen davant les DCPs degut al seu efecte sobre la metilació de l’ADN, emfatitzant la importància dels mecanismes epigenètics en la susceptibilitat de la migranya.

الوصف (مترجم): This thesis is focused on the genetic analysis of the following neurological paediatric paroxysmal disorders: benign paroxysmal torticollis of infancy (BPTI), alternating hemiplegia of childhood (AHC), paroxysmal kinesigenic dyskinesia (PKD) and GLUT1 deficiency syndrome (GLUT1DS); and on the genetic and epigenetic analysis of migraine, a neurological paroxysmal disorder mainly found in adults. The neurological paediatric paroxysmal disorders analyzed are rare and present a simptomatology and an inheritance that suggest a monogenic origin and a link with the neuronal channelopathies. The lack of significant cohorts of patients from which obtain transferable conclusions makes it difficult to study them. The main interest of their study, besides the own scientific interest, is based on finding the underlying causes of the disorder which would be the first step to find the appropriate treatment, improve the quality of life of the patients and/or be able to offer genetic counselling to the patients relatives. The results of this study are resumed below: - The mutational screening in 2 patients of BPTI identified the p.Glu533Lys mutation in the CACNA1A gene as the genetic cause of this disorder, in line with the functional studies that indicate that this mutation induces a loss-of-function of the coding protein. - The mutational screening in a cohort of 10 patients of AHC identified 3 mutations in the ATP1A3 gene (p.Asp801Asn, p.Glu815Lys and p.Gly947Arg) in 5 patients, highlighting the existence of a greater genetic heterogeneity than expected in this disorder. - The mutational screening in PKD identified 3 different mutations in the PRRT2 gene in 8 out of 10 patients (c.649dupC, c.649delC and c.219_220delGA), describing for the first time the mutation c.219_220delGA and also the presence of both the duplication and the deletion in the c.649 position in the same patient. - The mutational screening in 5 patients of GLUT1DS identified de novo mutations in the SLC2A1 gene in 3 patients, specifically c.667C>T, c.710_711delGA and a deletion affecting the whole first exon, highlighting the interest in looking for deletions in GLUT1DS. Migraine is a common primary neurological disorder that presents with episodic and recurrent attacks of disabling headache. The criteria of the International Headache Society divide the disorder into different subclasses, including migraine without aura (MO), migraine with aura (MA) and hemiplegic migraine (HM). The results of the genetic and epigenetic studies of migraine are resumed below: - The mutational screening of HM identified 4 mutations in the CACNA1A gene (p.Ser218Leu, p.Thr501Met, p.Arg583Gln and p.Thr666Met), 2 mutations in the ATP1A2 gene (p.Ala606Thr i p.Glu825Lys) and the mutation p.Thr501Met in the SCN1A gene. - The genome wide association study (GWAS) of MO identified 2 SNPs associated with MO, one in the MEF2D gene and the other close to the TGFBR2 gene. There were SNPs that showed suggestive evidence of replication at PHACTR1 and ASTN2 genes. Moreover, previous GWAS findings were replicated, finding the genes TRPM8 and LRP1 associated with migraine. This study allowed the identification of the first loci associated with MO. - The epigenetic study in a MA rat model identified DNA methylation differences due to the administration of valproate and topiramate drugs and/or due to the cortical spreading depression (CSD) effects in genes that could be related to the migraine susceptibility. These results could indicate that both treatments protect against CSD due to their effects on DNA methylation, highlighting the importance of the epigenetic mechanisms in the migraine susceptibility.

وصف الملف: application/pdf

الوصول الحر: http://hdl.handle.net/10803/285121Test

المؤلفون: Vila-Pueyo, Marta, Cuenca León, Ester, Queirós, Ana C., Kulis, Marta, Sintas Vives, Cèlia, Cormand Rifà, Bru, Martín-Subero, José Ignacio, Pozo-Rosich, Patricia, Fernàndez Castillo, Noèlia, Macaya Ruiz, Alfons

المصدر: Articles publicats en revistes (Genètica, Microbiologia i Estadística)

مصطلحات موضوعية: Models animals en la investigació, Epigenètica, Migranya, Animal models in research, Epigenetics, Migraine

الوصف: Background: Cortical spreading depolarization, the cause of migraine aura, is a short-lasting depolarization wave that moves across the brain cortex, transiently suppressing neuronal activity. Prophylactic treatments for migraine, such as topiramate or valproate, reduce the number of cortical spreading depression events in rodents. Objective: To investigate whether cortical spreading depolarization with and without chronic treatment with topiramate or valproate affect the DNA methylation of the cortex. Methods: Sprague-Dawley rats were intraperitoneally injected with saline, topiramate or valproate for four weeks when cortical spreading depolarization were induced and genome-wide DNA methylation was performed in the cortex of six rats per group. Results: The DNA methylation profile of the cortex was significantly modified after cortical spreading depolarization, with and without topiramate or valproate. Interestingly, topiramate reduced by almost 50% the number of differentially methylated regions, whereas valproate increased them by 17%, when comparing to the non-treated group after cortical spreading depolarization induction. The majority of the differentially methylated regions lay within intragenic regions, and the analyses of functional group over-representation retrieved several enriched functions, including functions related to protein processing in the cortical spreading depolarization without treatment group; functions related to metabolic processes in the cortical spreading depolarization with topiramate group; and functions related to synapse and ErbB, MAPK or retrograde endocannabinoid signaling in the cortical spreading depolarization with valproate group. Conclusions: Our results may provide insights into the underlying physiological mechanisms of migraine with aura and emphasize the role of epigenetics in migraine susceptibility.

وصف الملف: 12 p.; application/pdf

العلاقة: Versió postprint del document publicat a: https://doi.org/10.1177/03331024221146317Test; Cephalalgia, 2023, vol. 43, num. 2, p. 333102422114631; https://doi.org/10.1177/03331024221146317Test; http://hdl.handle.net/2445/197784Test; 724261

الإتاحة: https://doi.org/10.1177/03331024221146317Test
http://hdl.handle.net/2445/197784Test

المؤلفون: Gliga, Otilia, vila-pueyo, marta, Gallardo López, Víctor J., Pozo-Rosich, Patricia

المساهمون: Institut Català de la Salut, Vila-Pueyo M, Gliga O, Gallardo VJ Grup de Recerca de Cefalea i Dolor Neurològic, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Pozo-Rosich P Grup de Recerca de Cefalea i Dolor Neurològic, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Unitat de Cefalees, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus

المصدر: Scientia

مصطلحات موضوعية: Migranya, Astròcits, Neuròglia, DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Headache Disorders::Headache Disorders, Primary::Migraine Disorders, ANATOMY::Cells::Neuroglia::Astrocytes, ANATOMY::Cells::Neuroglia, ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos con cefaleas::cefaleas primarias::trastornos migrañosos, ANATOMÍA::células::neuroglía::astrocitos, ANATOMÍA::células::neuroglía

الوصف: Chronic Migraine; Headache; Microglia ; Migranya crònica; Mal de cap; Micròglia ; Migraña crónica; Dolor de cabeza; Microglía ; Migraine is a complex and debilitating neurological disease that affects 15% of the population worldwide. It is defined by the presence of recurrent severe attacks of disabling headache accompanied by other debilitating neurological symptoms. Important advancements have linked the trigeminovascular system and the neuropeptide calcitonin gene-related peptide to migraine pathophysiology, but the mechanisms underlying its pathogenesis and chronification remain unknown. Glial cells are essential for the correct development and functioning of the nervous system and, due to its implication in neurological diseases, have been hypothesised to have a role in migraine. Here we provide a narrative review of the role of glia in different phases of migraine through the analysis of preclinical studies. Current evidence shows that astrocytes and microglia are involved in the initiation and propagation of cortical spreading depolarization, the neurophysiological correlate of migraine aura. Furthermore, satellite glial cells within the trigeminal ganglia are implicated in the initiation and maintenance of orofacial pain, suggesting a role in the headache phase of migraine. Moreover, microglia in the trigeminocervical complex are involved in central sensitization, suggesting a role in chronic migraine. Taken altogether, glial cells have emerged as key players in migraine pathogenesis and chronification and future therapeutic strategies could be focused on targeting them to reduce the burden of migraine. ; The APC of this article was partly covered by a grant from the Japanese Headache Society. M.V.-P. was supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie IF grant agreement No. 101023175.

وصف الملف: application/pdf

العلاقة: International Journal of Molecular Sciences;24(16); https://doi.org/10.3390/ijms241612553Test; info:eu-repo/grantAgreement/EC/H2020/101023175; Vila-Pueyo M, Gliga O, Gallardo VJ, Pozo-Rosich P. The Role of Glial Cells in Different Phases of Migraine: Lessons from Preclinical Studies. Int J Mol Sci. 2023 Aug 8;24(16):12553.; https://hdl.handle.net/11351/10268Test

الإتاحة: https://doi.org/10.3390/ijms241612553Test
https://hdl.handle.net/11351/10268Test

المؤلفون: Gallardo López, Víctor J., vila-pueyo, marta, Pozo-Rosich, Patricia

المساهمون: Institut Català de la Salut, Gallardo VJ, Vila-Pueyo M Grup de Recerca de Cefalea i Dolor Neurològic, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Pozo-Rosich P Grup de Recerca de Cefalea i Dolor Neurològic, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Unitat de Cefalees, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus

المصدر: Scientia

مصطلحات موضوعية: Migranya - Aspectes genètics, Expressió gènica, MicroARN, DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Headache Disorders::Headache Disorders, Primary::Migraine Disorders, Other subheadings::Other subheadings::Other subheadings::/genetics, CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs, PHENOMENA AND PROCESSES::Genetic Phenomena::Gene Expression Regulation::Epigenesis, Genetic, ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos con cefaleas::cefaleas primarias::trastornos migrañosos, Otros calificadores::Otros calificadores::Otros calificadores::/genética, COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::elementos antisentido (genética)::ARN antiparalelo::microARN, FENÓMENOS Y PROCESOS::fenómenos genéticos::regulación de la expresión génica::epigénesis genética

الوصف: DNA methylation; Biomarkers; Epigenetics ; Metilació de l'ADN; Biomarcadors; Epigenètica ; Metilación del ADN; Biomarcadores; Epigenética ; Background Epigenetic mechanisms, including DNA methylation, microRNAs and histone modifications, may modulate the genetic expression in migraine and its interaction with internal and external factors, such as lifestyle and environmental changes. Objective To summarize, contextualize and critically analyze the published literature on the current state of epigenetic mechanisms in migraine in a narrative review. Findings The studies published to date have used different approaches and methodologies to determine the role of epigenetic mechanisms in migraine. Epigenetic changes seem to be involved in migraine and are increasing our knowledge of the disease. Conclusions Changes in DNA methylation, microRNA expression and histone modifications could be utilized as biomarkers that would be highly valuable for patient stratification, molecular diagnosis, and precision medicine in migraine. ; The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: MV-P was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie IF grant agreement No. 101023175.

وصف الملف: application/pdf

العلاقة: Cephalalgia;43(2); https://doi.org/10.1177/03331024221145916Test; info:eu-repo/grantAgreement/EC/H2020/101023175; Gallardo VJ, Vila-Pueyo M, Pozo-Rosich P. The impact of epigenetic mechanisms in migraine: Current knowledge and future directions. Cephalalgia. 2023 Feb;43(2):1–12.; https://hdl.handle.net/11351/9904Test; 000931410500007

الإتاحة: https://doi.org/10.1177/03331024221145916Test
https://hdl.handle.net/11351/9904Test

المؤلفون: Woldeamanuel, Yohannes Woubishet, Shrivastava, Surya, Vila Pueyo, Marta

المساهمون: Institut Català de la Salut, Woldeamanuel YW Division of Headache & Facial Pain, Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States. Shrivastava S Independent Researcher, Los Angeles, CA, United States. Vila-Pueyo M Grup de Recerca en Cefalea i Dolor Neurològic, Servei de Medicina, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus

المصدر: Scientia

مصطلحات موضوعية: Migranya - Tractament, Conducta (Psicologia), DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Headache Disorders::Headache Disorders, Primary::Migraine Disorders, Other subheadings::Other subheadings::/therapy, HEALTH CARE::Health Services Administration::Patient Care Management::Disease Management, PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Behavior, ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos con cefaleas::cefaleas primarias::trastornos migrañosos, Otros calificadores::Otros calificadores::/terapia, ATENCIÓN DE SALUD::administración de los servicios de salud::gestión de la atención al paciente::tratamiento de las enfermedades, PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::conducta

الوصف: Headache; Lifestyle and behavior; Migraine ; Dolor de cabeza; Estilo de vida y comportamiento; Migraña ; Mal de cap; Estil de vida i comportament; Migranya ; YW received research funding from the NINDS (National Institute of Neurological Disorders and Stroke), NIH (National Institutes of Health) (1K01NS124911-01). MV-P is a recipient of a Sara Borrell contract from the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Spain (CD20/00019).

وصف الملف: application/pdf

العلاقة: Frontiers in Neurology;13; https://doi.org/10.3389/fneur.2022.966424Test; info:eu-repo/grantAgreement/ES/PE2017-2020/CD20%2F00019; Woldeamanuel YW, Shrivastava S, Vila-Pueyo M. Editorial: Lifestyle modifications to manage migraine. Front Neurol. 2022 Aug 29;13:966424.; https://hdl.handle.net/11351/8464Test; 000853437700001

الإتاحة: https://doi.org/10.3389/fneur.2022.966424Test
https://hdl.handle.net/11351/8464Test

المؤلفون: Mínguez-Olaondo, Ane, Quintas, Sonia, Morollón Sánchez-Mateos, Noemí, López-Bravo, Alba, Vila Pueyo, Marta, Grozeva, Vesselina

المساهمون: Institut Català de la Salut, Mínguez-Olaondo A Neurology Department, Hospital Universitario Donostia, San Sebastián, Spain. Athenea Neuroclinics, Policlínica Guipúzcoa, Grupo Quirón Salud Donostia, San Sebastián, Spain. Neuroscience Area, Biodonostia Health Institute, Donostia, Spain. Medicine Faculty, University of Deusto, Bilbao, Spain. Clínica Universidad de Navarra, Pamplona, Spain. Quintas S Hospital Universitario de la Princesa, Madrid, Spain. Morollón Sánchez-Mateos N Headache and Neuralgia Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. López-Bravo A Hospital Reina Sofía, Tudela, Spain. Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain. Vila-Pueyo M Grup de Recerca en Cefalea i Dolor Neurològic, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Grozeva V Private Neurology Practice, Sofia, Bulgaria, Vall d'Hebron Barcelona Hospital Campus

المصدر: Scientia

مصطلحات موضوعية: Migranya - Complicacions, Pell - Malalties, DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Headache Disorders::Headache Disorders, Primary::Migraine Disorders, Other subheadings::Other subheadings::Other subheadings::/complications, ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos con cefaleas::cefaleas primarias::trastornos migrañosos, Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones

الوصف: Cutaneous allodynia; Risk factors; Treatment ; Alodinia cutánea; Factores de riesgo; Tratamiento ; Alodínia cutània; Factors de risc; Tractament ; Objective: In the present work, we conduct a narrative review of the most relevant literature on cutaneous allodynia (CA) in migraine. Background: CA is regarded as the perception of pain in response to non-noxious skin stimulation. The number of research studies relating to CA and migraine has increased strikingly over the last few decades. Therefore, the clinician treating migraine patients must recognize this common symptom and have up-to-date knowledge of its importance from the pathophysiological, diagnostic, prognostic and therapeutic point of view. Methods: We performed a comprehensive narrative review to analyze existing literature regarding CA in migraine, with a special focus on epidemiology, pathophysiology, assessment methods, risk for chronification, diagnosis and management. PubMed and the Cochrane databases were used for the literature search. Results: The prevalence of CA in patients with migraine is approximately 60%. The mechanisms underlying CA in migraine are not completely clarified but include a sensitization phenomenon at different levels of the trigemino-talamo-cortical nociceptive pathway and dysfunction of brainstem and cortical areas that modulate thalamocortical inputs. The gold standard for the assessment of CA is quantitative sensory testing (QST), but the validated Allodynia 12-item questionnaire is preferred in clinical setting. The presence of CA is associated with an increased risk of migraine chronification and has therapeutic implications. Conclusions: CA is a marker of central sensitization in patients with migraine that has been associated with an increased risk of chronification and may influence therapeutic decisions.

وصف الملف: application/pdf

العلاقة: Frontiers in Neurology;12; https://doi.org/10.3389/fneur.2021.831035Test; Mínguez-Olaondo A, Quintas S, Morollón Sánchez-Mateos N, López-Bravo A, Vila-Pueyo M, Grozeva V, et al. Cutaneous Allodynia in Migraine: A Narrative Review. Front Neurol. 2022 Jan 21;12:831035.; https://hdl.handle.net/11351/7871Test; 000753732600001

الإتاحة: https://doi.org/10.3389/fneur.2021.831035Test
https://hdl.handle.net/11351/7871Test

المؤلفون: Grozeva, Vesselina, Mínguez-Olaondo, Ane, Vila-Pueyo, Marta

المصدر: Frontiers in Neurology ; volume 12 ; ISSN 1664-2295

مصطلحات موضوعية: Neurology (clinical), Neurology

الوصف: Introduction: The coronavirus disease 2019 (COVID-19) pandemic represents a unified lifestyle modification model, which was developed by the globally applied measures. The lockdowns designed the perfect study settings for observing the interaction between migraine and the adopted changes in lifestyle. An experiment in vivo took place unexpectedly to determine how the lockdown lifestyle modifications can influence migraine. Subsection 1: Overall lifestyle modifications during the pandemic: People stay home, and outdoor activities and public contacts are restricted. Sleep is disturbed. Media exposure and prolonged screen use are increased. Working conditions change. In-person consultations and therapies are canceled. The beneficial effects of short-term stress, together with the harmful effects of chronic stress, were observed during the pandemic. Subsection 2: Short-term effects: Substantial lifestyle changes happened, and knowing how vulnerable migraine patients are, one could hypothesize that this would have resulted in severe worsening of headache. Surprisingly, even though the impacts of changing social conditions were significant, some patients (including children) experienced a reduction in their migraine during the first lockdown. Subsection 3: Long-term effects: Unfortunately, headache frequency returned to the basal state during the second pandemic wave. The risk factors that could have led to this worsening are the long-term disruption of sleep and dietary habits, stress, anxiety, depression, non-compliance to treatment, and working during the pandemic. Discussion: Sudden short-term lifestyle changes taking migraine patients out of their usual routine may be beneficial for headache management. It is not necessary to have a natural disaster in place for a drastic lifestyle modification with 6–8-week duration, if we know that this will improve migraine.

الإتاحة: https://doi.org/10.3389/fneur.2021.744796Test

المؤلفون: Holland, Philip R, Sureda-Gibert, Paula, Vila-Pueyo, Marta

المصدر: Cephalalgia ; volume 40, issue 4, page 327-329 ; ISSN 0333-1024 1468-2982

مصطلحات موضوعية: Neurology (clinical), General Medicine

الإتاحة: https://doi.org/10.1177/0333102420905131Test

المؤلفون: Vila-Pueyo, Marta¹ (AUTHOR) marta.vila@vhir.org, Gliga, Otilia¹ (AUTHOR), Gallardo, Víctor José¹ (AUTHOR), Pozo-Rosich, Patricia^1,2 (AUTHOR)

المصدر: International Journal of Molecular Sciences. Aug2023, Vol. 24 Issue 16, p12553. 16p.

مصطلحات موضوعية: *SPREADING cortical depression, *NEUROPEPTIDES, *NEUROGLIA, *MIGRAINE aura, *CALCITONIN gene-related peptide, *MIGRAINE, *SATELLITE cells

مستخلص: Migraine is a complex and debilitating neurological disease that affects 15% of the population worldwide. It is defined by the presence of recurrent severe attacks of disabling headache accompanied by other debilitating neurological symptoms. Important advancements have linked the trigeminovascular system and the neuropeptide calcitonin gene-related peptide to migraine pathophysiology, but the mechanisms underlying its pathogenesis and chronification remain unknown. Glial cells are essential for the correct development and functioning of the nervous system and, due to its implication in neurological diseases, have been hypothesised to have a role in migraine. Here we provide a narrative review of the role of glia in different phases of migraine through the analysis of preclinical studies. Current evidence shows that astrocytes and microglia are involved in the initiation and propagation of cortical spreading depolarization, the neurophysiological correlate of migraine aura. Furthermore, satellite glial cells within the trigeminal ganglia are implicated in the initiation and maintenance of orofacial pain, suggesting a role in the headache phase of migraine. Moreover, microglia in the trigeminocervical complex are involved in central sensitization, suggesting a role in chronic migraine. Taken altogether, glial cells have emerged as key players in migraine pathogenesis and chronification and future therapeutic strategies could be focused on targeting them to reduce the burden of migraine. [ABSTRACT FROM AUTHOR]

المؤلفون: Harriott, Andrea M., Strother, Lauren C., Vila-Pueyo, Marta, Holland, Philip R.

المصدر: Harriott , A M , Strother , L C , Vila-Pueyo , M & Holland , P R 2019 , ' Animal models of migraine and experimental techniques used to examine trigeminal sensory processing ' , Journal of Headache and Pain , vol. 20 , no. 1 , 91 . https://doi.org/10.1186/s10194-019-1043-7Test

مصطلحات موضوعية: Animal models, Electrophysiology, Headache, Migraine, Pain, Preclinical, Translation

الوصف: Background: Migraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of its accompanying disability and can encumber almost every aspect of daily life. Main body: Advancements in our understanding of the neurobiology of migraine headache have come in large from basic science research utilizing small animal models of migraine-related pain. In this current review, we aim to describe several commonly utilized preclinical models of migraine. We will discuss the diverse array of methodologies for triggering and measuring migraine-related pain phenotypes and highlight briefly specific advantages and limitations therein. Finally, we will address potential future challenges/opportunities to refine existing and develop novel preclinical models of migraine that move beyond migraine-related pain and expand into alternate migraine-related phenotypes. Conclusion: Several well validated animal models of pain relevant for headache exist, the researcher should consider the advantages and limitations of each model before selecting the most appropriate to answer the specific research question. Further, we should continually strive to refine existing and generate new animal and non-animal models that have the ability to advance our understanding of head pain as well as non-pain symptoms of primary headache disorders.

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1186/s10194-019-1043-7Test
https://kclpure.kcl.ac.uk/portal/en/publications/7014310f-bb8f-4505-994a-1009f5b77f52Test
https://kclpure.kcl.ac.uk/ws/files/119346967/Animal_models_of_migraine_HARRIOTT_Accepted19August2019Publishedonline29August2019_GOLD_VoR_CC_BY_.pdfTest
http://www.scopus.com/inward/record.url?scp=85071624744&partnerID=8YFLogxKTest