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1دورية أكاديمية
المصدر: Cancers, Vol 15, Iss 14, p 3700 (2023)
مصطلحات موضوعية: Ewing sarcoma, coronavirus disease 2019 (COVID-19), gastrointestinal stromal tumor (GIST), osteosarcoma, sarcoma, soft tissue sarcoma (STS), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Background: The COVID-19 pandemic has created a challenging environment for sarcoma patients. Most oncology societies published guidelines or recommendations prioritizing sarcoma patients and established telehealth as an efficient method of approaching them. The aim of this review is the assessment of current evidence regarding the utilization of telemedicine in diagnosis, treatment modalities, telerehabilitation and satisfaction among sarcoma patients and healthcare providers (HP). Methods: This systematic review was carried out using the databases PubMed and Ovid MEDLINE according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Results: The application of telemedicine to the management of sarcoma has yielded improved clinical and psychological outcomes. Specifically, significant progress has been demonstrated in the areas of tele-oncology and telerehabilitation during the last decade, and the COVID-19 outbreak has accelerated this transition toward them. Telehealth has been proven efficient in a wide spectrum of applications from consultations on physical therapy and psychological support to virtual care symptom management. Both HP and patients reported satisfaction with telehealth services at levels comparable to in-person visits. Conclusions: Telehealth has already unveiled many opportunities in tailoring individualized care, and its role in the management of sarcoma patients has been established in the post-COVID-19 era, as well.
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Tzoulia-Maria Tsalazidou-Founta, Evangelia A. Stasi, Maria Samara, Yorgos Mertzanis, Maria Papathanassiou, Pantelis G. Bagos, Spyros Psaroudas, Vasiliki Spyrou, Yorgos Lazarou, Athanasios Tragos, Yannis Tsaknakis, Elpida Grigoriadou, Athanasios Korakis, Maria Satra, Charalambos Billinis, ARCPROM project
المصدر: Genes, Vol 13, Iss 8, p 1388 (2022)
مصطلحات موضوعية: Ursus arctos, microsatellite loci, genetics, conservation, population structure, Genetics, QH426-470
الوصف: In order to optimize the appropriate conservation actions for the brown bear (Ursus arctos L.) population in Greece, we estimated the census (Nc) and effective (Ne) population size as well as the genetic status of brown bear sub-populations in three National Parks (NP): Prespa (MBPNP), Pindos (PINDNP), and Rhodopi (RMNP). The Prespa and Pindos sub-populations are located in western Greece and the Rhodopi population is located in eastern Greece. We extracted DNA from 472 hair samples and amplified through PCR 10 microsatellite loci. In total, 257 of 472 samples (54.5%) were genotyped for 6–10 microsatellite loci. Genetic analysis revealed that the Ne was 35, 118, and 61 individuals in MBPNP, PINDNP, and RMNP, respectively, while high levels of inbreeding were found in Prespa and Rhodopi but not in Pindos. Moreover, analysis of genetic structure showed that the Pindos population is genetically distinct, whereas Prespa and Rhodopi show mutual overlaps. Finally, we found a notable gene flow from Prespa to Rhodopi (10.19%) and from Rhodopi to Prespa (14.96%). Therefore, targeted actions for the conservation of the bears that live in the abovementioned areas must be undertaken, in order to ensure the species’ viability and to preserve the corridors that allow connectivity between the bear sub-populations in Greece.
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Andreas Koulouris, Christos Tsagkaris, Ippokratis Messaritakis, Nikolaos Gouvas, Maria Sfakianaki, Maria Trypaki, Vasiliki Spyrou, Manousos Christodoulakis, Elias Athanasakis, Evangelos Xynos, Maria Tzardi, Dimitrios Mavroudis, John Souglakos
المصدر: Cancers, Vol 13, Iss 14, p 3522 (2021)
مصطلحات موضوعية: colorectal cancer (CRC), microbiota, circulating tumor cells (CTCs), cell-free DNA (cfDNA), recurrence risk, liquid biopsy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Metastatic colorectal cancer (mCRC) remains a highly lethal malignancy, although considerable progress has resulted from molecular alterations in guiding optimal use of available treatments. CRC recurrence remains a great barrier in the disease management. Hence, the spotlight turns to newly mapped fields concerning recurrence risk factors in patients with resectable CRC with a focus on genetic mutations, microbiota remodeling and liquid biopsies. There is an urgent need for novel biomarkers to address disease recurrence since specific genetic signatures can identify a higher or lower recurrence risk (RR) and, thus, be used both as biomarkers and treatment targets. To a large extent, CRC is mediated by the immune and inflammatory interplay of microbiota, through intestinal dysbiosis. Clarification of these mechanisms will yield new opportunities, leading not only to the appropriate stratification policies, but also to more precise, personalized monitoring and treatment navigation. Under this perspective, early detection of post-operative CRC recurrence is of utmost importance. Ongoing trials, focusing on circulating tumor cells (CTCs) and, even more, circulating tumor DNA (ctDNA), seem to pave the way to a promising, minimally invasive but accurate and life-saving monitoring, not only supporting personalized treatment but favoring patients’ quality of life, as well.
وصف الملف: electronic resource
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4
المؤلفون: Lamprini Bounou, Philippos Orfanos, Vasiliki Spyrou, Konstantina-Ioanna Panagiotopoulou, Pagona Lagiou, Stamatia Katelani, Agapi-Iliana Skouloudaki
مصطلحات موضوعية: Health Knowledge, Attitudes, Practice, Cross-sectional study, Trainer, Attitude of Health Personnel, media_common.quotation_subject, education, hand hygiene knowledge, medical students, Nursing, Compulsory education, FOS: Health sciences, Education, 03 medical and health sciences, 0302 clinical medicine, Hygiene, Surveys and Questionnaires, hand hygiene, hand hygiene practices, Health care, Medicine and Health Sciences, Humans, 030212 general & internal medicine, Curriculum, General Nursing, media_common, nursing students, hand hygiene compliance, 030504 nursing, Greece, business.industry, Risk of infection, hand hygiene education, General Medicine, Cross-Sectional Studies, Medical Education, Students, Nursing, Guideline Adherence, 0305 other medical science, business, Psychology, Inclusion (education)
الوصف: To investigate medical and nursing students' education on hand hygiene, their attitude on hand hygiene education and how this education influences their hand hygiene knowledge and practices.Hospital-acquired infections are associated with prolonged hospitalisation and mortality. The most effective measure for their control is healthcare workers' hand hygiene compliance. Since medical and nursing students constitute the future healthcare workers, our study focuses on them.Cross-sectional study METHODS: This study was conducted during the academic year 2016-2017, using a modified World Health Organisation questionnaire. Our sample consisted of 132 medical and 111 nursing students from National and Kapodistrian University of Athens, Greece. In data analysis, the Mann-Whitney and Fisher's exact tests were applied to compare differences in continuous variables and proportions in categorical variables, respectively. Knowledge and practices overall scores were calculated per student group. Multiple linear regression analyses were performed to assess the influence of potential confounders on these scores.We found that 73.1% of medical and 98.2% of nursing students had received relevant education, which was reported as "only theoretical" by 77.4% of the former and as "hands-on and theoretical" by 88.1% of the latter group. Besides the risk of infection, knowledge acquired in lectures and trainer's behaviour were also considered very influential factors shaping hand hygiene attitude in both groups. Overall, medical students reported better hand hygiene practices than nursing ones (69.9% and 59.7%, respectively; p 0.001). The opposite finding was observed regarding their overall knowledge on hand hygiene (57.2% of medical versus 60.4% of nursing students, p = 0.04). The majority of students (86.6% of all participants; p 0.001) supported the inclusion of compulsory hand hygiene education in their curriculum. Compulsory education and seminars were assessed as the most effective measures to increase hand hygiene compliance (71.4% of all students).In our study, medical students scored better in practices questions than nursing students; this did not apply for the knowledge score. The majority of students supported the inclusion of compulsory education on hand hygiene principles in their Departments' curricula, highlighting compulsory education and seminars as the most effective measures to increase compliance with hand hygiene.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516ce0c78d16096b7ce742311a1490f3Test
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المؤلفون: Michail Nikolaou, Vasiliki Spyrou, Aikaterini Troullinou, Christos Tsagkaris, Eleni Pappa, Andreas Koulouris
المصدر: Journal of Hepatocellular Carcinoma
مصطلحات موضوعية: Sorafenib, Oncology, medicine.medical_specialty, Cabozantinib, Bevacizumab, medicine.medical_treatment, Review, Targeted therapy, Ramucirumab, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Atezolizumab, Internal medicine, tyrosine kinase inhibitors, medicine, business.industry, biomarkers, hepatocellular carcinoma, targeted therapy, digestive system diseases, Clinical trial, chemistry, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, immunotherapy, Lenvatinib, business, medicine.drug
الوصف: The last three years have seen remarkable progress in comprehending predisposing factors and upgrading our treatment arsenal concerning hepatocellular carcinoma (HCC). Until recently, there were no means to withstand the progression of viral hepatitis-associated liver cirrhosis to HCC. A deeper understanding of the molecular mechanism of the disease, the use of biomarkers, and the follow-up, allowed us to realize that conventional chemotherapy failing to increase survival in patients with advanced HCC tends to be exiled from clinical practice. Multi-kinase inhibitors (TKIs) such as sorafenib, lenvatinib targeting mainly the vascular endothelial growth factor receptors 1–3 VEGFRs 1–3 provided until recently the standard of care for these patients, as first- or second-line treatment. Since May 2020, the atezolizumab plus bevacizumab combination (immunotherapy plus anti-VEGF) has become the new reference standard in first-line HCC treatment. Additionally, anti-programmed cell death protein 1 (anti-PD-1) immunotherapy can be used as a second-line treatment following first-line treatment’s failure. Phase III clinical trials have recently suggested the efficacy of novel anti-angiogenic factors such as cabozantinib and ramucirumab as a second-line treatment option. With considerations about toxicity arising, clinical trials are investigating combinations of the aforementioned targeted therapies with immunotherapy as first-line treatment. This paper aims to perform a systematic review describing the evolving treatment options for HCC over the last decades, ranging from neoadjuvant treatment to systemic therapy of advanced-stage HCC. With the landscape of HCC treatment shifting towards novel agents the forming of a new therapeutic algorithm for HCC seems to be imperative.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2c37ef1c9b99509bb2f69238eede78Test
https://doi.org/10.2147/jhc.s300182Test -
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المؤلفون: Vasiliki Spyrou, Labrini V. Athanasiou, Dimitrios P. Bogdanos, Christos Liaskos, Athanasios Gkoutzourelas, Georgios S. Amiridis, Charalambos Billinis, Andreas L. Koutsoumpas
المصدر: Clinics and Research in Hepatology and Gastroenterology. 44:778-785
مصطلحات موضوعية: Saccharomyces cerevisiae, Paratuberculosis, Disease, Antibodies, Serology, 03 medical and health sciences, 0302 clinical medicine, Crohn Disease, medicine, Animals, Pancreas, Antibodies, Fungal, Crohn's disease, Membrane Glycoproteins, Sheep, Hepatology, biology, business.industry, Gastroenterology, Autoantibody, medicine.disease, biology.organism_classification, Disease Models, Animal, 030220 oncology & carcinogenesis, Immunology, biology.protein, Cattle, 030211 gastroenterology & hepatology, Antibody, business, Mycobacterium
الوصف: Summary Introduction Ruminants (cattle and sheep) with Mycobacterium avium (MAP)-induced paratuberculosis (ptb), the ruminant model of Crohn's disease (CD), exhibit pancreatic specific autoantibodies (PAB) against GP2 but not against CUZD1. Since anti-Saccharomyces cerevisiae antibodies (ASCAs) is a CD marker, we tested MAP-infected ptb ruminants for ASCA, and compared them with ruminants lacking evidence of anti-MAP serology or with ruminants, which were positive for anti-GP2 antibodies. Material and methods A total of 98 samples from ruminants (48 cattle and 50 sheep) were studied. IgG anti-MAP antibodies, and CD-related ASCA and anti-GP2 antibodies were tested by modified ELISAs. Results Nine cattle (18.75%) and 20 sheep (40%) were suffered from ptb. ASCA antibodies were present in 21/48 (43.7%) cattle and 10/50 (20%) sheep while anti-GP2 antibodies were present in 14/48 (29.2%) cattle, and 8/50 (16%) sheep. ASCA antibodies were more prevalent in anti-MAP antibody positive (14/29, 48.3%) than in anti-MAP negative ruminants (17/69, 24.6%, P = 0.022) and also in anti-GP2 antibody positive (13/23, 56.5%) than in anti-GP2 negative ruminants (18/75, 24%, P = 0.003). No association between ASCA and anti-MAP antibody concentrations were found (r = 0.159, P = 0.117). A significant association between ASCA and anti-GP2 antibody concentration were observed (r = 0.211 and P = 0.037). Conclusion ASCA are present in a significant proportion of ruminants with ptb and correlate with anti-GP2 antibody positivity, a finding further supporting the notion that Crohn's disease and ptb share common immunological mechanisms of antigen-driven loss of self-tolerance.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d2779fa3c8e9eb75bd388990f1d803Test
https://doi.org/10.1016/j.clinre.2019.12.013Test -
7
المؤلفون: E. Xynos, Elias Athanasakis, Ippokratis Messaritakis, Christos Tsagkaris, Maria Trypaki, Maria Tzardi, Nikolaos Gouvas, Maria Sfakianaki, Andreas Koulouris, Dimitrios Mavroudis, John Souglakos, Vasiliki Spyrou, Manousos Christodoulakis
المصدر: Cancers, Vol 13, Iss 3522, p 3522 (2021)
Cancersمصطلحات موضوعية: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, circulating tumor cells (CTCs), Colorectal cancer, Review, Disease, genetic mutations, Malignancy, colorectal cancer (CRC), Recurrence risk, 03 medical and health sciences, 0302 clinical medicine, Circulating tumor cell, Immune system, Quality of life, Internal medicine, microbiota, cell-free DNA (cfDNA), medicine, Liquid biopsy, RC254-282, liquid biopsy, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, business, recurrence risk
الوصف: Simple Summary CRC recurrence remains a great barrier in the disease management. Metastatic disease is a highly lethal malignancy. Novel biomarkers are urgently needed to address disease recurrence since specific genetic signatures can identify a higher or lower recurrence risk, thus serving as biomarkers and treatment targets. To a large extent, CRC is mediated by the immune and inflammatory interplay of microbiota, through intestinal dysbiosis. Clarification of these mechanisms will yield new opportunities, leading to appropriate stratification policies, and to more precise, personalized monitoring and treatment navigation. Under this perspective, early detection of post-operative CRC recurrence is of utmost importance. Ongoing trials, focusing on CTCs and, even more on ctDNA, seem to pave the way to a promising, minimally invasive, and life-saving monitoring, supporting personalized treatment and favoring patients’ quality of life. Abstract Metastatic colorectal cancer (mCRC) remains a highly lethal malignancy, although considerable progress has resulted from molecular alterations in guiding optimal use of available treatments. CRC recurrence remains a great barrier in the disease management. Hence, the spotlight turns to newly mapped fields concerning recurrence risk factors in patients with resectable CRC with a focus on genetic mutations, microbiota remodeling and liquid biopsies. There is an urgent need for novel biomarkers to address disease recurrence since specific genetic signatures can identify a higher or lower recurrence risk (RR) and, thus, be used both as biomarkers and treatment targets. To a large extent, CRC is mediated by the immune and inflammatory interplay of microbiota, through intestinal dysbiosis. Clarification of these mechanisms will yield new opportunities, leading not only to the appropriate stratification policies, but also to more precise, personalized monitoring and treatment navigation. Under this perspective, early detection of post-operative CRC recurrence is of utmost importance. Ongoing trials, focusing on circulating tumor cells (CTCs) and, even more, circulating tumor DNA (ctDNA), seem to pave the way to a promising, minimally invasive but accurate and life-saving monitoring, not only supporting personalized treatment but favoring patients’ quality of life, as well.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b832ed2608a4ca626b20be9e075380Test
https://doi.org/10.3390/cancers13143522Test -
8
الوصف: Background Although genetic studies have reported a number of loci associated with cutaneous melanoma (CM) risk, a comprehensive synopsis of genetic association studies published in the field and systematic meta-analysis for all eligible polymorphisms have not been reported. Methods We systematically annotated data from all genetic association studies published in the CM field (n = 145), including data from genome-wide association studies (GWAS), and performed random-effects meta-analyses across all eligible polymorphisms on the basis of four or more independent case-control datasets in the main analyses. Supplementary analyses of three available datasets derived from GWAS and GWAS-replication studies were also done. Nominally statistically significant associations between polymorphisms and CM were graded for the strength of epidemiological evidence on the basis of the Human Genome Epidemiology Network Venice criteria. All statistical tests were two-sided. Results Forty-two polymorphisms across 18 independent loci evaluated in four or more datasets including candidate gene studies and available GWAS data were subjected to meta-analysis. Eight loci were identified in the main meta-analyses as being associated with a risk of CM (P < .05) of which four loci showed a genome-wide statistically significant association (P < 1 x 10(-7)), including 16q24.3 (MC1R), 20q11.22 (MYH7B/PIGU/ASIP), 11q14.3 (TYR), and 5p13.2 (SLC45A2). Grading of the cumulative evidence by the Venice criteria suggested strong epidemiological credibility for all four loci with genome-wide statistical significance and one additional gene at 9p23 (TYRP1). In the supplementary meta-analyses, a locus at 9p21.3 (CDKN2A/MTAP) reached genome-wide statistical significance with CM and had strong epidemiological credibility. Conclusions To the best of our knowledge, this is the first comprehensive field synopsis and systematic meta-analysis to identify genes associated with an increased susceptibility to CM.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______2127::0c9b0d5106efa599a2d9ba02baf944c7Test
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3150282Test -
9
المصدر: Virology Journal, Vol 9, Iss 1, p 24 (2012)
Virology Journalمصطلحات موضوعية: Genes, Viral, Genotype, viruses, Molecular Sequence Data, Case Report, Mastitis, Homology (biology), Disease Outbreaks, lcsh:Infectious and parasitic diseases, Mammary Glands, Animal, Virology, Ecthyma, Contagious, Animals, Cluster Analysis, lcsh:RC109-216, Genital orf, Gene, Contagious ecthyma, Genetics, Mouth, Phylogenetic analysis, Sheep, Greece, biology, Phylogenetic tree, Strain (biology), Outbreak, Orf virus, Sequence Analysis, DNA, biology.organism_classification, Phylogeography, Infectious Diseases, Teat, DNA, Viral, Parapoxvirus, Flock, Orf
الوصف: Background Although orf is endemic around the world, there are few descriptions of Orf virus strains and comparisons of these strains. We report the sequence and phylogenetic analysis of the partial B2L gene of Orf virus from two outbreaks of the disease in Greece. The first was an outbreak of genital form of the disease in a flock imported from France, whilst the second was an outbreak of the disease in the udder skin of ewes and around the mouth of lambs in an indigenous flock. Results Phylogenetic analysis was performed on a part (498 bp) of the B2L gene of 35 Parapoxvirus isolates, including the two Orf virus isolates recovered from each of the two outbreaks in the present study. This analysis revealed that the maximum nucleotide and amino-acid variation amongst Orf virus strains worldwide (n = 33) was 8.1% and 9.6%, respectively. The homology of the nucleotide and amino-acid sequences between the two Greek isolates was 99.0% and 98.8%, respectively. The two Greek isolates clustered only with Orf virus strains. Conclusions We suggest that there can be differences between strains based on their geographical origin. However, differences in the origin of strains or in the clinical presentation of the disease may not be associated with their pathogenicity. More work is required to determine if differing clinical presentations are linked to viral strain differences or if other factors, e.g., flock immunity, method of exposure or genetic susceptibility, are more important to determine the clinical presentation of the infection.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cf35c37a566eb58a93a5891310afdfTest
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