المؤلفون: Martínez-Moreno, Alejandro, Toledo-Gil, Rosa, Bautista-Ortin, Ana Belén, Gómez-Plaza, Encarna, Yuste, José Enrique, Vallejo, Fernando

الوصف: Volatile organic compounds (VOCs) are crucial to the wine’s overall quality since they define the aromatic profile. The aim of this study was to investigate whether a 146-day extended maceration (EM) treatment positively affects the aromatic and sensory properties of Monastrell red wine. A total of 43 aromatic compounds belonging to different chemical classes were identified using solid-phase microextraction combined with gas chromatography–mass spectrometry (SPME/GC-MS). In general, EM treatment decreased both the number and total relative concentration of VOCs. Specifically, EM decreased the concentration of alcohols, terpenes and sulphur compounds compared to control wines. However certain compounds such as 2-ethyl-1-hexanol, phenylethyl and ethyl decanoate significantly increased with prolonged maceration. Conversely, EM treatment did not significantly affect the total relative concentrations of esters and ketones. From sensorial point of view, the triangular test showed a positive identification of wines (10/18) with a significant preference for EM wines. Moreover, descriptive analysis revealed that EM wines scored lower values in appearance, aroma and taste. Future research should aim to optimize maceration time to enhance the content of VOCs without compromising the sensory quality of the wine.

العلاقة: Fermentation 10 (7): 343 (2024); http://hdl.handle.net/10261/362753Test

الإتاحة: https://doi.org/10.3390/fermentation10070343Test
http://hdl.handle.net/10261/362753Test

المؤلفون: Gómez-Bellot, María José, Guerrero, Lilisbet, Yuste, José Enrique, Vallejo, Fernando, Sánchez-Blanco, María Jesús

الوصف: Deficit irrigation (DI) strategies are becoming increasingly common in areas where water resources are limited. The application of moderate levels of DI can result in water savings with a small reduction in yield but with a higher quality of the product. The aim of this work was to evaluate the effect of applying a certain level of water deficit (40% water holding capacity) on the yield and quality of the common bean ( Phaseolus vulgaris L.), specifically the cultivar ‘Triunfo-70’. Bioactive compounds were investigated by applying an LC-MS-based untargeted metabolomics approach as an analytical tool for identifying novel markers associated with a water deficit in beans. The results showed that beans harvested 30 days after DI application experienced water stress, as indicated by the decrease in the leaf water potential and gas exchange values (stomatal conductance and photosynthesis). In addition, the number of pods per plant was significantly reduced by the DI treatment. The water deficit induced significant alterations in various bioactive compounds (including organic acids, polyphenols, hydroxybenzoic acids, lipids, and phospholipids) when compared to the control treatment. Additionally, twelve new biomarkers were identified in this study for the first time in the common bean under DI. These findings suggested that DI acted as an elicitor, increasing phenylpropanoid metabolism, while concurrently reducing the production of compounds associated with fatty acid metabolism. Additionally, new metabolites were tentatively identified in common beans. This study represents the successful application of the untargeted metabolomics approach to finding bioactive secondary metabolites in beans under different irrigation conditions.

العلاقة: Horticulturae 10 (7): 663 (2024); http://hdl.handle.net/10261/362728Test

الإتاحة: https://doi.org/10.3390/horticulturae10070663Test
http://hdl.handle.net/10261/362728Test

المؤلفون: Azorín-Ortuño, María, Yáñez-Gascón, María J., Vallejo, Fernando, Pallarés, Francisco J., Larrosa, Mar, Lucas Rodríguez, Ricardo, Morales, Juan C., Tomás-Barberán, Francisco A., García-Conesa, María T., Espín, Juan C.

المساهمون: Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica, Ministerio de Ciencia e Innovación (MICIN). España, Comunidad Autónoma de Murcia

مصطلحات موضوعية: Bioavailability, Dihydroresveratrol, Disposition, Metabolites, Polyphenol

الوصف: Scope: trans-Resveratrol (RES) and/(or) its metabolites exert many effects in vivo. Our aim was to study the metabolism and tissue distribution of RES using the pig, a mammal physiologically close to humans. Methods and results: Forty-seven tissues, organs and fluids were analyzed 6h after intragastric RES administration (5.9mg/kg body weight) using HPLC-MS/MS. Twelve RES and seven dihydroresveratrol (DH-RES) metabolites were detected. DH-RES was the main metabolite in cecum, colon and rectum, whereas RES-3-O-glucuronide was the most abundant one in fluids and organs. Approximately 74.5% of the total RES administered was recovered in the form of RES, DH-RES and derived metabolites (65.1% along the gastrointestinal tract, 7.7% in urine, 1.2% in bile and 0.5% in organs). We report here, for the first time, the occurrence of RES ribosyl-sulfate derivative, DH-RES diglucuronide, DH-RES sulfoglucuronide and DH-RES disulfate as well as the metabolic profile of RES and DH-RES in the aorta, lymph, lymph node, ovaries, uterus, cerebellum, pancreas, urinary bladder tissue, fat and muscle. Conclusion: This study contributes to the clarification of the metabolism and tissue distribution of RES and could help to further understand the mechanisms underlying its effects. ; Ministerio de Ciencia e Innovación CICYT-BFU2007-60576, CSD2007-00063 ; Comunidad Autónoma de Murcia 04486

العلاقة: Molecular Nutrition and Food Research, 55 (8), 1154-1168.; CICYT-BFU2007-60576; CSD2007-00063; 04486; https://doi.org/10.1002/mnfr.201100140Test; https://idus.us.es/handle//11441/154367Test

الإتاحة: https://doi.org/10.1002/mnfr.201100140Test
https://idus.us.es/handle//11441/154367Test

المؤلفون: Ozturk, Tarik, Ávila-Gálvez, María Ángeles, Mercier, Sylvie, Vallejo, Fernando, Bred, Alexis, Fraisse, Didier, Morand, Christine, Pelvan, Ebru, Monfoulet, Laurent-Emmanuel, González-Sarrías, Antonio

الوصف: Recently, the development of functional beverages has been enhanced to promote health and nutritional well-being. Thus, the fermentation of plant foods with lactic acid bacteria can enhance their antioxidant capacity and others like anti-inflammatory activity, which may depend on the variations in the total content and profile of (poly)phenols. The present study aimed to investigate the impact of fermentation with two strains of Lactiplantibacillus plantarum of several herbal infusions from thyme, rosemary, echinacea, and pomegranate peel on the (poly)phenolic composition and whether lacto-fermentation can contribute to enhance their in vitro antioxidant and anti-inflammatory effects on human colon myofibroblast CCD18-Co cells. HPLC-MS/MS analyses revealed that fermentation increased the content of the phenolics present in all herbal infusions. In vitro analyses indicated that pomegranate infusion showed higher antioxidant and anti-inflammatory effects, followed by thyme, echinacea, and rosemary, based on the total phenolic content. After fermentation, despite increasing the content of phenolics, the antioxidant and anti-inflammatory effects via reduction pro-inflammatory markers (IL-6, IL-8 and PGE 2 ) were similar to those of their corresponding non-fermented infusions, with the exception of a greater reduction in lacto-fermented thyme. Overall, the findings suggest that the consumption of lacto-fermented herbal infusions could be beneficial in alleviating intestinal inflammatory disorders.

العلاقة: Antioxidants 13 (5): 562 (2024); http://hdl.handle.net/10261/355840Test

الإتاحة: https://doi.org/10.3390/antiox13050562Test
http://hdl.handle.net/10261/355840Test

المؤلفون: Molina-López, Cristina, Hurtado-Navarro, Laura, García, Carlos J., Angosto-Bazarra, Diego, Vallejo, Fernando, Tapia-Abellán, Ana, Marques-Soares, Joana R., Vargas, Carmen, Bujan-Rivas, Segundo, Tomás-Barberán, Francisco A., Arostegui, Juan I., Pelegrin, Pablo

المصدر: Nature Communications ; volume 15, issue 1 ; ISSN 2041-1723

مصطلحات موضوعية: General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary

الوصف: Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory condition resulting from monoallelic NLRP3 variants that facilitate IL-1β production. Although these are gain-of-function variants characterized by hypersensitivity to cell priming, patients with CAPS and animal models of the disease may present inflammatory flares without identifiable external triggers. Here we find that CAPS-associated NLRP3 variants are forming constitutively active inflammasome, which induce increased basal cleavage of gasdermin D, IL-18 release and pyroptosis, with a concurrent basal pro-inflammatory gene expression signature, including the induction of nuclear receptors 4 A. The constitutively active NLRP3-inflammasome of CAPS is responsive to the selective NLRP3 inhibitor MCC950 and its activation is regulated by deubiquitination. Despite their preactivated state, the CAPS inflammasomes are responsive to activation of the NF-κB pathway. NLRP3-inflammasomes with CAPS-associated variants affect the immunometabolism of the myeloid compartment, leading to disruptions in lipids and amino acid pathways and impaired glycolysis, limiting IL-1β production. In summary, NLRP3 variants causing CAPS form a constitutively active inflammasome inducing pyroptosis and IL-18 release without cell priming, which enables the host’s innate defence against pathogens while also limiting IL-1β–dependent inflammatory episodes through immunometabolism modulation.

الإتاحة: https://doi.org/10.1038/s41467-024-44990-0Test
https://www.nature.com/articles/s41467-024-44990-0.pdfTest
https://www.nature.com/articles/s41467-024-44990-0Test

المؤلفون: Cortés-Martín, Adrián, Iglesias-Aguirre, Carlos E., Marín, Alicia, Romo-Vaquero, María, Vallejo, Fernando, Espín, Juan Carlos, Victoria Selma, María

المساهمون: European Regional Development Fund

المصدر: Food & Function ; volume 15, issue 5, page 2422-2432 ; ISSN 2042-6496 2042-650X

الوصف: Urolithin-A drives the effects of pomegranate on the microbial metabolism of bile acids and cholesterol with possible consequences on human health.

الإتاحة: https://doi.org/10.1039/d3fo05014aTest
http://pubs.rsc.org/en/content/articlepdf/2024/FO/D3FO05014ATest

المؤلفون: Barber, Claudia, Sabater, Carlos, Dolores Frutos, María, Vallejo, Fernando, Guyonnet, Denis, Daniel, Noëmie, Guarner, Francisco, Carlos Espín, Juan, Margolles, Abelardo, Azpiroz, Fernando

المصدر: Journal of Functional Foods ; volume 113, page 106032 ; ISSN 1756-4646

مصطلحات موضوعية: Nutrition and Dietetics, Medicine (miscellaneous), Food Science

الإتاحة: https://doi.org/10.1016/j.jff.2024.106032Test
https://api.elsevier.com/content/article/PII:S1756464624000343?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1756464624000343?httpAccept=text/plainTest

المؤلفون: Baños Vallejo, Fernando

المصدر: Medievalia; Vol. 18, Núm. 2 (2015): «La construcción de la santidad femenina de los siglos XV al XVII»; p. 43-63

مصطلحات موضوعية: Lives of Mary, prosopography of the Virgin, mystic beauty, apocryphal gospels, Juan López de Salamanca, mystic dialogue, Vidas de María, prosopografía de la Virgen, belleza mística, apócrifos, diálogo místico

الوصف: Resum disponible en anglès i castellà
There are very few descriptions of the Virgin’s physical beauty in the texts we know generically as “Lives of Mary”. This shortage could be explained by the fact that this topic is not in the apocryphal gospels related with the Pseudo-Matthew, which are the usual source of stories about the early life of Mary. Here examples of references to the beauty of the Virgin are presented, eight in Spanish works, compared with two Catalan and three Latin and Greek sources. As the corpus is classified, the particulars of the three Castilian stories of the late Middle Ages and Early Modernity that do contain prosopographies of the Mother of God are shown: the metaphorical and symbolic approach of Juan López de Salamanca (1465-1468), the synthesis of sources not without innovations by Juan de Robles (before 1511), and the more literal, physical expression of Gomez García (around 1512). Special consideration will receive the Libro de las historias de Nuestra Señora, by López de Salamanca, which provides the largest and most complex passage about the beauty of the Virgin. As regards to the shape of the text, it is remarkable the singularity of dialogue between Mary herself and a young countess (actually the person to whom the work is dedicated), converted into a disciple of the Virgin. In terms of content, it is striking the transmutation of the corporeal into doctrinal through metaphor.
En los textos que conocemos genéricamente como “vidas de María” apenas hay descripciones de la belleza física de la Virgen. Esa escasez se explicaría porque tal motivo no se encuentra en los evangelios apócrifos relacionados con el Pseudo- Mateo, que son la fuente habitual de los relatos sobre la infancia y juventud de María. Aquí se presentan ejemplos de alusiones a la hermosura de la Virgen de ocho obras castellanas, se comparan con dos de catalanas y de tres fuentes latinas y griegas. Al tiempo que se clasifica el corpus, se muestran las particularidades de los tres relatos castellanos de finales de la Edad Media y temprana Edad Moderna que sí contienen prosopografías de la Madre de Dios: el planteamiento metafórico y simbólico de Juan López de Salamanca (1465-1468), la síntesis de fuentes no exenta de innovaciones que ofrece Juan de Robles (antes de 1511), y la expresión más literal y física de Gómez García (hacia 1512). Recibirá especial consideración el Libro de las historias de Nuestra Señora, de López de Salamanca, que aporta el pasaje más extenso y más complejo sobre la belleza de la Virgen. La forma del texto destaca por la singularidad de presentarse como diálogo entre la propia María y una joven condesa (en realidad la dedicataria de la obra), convertida así en discípula de la Virgen. En cuanto al contenido, llama la atención la transmutación de lo corporal en doctrinal a través de la metáfora.

وصف الملف: application/pdf

العلاقة: https://www.raco.cat/index.php/Medievalia/article/view/308811/398804Test

الوصول الحر: https://www.raco.cat/index.php/Medievalia/article/view/308811Test

المؤلفون: Fuentes, Pablo (ORCID 0000-0001-6424-2533), Camarero, Cristobal (ORCID 0000-0001-6418-2614), Herreros, David, Mateev, Vladimir (ORCID 0000-0002-9943-6837), Vallejo, Fernando, Martinez, Carmen (ORCID 0000-0002-9815-239X)

المصدر: IEEE Transactions on Learning Technologies. Apr 2022 15(2):238-251.

تمت مراجعته من قبل الزملاء: Y

Page Count: 14

الواصفات: Computer Science Education, Computer System Design, Programming Languages, Fatigue (Biology), Handheld Devices, Troubleshooting, College Students, Foreign Countries, Student Satisfaction, Distance Education, COVID-19, Pandemics

مصطلحات جغرافية: Spain

مستخلص: Understanding the architecture of a processor can be uninteresting and deterring for computer science students, since low-level details of computer architecture are often perceived to lack real-world impact. These courses typically have a strong practical component where students learn the fundamentals of the computer architecture and the handling of input/output operations through the development of simple programs in a low-level assembly programming language. Since these practical sessions require a strong involvement, student attendance and withdrawal rates are poor, lowering academic results and introducing a negative feedback loop that preconditions students to dislike them. This article introduces a new methodology for the practical sessions of Computer Organization and Design courses. This methodology disavows the use of simulators and focuses on actual hardware to promote a feeling of proximity to the execution and outcome of the programs. The proposed setup uses Raspberry Pi devices to encourage students to work autonomously, due to their low cost, capability of running an OS, and rich ecosystem of simple hardware devices. The setup is completed with RISC OS, which combines a simple window-based graphical interface with a low-level management of the hardware without requiring software abstraction layers. The article presents the methodology and the UCDebug tool, developed to help students debug their codes in RISC OS. After the introduction of the new setup at the University of Cantabria, academic results and student satisfaction have improved. The setup has also allowed to sustain a similar organization of the courses throughout the COVID-19 pandemic.

Abstractor: As Provided

المؤلفون: Gómez-Bellot, M. J., García Hernández Gil, Carlos Javier, Parra González, Andrés, Vallejo, Fernando, Ortuño Gallud, M. Fernanda

المساهمون: Agencia Estatal de Investigación (España), European Commission, Vallejo, Fernando

مصطلحات موضوعية: Irrigation, Pomegranate, Untargeted metabolomics, LC–MS

الوصف: Water deficit is one of the most important abiotic factors that reduce the agricultural productivity. The impact of irrigation levels on bioactive compounds of one commercial pomegranate cultivar (‘Mollar de Elche’) was studied through LC–MS-based untargeted metabolomics approach. Two treatments were applied to explore crop responses to the timing and the regime of the irrigation applications. The main goal of the present study was to validate the untargeted metabolomics approach as analytical tool to find new markers related with the water deficit. Robust classification and prediction model was built with the use of supervised technique, partial least squares discriminant analysis (PLS-DA). The results revealed that pomegranate juices obtained from plants grown under DIr conditions experimented physiological stress, which significantly increased their bioactive compounds (polyphenols, phenylpropanoids, peptides, benzoic acid, tannins, and phospholipids) in comparison with the Control treatments. The results indicate that controlled irrigation stress would increase the production of bioactive compounds by increasing the phenylpropanoids metabolism. New metabolites were tentatively identified in pomegranate juice by the untargeted metabolomics techniques. This study showed, for the first time, the satisfactory application of the untargeted metabolomics approach using an UHPLC-QTOF system to identify bioactive secondary metabolites from pomegranate juices to discriminate among different irrigation conditions ; This research was funded by the Spanish AEI (grant number PCI 2019-103608) under the PRIMA programme in the frame of the PRECIMED project. PRIMA is an Art.185 initiative supported and co-funded under Horizon 2020, the European Union’s Programme for Research and Innovation ; Peer reviewed

العلاقة: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PCI2019-103608/ES/GESTION DEL RIEGO DE PRECISION PARA MEJORAR LA EFICIENCIA DEL USO DEL AGUA Y NUTRIENTES EN LA REGION MEDITERRANEA/; info:eu-repo/grantAgreement/EC/H2020//; Publisher's version; The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1007/s00217-023-04340-8Test; https://doi.org/10.1007/s00217-023-04340-8Test; Sí; European Food Research and Technology A 249: 2947–2956 (2023); http://hdl.handle.net/10261/358962Test

الإتاحة: https://doi.org/10.1007/s00217-023-04340-8Test
http://hdl.handle.net/10261/358962Test