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1كتاب إلكترونيFrom Milton Keynes to Ayodhya : The Vishwa Hindu Parishad and the Global Campaign for the Ram Temple
المؤلفون: Anderson, Edward T.G., author
المصدر: Hindu Nationalism in the Indian Diaspora : Transnational Politics and British Multiculturalism, 2024.
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2تقرير
المؤلفون: Giraldi Méndez, Mónica Gabriela
المساهمون: Gasca García, Alejandra
مصطلحات موضوعية: Enfermedades crónicas, Cáncer cervical, VHP, Obesidad, Diabetes, Síndrome metabólico, Licenciatura, Medicina
الوصف: The diseases with the highest morbidity and mortality in Mexico are heart diseases, diabetes, and malignant tumors. Cervical cancer is the fourth most prevalent type of cancer in the world and in Mexico it is the second most prevalent, with around 9,430 new cases reported each year. Timely screening in both types of diseases is of great relevance to avoid complications and with strategies to provide early diagnosis, timely treatment that culminate in a better quality of life for patients. This research was carried out at the CST-III Dr. Gustavo A. Rovirosa Pérez, in the period from April 2023 to September 2023, the inclusion criterion being having a result with any degree of alteration of a cervical cytology test, subsequently investigated the presence of any comorbidity diabetes mellitus, systemic arterial hypertension, obesity, the result of the cytology included in its report the presence of infections corresponding to bacterial vaginosis, candidiasis, presence of herpes or trichomonas. In addition to analyzing risk factors such as smoking, initiation of sexual life, history of HPV, family planning methods. It is observational, cross-sectional with a descriptive purpose of observing the association between chronic diseases and histopathological alterations in cervical cytology. Raise awareness of the importance of vaccination projects against HPV, the main risk factor for the development of cervical cancer, the reduction of interaction between diseases, timely screening tests, in addition to understanding the complexity of the health-disease process is complex, not only because the altered mechanisms, but due to the social context of the patients, is the most important conclusion of what has been done, since both diseases are preventable. ; Las enfermedades con mayor carga de morbimortalidad en México son enfermedades del corazón, diabetes, tumores malignos. El cáncer cervical es el cuarto tipo de cáncer más prevalente en el mundo y en México es el segundo al año se reportan alrededor de 9430 casos nuevos. El ...
وصف الملف: 1 recurso en línea (37 páginas); application/pdf
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3دورية أكاديمية
المؤلفون: M. R. Karimi Estahbanati
المصدر: Microorganisms, Vol 11, Iss 10, p 2566 (2023)
مصطلحات موضوعية: sterilizer, 510(k), sterilant, medical device, VHP, Biology (General), QH301-705.5
الوصف: Vaporized hydrogen peroxide (VHP) terminal sterilization is one of the most promising techniques for sterilizing temperature-sensitive medical instruments like endoscopes. This technique requires only electricity and sterilant containers to perform the sterilization process in less than 1 h without any substantial safety concerns for patients, personnel, and the environment. This review studies recent advances and future trends in VHP sterilization cycle development using U.S. patent applications and 510(k) premarket notifications. In this regard, the patents focused on increasing VHP concentration or handling residual moisture are discussed in depth. The expired patents are analyzed to introduce existing unencumbered technologies, and active patents are presented to show the most current novelties and technology trends. In addition, 510(k) premarket notifications are explored to evaluate implemented technologies in US market-leading commercial products.
وصف الملف: electronic resource
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4دورية أكاديمية
المؤلفون: Daniela Rondinone, Tautvydas Karitonas, Enrico Allegra
المصدر: Cogent Engineering, Vol 9, Iss 1 (2022)
مصطلحات موضوعية: Powered Air-Purifying Respirators (PAPR), Personal Protective Equipment (PPE), decontamination, Vaporised Hydrogen Peroxide (VHP), infection control, compatibility, Engineering (General). Civil engineering (General), TA1-2040
الوصف: This study aimed to evaluate VHP as a decontamination method for decontaminating reusable PAPR; determine if PAPR is compatible with VHP; and determine how long it takes for hydrogen peroxide to off-gas for the mask to be safe for reuse. Off-gassing validation study which consisted of doing three VHP decontamination processes followed by three Off-Gassing Tests to confirm the efficacy of the VHP cycle and time required for the VHP concentration to reach 0 ppm. HALT, which consisted of exposing the PAPR to 50 VHP decontamination cycles followed by a Visual Appearance Test to determine if the VHP process impacted the PAPR material’s visual properties. The results from this study show that VHP is an effective and repeatable process for decontaminating PAPR, and the Off-Gassing Test shows that with the appropriate off-gassing set up, it is possible to off-gas one PAPR within 8 hours of completing the decontamination cycle. The results from the Visual Appearance Test show that exposing a PAPR to 50 decontamination cycles does not present significant changes in the PAPR material’s colour, opacity, or overall visual appearance.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2331-1916Test
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5دورية أكاديمية
المؤلفون: Meng Chen, Jiancheng Qi, Yaohua Du, Zhi Cheng, Tianyu Cai, Chao Li
المصدر: Biosafety and Health, Vol 3, Iss 1, Pp 56-64 (2021)
مصطلحات موضوعية: Microbial contamination control, VHP surface disinfection, Live/dead identification, Bactericidal rate, Disinfection efficacy assurance, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270
الوصف: Vaporized hydrogen peroxide (VHP) is a highly active disinfectant, and VHP decontamination systems have been widely applied in hospitals, microbiological laboratories, and pharmaceutical industries. However, the decomposition of VHP into non-toxic by-products is essential. Evaluation of the disinfection efficacy of VHP is crucial to ensuring the reliability of VHP disinfection and controlling microbial contamination. In this study, a rapid and sensitive strategy is proposed to evaluate the efficacy of VHP in surface disinfection by detecting the survived and killed bacteria from VHP-exposed biological indicators (BIs). A dual-channel solid-phase cytometer is designed, and fluorescent dyes are used as indicators to automatically and accurately distinguish live cells from dead cells in the mixtures of bacteria. To verify the availability and effectiveness of the laser scanning cytometry, experiments on its application in estimating the efficacy of VHP disinfection practice have been carried out in this study, and its estimation effect compared with that of the traditional plate counting method. Results show that the proposed assay might distinctly identify live or killed cells labeled by green and red fluorescent dyes and examined the disinfection efficacy in 30 min by calculating the bactericidal rate. Compared with the plate counting method, the proposed approach is accurate and practical, with an average detection efficiency of 98.47% ± 1.55%. Moreover, an excellent correlation between the concentrations of B. subtilis var niger (ATCC 9372) measured by the proposed detection system and by the plate counting method is noticed (R2 = 0.9971), indicating that this approach had advantages in the detection of trace microorganisms. To summarize, the proposed strategy appears practical and significant in many fields in which microbial counting and identification are required.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2590053620301130Test; https://doaj.org/toc/2590-0536Test
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6دورية أكاديمية
المؤلفون: C.-G. Wang, Z. Li, S. Liu, C.T. Ng, M. Marzuki, P.S. Jeslyn Wong, B. Tan, A. Lee, C.F. Hui Lim, P. Bifani, Z. Fang, J.C. Ching Wong, Y.X. Setoh, Y.Y. Yang, C.H. Mun, S.Z. Fiona Phua, W.Q. Lim, L. Lin, A.R. Cook, H. Tanoto, L.-C. Ng, A. Singhal, Y.W. Leong, X.J. Loh
المصدر: Materials Today Advances, Vol 11, Iss , Pp 100148- (2021)
مصطلحات موضوعية: Decontamination, Respirator, Vaporized hydrogen peroxide (VHP), UV, COVID-19, SARS-CoV-2, Materials of engineering and construction. Mechanics of materials, TA401-492
الوصف: The coronavirus disease 2019 (COVID-19) pandemic had caused a severe depletion of the worldwide supply of N95 respirators. The development of methods to effectively decontaminate N95 respirators while maintaining their integrity is crucial for respirator regeneration and reuse. In this study, we systematically evaluated five respirator decontamination methods using vaporized hydrogen peroxide (VHP) or ultraviolet (254 nm wavelength, UVC) radiation. Through testing the bioburden, filtration, fluid resistance, and fit (shape) of the decontaminated respirators, we found that the decontamination methods using BioQuell VHP, custom VHP container, Steris VHP, and Sterrad VHP effectively inactivated Cardiovirus (3-log10 reduction) and bacteria (6-log10 reduction) without compromising the respirator integrity after 2–15 cycles. Hope UVC system was capable of inactivating Cardiovirus (3-log10 reduction) but exhibited relatively poorer bactericidal activity. These methods are capable of decontaminating 10–1000 respirators per batch with varied decontamination times (10–200 min). Our findings show that N95 respirators treated by the previously mentioned decontamination methods are safe and effective for reuse by industry, laboratories, and hospitals.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2590049821000187Test; https://doaj.org/toc/2590-0498Test
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7دورية أكاديمية
المؤلفون: Sheila Thomas, Srishtee Arora, Wen Liu, Kelly Churion, You Wu, Magnus Höök
المصدر: mBio, Vol 12, Iss 4 (2021)
مصطلحات موضوعية: Staphylococcus aureus, fibrinogen-binding proteins, vhp, vWbp homolog, Microbiology, QR1-502
الوصف: ABSTRACT Staphylococcus aureus can target a variety of tissues, causing life-threatening infections. The basis for this diversity stems from the microorganism’s ability to spread in the vascular system throughout the body. To survive in blood, S. aureus coats itself with a fibrinogen (Fg)/fibrin shield. The protective shield is assembled by the coordinated actions of a number of Fg-binding bacterial proteins that manipulate the host’s blood coagulation system. Several of the Fg binders appear redundant, sharing similar functional motifs. This observation led us to screen for the presence of novel proteins with significant amino acid identities to von Willebrand factor-binding protein (vWbp), a key component in the shield assembly machinery. One identified protein showed significant sequence identity with the C-terminal region of vWbp, and we consequently named it vWbp homologous protein (vhp). The vhp gene lies within a cluster of genes that encode other virulence factors in S. aureus. Although each isolate only contains one copy of the vhp gene, S. aureus has at least three distinct alleles, vhpA, B, and C, that are present in the core genome. All three vhp isoforms bind Fg with high affinity, targeting a site located in the D fragment of Fg. We further identified an ∼79 amino acid-long, conserved segment within the C-terminal region of vWbp that shares high sequence identities (54 to 67%) with the vhps and binds soluble Fg with high affinity. Further analysis of this conserved motif and the intact vhps revealed intriguing differences in the Fg binding behavior, perhaps suggesting that these proteins have similar but discrete functions in the shield assembly. IMPORTANCE The life-threatening diseases caused by multidrug-resistant Staphylococcus aureus strains are a worldwide medical problem due to treatment limitations and the lack of an effective vaccine. The ability of S. aureus to coat itself with a protective fibrinogen (Fg)/fibrin shield allows the organism to survive in blood and to disseminate and cause invasive diseases. This process represents a promising target for novel antistaphylococcal treatment strategies but is incompletely understood. S. aureus expresses a number of Fg-binding proteins. Some of these proteins have apparently redundant functions. Proteins with similar functions often share a structural or functional motif with each other. In this study, we identified a protein homologous to the C-terminal of von Willebrand factor-binding protein (vWbp), a key contributor in the Fg shield assembly that also binds Fg. Further analysis allowed us to identify a common Fg-binding motif.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2150-7511Test
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8دورية أكاديمية
المؤلفون: Meenu Upadhyay (10290216), Markus Meuwly (1433455)
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, nanosecond time scale, experimentally measured rate, 182 ± 66, vibrationally activated decomposition, thermally prepared reactants, experimentally reported yields, dissociation energy (<, actual rates depend, full reaction pathway, estimated thermal rate, choo criegee intermediate, oo , 3 , 3 , 2 , vhp eliminate oh, oh elimination rates, oh yields, oh elimination, vibrationally excited, reaction times, reactants influences
الوصف: The full reaction pathway between the syn -CH 3 CHOO Criegee Intermediate via vinyl hydroxyperoxide (VHP) to CH 2 COH+OH is followed for vibrationally excited and thermally prepared reactants. Reactivity along the entire pathway was characterized from an aggregate of more than 10 μs of reactive MD simulations using energy functions with accuracies at the Møller–Plesset second order level of theory. Reaction times for OH elimination are on the nanosecond time scale, and the energy dependence of the rates is consistent with experiments in the jet. The actual rates depend on the O–O dissociation energy ( D e OO = 31.5 kcal/mol at the MP2/aug-cc-pVTZ level or D e OO = 23.5 kcal/mol closer to earlier CASPT2 calculations). Also, the initial preparation of the reactants influences both the VHP formation/OH elimination rates and the OH yields. For most conditions with initial vibrational excitation 80% or more of syn -CH 3 CHOO progress to OH elimination on the 5 ns time scale. However, for internally cold conformational ensembles generated at low temperature (50 K) only 20% to 30% of VHP eliminate OH on the 5 ns time scale which increases to 55% to 67% depending on excitation energy from simulations on the 15 ns time scale. For thermal preparation of syn -CH 3 CHOO, which is relevant in the atmosphere, 35% of the trajectories lead to OH-elimination within 1 ns. This compares with experimentally reported yields of 24% to 64% in a collisional environment. The estimated thermal rate at 300 K is 10 3 s –1 , extrapolated from results at 500 to 900 K, is consistent with the experimentally measured rate of 182 ± 66 s –1 .
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9دورية أكاديمية
مصطلحات موضوعية: Cell Biology, Ecology, Immunology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, COVID -19. Knowledge, Twenty-three building materials, Organic Compounds Vaporous hydrogen., SARS-CoV -2 virus, Hydrogen Peroxide Vapor, VHP deposition velocities, 6 h period, N 95 respirators, O 3, disinfectant concentrations, velocity
الوصف: Vaporous hydrogen peroxide (VHP) has been used to disinfect a wide range of biological contaminants in buildings. It has attracted renewed attention for inactivation of the SARS-CoV-2 virus on N95 respirators, allowing their subsequent reuse, as well as potential use for decontamination of indoor spaces frequented by those who have COVID-19. Knowledge of VHP removal to indoor materials and associated emissions of organic compounds have not been widely reported but would be valuable for indoor disinfection planning. Twenty-three building materials were individually exposed to VHP at typical disinfectant concentrations in small chamber experiments. Deposition velocities for VHP and area-normalized masses of organic compound release were quantified for each material and compared with results from studies involving ozone (O 3 ) and chlorine dioxide (OClO) at similar disinfectant concentrations using similar materials in the same experimental system. Higher (typically >200 cm h –1 ) but relatively constant VHP deposition velocities were observed for most materials. In contrast, the deposition velocity for O 3 and OClO decayed when exposed to the same materials. Relatively low levels (<2 mg m –2 ) of quantified emissions were released from materials over an approximate 6 h period following exposure to VHP, values lower than those observed for ozone.
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10دورية أكاديمية
المؤلفون: Wang, C. -G., Li, Z., Liu, S., Ng, C. T., Marzuki, M., Jeslyn Wong P.S., Tan, B., Lee, A., Hui Lim C.F., Bifani, P., Fang, Z., Ching Wong J.C., Setoh, Y. X., Yang, Y. Y., Mun, C. H., Fiona Phua S.Z., Lim, W. Q., Lin, L., Cook, A. R., Tanoto, H., Ng, L. -C., Singhal, A., Leong, Y. W., Loh, X. J.
المساهمون: COLLEGE OF DESIGN AND ENGINEERING, SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
المصدر: Scopus OA2021
مصطلحات موضوعية: COVID-19, Decontamination, N95, Respirator, Reuse, SARS-CoV-2, UV, Vaporized hydrogen peroxide (VHP)
الوصف: 10.1016/j.mtadv.2021.100148 ; Materials Today Advances ; 11 ; 100148
العلاقة: Wang, C. -G., Li, Z., Liu, S., Ng, C. T., Marzuki, M., Jeslyn Wong P.S., Tan, B., Lee, A., Hui Lim C.F., Bifani, P., Fang, Z., Ching Wong J.C., Setoh, Y. X., Yang, Y. Y., Mun, C. H., Fiona Phua S.Z., Lim, W. Q., Lin, L., Cook, A. R., Tanoto, H., Ng, L. -C., Singhal, A., Leong, Y. W., Loh, X. J. (2021-09-01). N95 respirator decontamination: a study in reusability. Materials Today Advances 11 : 100148. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mtadv.2021.100148Test; https://scholarbank.nus.edu.sg/handle/10635/232034Test
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