المؤلفون: J. Surey, H. R. Stagg, T. A. Yates, M. Lipman, P. J. White, A. Charlett, L. Muñoz, L. Gosce, M. X. Rangaka, M. Francis, V. Hack, H. Kunst, I. Abubakar

المصدر: BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021)

مصطلحات موضوعية: Tuberculosis, Latent tuberculosis treatment, Randomised controlled trial, Rifapentine, Infectious and parasitic diseases, RC109-216

الوصف: Abstract Background Ending the global tuberculosis (TB) epidemic requires a focus on treating individuals with latent TB infection (LTBI) to prevent future cases. Promising trials of shorter regimens have shown them to be effective as preventative TB treatment, however there is a paucity of data on self-administered treatment completion rates. This pilot trial assessed treatment completion, adherence, safety and the feasibility of treating LTBI in the UK using a weekly rifapentine and isoniazid regimen versus daily rifampicin and isoniazid, both self-administered for 12 weeks. Methods An open label, randomised, multi-site pilot trial was conducted in London, UK, between March 2015 and January 2017. Adults between 16 and 65 years with LTBI at two TB clinics who were eligible for and agreed to preventative therapy were consented and randomised 1:1 to receive either a weekly combination of rifapentine/isoniazid (‘intervention’) or a daily combination of rifampicin/isoniazid (‘standard’), with both regimens taken for twelve weeks; treatment was self-administered in both arms. The primary outcome, completion of treatment, was self-reported, defined as taking more than 90% of prescribed doses and corroborated by pill counts and urine testing. Adverse events were recorded. Results Fifty-two patients were successfully enrolled. In the intervention arm 21 of 27 patients completed treatment (77.8, 95% confidence interval [CI] 57.7–91.4), compared with 19 of 25 (76.0%, CI 54.9–90.6) in the standard of care arm. There was a similar adverse effect profile between the two arms. Conclusion In this pilot trial, treatment completion was comparable between the weekly rifapentine/isoniazid and the daily rifampicin/isoniazid regimens. Additionally, the adverse event profile was similar between the two arms. We conclude that it is safe and feasible to undertake a fully powered trial to determine whether self-administered weekly treatment is superior/non-inferior compared to current treatment. Trial registration The trial was funded by the NIHR, UK and registered with ISRCTN ( 26/02/2013-No.04379941 ).

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2334Test

الوصول الحر: https://doaj.org/article/5e13b92cf17f4c9e8cd34ec43509a8b1Test

المؤلفون: J. Surey (10021748), H. R. Stagg (10021751), T. A. Yates (10021754), M. Lipman (7231517), P. J. White (10021757), A. Charlett (10021760), L. Muñoz (10021763), L. Gosce (10021766), M. X. Rangaka (10021769), M. Francis (9222441), V. Hack (10021772), H. Kunst (7642823), I. Abubakar (7671611)

مصطلحات موضوعية: Medicine, Pharmacology, Immunology, Cancer, Science Policy, Infectious Diseases, Tuberculosis, Latent tuberculosis treatment, Randomised controlled trial, Rifapentine

الوصف: Additional file 1: Appendix 1: Dosing schedule. Appendix 2: Standardised questionnaire. Appendix 3: MARS™ Adherence Questionnaire. Appendix 4: Adverse events and discontinuation rules. Appendix 5: Comparison of self-reported adherence and isoniazid urine test. Appendix 6: Adverse events

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_1_of_An_open_label_randomised_controlled_trial_of_rifapentine_versus_rifampicin_based_short_course_regimens_for_the_treatment_of_latent_tuberculosis_in_England_the_HALT_LTBI_pilot_study/13627070Test

الإتاحة: https://doi.org/10.6084/m9.figshare.13627070.v1Test

المؤلفون: J. Surey (10021748), H. R. Stagg (10021751), T. A. Yates (10021754), M. Lipman (7231517), P. J. White (10021757), A. Charlett (10021760), L. Muñoz (10021763), L. Gosce (10021766), M. X. Rangaka (10021769), M. Francis (9222441), V. Hack (10021772), H. Kunst (7642823), I. Abubakar (7671611)

مصطلحات موضوعية: Medicine, Pharmacology, Immunology, Cancer, Science Policy, Infectious Diseases, Tuberculosis, Latent tuberculosis treatment, Randomised controlled trial, Rifapentine

الوصف: Additional file 2:. CONSORT 2010 checklist of information to include when reporting a randomised trial

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_2_of_An_open_label_randomised_controlled_trial_of_rifapentine_versus_rifampicin_based_short_course_regimens_for_the_treatment_of_latent_tuberculosis_in_England_the_HALT_LTBI_pilot_study/13627073Test

الإتاحة: https://doi.org/10.6084/m9.figshare.13627073.v1Test

المؤلفون: V. Hackstein, P. Fauth-Mayer, M. Rothermel, N. Haala

المصدر: ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, Vol X-2-2024, Pp 89-96 (2024)

مصطلحات موضوعية: Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820

الوصف: While originally developed for novel view synthesis, Neural Radiance Fields (NeRFs) have recently emerged as an alternative to multi-view stereo (MVS). Triggered by a manifold of research activities, promising results have been gained especially for textureless, transparent, and reflecting surfaces, while such scenarios remain challenging for traditional MVS-based approaches. However, most of these investigations focus on close-range scenarios, with studies for airborne scenarios still missing. For this task, NeRFs face potential difficulties at areas of low image redundancy and weak data evidence, as often found in street canyons, facades or building shadows. Furthermore, training such networks is computationally expensive. Thus, the aim of our work is twofold: First, we investigate the applicability of NeRFs for aerial image blocks representing different characteristics like nadir-only, oblique and high-resolution imagery. Second, during these investigations we demonstrate the benefit of integrating depth priors from tie-point measures, which are provided during presupposed Bundle Block Adjustment. Our work is based on the state-of-the-art framework VolSDF, which models 3D scenes by signed distance functions (SDFs), since this is more applicable for surface reconstruction compared to the standard volumetric representation in vanilla NeRFs. For evaluation, the NeRF-based reconstructions are compared to results of a publicly available benchmark dataset for airborne images.

وصف الملف: electronic resource

العلاقة: https://isprs-annals.copernicus.org/articles/X-2-2024/89/2024/isprs-annals-X-2-2024-89-2024.pdfTest; https://doaj.org/toc/2194-9042Test; https://doaj.org/toc/2194-9050Test

الوصول الحر: https://doaj.org/article/1878f947b0e142889368a3ff6568e54cTest

المؤلفون: Tom A Yates, Molebogeng X Rangaka, Marie Francis, Andre Charlett, Peter J White, V. Hack, Lara Goscé, Helen R. Stagg, Heinke Kunst, Laura Muñoz, Ibrahim Abubakar, Julian Surey, Marc Lipman

المساهمون: National Institute for Health Research, Medical Research Council (MRC)

المصدر: BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021)
Surey, J, Stagg, H R, Yates, T A, Lipman, M, White, P J, Charlett, A, Muñoz, L, Goscé, L, Rangaka, M X, Francis, M, Hack, V, Kunst, H & Abubakar, I 2021, ' An open label, randomised controlled trial of rifapentine versus rifampicin based short course regimens for the treatment of latent tuberculosis in England : the HALT LTBI pilot study ', BMC Infectious Diseases, vol. 21, 90 . https://doi.org/10.1186/s12879-021-05766-9Test
BMC INFECTIOUS DISEASES
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
BMC Infectious Diseases

مصطلحات موضوعية: Male, Antitubercular Agents, Pilot Projects, Self Administration, 030204 cardiovascular system & hematology, law.invention, 0302 clinical medicine, Randomized controlled trial, law, 1108 Medical Microbiology, London, 030212 general & internal medicine, Randomised controlled trial, Latent tuberculosis, Isoniazid, Middle Aged, Infectious Diseases, Treatment Outcome, Drug Therapy, Combination, Female, Rifampin, Life Sciences & Biomedicine, Research Article, medicine.drug, 0605 Microbiology, Adult, medicine.medical_specialty, Tuberculosis, Adolescent, Microbiology, Drug Administration Schedule, Rifapentine, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Young Adult, Latent Tuberculosis, Latent tuberculosis treatment, Internal medicine, medicine, Humans, lcsh:RC109-216, Adverse effect, Science & Technology, business.industry, 1103 Clinical Sciences, medicine.disease, Regimen, business, Rifampicin

الوصف: Background Ending the global tuberculosis (TB) epidemic requires a focus on treating individuals with latent TB infection (LTBI) to prevent future cases. Promising trials of shorter regimens have shown them to be effective as preventative TB treatment, however there is a paucity of data on self-administered treatment completion rates. This pilot trial assessed treatment completion, adherence, safety and the feasibility of treating LTBI in the UK using a weekly rifapentine and isoniazid regimen versus daily rifampicin and isoniazid, both self-administered for 12 weeks. Methods An open label, randomised, multi-site pilot trial was conducted in London, UK, between March 2015 and January 2017. Adults between 16 and 65 years with LTBI at two TB clinics who were eligible for and agreed to preventative therapy were consented and randomised 1:1 to receive either a weekly combination of rifapentine/isoniazid (‘intervention’) or a daily combination of rifampicin/isoniazid (‘standard’), with both regimens taken for twelve weeks; treatment was self-administered in both arms. The primary outcome, completion of treatment, was self-reported, defined as taking more than 90% of prescribed doses and corroborated by pill counts and urine testing. Adverse events were recorded. Results Fifty-two patients were successfully enrolled. In the intervention arm 21 of 27 patients completed treatment (77.8, 95% confidence interval [CI] 57.7–91.4), compared with 19 of 25 (76.0%, CI 54.9–90.6) in the standard of care arm. There was a similar adverse effect profile between the two arms. Conclusion In this pilot trial, treatment completion was comparable between the weekly rifapentine/isoniazid and the daily rifampicin/isoniazid regimens. Additionally, the adverse event profile was similar between the two arms. We conclude that it is safe and feasible to undertake a fully powered trial to determine whether self-administered weekly treatment is superior/non-inferior compared to current treatment. Trial registration The trial was funded by the NIHR, UK and registered with ISRCTN (26/02/2013-No.04379941).

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9141b0d81dc7dee4f14b991a27af852cTest
https://doaj.org/article/5e13b92cf17f4c9e8cd34ec43509a8b1Test

المؤلفون: Surey, J., H. R. Stagg, T. A. Yates, M. Lipman, P. J. White, A. Charlett, L. Muñoz, L. Gosce, M. X. Rangaka, M. Francis, V. Hack, H. Kunst, I. Abubakar

مصطلحات موضوعية: humanities

الوصف: Additional file 2:. CONSORT 2010 checklist of information to include when reporting a randomised trial

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7f529ae58f963bdacca46f1121463cTest

المؤلفون: Kirmeier E. a, Eriksson L. I. c, Lewald H. a, Jonsson Fagerlund, M. c Hoeft, A. f Hollmann, M. g Meistelman, C. e Hunter, J. M. d Ulm, K. b Blobner, M. aEmail Author, Abad Gurumeta, A. Abernethy, C. Abigail, P. Achaibar, K. Adam, E. Afshari, Agudelo Montoya, M. E. Akgün, F. N. Aletti, G. Alkış, N. Allan, K. Allan, A. Allaouchiche, B. Allcock, C. Almasy, E. Amey, I. Amigoni, M. Andersen, E. Andersson, P. Anipchenko, N. Antunes, P. Armstrong, E. Aslam, T. N. Aslin, B. Assunção, J. P. Ausserer, J. Avvai, M. Awad, Ayas Montero, B. Ayuso, M. Azevedo, P. Badarau, V. Badescu, Baiardo Redaelli, M. Baird, C. Baird, Y. Baker, T. Balaji, P. Bălan, C. Balandin, A. Balescu-Arion, C. Baliuliene, Baltasar Isabel, J. Baluch, S. N. Bandrabur, D. Bankewitz, C. Barber, K. Barbera, F. Barcraft-Barnes, H. Barletti, V. Barnett, G. Baron, K. Barros, A. Barsan, V. Bartlett, P. Batistaki, C. Baumgarten, G. Baytas, V. Beauchamp, Becerra Cayetano, I. A. Bell, S. Bellandi, M. Belletti, Belmonte Cuenca, J. Benitez-Cano, A. Beretta, L. Berger, M. Bergmann, N. Bergmark, Bermudez Lopez, M. Bernotaite, M. Beurskens, C. Bidd, H. Bifulco, F. Bignami, E. Bilic, A. Bilskiene, D. Bischoff, P. Bishop, L. Bjonness, T. Blaylock, H. Blethyn, K. Blincoe, T. Blokhin, I. Blunt, N. Boer, C. Bois, G. Bonicolini, E. Booth, J. Borecka-Kedzierska, M. Borstnar, K. Borys, M. Boselli, E. Bouvet, L. Bouwman, A. Bowen, L. Bowrey, S. Boxall, L. Božić, T. Bradley, T. Branco, T. Brazzi, L. Brazzoni, M. Brear, T. Brogly, N. Brohi, F. Broms, J. Bubliauskas, A. Bucolo, G. E. Buerkle, H. Buggy, D. Buhre, W. Bukauskas, T. Butturini, F. Byttner, Cabrera Díaz, I. Calderon, A. Calhau, R. Callejo, A. Cammu, G. Campesato, M. Can, Ö. S. Candeias, M. Cantor, A. Carise, E. Carmona, C. Carreteiro, J. Carrieri, C. Carter, A. Casal, M. Casanova, I. Cascella, M. Casero, L. M. Casiraghi, G. M. Castelo-Branco, Castro Arranz, C. Cernea, D. D. Cervantes, J. Chandler, B. Charnock, R. Chatzimicali, A. Chinery, E. Chishti, A. Chondhury, P. Christie, E. Christodoudiles, G. Ciardo, S. Cimpeanu, L. Cindea, I. Cinnella, G. Clark, S. Clayton, M. Cocu, S. Collyer, T. Colvin, C. Cope, S. Copeta, F. Copotoiu, S. -M., Correia de Barros, F. Corso, R. M. Cortegiani, A. Costa, G. Cowton, A. Cox, N. Craig, J. Cricca, V. Cronin, J. Cunha, M. Cuomo, A. Curley, K. Czuczwar, M. Dabrowska, D. Damster, Danguy des Déserts, M. Daniliuc, A. Danninger, T. Darwish, I. Dascalu, C. Davies, K. Davies, De Boer, De Flaviis, De Selincourt, G. Deana, C. Debaene, B. Debreceni, G. Dedhia, Delgado Garcia, Della Rocca, G. Delroy-Buelles, L. Desai, T. Dhillon, Di Giacinto, Di Mauro, Diaz Gomez, T. V. Dimitrovski, A. Dinic, V. Dîrzu, D. -S., Divander M. B., Dolinar J., Domingues S., Doolan J., Downes C., Dragoescu N. A., Droc G., Dum E., Dumitrescu A., Duncan L., Dzurňáková P., Eberl S., Edwards J., Edwards M., Ekelund K., Ekengren P., Elghouty E., Ellerkmann R., Ellis H., Elme A., Ernst T., Errando C. L., Estenes S., Ewaldsson C., Farid N., Featherstone J., Febres D., Fedorov S., Feggeler J., Feijten P., Fellmann T., Fernandez Candil, Fernandez Castineira, Fernández Castineira, J. Fernando, A. Ferrando, C. Ferreira, L. Ferreira, P. Feyling, A. Filipescu, D. Fleischer, A. Floris, L. Foerster, U. Fox, B. Franke, U. Frasca, D. Frey, C. Frost, V. Fullin, G. Fumagalli, J. Furneval, J. Fusari, M. Gallacher, S. Galushka, S. Gambale, G. Gambino, I. Garcia-Perez, M. L. Garg, S. Garlak, J. Gavranovic, Z. Gavrilov, R. Gaynor, Gecaj Gashi, A. Georghiou, M. Gerjevic, B. Gferer, G. Giarratano, A. Gibson, A. Gievski, V. Giles, J. Gillberg, L. Gilowska, Gilsanz Rodriguez, F. Gioia, A. Giovannoni, C. Girotra, V. Gkinas, D. Gkiokas, G. Godoroja, D. Goebel, U. Goel, V. Gonzalez, M. Goranovic, T. Gornik-Wlaszczuk, E. Gosavi, S. Gottfridsson, P. Gottschalk, A. Granell, M. Granstrom, A. Grassetto, A. Greenwood, A. Grigoras, I. Grintescu, I. Gritsan, A. Gritsan, G. Grynyuk, A. Guadagnin, G. M. Guarnieri, M. Güçlü, Guerrero Diez, M. Gunenc, F. Günther, U. Gupta, P. Guttenthaler, V. Hack, Y. Hafisayena, A. Hagau, N. Haldar, J. Hales, D. Hancı, V. Hanna-Jumma, S. Harazim, H. Harlet, P. Harper, D. Harris, B. Harvey, O. Hashimi, M. Hawkins, L. Hayes, C. Heaton, J. Heier, T. Helliwell, L. Hemmes, S. Henderson, K. Hermanides, J. Hermanns, Herrera Hueso, B. Hestenes, S. Hettiarachchi, R. Highgate, J. Hodgson, K. Hoelbling, D. Holland, J. Horhota, L. Hormis, A. Hribar, R. Hua, A. Humphreys, S. Humphries, R. Humpliková, S. Hunt, J. Husnain, A. Hussein, A. Hyams, B. Iannuccelli, F. Ilette, K. Ilyas, C. Inan, T. India, I. Ionițăv, V. Irwin, F. Jain, V. Janez, B. Jankovic, R. Jenkins, S. Jenko, M. Jimenez, Jiménez Gomez, B. Joachim, S. Joelsson-Alm, E. John, J. Jonikaite, L. Jovic, M. Jungwirth, B. Junke, E. Kabakov, B. Kadaoui, S. -D., Kanski A., Karadag S., Karbonskiene A., Karjagin J., Kasnik D., Katanolli F., Katsika E., Kaufmann K., Keane H., Kelly M., Kent M., Keraitiene G., Khudhur A., Khuenl-Brady K., Kidd L., King S., Kirchgäßner K., Klancir T., Klucniks A., Knotzer J., Knowlden P., Koers L., Kompan J., Koneti K. K., Kooij F., Koolen E., Koopman - van Gemert, A. W. M. M. Kopp, K. Korfiotis, D. Korolkov, O. Kosinová, M. Köstenberger, M. Kotzinger, O. Kovačević, M. Kranke, P. Kranke, E. Kraus, C. Kraus, S. Kubitzek, C. Kucharski, R. Kucukguclu, S. Kudrashou, A. Kumar, V. Kummen, L. Kunit, C. Kushakovsky, V. Kuvaki, B. Kuzmanovska, B. Kyttari, A. Landoni, G. Lau, G. Lazarev, K. Legett, S. Legrottaglie, A. M. Leonardi, S. Leong, M. Lercher, H. Leuvrey, M. Leva, B. Levstek, M. Limb, J. Lindholm, E. Linton, F. Liperi, C. Lipski, F. Lirk, P. Lisi, A. Lišková, Lluch Oltra, A. Loganathan, V. Lombardi, S. Lopez, Lopez Rodríguez, M. Lorenzini, L. Lowicka, M. Lugovoy, A. Luippold, M. Lumb, A. Macas, A. Macgregor, M. Machado, H. Maciariello, M. Madeira, I. Maitan, S. Majewski, J. Maldini, B. Malewski, G. Manfredini, L. Männer, O. Marchand, B. Marcu, A. Margalef, J. Margarson, M. Marinheiro, L. Markic, Markovic Bozic, J. Marrazzo, F. Martin, Martin Ayuso, M. Martinez, E. Martino, E. A. Martinson, V. Marusic-Gaser, K. Mascarenhas, C. Mathis, C. Matsota, P. Mavrommati, Mazul Sunko, B. McCourt, K. McGill, N. McKee, R. Meço, B. C. Meier, S. Melbourne, S. Melbybråthen, G. Meli, A. Melia, A. Melotti, R. M. Menga, M. R. Mercer, P. Merotra, S. Mescolini, S. Metterlein, T. Michalov, M. Michlig, S. Midgley, S. Milić, M. Milojevic, M. Miñana, A. Minto, G. Mirabella, L. Mirea, L. Mittelstädt, L. Moeglen, A. Moise, A. Mokini, Z. Molin, A. Moltó, L. Monea, M. C. Montalto, F. Montgomery, J. Montgomery, C. Montillo, G. Moore, S. Moore, F. Moreira, Z. Moreno, T. Moreno, R. Moret, E. Moreton, S. Morgan, Moro Velasco, C. Morri, D. Moull, A. Moura, F. Mráz, P. Mrozek, K. Mukhtar, K. Muniyappa, S. Murray, H. Murthy, B. V. Mushambi, M. Nadolski, M. Nardelli, P. Nardin, Navarro Pérez, R. Naveiro, A. Negri, Nesek Adam, V. Neskovic, V. Neuwersch, S. Neves, M. Nguyen, Ní Eochagáin, A. Nicholas, C. Nightingale, J. Norrie, K. Novak-Jankovic, V. Novakova, A. Novillo, M. Numan, S. Oduro-Dominah, L. Oldner, A. Oliveira, I. Ologoiu, D. Oloktsidou, I. O'Reilly, R. Orlando, A. Ovezov, A. Ozbilgin, S. Paal, Padin Barreiro, L. Palugniok, R. Papaioannou, A. Papapostolou, K. Paranthaman, Pardey Bracho, G. Parente, S. Parfeni, A. Pasin, L. Passey, S. Pastor, E. Patch, S. Patil, A. Paunescu, M. -A., Pehboeck D., Pereira M., Pereira C., Perez Caballero, Pérez García, Pérez Soto, Perez Tejero, G. Perez-Cerda, F. Pesenti, A. Petta, R. Philippe, S. Pickering, Pico Veloso, J. Pina, P. Pinho-Oliveira, V. Pinol, S. Pinto, R. Pistidda, L. Pitterle, M. Piwowarczyk, P. Plotnikova, O. Pohl, H. Poldermann, J. Polkovicová, L. Pompei, L. Popescu, M. Popović, Pota V, Potocnik M., Potręć B., Potter A., Pramod N., Prchalova M., Preckel B., Pugh R., Pulletz M., Radoeshki A., Rafi A., Ragazzi R., Raineri Santi, M. Rajamanickam, T. Rajput, Z. Ramachandran, R. Ramasamy, R. Ramessur, S. Rao, R. Rasmussen, A. Rato, A. Razaque, Real Navacerrada, M. I. Reavley, C. Reid, J. Reschreiter, H. Rial, Ribas Carrasco, P. Ribeiro, S. Rich, N. Richardson, L. Rimaitis, K. Rimaitis, M. Ringvold, E. -M., Ripke F., Ristescu I., Ritchie K., Ródenas F., Rodrigues P., Rogers E., Rogerson D., Romagnoli S., Romero E., Rondovic G., Rose B. O., Roth W., Rotter, M. -T., Rousseau G., Rudjord A., Rueffert H., Rundgren M., Rupprecht K., Rushton A., Russotto V., Rypulak E., Ryszka M., Sà J., Sà Couto, P. Saby, S. Sagic, J. Saleh, O. Sales, Sánchez Sánchez, Y. Sanghera, Şanli Karip, Santiveri Papiol, F. J. Santos, S. Sarno, S. Saul, D. Saunders, D. Savic, N. Scalco, L. Scanlon, D. Schaller, S. Schax, C. Scheffer, G. J. Schening, A. Schiavone, V. Schmidt-Ehrenberg, F. Schmidt-Mutter, C. Schönberg, C. Schopflin, C. Schreiber, J. -U., Schultz M., Schurig M., Scott C., Sebestian S., Sehgal S., Sem V., Semenas E., Serafini E., Serchan P., Shields M., Shobha R., Shosholcheva M., Siamansour T., Siddaiah N., Siddiqi K., Sinclair R., Singh P., Singh R., Sinha A., Skinner A., Smee E., Smekalova O., Smith N., Smith T., Smitz C., Smole D., Sojčić N., Soler Pedrola, M. Somanath, S. Sonksen, J. Sorella, M. C. Sörmus, A. Soro, M. Soto, C. Spada, A. Spadaro, S. Spaeth, J. Sparr, H. Spielmann, A. Spindler-Vesel, A. Stamelos, Stancombe L, L. Stanculescu, A. Standl, T. Standley, T. Stanek, O. Stanisavljević, S. Starczewska, M. Stäuble, C. Steen, J. Stefan, O. M. Stell, E. Stera, C. Stevens, M. Stoerckel, M. Stošić, B. Stourac, P. Stroumpoulis, K. Struck, Suarez de la Rica, A. Sultanpori, Sundara Rajan, R. Suying, O. Svensen, C. Swan, L. Syrogianni, P. Sysiak, J. Szederjesi, J. Taddei, Tan Hao, E. Tanou, V. Tarabová, Tardaguila Sancho, P. Tarroso, M. Tartaglione, M. Taylor, E. Tbaily, L. Telford, R. Terenzoni, M. Theodoraki, K. Thornley, H. Tiganiuc, L. Toim, H. Tomescu, D. Tommasino, C. Toni, J. Toninelli, A. Toretti, I. Townley, S. Trepenaitis, D. Trethowan, B. Tsaousi, G. Tsiftsi, A. Tudor, A. Turan, G. Turhan, S. Ç. Unic-Stojanovic, D. Unterbuchner, C. Unzueta, C. Uranjek, J. Ursic, T. Vaida, Valldeperas Ferrer, Valldeperas Hernandez, M. I. Valsamidis, Van Beek, Van dasselaer, Van Der Beek, Van Duivenvoorde, van Klei, W. A., Van Poorter, Van Zaane, Van Zundert, Van Zyl, Vargas Munoz, A. M. Varsani, N. Vasconcelos, P. Vassilakis, G. Vecchiatini, T. Vecera, L. Vercauteren, M. Verdouw, B. Verheyen, V. Verri, Vicari Sottosanti, L. G. Vico, Vidal Mitjans, P. Vilardi, A. Vissicchio, D. Vitale, G. Vitković, B. Vizcaychipi, M. P. Voicu, A. Voje, M. Volfová, I. Volta, C. A., Von Lutterotti, von Tiesenhausen, A. Vrecic-Slabe, S. Vukcevic, D. Vukovic, R. Vullo, P. A. Wade, A. Wallberg, H. Wallden, J. Wallner, Walther Sturesson, L. Watson, D. Weber, Wegiel Leskiewiq, A. Weller, D. Wensing, C. Werkmann, M. Westberg, H. Wikström, E. Williams, B. Wilson, R. Wirth, S. Wittmann, M. Wood, L. Wright, S. Zachoval, C. Zambon, M. Zampieri, S. Zampone, S. Zangrillo, A. Zani, G. Zavackiene, A. Zieglerder, R. Zonneveldt, H. Zsisku, L. Zucker, T. -P., Żukowski M., Zuleika M., Zupanĕiĕ D.

المساهمون: Kirmeier, E. a., Eriksson, L. I. c., Lewald, H. a., Jonsson, Fagerlund, Hoeft, M. c., Hollmann, A. f., Meistelman, M. g., Hunter, C. e., Ulm, J. M. d., Blobner, K. b., M., aEmail Author, Abad, Gurumeta, A., Abernethy, C., Abigail, P., Achaibar, K., Adam, E., Afshari, Agudelo, Montoya, M. E., Akgün, F. N., Aletti, G., Alkış, N., Allan, K., Allan, A., Allaouchiche, B., Allcock, C., Almasy, E., Amey, I., Amigoni, M., Andersen, E., Andersson, P., Anipchenko, N., Antune, P., Armstrong, E., Aslam, T. N., Aslin, B., Assunção, J. P., Ausserer, J., Avvai, M., Awad, Ayas, Montero, B., Ayuso, M., Azevedo, P., Badarau, V., Badescu, Baiardo, Redaelli, M., Baird, C., Baird, Y., Baker, T., Balaji, P., Bălan, C., Balandin, A., Balescu-Arion, C., Baliuliene, Baltasar, Isabel, J., Baluch, S. N., Bandrabur, D., Bankewitz, C., Barber, K., Barbera, F., Barcraft-Barne, H., Barletti, V., Barnett, G., Baron, K., Barro, A., Barsan, V., Bartlett, P., Batistaki, C., Baumgarten, G., Bayta, V., Beauchamp, Becerra, Cayetano, I. A., Bell, S., Bellandi, M., Belletti, Belmonte, Cuenca, J., Benitez-Cano, A., Beretta, L., Berger, M., Bergmann, N., Bergmark, Bermudez, Lopez, M., Bernotaite, M., Beursken, C., Bidd, H., Bifulco, F., Bignami, E., Bilic, A., Bilskiene, D., Bischoff, P., Bishop, L., Bjonne, T., Blaylock, H., Blethyn, K., Blincoe, T., Blokhin, I., Blunt, N., Boer, C., Boi, G., Bonicolini, E., Booth, J., Borecka-Kedzierska, M., Borstnar, K., Bory, M., Boselli, E., Bouvet, L., Bouwman, A., Bowen, L., Bowrey, S., Boxall, L., Božić, T., Bradley, T., Branco, T., Brazzi, L., Brazzoni, M., Brear, T., Brogly, N., Brohi, F., Brom, J., Bubliauska, A., Bucolo, G. E., Buerkle, H., Buggy, D., Buhre, W., Bukauska, T., Butturini, F., Byttner, Cabrera, Díaz, I., Calderon, A., Calhau, R., Callejo, A., Cammu, G., Campesato, M., Can, Ö. S., Candeia, M., Cantor, A., Carise, E., Carmona, C., Carreteiro, J., Carrieri, C., Carter, A., Casal, M., Casanova, I., Cascella, M., Casero, L. M., Casiraghi, G. M., Castelo-Branco, Castro, Arranz, C., Cernea, D. D., Cervante, J., Chandler, B., Charnock, R., Chatzimicali, A., Chinery, E., Chishti, A., Chondhury, P., Christie, E., Christodoudile, G., Ciardo, S., Cimpeanu, L., Cindea, I., Cinnella, G., Clark, S., Clayton, M., Cocu, S., Collyer, T., Colvin, C., Cope, S., Copeta, F., Copotoiu, S., -M., Correia de, Barro, F., Corso, R. M., Cortegiani, A., Costa, G., Cowton, A., Cox, N., Craig, J., Cricca, V., Cronin, J., Cunha, M., Cuomo, A., Curley, K., Czuczwar, M., Dabrowska, D., Damster, Danguy des, Désert, M., Daniliuc, A., Danninger, T., Darwish, I., Dascalu, C., Davie, K., Davie, De, Boer, De, Flavii, De, Selincourt, G., Deana, C., Debaene, B., Debreceni, G., Dedhia, Delgado, Garcia, Della, Rocca, G., Delroy-Buelle, L., Desai, T., Dhillon, Di, Giacinto, Di, Mauro, Diaz, Gomez, T. V., Dimitrovski, A., Dinic, V., Dîrzu, D., -S., Divander, M. B., Dolinar, J., Domingues, S., Doolan, J., Downes, C., Dragoescu, N. A., Droc, G., Dum, E., Dumitrescu, A., Duncan, L., Dzurňáková, P., Eberl, S., Edwards, J., Edwards, M., Ekelund, K., Ekengren, P., Elghouty, E., Ellerkmann, R., Ellis, H., Elme, A., Ernst, T., Errando, C. L., Estenes, S., Ewaldsson, C., Farid, N., Featherstone, J., Febres, D., Fedorov, S., Feggeler, J., Feijten, P., Fellmann, T., Fernandez, Candil, Fernandez, Castineira, Fernández, Castineira, J., Fernando, A., Ferrando, C., Ferreira, L., Ferreira, P., Feyling, A., Filipescu, D., Fleischer, A., Flori, L., Foerster, U., Fox, B., Franke, U., Frasca, D., Frey, C., Frost, V., Fullin, G., Fumagalli, J., Furneval, J., Fusari, M., Gallacher, S., Galushka, S., Gambale, G., Gambino, I., Garcia-Perez, M. L., Garg, S., Garlak, J., Gavranovic, Z., Gavrilov, R., Gaynor, Gecaj, Gashi, A., Georghiou, M., Gerjevic, B., Gferer, G., Giarratano, A., Gibson, A., Gievski, V., Gile, J., Gillberg, L., Gilowska, Gilsanz, Rodriguez, F., Gioia, A., Giovannoni, C., Girotra, V., Gkina, D., Gkioka, G., Godoroja, D., Goebel, U., Goel, V., Gonzalez, M., Goranovic, T., Gornik-Wlaszczuk, E., Gosavi, S., Gottfridsson, P., Gottschalk, A., Granell, M., Granstrom, A., Grassetto, A., Greenwood, A., Grigora, I., Grintescu, I., Gritsan, A., Gritsan, G., Grynyuk, A., Guadagnin, G. M., Guarnieri, M., Güçlü, Guerrero, Diez, M., Gunenc, F., Günther, U., Gupta, P., Guttenthaler, V., Hack, Y., Hafisayena, A., Hagau, N., Haldar, J., Hale, D., Hancı, V., Hanna-Jumma, S., Harazim, H., Harlet, P., Harper, D., Harri, B., Harvey, O., Hashimi, M., Hawkin, L., Haye, C., Heaton, J., Heier, T., Helliwell, L., Hemme, S., Henderson, K., Hermanide, J., Hermann, Herrera, Hueso, B., Hestene, S., Hettiarachchi, R., Highgate, J., Hodgson, K., Hoelbling, D., Holland, J., Horhota, L., Hormi, A., Hribar, R., Hua, A., Humphrey, S., Humphrie, R., Humpliková, S., Hunt, J., Husnain, A., Hussein, A., Hyam, B., Iannuccelli, F., Ilette, K., Ilya, C., Inan, T., India, I., Ionițăv, V., Irwin, F., Jain, V., Janez, B., Jankovic, R., Jenkin, S., Jenko, M., Jimenez, Jiménez, Gomez, B., Joachim, S., Joelsson-Alm, E., John, J., Jonikaite, L., Jovic, M., Jungwirth, B., Junke, E., Kabakov, B., Kadaoui, S., -D., Kanski, A., Karadag, S., Karbonskiene, A., Karjagin, J., Kasnik, D., Katanolli, F., Katsika, E., Kaufmann, K., Keane, H., Kelly, M., Kent, M., Keraitiene, G., Khudhur, A., Khuenl-Brady, K., Kidd, L., King, S., Kirchgäßner, K., Klancir, T., Klucniks, A., Knotzer, J., Knowlden, P., Koers, L., Kompan, J., Koneti, K. K., Kooij, F., Koolen, E., Koopman, - van Gemert, A. W. M. M., Kopp, K., Korfioti, D., Korolkov, O., Kosinová, M., Köstenberger, M., Kotzinger, O., Kovačević, M., Kranke, P., Kranke, E., Krau, C., Krau, S., Kubitzek, C., Kucharski, R., Kucukguclu, S., Kudrashou, A., Kumar, V., Kummen, L., Kunit, C., Kushakovsky, V., Kuvaki, B., Kuzmanovska, B., Kyttari, A., Landoni, G., Lau, G., Lazarev, K., Legett, S., Legrottaglie, A. M., Leonardi, S., Leong, M., Lercher, H., Leuvrey, M., Leva, B., Levstek, M., Limb, J., Lindholm, E., Linton, F., Liperi, C., Lipski, F., Lirk, P., Lisi, A., Lišková, Lluch, Oltra, A., Loganathan, V., Lombardi, S., Lopez, Lopez, Rodríguez, M., Lorenzini, L., Lowicka, M., Lugovoy, A., Luippold, M., Lumb, A., Maca, A., Macgregor, M., Machado, H., Maciariello, M., Madeira, I., Maitan, S., Majewski, J., Maldini, B., Malewski, G., Manfredini, L., Männer, O., Marchand, B., Marcu, A., Margalef, J., Margarson, M., Marinheiro, L., Markic, Markovic, Bozic, J., Marrazzo, F., Martin, Martin, Ayuso, M., Martinez, E., Martino, E. A., Martinson, V., Marusic-Gaser, K., Mascarenha, C., Mathi, C., Matsota, P., Mavrommati, Mazul, Sunko, B., Mccourt, K., Mcgill, N., Mckee, R., Meço, B. C., Meier, S., Melbourne, S., Melbybråthen, G., Meli, A., Melia, A., Melotti, R. M., Menga, M. R., Mercer, P., Merotra, S., Mescolini, S., Metterlein, T., Michalov, M., Michlig, S., Midgley, S., Milić, M., Milojevic, M., Miñana, A., Minto, G., Mirabella, L., Mirea, L., Mittelstädt, L., Moeglen, A., Moise, A., Mokini, Z., Molin, A., Moltó, L., Monea, M. C., Montalto, F., Montgomery, J., Montgomery, C., Montillo, G., Moore, S., Moore, F., Moreira, Z., Moreno, T., Moreno, R., Moret, E., Moreton, S., Morgan, Moro, Velasco, C., Morri, D., Moull, A., Moura, F., Mráz, P., Mrozek, K., Mukhtar, K., Muniyappa, S., Murray, H., Murthy, B. V., Mushambi, M., Nadolski, M., Nardelli, P., Nardin, Navarro, Pérez, R., Naveiro, A., Negri, Nesek, Adam, V., Neskovic, V., Neuwersch, S., Neve, M., Nguyen, Ní, Eochagáin, A., Nichola, C., Nightingale, J., Norrie, K., Novak-Jankovic, V., Novakova, A., Novillo, M., Numan, S., Oduro-Dominah, L., Oldner, A., Oliveira, I., Ologoiu, D., Oloktsidou, I., O'Reilly, R., Orlando, A., Ovezov, A., Ozbilgin, S., Paal, Padin, Barreiro, L., Palugniok, R., Papaioannou, A., Papapostolou, K., Paranthaman, Pardey, Bracho, G., Parente, S., Parfeni, A., Pasin, L., Passey, S., Pastor, E., Patch, S., Patil, A., Paunescu, M., -A., Pehboeck, D., Pereira, M., Pereira, C., Perez, Caballero, Pérez, García, Pérez, Soto, Perez, Tejero, G., Perez-Cerda, F., Pesenti, A., Petta, R., Philippe, S., Pickering, Pico, Veloso, J., Pina, P., Pinho-Oliveira, V., Pinol, S., Pinto, R., Pistidda, L., Pitterle, M., Piwowarczyk, P., Plotnikova, O., Pohl, H., Poldermann, J., Polkovicová, L., Pompei, L., Popescu, M., Popović, Pota, V, Potocnik, M., Potręć, B., Potter, A., Pramod, N., Prchalova, M., Preckel, B., Pugh, R., Pulletz, M., Radoeshki, A., Rafi, A., Ragazzi, R., Raineri, Santi, M., Rajamanickam, T., Rajput, Z., Ramachandran, R., Ramasamy, R., Ramessur, S., Rao, R., Rasmussen, A., Rato, A., Razaque, Real, Navacerrada, M. I., Reavley, C., Reid, J., Reschreiter, H., Rial, Ribas, Carrasco, P., Ribeiro, S., Rich, N., Richardson, L., Rimaiti, K., Rimaiti, M., Ringvold, E., -M., Ripke, F., Ristescu, I., Ritchie, K., Ródenas, F., Rodrigues, P., Rogers, E., Rogerson, D., Romagnoli, S., Romero, E., Rondovic, G., Rose, B. O., Roth, W., Rotter, M., -T., Rousseau, G., Rudjord, A., Rueffert, H., Rundgren, M., Rupprecht, K., Rushton, A., Russotto, V., Rypulak, E., Ryszka, M., Sà, J., Sà, Couto, P., Saby, S., Sagic, J., Saleh, O., Sale, Sánchez, Sánchez, Y., Sanghera, Şanli, Karip, Santiveri, Papiol, F. J., Santo, S., Sarno, S., Saul, D., Saunder, D., Savic, N., Scalco, L., Scanlon, D., Schaller, S., Schax, C., Scheffer, G. J., Schening, A., Schiavone, V., Schmidt-Ehrenberg, F., Schmidt-Mutter, C., Schönberg, C., Schopflin, C., Schreiber, J., -U., Schultz, M., Schurig, M., Scott, C., Sebestian, S., Sehgal, S., Sem, V., Semenas, E., Serafini, E., Serchan, P., Shields, M., Shobha, R., Shosholcheva, M., Siamansour, T., Siddaiah, N., Siddiqi, K., Sinclair, R., Singh, P., Singh, R., Sinha, A., Skinner, A., Smee, E., Smekalova, O., Smith, N., Smith, T., Smitz, C., Smole, D., Sojčić, N., Soler, Pedrola, M., Somanath, S., Sonksen, J., Sorella, M. C., Sörmu, A., Soro, M., Soto, C., Spada, A., Spadaro, S., Spaeth, J., Sparr, H., Spielmann, A., Spindler-Vesel, A., Stamelo, Stancombe, L, L., Stanculescu, A., Standl, T., Standley, T., Stanek, O., Stanisavljević, S., Starczewska, M., Stäuble, C., Steen, J., Stefan, O. M., Stell, E., Stera, C., Steven, M., Stoerckel, M., Stošić, B., Stourac, P., Stroumpouli, K., Struck, Suarez de la, Rica, A., Sultanpori, Sundara, Rajan, R., Suying, O., Svensen, C., Swan, L., Syrogianni, P., Sysiak, J., Szederjesi, J., Taddei, Tan, Hao, E., Tanou, V., Tarabová, Tardaguila, Sancho, P., Tarroso, M., Tartaglione, M., Taylor, E., Tbaily, L., Telford, R., Terenzoni, M., Theodoraki, K., Thornley, H., Tiganiuc, L., Toim, H., Tomescu, D., Tommasino, C., Toni, J., Toninelli, A., Toretti, I., Townley, S., Trepenaiti, D., Trethowan, B., Tsaousi, G., Tsiftsi, A., Tudor, A., Turan, G., Turhan, S. Ç., Unic-Stojanovic, D., Unterbuchner, C., Unzueta, C., Uranjek, J., Ursic, T., Vaida, Valldeperas, Ferrer, Valldeperas, Hernandez, M. I., Valsamidi, Van, Beek, Van, Dasselaer, Van Der, Beek, Van, Duivenvoorde, Van, Klei, W., A., Van, Poorter, Van, Zaane, Van, Zundert, Van, Zyl, Vargas, Munoz, A. M., Varsani, N., Vasconcelo, P., Vassilaki, G., Vecchiatini, T., Vecera, L., Vercauteren, M., Verdouw, B., Verheyen, V., Verri, Vicari, Sottosanti, L. G., Vico, Vidal, Mitjan, P., Vilardi, A., Vissicchio, D., Vitale, G., Vitković, B., Vizcaychipi, M. P., Voicu, A., Voje, M., Volfová, I., Volta, C., A., Von, Lutterotti, Von, Tiesenhausen, A., Vrecic-Slabe, S., Vukcevic, D., Vukovic, R., Vullo, P. A., Wade, A., Wallberg, H., Wallden, J., Wallner, Walther, Sturesson, L., Watson, D., Weber, Wegiel, Leskiewiq, A., Weller, D., Wensing, C., Werkmann, M., Westberg, H., Wikström, E., William, B., Wilson, R., Wirth, S., Wittmann, M., Wood, L., Wright, S., Zachoval, C., Zambon, M., Zampieri, S., Zampone, S., Zangrillo, A., Zani, G., Zavackiene, A., Zieglerder, R., Zonneveldt, H., Zsisku, L., Zucker, T., -P., Żukowski, M., Zuleika, M., Zupanĕiĕ, D., Kirmeier, E, Eriksson, L, Lewald, H, Jonsson Fagerlund, M, Hoeft, A, Hollmann, M, Meistelman, C, Hunter, J, Ulm, K, Blobner, M, Abad Gurumeta, A, Abernethy, C, Abigail, P, Achaibar, K, Adam, E, Afshari, A, Agudelo Montoya, M, Akgun, F, Aletti, G, Alkis, N, Allan, K, Allan, A, Allaouchiche, B, Allcock, C, Almasy, E, Amey, I, Amigoni, M, Andersen, E, Andersson, P, Anipchenko, N, Antunes, P, Armstrong, E, Aslam, T, Aslin, B, Assuncao, J, Ausserer, J, Avvai, M, Awad, N, Ayas Montero, B, Ayuso, M, Azevedo, P, Badarau, V, Badescu, R, Baiardo Redaelli, M, Baird, C, Baird, Y, Baker, T, Balaji, P, Balan, C, Balandin, A, Balescu-Arion, C, Baliuliene, V, Baltasar Isabel, J, Baluch, S, Bandrabur, D, Bankewitz, C, Barber, K, Barbera, F, Barcraft-Barnes, H, Barletti, V, Barnett, G, Baron, K, Barros, A, Barsan, V, Bartlett, P, Batistaki, C, Baumgarten, G, Baytas, V, Beauchamp, N, Becerra Cayetano, I, Bell, S, Bellandi, M, Belletti, A, Belmonte Cuenca, J, Benitez-Cano, A, Beretta, L, Berger, M, Bergmann, N, Bergmark, K, Bermudez Lopez, M, Bernotaite, M, Beurskens, C, Bidd, H, Bifulco, F, Bignami, E, Bilic, A, Bilskiene, D, Bischoff, P, Bishop, L, Bjonness, T, Blaylock, H, Blethyn, K, Blincoe, T, Blokhin, I, Blunt, N, Boer, C, Bois, G, Bonicolini, E, Booth, J, Borecka-Kedzierska, M, Borstnar, K, Borys, M, Boselli, E, Bouvet, L, Bouwman, A, Bowen, L, Bowrey, S, Boxall, L, Bozic, T, Bradley, T, Branco, T, Brazzi, L, Brazzoni, M, Brear, T, Brogly, N, Brohi, F, Broms, J, Bubliauskas, A, Bucolo, G, Buerkle, H, Buggy, D, Buhre, W, Bukauskas, T, Butturini, F, Byttner, A, Cabrera Diaz, I, Calderon, A, Calhau, R, Callejo, A, Cammu, G, Campesato, M, Can, O, Candeias, M, Cantor, A, Carise, E, Carmona, C, Carreteiro, J, Carrieri, C, Carter, A, Casal, M, Casanova, I, Cascella, M, Casero, L, Casiraghi, G, Castelo-Branco, L, Castro Arranz, C, Cernea, D, Cervantes, J, Chandler, B, Charnock, R, Chatzimicali, A, Chinery, E, Chishti, A, Chondhury, P, Christie, E, Christodoudiles, G, Ciardo, S, Cimpeanu, L, Cindea, I, Cinnella, G, Clark, S, Clayton, M, Cocu, S, Collyer, T, Colvin, C, Cope, S, Copeta, F, Copotoiu, S, Correia de Barros, F, Corso, R, Cortegiani, A, Costa, G, Cowton, A, Cox, N, Craig, J, Cricca, V, Cronin, J, Cunha, M, Cuomo, A, Curley, K, Czuczwar, M, Dabrowska, D, Damster, S, Danguy des Deserts, M, Daniliuc, A, Danninger, T, Darwish, I, Dascalu, C, Davies, K, Davies, S, De Boer, H, De Flaviis, A, De Selincourt, G, Deana, C, Debaene, B, Debreceni, G, Dedhia, J, Delgado Garcia, I, Della Rocca, G, Delroy-Buelles, L, Desai, T, Dhillon, P, Di Giacinto, I, Di Mauro, P, Diaz Gomez, T, Dimitrovski, A, Dinic, V, Dirzu, D, Divander, M, Dolinar, J, Domingues, S, Doolan, J, Downes, C, Dragoescu, N, Droc, G, Dum, E, Dumitrescu, A, Duncan, L, Dzurnakova, P, Eberl, S, Edwards, J, Edwards, M, Ekelund, K, Ekengren, P, Elghouty, E, Ellerkmann, R, Ellis, H, Elme, A, Ernst, T, Errando, C, Estenes, S, Ewaldsson, C, Farid, N, Featherstone, J, Febres, D, Fedorov, S, Feggeler, J, Feijten, P, Fellmann, T, Fernandez Candil, J, Fernandez Castineira, A, Fernandez Castineira, J, Fernando, A, Ferrando, C, Ferreira, L, Ferreira, P, Feyling, A, Filipescu, D, Fleischer, A, Floris, L, Foerster, U, Fox, B, Franke, U, Frasca, D, Frey, C, Frost, V, Fullin, G, Fumagalli, J, Furneval, J, Fusari, M, Gallacher, S, Galushka, S, Gambale, G, Gambino, I, Garcia-Perez, M, Garg, S, Garlak, J, Gavranovic, Z, Gavrilov, R, Gaynor, L, Gecaj Gashi, A, Georghiou, M, Gerjevic, B, Gferer, G, Giarratano, A, Gibson, A, Gievski, V, Giles, J, 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Livia, Männer, Olja, Marchand, Bahareh, Marcu, Alexandra, Margalef, Jordi, Margarson, Michael, Marinheiro, Lucia, Markic, Ana, Markovic Bozic, Jasmina, Marrazzo, Francesco, Martin, Jane, Martin Ayuso, Maria, Martinez, Esteher, Martino, Enrico Antonio, Martinson, Victoria, Marusic-Gaser, Katarina, Mascarenhas, Catia, Mathis, Cindy, Matsota, Paraskevi, Mavrommati, Eleni, Mazul Sunko, Branka, McCourt, Killian, McGill, Neil, McKee, Raymond, Meço, Başak Ceyda, Meier, Sonja, Melbourne, Susan, Melbybråthen, Grethe, Meli, Andrea, Melia, Aiden, Melotti, Rita Maria, Menga, Maria Rosaria, Mercer, Pauline, Merotra, Susan, Mescolini, Silvia, Metterlein, Thoma, Michalov, Martin, Michlig, Sam, Midgley, Susan, Milić, Morena, Milojevic, Milan, Miñana, Amanda, Minto, Gary, Mirabella, Lucia, Mirea, Liliana, Mittelstädt, Ludger, Moeglen, Aude, Moise, Alida, Mokini, Zhirajr, Molin, Anna, Moltó, Lui, Monea, Maria Concetta, Montalto, Francesca, Montgomery, Jane, Montgomery, Claire, Montillo, Gerardo, Moore, Sally, Moore, Faye, Moreira, Zelia, Moreno, Tania, Moreno, Ricardo, Moret, Enrique, Moreton, Sarah, Morgan, Marianne, Moro Velasco, Concepción, Morri, Davide, Moull, Alice, Moura, Fernando, Mráz, Peter, Mrozek, Katarzyna, Mukhtar, Karim, Muniyappa, Sudeshkumar, Murray, Heather, Murthy, Burra VS, Mushambi, Mary, Nadolski, Maria, Nardelli, Pasquale, Nardin, Giordano, Navarro Pérez, Rosalía, Naveiro, Andrea, Negri, Manuela, Nesek Adam, Visnja, Neskovic, Vojislava, Neuwersch, Stefan, Neves, Miriam, Nguyen, Bavinh, Ní Eochagáin, Aisling, Nicholas, Caroline, Nightingale, Jeremy, Norrie, Kylie, Novak-Jankovic, Vesna, Novakova, Andrea, Novillo, Marta, Numan, Sandra, Oduro-Dominah, Louise, Oldner, Ander, Oliveira, Isabel, Ologoiu, Daniela, Oloktsidou, Irini, O'Reilly, Rosalind, Orlando, Alessandro, Ovezov, Alexey, Ozbilgin, Sule, Paal, Peter, Padin Barreiro, Lidia, Palugniok, Ryszard, Papaioannou, Alexandra, Papapostolou, Konstantino, Paranthaman, Prabhakar, Pardey Bracho, Gilda, Parente, Suzana, Parfeni, Alexandru, Pasin, Laura, Passey, Samuel, Pastor, Ernesto, Patch, Sarah, Patil, Andan, Paunescu, Marilena-Alina, Pehboeck, Daniel, Pereira, Manuela, Pereira, Carla, Perez Caballero, Paula, Pérez García, Aníbal, Pérez Soto, Antonia, Perez Tejero, Gisela, Perez-Cerda, Francisco, Pesenti, Antonio, Petta, Rocco, Philippe, Simon, Pickering, David, Pico Veloso, Jandro, Pina, Pedro, Pinho-Oliveira, Vítor, Pinol, Santiago, Pinto, Rita, Pistidda, Laura, Pitterle, Manuela, Piwowarczyk, Paweł, Plotnikova, Olga, Pohl, Holger, Poldermann, Jorinde, Polkovicová, Lucia, Pompei, Livia, Popescu, Mihai, Popović, Radmila, Pota, Vincenzo, Potocnik, Miriam, Potręć, Beata, Potter, Alison, Pramod, Nalwaya, Prchalova, Martina, Preckel, Benedikt, Pugh, Richard, Pulletz, Mark, Radoeshki, Aleksandar, Rafi, Amir, Ragazzi, Riccardo, Raineri Santi, Maurizio, Rajamanickam, Tamiselvan, Rajput, Zahra, Ramachandran, Rajeskar, Ramasamy, Radhika, Ramessur, Suneil, Rao, Roshan, Rasmussen, Ander, Rato, André, Razaque, Usman, Real Navacerrada, M. Isabel, Reavley, Caroline, Reid, Jame, Reschreiter, Henrik, Rial, Erick, Ribas Carrasco, Patricia, Ribeiro, Sandy, Rich, Nathalie, Richardson, Lydia, Rimaitis, Kestuti, Rimaitis, Mariu, Ringvold, Else-Marie, Ripke, Fabian, Ristescu, Irina, Ritchie, Keith, Ródenas, Frederic, Rodrigues, Patrícia, Rogers, Emma, Rogerson, David, Romagnoli, Stefano, Romero, Esther, Rondovic, Goran, Rose, Bernd Oliver, Roth, Winfried, Rotter, Marie-Therese, Rousseau, Guy, Rudjord, Ander, Rueffert, Henrik, Rundgren, Malin, Rupprecht, Korbinian, Rushton, Andrew, Russotto, Vincenzo, Rypulak, Elżbieta, Ryszka, Maciej, Sà, Jacinta, Sà Couto, Paula, Saby, Sandrine, Sagic, Jelena, Saleh, Omar, Sales, Gabriele, Sánchez Sánchez, Yván, Sanghera, Sumayer, Şanli Karip, Ceren, Santiveri Papiol, Francisco Javier, Santos, Sofia, Sarno, Stephen, Saul, Daniel, Saunders, David, Savic, Nenad, Scalco, Loïc, Scanlon, Deborah, Schaller, Stefan, Schax, Christoph, Scheffer, Gert Jan, Schening, Anna, Schiavone, Vincenzo, Schmidt-Ehrenberg, Florian, Schmidt-Mutter, Catherine, Schönberg, Christina, Schopflin, Christian, Schreiber, Jan-Uwe, Schultz, Marcu, Schurig, Marlen, Scott, Carmen, Sebestian, Siby, Sehgal, Selena, Sem, Victoria, Semenas, Egidiju, Serafini, Elena, Serchan, Pashalitsa, Shields, Martin, Shobha, Ramakrishnan, Shosholcheva, Mirjana, Siamansour, Tanja, Siddaiah, Narendra, Siddiqi, Khalid, Sinclair, Rhona, Singh, Permendra, Singh, Rajendra, Sinha, Aneeta, Sinha, Ashok, Skinner, Amanda, Smee, Elizabeth, Smekalova, Olga, Smith, Neil, Smith, Thoma, Smitz, Carine, Smole, Daniel, Sojčić, Nataša, Soler Pedrola, Maria, Somanath, Sameer, Sonksen, Julian, Sorella, Maria Christina, Sörmus, Alar, Soro, Marina, Soto, Carmen, Spada, Anna, Spadaro, Savino, Spaeth, Johanne, Sparr, Harald, Spielmann, Annika, Spindler-Vesel, Alenka, Stamelos, Matthaio, Stancombe L, Liucia, Stanculescu, Andreea, Standl, Thoma, Standley, Tom, Stanek, Ondrej, Stanisavljević, Snežana, Starczewska, Malgorzata, Stäuble, Christiane, Steen, Julie, Stefan, Oana Maria, Stell, Elizabeth, Stera, Caterina, Stevens, Marku, Stoerckel, Marlène, Stošić, Biljana, Stourac, Petr, Stroumpoulis, Konstantino, Struck, Rafael, Suarez de la Rica, Alejandro, Sultanpori, Altaf, Sundara Rajan, Rajinikanth, Suying, Ong, Svensen, Christer, Swan, Louise, Syrogianni, Paulina, Sysiak, Justyna, Szederjesi, Jano, Taddei, Stefania, Tan Hao, Ern, Tanou, Virginia, Tarabová, Katarina, Tardaguila Sancho, Paula, Tarroso, Maria, Tartaglione, Marco, Taylor, Emma, Tbaily, Lee, Telford, Richard, Terenzoni, Massimo, Theodoraki, Kassiani, Thornley, Helen, Tiganiuc, Liviu, Toim, Hardo, Tomescu, Dana, Tommasino, Concezione, Toni, Jessica, Toninelli, Arturo, Toretti, Ilaria, Townley, Stephen, Trepenaitis, Dariu, Trethowan, Brian, Tsaousi, Georgia, Tsiftsi, Aikaterini, Tudor, Adrada, Turan, Güldem, Turhan, Sanem Çakar, Unic-Stojanovic, Dragana, Unterbuchner, Christoph, Unzueta, Carmen, Uranjek, Jasna, Ursic, Tomaz, Vaida, Simona, Valldeperas Ferrer, Silvia, Valldeperas Hernandez, Maria Inmaculada, Valsamidis, Dimitri, Van Beek, Rienk, Van dasselaer, Nick, Van Der Beek, Tim, Van Duivenvoorde, Yoni, van Klei, Wilton A., Van Poorter, Fran, Van Zaane, Ba, Van Zundert, Tom, Van Zyl, Rebekka, Vargas Munoz, Ana Milena, Varsani, Nimu, Vasconcelos, Pedro, Vassilakis, Georgio, Vecchiatini, Tommaso, Vecera, Lubomir, Vercauteren, Marcel, Verdouw, Ba, Verheyen, Veerle, Verri, Marco, Vicari Sottosanti, Luigi Giancarlo, Vico, Manuel, Vidal Mitjans, Patricia, Vilardi, Anna, Vissicchio, Daniela, Vitale, Giovanni, Vitković, Bibiana, Vizcaychipi, Marcela Paola, Voicu, Alexandra, Voje, Minca, Volfová, Ivana, Volta, Carlo Alberto, Von Lutterotti, Theresa, von Tiesenhausen, Anna, Vrecic-Slabe, Simona, Vukcevic, Dejan, Vukovic, Rade, Vullo, P. Agostina, Wade, Andrew, Wallberg, Hanna, Wallden, Jakob, Wallner, Johann, Walther Sturesson, Louise, Watson, Davina, Weber, Stefan, Wegiel Leskiewiq, Anna, Weller, Debbie, Wensing, Carine, Werkmann, Marku, Westberg, Henrik, Wikström, Erik, Williams, Benedict, Wilson, Robin, Wirth, Steffen, Wittmann, Maria, Wood, Laura, Wright, Stella, Zachoval, Christian, Zambon, Massimo, Zampieri, Silvia, Zampone, Salvatore, Zangrillo, Alberto, Zani, Gianluca, Zavackiene, Asta, Zieglerder, Raphael, Zonneveldt, Harry, Zsisku, Lajo, Zucker, Tom-Philipp, Żukowski, Maciej, Zuleika, Mehrun, Zupanĕiĕ, Darja

المصدر: Kirmeier, E, Eriksson, L I, Lewald, H, Jonsson Fagerlund, M, Hoeft, A, Hollmann, M, Meistelman, C, Hunter, J M, Ulm, K, Blobner, M & POPULAR Contributors 2019, ' Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR) : a multicentre, prospective observational study ', The Lancet Respiratory Medicine, vol. 7, no. 2, pp. 129-140 . https://doi.org/10.1016/S2213-2600Test(18)30294-7
lancet. Respiratory medicine, 7(2), 129-140. Elsevier Limited
The Lancet Respiratory Medicine, 7(2), 129-140. Elsevier Limited
LANCET RESPIRATORY MEDICINE
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, pulmonary complications, muscle relaxants, Post-anaesthesia complications, Neuromuscular Blockade, pulmonary complication, muscle relaxant, neuromuscular block, postoperative pulmonary complication, business.industry, Retrospective cohort study, post-operative pulmonary complications, Neuromuscular monitoring, Neuromuscular Blocking Agents, Sugammadex, NO, Anaesthesia, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Anesthesia, Medicine, General anaesthesia, Neuromuscular Agents, 030212 general & internal medicine, MED/41 - ANESTESIOLOGIA, Prospective cohort study, business, medicine.drug

الوصف: Background: Results from retrospective studies suggest that use of neuromuscular blocking agents during general anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use of neuromuscular blocking agents is associated with postoperative pulmonary complications. Methods: We did a multicentre, prospective observational cohort study. Patients were recruited from 211 hospitals in 28 European countries. We included patients (aged ≥18 years) who received general anaesthesia for any in-hospital procedure except cardiac surgery. Patient characteristics, surgical and anaesthetic details, and chart review at discharge were prospectively collected over 2 weeks. Additionally, each patient underwent postoperative physical examination within 3 days of surgery to check for adverse pulmonary events. The study outcome was the incidence of postoperative pulmonary complications from the end of surgery up to postoperative day 28. Logistic regression analyses were adjusted for surgical factors and patients' preoperative physical status, providing adjusted odds ratios (ORadj) and adjusted absolute risk reduction (ARRadj). This study is registered with ClinicalTrials.gov, number NCT01865513. Findings: Between June 16, 2014, and April 29, 2015, data from 22 803 patients were collected. The use of neuromuscular blocking agents was associated with an increased incidence of postoperative pulmonary complications in patients who had undergone general anaesthesia (1658 [7·6%] of 21 694); ORadj 1·86, 95% CI 1·53–2·26; ARRadj −4·4%, 95% CI −5·5 to −3·2). Only 2·3% of high-risk surgical patients and those with adverse respiratory profiles were anaesthetised without neuromuscular blocking agents. The use of neuromuscular monitoring (ORadj 1·31, 95% CI 1·15–1·49; ARRadj −2·6%, 95% CI −3·9 to −1·4) and the administration of reversal agents (1·23, 1·07–1·41; −1·9%, −3·2 to −0·7) were not associated with a decreased risk of postoperative pulmonary complications. Neither the choice of sugammadex instead of neostigmine for reversal (ORadj 1·03, 95% CI 0·85–1·25; ARRadj −0·3%, 95% CI −2·4 to 1·5) nor extubation at a train-of-four ratio of 0·9 or more (1·03, 0·82–1·31; −0·4%, −3·5 to 2·2) was associated with better pulmonary outcomes. Interpretation: We showed that the use of neuromuscular blocking drugs in general anaesthesia is associated with an increased risk of postoperative pulmonary complications. Anaesthetists must balance the potential benefits of neuromuscular blockade against the increased risk of postoperative pulmonary complications. Funding: European Society of Anaesthesiology.

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054c76356f786a3e022ed7231df33db4Test
https://doi.org/10.1016/s2213-2600Test(18)30294-7

المؤلفون: Lara Goscé, N Ghimire, Robert W Aldridge, Devan Vaghela, Nathan Green, Peter J White, Jo Southern, V. Hack, T Mpofu, Heinke Kunst, Rishi K Gupta, M Lipman, Dee Menezes, Ananna Rahman, A Imran, Ibrahim Abubakar

المصدر: Optimising TB management.

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, Latent tuberculosis, medicine.diagnostic_test, business.industry, Medical record, Emergency department, Disease, medicine.disease, Substance abuse, Risk groups, medicine, Sputum, medicine.symptom, business, Chest radiograph

الوصف: Background Emergency Department (ED) presentations could present a valuable opportunity to identify high-risk individuals with latent tuberculosis infection (LTBI) and active tuberculosis (TB) disease. We aimed to investigate the prevalence and cost-effectiveness of screening for LTBI and pulmonary TB disease among migrants and under-served groups attending London EDs. Methods We recruited adults attending EDs (18/7/2013–25/5/2017) who were either recent entrants from high TB-incidence countries; or had a history of homelessness, imprisonment, or substance use disorder. We assessed the yield of screening for LTBI (using an interferon-gamma release assay; IGRA) and active pulmonary TB (with a symptom screen, followed by chest radiograph and sputum Xpert MTB/RIF if positive). A cost-effectiveness analysis was performed by calculating cost per true-positive LTBI test. Results A total of 1420 participants were screened for LTBI. Median age was 45 years (IQR 34–60), and the majority were born outside the UK (1,162/1,420; 81.8%). A total of 241/1,420 participants (17.0%) had a history of either substance use disorder, homelessness or imprisonment. Of those with available IGRA results, 214/1,246 (17.2%) were positive. Male sex, age >35 years, non-UK country of birth, and previous TB contact were independent risk factors for being IGRA-positive. Of the 214 with a positive IGRA, 120 (56%) were followed-up by health record review for evidence of progression to TB disease; 5/120 (4.2%) were diagnosed with TB disease (median interval to TB 162 days (IQR 55–108.5)). In the economic analysis, the average cost per patient recruited of correctly diagnosing an LTBI case was £834 (compared to an estimated £1007 per LTBI case diagnosed through primary care). Only 14/513 (2.7%) participants screened for active TB had a positive symptom screen so were eligible for further testing. No cases of active TB were diagnosed. Conclusions Targeted LTBI screening in EDs could be considered to complement the primary care LTBI screening programme. In contrast, active TB screening in EDs using our symptom screen-led algorithm should not be pursued as the yield is likely to be minimal. Other active TB screening models (e.g. routine, automated reviews of ED chest radiographs) could be considered as a focus of future research.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b5705b3839f88f9617f5216f56562618Test
https://doi.org/10.1136/thorax-2018-212555.153Test

المؤلفون: C Herfarth, H. Lipps, Wulf Dröge, A Hochlehnert, Bernd Sido, V. Hack

المصدر: Gut. 42:485-492

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Erythrocytes, Glutamate-Cysteine Ligase, Inflammation, medicine.disease_cause, Peripheral blood mononuclear cell, Inflammatory bowel disease, chemistry.chemical_compound, Crohn Disease, Intestinal mucosa, Internal medicine, medicine, Humans, Amino Acids, Intestinal Mucosa, Gamma-glutamyltransferase, Muscle, Skeletal, Aged, Crohn's disease, biology, Inflammation and Inflammatory Bowel Disease, Gastroenterology, gamma-Glutamyltransferase, Glutathione, Middle Aged, medicine.disease, digestive system diseases, Endocrinology, chemistry, Immunology, Leukocytes, Mononuclear, biology.protein, Colitis, Ulcerative, Female, medicine.symptom, Oxidation-Reduction, Oxidative stress

الوصف: Background—Reactive oxygen species contribute to tissue injury in inflammatory bowel disease (IBD). The tripeptide glutathione (GSH) is the most important intracellular antioxidant. Aims—To investigate constituent amino acid plasma levels and the GSH redox status in different compartments in IBD with emphasis on intestinal GSH synthesis in Crohn's disease. Methods—Precursor amino acid levels were analysed in plasma and intestinal mucosa. Reduced (rGSH) and oxidised glutathione (GSSG) were determined enzymatically in peripheral blood mononuclear cells (PBMC), red blood cells (RBC), muscle, and in non-inflamed and inflamed ileum mucosa. Mucosal enzyme activity of γ-glutamylcysteine synthetase (γGCS) and γ-glutamyl transferase (γGT) was analysed. Blood of healthy subjects and normal mucosa from a bowel segment resected for tumour growth were used as controls. Results—Abnormally low plasma cysteine and cystine levels were associated with inflammation in IBD (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5d6213935e5d312c52a38c62e35aa7Test
https://doi.org/10.1136/gut.42.4.485Test

المؤلفون: F. McMeechan, T. Rich, V. Hack

المصدر: Handbook of Biodiversity Methods ISBN: 9780521823685

مصطلحات موضوعية: education.field_of_study, Population estimate, Geography, Ecology, Trend detection, Population, Biodiversity, media_common.cataloged_instance, Presence absence, European union, education, Field methods, media_common

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::53b8eb4ccaa19342414608943775d833Test
https://doi.org/10.1017/cbo9780511542084.016Test