المؤلفون: Julia D. Michels-Zetsche, Vicky Gassmann, Jasmin K. Jasuja, Benjamin Neetz, Philipp Höger, Jan Meis, Simone Britsch, Urte Sommerwerck, Sebastian Fähndrich, Florian Bornitz, Michael M. Müller, Felix J.F. Herth, Franziska C. Trudzinski

المصدر: Respiratory Research, Vol 25, Iss 1, Pp 1-10 (2024)

مصطلحات موضوعية: Multidrug-resistant bacteria, Weaning, Prolonged weaning, Weaning failure, Mortality in weaning, Diseases of the respiratory system, RC705-779

الوصف: Abstract Background Although multidrug-resistant bacteria (MDR) are common in patients undergoing prolonged weaning, there is little data on their impact on weaning and patient outcomes. Methods This is a retrospective analysis of consecutive patients who underwent prolonged weaning and were at a university weaning centre from January 2018 to December 2020. The influence of MDR colonisation and infection on weaning success (category 3a and 3b), successful prolonged weaning from invasive mechanical ventilation (IMV) with or without the need for non-invasive ventilation (NIV) compared with category 3c (weaning failure 3cI or death 3cII) was investigated. The pathogen groups considered were: multidrug-resistant gram-negative bacteria (MDRGN), methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus spp. (VRE). Results A total of 206 patients were studied, of whom 91 (44.2%) showed evidence of MDR bacteria (32% VRE, 1.5% MRSA and 16% MDRGN), with 25 patients also meeting the criteria for MDR infection. 70.9% of the 206 patients were successfully weaned from IMV, 8.7% died. In 72.2% of cases, nosocomial pneumonia and other infections were the main cause of death. Patients with evidence of MDR (infection and colonisation) had a higher incidence of weaning failure than those without evidence of MDR (48% vs. 34.8% vs. 21.7%). In multivariate analyses, MDR infection (OR 4.9, p = 0.004) was an independent risk factor for weaning failure, along with male sex (OR 2.3, p = 0.025), Charlson Comorbidity Index (OR 1.2, p = 0.027), pH (OR 2.7, p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1465-993XTest

الوصول الحر: https://doaj.org/article/c01ab54fb87e440ea0431b2c3bb21e0cTest

المؤلفون: Lukas Andreas Heger, Nils Elsen, Marina Rieder, Nadine Gauchel, Urte Sommerwerck, Christoph Bode, Daniel Duerschmied, Mark Oette, Ingo Ahrens

المصدر: BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-9 (2022)

مصطلحات موضوعية: COVID-19, Point of care, PCR test, Length of stay, Patient flow, Infectious and parasitic diseases, RC109-216

الوصف: Abstract Background Point-of-care (POC) polymerase chain reaction (PCR) tests have the ability to improve testing efficiency in the Coronavirus disease 2019 (COVID-19) pandemic. However, real-world data on POC tests is scarce. Objective To evaluate the efficiency of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) POC test in a clinical setting and examine the prognostic value of cycle threshold (CT) on admission on the length of hospital stay (LOS) in COVID-19 patients. Methods Patients hospitalised between January and May 2021 were included in this prospective cohort study. Patients’ nasopharyngeal swabs were tested for SARS-CoV-2 with Allplex™2019-nCoV (Seegene Inc.) real-time (RT) PCR assay as gold standard as well as a novel POC test (Bosch Vivalytic SARS-CoV-2 [Bosch]) and the SARS-CoV-2 Rapid Antigen Test (Roche) accordingly. Clinical sensitivity and specificity as well as inter- and intra-assay variability were analyzed. Results 120 patients met the inclusion criteria with 46 (38%) having a definite COVID-19 diagnosis by RT-PCR. Bosch Vivalytic SARS-CoV-2 POC had a sensitivity of 88% and specificity of 96%. The inter- and intra- assay variability was below 15%. The CT value at baseline was lower in patients with LOS ≥ 10 days when compared to patients with LOS

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2334Test

الوصول الحر: https://doaj.org/article/2da1c0866bcf44d49689d27c6ad0691cTest

المؤلفون: James Greenwood, Carsten Schwarz, Urte Sommerwerck, Edward F Nash, Michael Tamm, Weihua Cao, Paul Mastoridis, Laurie Debonnett, Kamal Hamed

المصدر: Therapeutic Advances in Respiratory Disease, Vol 11 (2017)

مصطلحات موضوعية: Diseases of the respiratory system, RC705-779

الوصف: Background: This study assessed the ease of use of tobramycin inhalation powder (TIP) administered via T-326 inhaler versus tobramycin inhalation solution (TIS) and colistimethate sodium (COLI), both administered via nebulizers, for the treatment of chronic pulmonary Pseudomonas aeruginosa infection in patients with cystic fibrosis (CF). Methods: A real-world, open-label, crossover, interventional phase IV study was conducted in CF patients aged ⩾6 years with forced expiratory volume in 1 second (FEV 1 ) ⩾25% to ⩽90% predicted. Patients were assigned to one of the three treatment arms in Cycle 1; all patients received TIP in Cycle 2. Each cycle consisted of 28 days on and 28 days off the treatment. Results: A total of 60 patients [mean (standard deviation) age, 27.6 (8.4) years] were allocated to three treatment arms [TIS/TIP ( n = 14); COLI/TIP ( n = 28); TIP/TIP ( n = 18)] in Cycle 1. The mean total administration time, which included device setup and cleaning, in Cycle 1 versus Cycle 2 for TIS/TIP, COLI/TIP, and TIP/TIP arms were 37.0 versus 5.0 min, 16.4 versus 3.8 min, and 4.2 versus 3.4 min, respectively. The difference in mean total administration time was significantly shorter in Cycle 2 than in Cycle 1 for TIS/TIP ( p = 0.0112) and COLI/TIP ( p = 0.0016) arms. Overall, 12 patients were found to have contaminated devices across the two treatment cycles. In the TIP/TIP arm, no contamination of the T-326 inhaler was observed in either cycle. Treatment satisfaction, assessed by the Treatment Satisfaction Questionnaire for Medication and ACCEPT® questionnaire, was better overall for TIP compared with TIS and COLI. There were no unexpected adverse events and most were mild or moderate in intensity. Conclusion: The T-326 inhaler used to deliver TIP was easy to use, required shorter total administration time, and was much less frequently contaminated than the nebulizers. The safety findings observed for TIP were generally consistent with its established safety profile.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1753-4658Test; https://doaj.org/toc/1753-4666Test

الوصول الحر: https://doaj.org/article/e3999af326534496bcf2141fb280bb8cTest

المؤلفون: Nadine Gauchel, Daniel Duerschmied, Nils Elsen, Lukas Andreas Heger, Urte Sommerwerck, Christoph Bode, Ingo Ahrens, Marc Oette, Marina Rieder

المصدر: BMC Infectious Diseases. 22

مصطلحات موضوعية: medicine.medical_specialty, Cycle threshold, Coronavirus disease 2019 (COVID-19), Clinical pathology, business.industry, SARS-CoV-2, Point-of-care testing, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19, Diagnostic accuracy, Real-Time Polymerase Chain Reaction, Risk Assessment, Sensitivity and Specificity, COVID-19 Testing, Infectious Diseases, Point-of-Care Testing, Emergency medicine, medicine, Humans, Prospective Studies, Risk assessment, business

الوصف: Background Point-of-care (POC) polymerase chain reaction (PCR) tests have the ability to improve testing efficiency in the Coronavirus disease 2019 (COVID-19) pandemic. However, real-world data on POC tests is scarce. Objective To evaluate the efficiency of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) POC test in a clinical setting and examine the prognostic value of cycle threshold (CT) on admission on the length of hospital stay (LOS) in COVID-19 patients. Methods Patients hospitalised between January and May 2021 were included in this prospective cohort study. Patients’ nasopharyngeal swabs were tested for SARS-CoV-2 with Allplex™2019-nCoV (Seegene Inc.) real-time (RT) PCR assay as gold standard as well as a novel POC test (Bosch Vivalytic SARS-CoV-2 [Bosch]) and the SARS-CoV-2 Rapid Antigen Test (Roche) accordingly. Clinical sensitivity and specificity as well as inter- and intra-assay variability were analyzed. Results 120 patients met the inclusion criteria with 46 (38%) having a definite COVID-19 diagnosis by RT-PCR. Bosch Vivalytic SARS-CoV-2 POC had a sensitivity of 88% and specificity of 96%. The inter- and intra- assay variability was below 15%. The CT value at baseline was lower in patients with LOS ≥ 10 days when compared to patients with LOS s = − 0.31; p = 0.038) but only age was associated with the probability of an increased LOS in a multiple logistic regression analysis (OR 1.105 [95% CI, 1.03–1.19]; p = 0.006). Conclusion Our data indicate that POC testing with Bosch Vivalytic SARS-CoV-2 is a valid strategy to identify COVID-19 patients and decrease turnaround time to definite COVID-19 diagnosis. Also, our data suggest that age at admission possibly with CT value as a combined parameter could be a promising tool for risk assessment of increased length of hospital stay and severity of disease in COVID-19 patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3723c24a533b2c74b32a2c959627de59Test
https://doi.org/10.1186/s12879-022-07447-7Test

المؤلفون: Karin Palmowski, Urte Sommerwerck, Thomas Luft

المصدر: Seltene Lungenerkrankungen ISBN: 9783662636503

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c7769f3107a8f9b80cb085676d189b5eTest
https://doi.org/10.1007/978-3-662-63651-0_37Test

المؤلفون: Gerhard Schmalz, Urte Sommerwerck, J Garbade, Dirk Ziebolz, Otto Kollmar

المصدر: Schmalz, G., Garbade, J., Sommerwerck, U., Kollmar, O., & Ziebolz, D. (2021). Oral health-related quality of life of patients after solid organ transplantation is not affected by oral conditions: results of a multicentre cross-sectional study. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e437-e444). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24277Test
Medicina Oral, Patología Oral y Cirugía Bucal

مصطلحات موضوعية: medicine.medical_specialty, Cross-sectional study, cell free dna, Oral Health, Oral health, Independent predictor, oral lichen planus, Quality of life, Surveys and Questionnaires, Internal medicine, Healthy control, medicine, Humans, General Dentistry, UNESCO:CIENCIAS MÉDICAS, Periodontitis, saliva, business.industry, Research, Organ Transplantation, oral cancer, Medically compromised patients in Dentistry, medicine.disease, humanities, stomatognathic diseases, Cross-Sectional Studies, Otorhinolaryngology, leukoplakia, Quality of Life, Oral examination, Surgery, Solid organ transplantation, business, dna integrity index

الوصف: Background This multicentre cross-sectional study aimed in examination of oral health-related quality of life (OHRQoL) of patients after solid organ transplantation (SOT). Material and Methods Patients after SOT (liver, lung and heart) at one out of three German centers (Goettingen, Essen, Leipzig) were included. For comparison, a healthy control (HC) was recruited. OHRQoL was assessed by German short form of oral health impact profile (OHIP G14). Oral examination comprised: decayed-, missing- and filled-teeth index (DMF-T), remaining teeth and periodontitis severity. Results In total, 196 patients after SOT and 130 HC with comparable age, gender and smoking habits were included (p>0.05). DMF-T and number of remaining teeth was worse in SOT group (p0.05). Number of remaining teeth was not an independent predictor of OHIP G14 sum score in SOT (β -0.082, CI95 -0.156 - 0.045, p=0.28). Conclusions OHRQoL of SOT recipients is not affected by their oral condition, leading to the assumption that the individual perception of patients physical oral health is not in line with the clinical situation. Key words:Oral health, oral health-related quality of life, solid organ transplantation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191e98ddbdc6e3184c4f02eeca3d9397Test
https://hdl.handle.net/10550/88043Test

المؤلفون: Celina Heinze, Vasiliki Bessa, Gerhard Weinreich, Daniel Jokisch, Clemens Aigner, Kurt Rasche, Wolfram Windisch, Urte Sommerwerck, Markus Kamler, Martha Jokisch, Christian Taube, Michael Neurath

المصدر: Advances in Experimental Medicine and Biology ISBN: 9783030702052

مصطلحات موضوعية: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Trail Making Test, Medizin, Audiology, Executive functions, Transplantation, Benton Visual Retention Test, 03 medical and health sciences, 0302 clinical medicine, Memory span, Verbal fluency test, Medicine, 030212 general & internal medicine, Neuropsychological assessment, Verbal memory, business

الوصف: Cognitive functioning after transplantation, which could influence medication compliance and independence, has not been well studied. This study investigated cognitive impairment after lung transplantation. Patients undergoing bilateral transplant between March 2013 and October 2015 underwent comprehensive neuropsychological assessment at 60.1 ± 44.1 months post-transplantation: verbal memory (Auditory-Verbal Learning Test, digit span forward), visual memory (Corsi Block-Tapping Test forward, Benton Visual Retention Test), concentration/speed of processing/attention (D2 Test of Attention, Trail Making Test (TMT) A, Grooved Pegboard), and executive functioning (TMT B, Stroop Color-Word Test, semantic and phonematic verbal fluency, digit span backward, Corsi Block-Tapping Test backward). Mean scores were compared with a normative dataset using a one-sample t-test. A cognitive domain was judged impaired if the score on two or more domain-specific tests was greater than one standard deviation below the normative dataset age range mean. Of 124 lung transplant recipients (51% male, 54.3 ± 9.0 years), 70% showed cognitive impairment in one or more domains. Executive function was most often impaired (78% of recipients not within the age range) followed by verbal memory impairment (72% not within the age range). Cognitive function reductions were largely independent of age, gender, education, immunosuppressive medications, and time since transplantation. The findings show that cognitive impairment is common after lung transplantation and should be subject to rehabilitation and psychological resilience strategies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ac820038855bb10eb7edfef0380232Test
https://www.ncbi.nlm.nih.gov/pubmed/33034844Test

المؤلفون: Urte, Sommerwerck, Daniel, Jokisch, Gerhard, Weinreich, Michael, Neurath, Celina, Heinze, Vasiliki, Bessa, Clemens, Aigner, Markus, Kamler, Christian, Taube, Kurt, Rasche, Wolfram, Windisch, Martha, Jokisch

المصدر: Advances in experimental medicine and biology. 1324

مصطلحات موضوعية: Male, Executive Function, Cognition, Trail Making Test, Humans, Female, Neuropsychological Tests, Lung Transplantation

الوصف: Cognitive functioning after transplantation, which could influence medication compliance and independence, has not been well studied. This study investigated cognitive impairment after lung transplantation. Patients undergoing bilateral transplant between March 2013 and October 2015 underwent comprehensive neuropsychological assessment at 60.1 ± 44.1 months post-transplantation: verbal memory (Auditory-Verbal Learning Test, digit span forward), visual memory (Corsi Block-Tapping Test forward, Benton Visual Retention Test), concentration/speed of processing/attention (D2 Test of Attention, Trail Making Test (TMT) A, Grooved Pegboard), and executive functioning (TMT B, Stroop Color-Word Test, semantic and phonematic verbal fluency, digit span backward, Corsi Block-Tapping Test backward). Mean scores were compared with a normative dataset using a one-sample t-test. A cognitive domain was judged impaired if the score on two or more domain-specific tests was greater than one standard deviation below the normative dataset age range mean. Of 124 lung transplant recipients (51% male, 54.3 ± 9.0 years), 70% showed cognitive impairment in one or more domains. Executive function was most often impaired (78% of recipients not within the age range) followed by verbal memory impairment (72% not within the age range). Cognitive function reductions were largely independent of age, gender, education, immunosuppressive medications, and time since transplantation. The findings show that cognitive impairment is common after lung transplantation and should be subject to rehabilitation and psychological resilience strategies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::2765bf6301d93e55567e626bb8b21106Test
https://pubmed.ncbi.nlm.nih.gov/33034844Test

المؤلفون: Urte Sommerwerck, Ulrich Mairose, Kurt Rasche, Ahmad Alkhatib, Daniel Gödde

المصدر: Pneumo News. 10:6-8

الوصف: Das Antibiotikum Nitrofurantoin wird zur Therapie von Patienten mit unkompliziertem Harnwegsinfekt eingesetzt. Ein 75-jahriger Mann mit persistierender Infektion nahm es einen Monat ein und entwickelte eine Belastungsdyspnoe, weshalb er beim Pneumologen vorstellig wurde.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5ecb741c91f8de00dd57cac98fb3b1f3Test
https://doi.org/10.1007/s15033-018-1085-6Test

المؤلفون: Frederike, Kruse, Bjoern E, Kleibrink, Thomas, Rabis, Yi, Wang, Gerhard, Weinreich, Markus, Kamler, Christian, Taube, Kurt, Rasche, Urte, Sommerwerck

المصدر: Advances in experimental medicine and biology. 1160

مصطلحات موضوعية: Adult, Male, Exercise Tolerance, Sleep Apnea Syndromes, Polysomnography, Quality of Life, Humans, Female, Middle Aged, Transplant Recipients, Lung Transplantation

الوصف: The prevalence of sleep-disordered breathing (SDB) after lung transplantation (LTX) is high. It is well-established that SDB is associated with decreased health-related quality of life (HRQoL), but the impact of SDB on exercise capacity is less clear. In this study we investigated HRQoL and exercise capacity in LTX recipients with or without SDB. In addition, we also investigated associations between sleep parameters and both HRQoL and exercise capacity. There were 53 stable LTX recipients (age 18 years, 31 males, time from LTX 9-120 months) enrolled into the study. They all underwent polysomnography examination. HRQoL was assessed using the Short Form-36 (SF-36). Exercise capacity was measured using the 6-min walk test and cardiopulmonary exercise testing (CPET). We found inverse correlations between severity of SDB and both the predicted maximal workload (r = 0.24, p = 0.04) and maximal oxygen uptake (r = -0.26, p = 0.03) during CPET. Relative oxygen uptake positively correlated with sleep efficiency (r = 0.27, p = 0.03). SF-36 scores did not differ between patients with and without SDB, and were not significantly associated with SDB parameters. In conclusion, the presence of SDB is associated with a slight reduction in maximal exercise capacity in LTX recipients, and there is no appreciable relationship between SDB and HRQoL.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::e1c502448ea85da33490e513a0d28c5aTest
https://pubmed.ncbi.nlm.nih.gov/30680642Test