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1دورية أكاديمية
المؤلفون: Mozzillo E., Marigliano M., Cuccurullo I., Berchielli F., Auricchio R., Maffeis C., Rosanio F. M., Iafusco D., Pedrolli C., Pertile R., Delvecchio M., Passanisi S., Salzano G., Di Candia F., Franceschi R.
المساهمون: Mozzillo, E., Marigliano, M., Cuccurullo, I., Berchielli, F., Auricchio, R., Maffeis, C., Rosanio, F. M., Iafusco, D., Pedrolli, C., Pertile, R., Delvecchio, M., Passanisi, S., Salzano, G., Di Candia, F., Franceschi, R.
مصطلحات موضوعية: Celiac disease, Glucose control, Maintaining GFD, Type1 diabetes mellitus
الوصف: Aims: Gluten-free diets (GFD) were considered as high glycemic index and/or high content of saturated fats; this could affect keeping good metabolic control in individuals with both type 1 diabetes (T1D) and celiac disease (CD). Our objective was to analyze time in range and other continuous glucose monitoring (CGM) metrics with real-time CGM systems, in youths with T1D and CD, compared to those with T1D only. Methods: An observational case-control study, comparing youths aged 8-18 years with T1D and CD, with people with T1D only was performed. The degree of maintaining GFD was assessed through anti-tissue transglutaminase antibodies and dietary interview, and maintaining Mediterranean diet through the KIDMED questionnaire. Results: 86 youths with T1D and CD, 167 controls with T1D only, were included in the study and the two groups reported similar real-time CGM metrics. Among the first group, 29 % were not completely maintaining GFD and compared to people with T1D only they showed higher hyperglycemia rates (% time above range: 38.72 ± 20.94 vs 34.34 ± 20.94; P = 0.039). Conclusions: Individuals with T1D and CD who maintain GFD presented similar glucose metrics compared to youths with T1D only. Individuals not strictly maintaining GFD presented higher hyperglycemia rates.
العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:001155980700001; volume:207; journal:DIABETES RESEARCH AND CLINICAL PRACTICE; https://hdl.handle.net/11588/955510Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85181948442
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2دورية أكاديمية
المؤلفون: Elsherbiny NM, Ramadan M, Abu Faddan NH, Hassan EA, Ali ME, Abd El-Rehim ASE, Abbas WA, Abozaid MAA, Hassanin E, Mohamed GA, Hetta HF, Salah M
المصدر: International Journal of General Medicine, Vol Volume 15, Pp 6173-6187 (2022)
مصطلحات موضوعية: gut microbiota, dysbiosis, type1 diabetes mellitus, children, Medicine (General), R5-920
الوصف: Nahla M Elsherbiny,1 Mohammed Ramadan,2 Nagla H Abu Faddan,3 Elham Ahmed Hassan,4 Mohamed E Ali,2 Abeer Sharaf El-Din Abd El-Rehim,4 Wael A Abbas,5 Mohamed AA Abozaid,5 Ebtisam Hassanin,6 Ghada A Mohamed,7 Helal F Hetta,1 Mohammed Salah8 1Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt; 2Department of Microbiology and Immunology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt; 3Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt; 4Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt; 5Department of Internal Medicine, Gastroenterology and Hepatology Unit, Faculty of Medicine, Assiut University, Assiut, Egypt; 6Clinical Pathology, Ministry of Health, Assiut, Egypt; 7Department of Internal Medicine, Endocrine Unit, Faculty of Medicine, Assiut University, Assiut, Egypt; 8Department of Microbiology and Immunology, Faculty of pharmacy, Port Said University, Port Said, EgyptCorrespondence: Elham Ahmed Hassan, Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt, Tel +20 882410285, Fax +20 882333327, Email mam_elham75@yahoo.com; elham.abdelhalem@med.aun.edu.egPurpose: To investigate the compositional and functional characteristics of T1DM-associated gut microbiota in two Egyptian cities and to study the geographical locality effects.Patients and Methods: This case-control study included 32 children with controlled T1DM and 16 controls, selected from two different regions of Egypt. The gut microbiota of both diabetic and control children was analyzed through 16S rRNA gene sequencing; this was done using the Illumina MiSeq platform.Results: Consistent findings among the diabetic children included significantly lower alpha diversity than the control children, as well as a lower mean Firmicutes/Bacteroidetes (F/B) ratio, and reduced proportions of Firmicutes and the genera Prevotella and Ruminococcus. In the diabetic children, there were also significantly enriched representations of Actinobacteria, Bacteroidetes, and Proteobacteria and the genera Lactobacilli, Bacteroides, and Faecalibacterium. When comparing the two diabetic groups, the Ismailia group (IsDM) was found to have a significantly higher F/B ratio and diversity indices, with resultant differences at the functional level.Conclusion: There are a number of consistent changes in the microbiota profile characterizing the diabetic groups irrespective of the geographical location including significantly lower alpha diversity, mean Firmicutes/ Bacteroidetes (F/B) ratio, and reduced proportions of Firmicutes and genera Prevotella and Ruminococcus. There are also significantly enriched representations of Actinobacteria, Bacteroidetes, and Proteobacteria and genera Lactobacilli, Bacteroides, and Faecalibacterium pointing to the greater driving power of the disease.Keywords: gut microbiota, dysbiosis, type 1 diabetes mellitus, children
وصف الملف: electronic resource
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المؤلفون: Masaki Suzuki, Shin Urai, Hidenori Fukuoka, Yushi Hirota, Masaaki Yamamoto, Yuko Okada, Naoki Yamamoto, Hiroki Shichi, Yasunori Fujita, Keitaro Kanie, Genzo Iguchi, Yutaka Takahashi, Wataru Ogawa
المصدر: Journal of Diabetes Investigation. 13(9):1585-1595
مصطلحات موضوعية: Adult, Subtypes, Lumbar Vertebrae, Endocrinology, Diabetes and Metabolism, General Medicine, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Bone Density, Internal Medicine, Bone mineral density, Humans, Insulin, Type1 diabetes mellitus, Retrospective Studies
الوصف: Aims/Introduction The bone mineral density in patients with type 1 diabetes mellitus is reduced due to impaired insulin secretion. However, it is unclear whether the rate of bone mineral density reduction is affected by the type 1 diabetes mellitus subtype. This study aimed to clarify the difference in bone mineral density across type 1 diabetes mellitus subtypes: slowly progressive (SP), acute-onset (AO), and fulminant (F). Methods This was a retrospective, single-center, cross-sectional study conducted on 98 adult type 1 diabetes mellitus patients. The main outcome included the bone mineral density Z-score (BMD-Z) measured at the lumbar spine and femoral neck. Results The lumbar spine BMD-Z was lower in the acute-onset than in the slowly progressive subtype (P = 0.03). No differences were observed when compared with the fulminant subtype. The femoral neck BMD-Z tended to be higher in the slowly progressive than in the acute-onset and fulminant subtypes. Multiple regression analyses showed that the lumbar spine BMD-Z was associated with subtypes (AO vs SP) (P = 0.01), but not subtypes (F vs SP), adjusted for sex, duration, retinopathy, and C-peptide immunoreactivity (CPR). When the patients were divided into disease duration tertiles, in the first and second tertiles, the CPR levels were lower in the acute-onset or fulminant than in the slowly progressive subtype. In contrast, the lumbar spine and femoral neck BMD-Z differed between the acute-onset and slowly progressive only in the second tertiles (both P
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329046e579e4f6bab113c11df0148641Test
https://hdl.handle.net/20.500.14094/0100476358Test -
4دورية أكاديمية
المؤلفون: Mozzillo, Enza, Marigliano, Marco, Cuccurullo, Irene, Berchielli, Federica, Auricchio, Renata, Maffeis, Claudio, Maria Rosanio, Francesco, Iafusco, Dario, Pedrolli, Carlo, Pertile, Riccardo, Delvecchio, Maurizio, Passanisi, Stefano, Salzano, Giuseppina, Di Candia, Francesca, Franceschi, Roberto
المساهمون: Mozzillo, Enza, Marigliano, Marco, Cuccurullo, Irene, Berchielli, Federica, Auricchio, Renata, Maffeis, Claudio, Maria Rosanio, Francesco, Iafusco, Dario, Pedrolli, Carlo, Pertile, Riccardo, Delvecchio, Maurizio, Passanisi, Stefano, Salzano, Giuseppina, Di Candia, Francesca, Franceschi, Roberto
مصطلحات موضوعية: Celiac disease, Glucose control, Maintaining GFD, Type1 diabetes mellitus
الوصف: Aims: Gluten-free diets (GFD) were considered as high glycemic index and/or high content of saturated fats; this could affect keeping good metabolic control in individuals with both type 1 diabetes (T1D) and celiac disease (CD). Our objective was to analyze time in range and other continuous glucose monitoring (CGM) metrics with real-time CGM systems, in youths with T1D and CD, compared to those with T1D only. Methods: An observational case-control study, comparing youths aged 8-18years with T1D and CD, with people with T1D only was performed. The degree of maintaining GFD was assessed through anti-tissue transglutaminase antibodies and dietary interview, and maintaining Mediterranean diet through the KIDMED questionnaire. Results: 86 youths with T1D and CD, 167 controls with T1D only, were included in the study and the two groups reported similar real-time CGM metrics. Among the first group, 29% were not completely maintaining GFD and compared to people with T1D only they showed higher hyperglycemia rates (% time above range: 38.72±20.94 vs 34.34±20.94; P=0.039). Conclusions: Individuals with T1D and CD who maintain GFD presented similar glucose metrics compared to youths with T1D only. Individuals not strictly maintaining GFD presented higher hyperglycemia rates.
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38142746; volume:207; firstpage:111074; journal:DIABETES RESEARCH AND CLINICAL PRACTICE; https://hdl.handle.net/11591/517148Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85181948442
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المصدر: 岡山赤十字病院医学雑誌 = The Okayama Red Cross Hospital Journal of Medicine. 32(1):58-65
مصطلحات موضوعية: fulminant type1 diabetes mellitus, mTOR inhibitor, immune checkpoint inhibitor, Everolimus, Tacrolimus
الوصف: 分子標的薬，免疫抑制剤，免疫チェックポイント阻害剤による高血糖が増加している．切除不能癌や膠原病関連で使用される機会が増えているが，免疫チェックポイント阻害剤の免疫関連有害事象（irAE）中で内分泌障害の頻度は比較的高く，急激な発症から 1 型および劇症 1 型糖尿病は重症化リスクが高いと考えられる．ほとんどは抗 PD- 1 抗体・抗 PD‐L1 抗体に関連したもので発症頻度は0.2～ 2 ％程度と推定され，投与開始から発症までは 1 週間から 1 年以上までと様々である．mTOR 阻害剤 Everolimus，免疫抑制剤 Tacrolimus による 2型糖尿病性ケトーシス，免疫チェックポイント阻害剤による劇症 1 型糖尿病ケトアシドーシスの特徴と経過に関して報告する．
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=jairo_______::6fefcf9ce28d348158d8be197380d853Test
http://id.nii.ac.jp/1063/00017282Test/ -
6دورية أكاديمية
المؤلفون: A, Mahdi Ahmed
المصدر: Sudan Medical Laboratory Journal; Vol. 6 No. 1 (2018): SUDAN MEDICAL LABORATORY JOURNAL ; 1858-6147
مصطلحات موضوعية: Type1 Diabetes Mellitus, C-and glycemic control, C-peptides, BMI
الوصف: Background: Diabetes Mellitus (DM) is a major health problem worldwide. It can lead to life-threatening complication. So C-peptide (Cp) serves as a surrogate of pancreatic beta-cell reserve which can predict complication. Objectives: To evaluate the clinical significance of basal Cp as a predictor of type 1diabetes (T1D) and investigate the association of serum C-peptide level and BMI, HbA1c, age ,age of onset and duration of disease in children with diabetes mellitus . Methods: It was a descriptive cross sectional study conducted at Mohammed Elamin Hamid Pediatric Hospital during the period from November to April 2018. In this study 40 blood samples were collected and analyzed colorimetrically using ELISA technique, 40 samples (18 boys and 22 girls) from children with diabetes mellitus conducted in it. Statistical analysis: all the data was analyzed using (SPSS) version 21. The results were expressed as Mean±SD and percentage. One sample t-test and personal correlation test used to correlate between C-peptide and age, age of onset, duration of disease, HbA1c and BMI at p-value of < 0.05 considered as significant. Results: It demonstrated that C-peptide was significantly decreased in diabetic patients compared to the mean of normal value (0.45±0.52, 1.55), (p value = 0.001), While HbA1C was significantly increased in diabetic patients compared to the mean of normal value (10.1± 2.5, 5.25). Also we found that C-peptide was weakly negative insignificant correlated with age, age of onset and HbA1C (R = -0.016, -0.016 and -0.046 respectively), (p value = 0.9, 0.9 and 0.7 respectively), while weakly positive insignificant correlated with BMI (R = 0.021), (p value = 0.8). Conclusion: The study has concluded that the children with diabetes mellitus have significant decrease in C-peptide level and significant increase in HbA1c level in both male and female, compared to the reference value.
وصف الملف: application/pdf
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7دورية أكاديمية
المؤلفون: Dalia S. Abd Elaziz, Mona H. Hafez, Nermeen M. Galal, Safa S. Meshaal, Aisha M. El Marsafy
المصدر: Journal of Advanced Research, Vol 5, Iss 6, Pp 647-655 (2014)
مصطلحات موضوعية: CD4+ CD25+ cells, Autoimmunity, Type1 diabetes mellitus, T regulatory cells, Children, Medicine (General), R5-920, Science (General), Q1-390
الوصف: The existence of multiple autoimmune disorders in diabetics may indicate underlying primary defects of immune regulation. The study aims at estimation of defects of CD4+ CD25+high cells among diabetic children with multiple autoimmune manifestations, and identification of disease characteristics in those children. Twenty-two cases with type 1 diabetes associated with other autoimmune diseases were recruited from the Diabetic Endocrine and Metabolic Pediatric Unit (DEMPU), Cairo University along with twenty-one normal subjects matched for age and sex as a control group. Their anthropometric measurements, diabetic profiles and glycemic control were recorded. Laboratory investigations included complete blood picture, glycosylated hemoglobin, antithyroid antibodies, celiac antibody panel and inflammatory bowel disease markers when indicated. Flow cytometric analysis of T-cell subpopulation was performed using anti-CD3, anti-CD4, anti-CD8, anti-CD25 monoclonal antibodies. Three cases revealed a proportion of CD4+ CD25+high below 0.1% and one case had zero counts. However, this observation did not mount to a significant statistical difference between the case and control groups neither in percentage nor absolute numbers. Significant statistical differences were observed between the case and the control groups regarding their height, weight centiles, as well as hemoglobin percentage, white cell counts and the absolute lymphocytic counts. We concluded that, derangements of CD4+ CD25+high cells may exist among diabetic children with multiple autoimmune manifestations indicating defects of immune controllers.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2090123213001185Test; https://doaj.org/toc/2090-1232Test
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المؤلفون: Khater, Nahed Mahmoud, ELrahman, Hadeel Mohammed Abd, Mohammed, Randa Hussieny, Elashery, Mahmoud Ali
المصدر: Egyptian Journal of Hospital Medicine; Vol. 86 No. 1 (2022); 324-328
مصطلحات موضوعية: Visfatin, Pediatric, Type1 Diabetes mellitus, Assessment, endocrine system diseases
الوصف: Background: Type 1 diabetes mellitus (T1DM) is a chronic illness characterized by the body’s inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. Visfatin is a ubiquitous intracellular enzyme, known as nicotine amide phosphoribosyl transferase (NAMPT) and pre-B-cell colony-enhancing factor (PBEF-1).Objective: The aim of this study was to evaluate serum visfatin level in children and adolescent with type 1 diabetes mellitus (T1DM).Patients and methods: The present study was a case-control study observation that was conducted in Pediatric Endocrinology Unit, Pediatric Ward, Zagazig University Hospitals. The study included 46 children; 23 with T1DM and 23 healthy age- and sex- matched children.Results: In this study, we found that serum visfatin level in diabetic group is statistically highly significant lower than healthy group. The mean serum level of visfatin in healthy group was 19.53 ± 10.5 ng/ml, while in T1DM patients was 2.85 ± 2.09 ng/ml. The best cutoff of serum visfatin level in excluding T1DM was ≥ 3.6 ng/ml with area under curve 0.968 with sensitivity 91.3%, specificity 82.6%, positive predictive value 84%, negative predictive value 90.5%, positive likelihood ratio 5.25, negative likelihood ratio 0.11 and accuracy 87% (p < 0.001). The result showed that serum visfatin could be helpful in prediction of T1DM among children and adolescents with an accuracy 87%.Conclusion: Serum visfatin level is lower in T1DM patients compared to healthy control. Visfatin play a role in early prediction and understanding the mechanism of its action in T1DM could lead to new therapeutic targets.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=78975075580c::825b889d42a205378553ef40363fce6eTest
https://www.ajol.info/index.php/ejhm/article/view/223576Test -
9دورية أكاديمية
مصطلحات موضوعية: Everolimus, mTOR inhibitor, Tacrolimus, immune checkpoint inhibitor, fulminant type1 diabetes mellitus
العلاقة: https://redcross.repo.nii.ac.jp/?action=repository_uri&item_id=17897Test; http://id.nii.ac.jp/1063/00017282Test/; 岡山赤十字病院医学雑誌 = The Okayama Red Cross Hospital Journal of Medicine, 32(1), 58-65(2021-11-30); https://redcross.repo.nii.ac.jp/?action=repository_action_common_download&item_id=17897&item_no=1&attribute_id=22&file_no=1Test
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10دورية أكاديمية
المؤلفون: Maral F. Thabit, Hana A. Abduljabbar, Shayma G. Abid
المصدر: مجلة كلية الطب, Vol 54, Iss 4 (2013)
مصطلحات موضوعية: type1 diabetes mellitus, immunological marker (Anti-GAD), Medicine, Medicine (General), R5-920
الوصف: Background: type 1diabetes (T1DM) is a form of diabetes mellitus that results from autoimmune destruction of insulin-producing beta cells of the pancreas, leading to permanent insulin deficiency ,categorized as either being positive or negative for various auto antibodies related to pancreatic function .An anti glutamic acid decarboxylase autoantibody(Anti-GAD) is recognized as one of the major serological markers for type 1 diabetes mellitus. Objectives: to determine the prevalence of the immunological marker (Anti-GAD) among a sample of type1diabetus mellitus patients and to identify some factors that might be associated with its seroposivity. Method: A cross-sectional retrospective study was carried out during February to May, 2011 in specialized diabetic clinic of Children Welfare Teaching Hospital, Baghdad .The study sample included 120 type1diabetus patients for whom(Anti-GAD) had been determined, patients reports were studied and analyzed statistically. Results: The demographic characteristics of this studied sample with higher percentage 57.5% of females, 46.7%in the age group 10-14 years, 12.5% had family history of other autoimmune diseases and the majority 69.2% had healthy Body Mass Index (BMI).while the clinical characteristics revealed higher percentage 47% with onset of the disease (5-9) years, 64.2% having a duration of disease (1-4)years ,86.7% presented with classical type of presentation and 52.5% had good control of diabetes . The prevalence of Anti-GAD in this studied sample was 66.7%. Seropositivity of Anti-GAD was significantly associated with delayed age of patients at diagnosis with mean age (7.5± 3.25) years, short duration of the diseases with mean (3.85±2.57) years, female gender (65%) compared to (35%) of male gender had positive Anti-GAD test, while seropositivity of Anti-GAD was not related to other study variables (age of patients, control of diabetes mellitus, BMI, and family history of other autoimmune disease). Conclusions: High prevalence of Anti-GAD and its titer in this studied sample, seropositivity was related mainly to female gender, delayed age at diagnosis and short duration of diabetes.
وصف الملف: electronic resource
العلاقة: http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/697Test; https://doaj.org/toc/0041-9419Test; https://doaj.org/toc/2410-8057Test
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