المؤلفون: Grauslund, Jakob, Stokholm, Lonny, Andersen, Nis, Andresen, Jens, Bek, Toke, Knudsen, Søren Tang, Subhi, Yousif

المصدر: Grauslund , J , Stokholm , L , Andersen , N , Andresen , J , Bek , T , Knudsen , S T & Subhi , Y 2024 , ' Risk of 2‐year progression from no diabetic retinopathy to proliferative diabetic retinopathy in accordance with glycaemic regulation in 145 527 persons with diabetes in a national cohort ' , Acta Ophthalmologica , vol. 102 , no. 3 , pp. e407-e409 . https://doi.org/10.1111/aos.15806Test

مصطلحات موضوعية: Diabetes Mellitus, Type 1/complications, Diabetic Retinopathy/epidemiology, Disease Progression, Humans, Risk Factors

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/e507f5b6-5887-4f3d-8cae-7457d88a12a4Test

الإتاحة: https://doi.org/10.1111/aos.15806Test
https://portal.findresearcher.sdu.dk/da/publications/e507f5b6-5887-4f3d-8cae-7457d88a12a4Test

المؤلفون: Altıkardeş, Dilara Karşıdağ, Nefs, Giesje, Hacışahinoğulları, Hülya, Smeets, Tom, Pouwer, Frans

المصدر: Altıkardeş , D K , Nefs , G , Hacışahinoğulları , H , Smeets , T & Pouwer , F 2024 , ' Reliability and validity of the Turkish version of the problem areas in diabetes (PAID) survey : Results from diabetes MILES - Turkey ' , Primary Care Diabetes , vol. 18 , no. 2 , pp. 218-223 . https://doi.org/10.1016/j.pcd.2024.01.001Test

مصطلحات موضوعية: Diabetes-specific distress, PAID, PAID-5, Prevalence, Turkey, Validity, Reproducibility of Results, Humans, Psychometrics, Diabetes Mellitus, Type 2/diagnosis, Type 1/diagnosis, Turkey/epidemiology, Adult, Surveys and Questionnaires

الوصف: Background and Aims: To 1) assess the reliability and validity of the Turkish version of the Problem Areas in Diabetes (PAID), PAID-5 and PAID-1 survey among Turkish adults with type 1 or type 2 diabetes, 2) estimate the level of elevated diabetes-specific distress (DD), and 3) determine the demographic and clinical correlates of DD-symptom severity. Methods and Results: From 2017–2019, 252 adults with type 1(n = 80) (T1DM) or type 2 diabetes (n = 172) (T2DM) self-reported demographic factors, DD(PAID) and related psychological and clinical questionnaires. We examined PAID internal consistency, structural and convergent validity. Associations of measures with DD were explored with hierarchical linear regression analysis. PCA yielded a 3-factor solution for PAID-20 and a 2-factor solution for PAID-5. Cronbach's α for PAID/PAID-5 subscales ranged from 0.63–0.90. All PAID versions correlated most strongly to BIPQ and HFS. The prevalence of elevated distress (PAID-20 ≥33) was 40% in T1DM and 15% in T2DM. DD severity was significantly positively associated (p < 0.01) with more negative diabetes perceptions (BIPQ) and type 1 diabetes. Conclusions: The Turkish translation of the PAID and its short forms appeared to have satisfactory psychometric properties. Elevated diabetes distress was more common in T1DM.

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/61a9452f-1cb3-4492-955d-ddaf81ca2ffaTest

الإتاحة: https://doi.org/10.1016/j.pcd.2024.01.001Test
https://portal.findresearcher.sdu.dk/da/publications/61a9452f-1cb3-4492-955d-ddaf81ca2ffaTest

المؤلفون: Rasmussen, Nicklas H., Driessen, Johanna H.M., Kvist, Annika Vestergaard, Souverein, Patrick C., van den Bergh, Joop P., Vestergaard, Peter

المصدر: Rasmussen , N H , Driessen , J H M , Kvist , A V , Souverein , P C , van den Bergh , J P & Vestergaard , P 2024 , ' Fracture patterns and associated risk factors in pediatric and early adulthood type 1 diabetes : Findings from a nationwide retrospective cohort study ' , Bone , vol. 180 , 116997 . https://doi.org/10.1016/j.bone.2023.116997Test

مصطلحات موضوعية: Falls, Fracture patterns, Fractures, Lower arm fractures, Lower leg fractures, Pediatric and early adulthood type 1 diabetes, Humans, Risk Factors, Male, Diabetes Mellitus, Type 1/complications, Adolescent, Hypoglycemia/complications, Female, Adult, Retrospective Studies, Child, Osteoporotic Fractures/epidemiology

الوصف: Purpose: People with pediatric and early adulthood type 1 diabetes (T1D) might have a higher fracture risk at several sites compared to the general population. Therefore, we assessed the hazard ratios (HR) of various fracture sites and determined the risk factors associated with fractures among people with newly diagnosed childhood and adolescence T1D. Methods: All people from the UK Clinical Practice Research Datalink GOLD (1987–2017), below 20 years of age with a T1D diagnosis code (n = 3100) and a new insulin prescription, were included and matched 1:1 by sex, age, and practice to a control without diabetes. Cox regression was used to estimate HRs of any, major osteoporotic fractures (MOFs) and peripheral fractures (lower-arm and lower-legs) for people with T1D compared to controls. The analyses were adjusted for sex, age, diabetic complications, medication (glucocorticoids, anti-depressants, anxiolytics, bone medication, anti-convulsive), Charlson-comorbidity-index (CCI), hypoglycemia, falls and alcohol. T1D was further stratified by diabetes duration, presence of diabetic microvascular complications (retinopathy, nephropathy, and neuropathy) and boys versus girls. Results: The crude HRs for any fracture (HR: 1.30, CI95%: 1.11–1.51), lower-arm (HR: 1.22, CI95%: 1.00–1.48), and lower-leg fractures (HR: 1.54, CI95%: 1.11–2.13) were statistically significant increase in T1D compared to controls, but the effect disappeared in the adjusted analyses. For MOFs, no significant differences were seen. Risk factors in the T1D cohort were few, but the most predominantly one was a previous fracture (any fracture: HR: 2.00, CI95%: 1.70–2.36; MOFs: HR: 1.89, CI95%: 1.44–2.48, lower- arm fractures: HR: 2.08, CI95%: 1.53–2.82 and lower-leg fractures: HR: 2.08, CI95%: 1.34–3.25). Others were a previous fall (any fracture: HR: 1.54, CI95%: 1.20–1.97), hypoglycemia (Any fracture: HR: 1.46, CI95%: 1.21–1.77 and lower-leg fractures: HR: 2.34, CI95%: 1.47–3.75), and anxiolytic medication (Any fracture: HR: 1.52, CI95%: 1.10–2.11). ...

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/3e6d054d-d81d-4ece-9ff8-f167589358c5Test

الإتاحة: https://doi.org/10.1016/j.bone.2023.116997Test
https://portal.findresearcher.sdu.dk/da/publications/3e6d054d-d81d-4ece-9ff8-f167589358c5Test

المؤلفون: Rasmussen, Nicklas H., Driessen, Johanna H.M., Kvist, Annika Vestergaard, Souverein, Patrick C., van den Bergh, Joop, Vestergaard, Peter

المصدر: Rasmussen , N H , Driessen , J H M , Kvist , A V , Souverein , P C , van den Bergh , J & Vestergaard , P 2024 , ' Fracture patterns in adult onset type 1 diabetes and associated risk factors – A nationwide cohort study ' , Bone , vol. 179 , 116977 . https://doi.org/10.1016/j.bone.2023.116977Test

مصطلحات موضوعية: Falls, Fracture patterns, Fractures, Lower arm fractures, Lower leg fractures, Type 1 diabetes, Humans, Risk Factors, Male, Diabetes Mellitus, Type 1/complications, Type 2/complications, Retinal Diseases/complications, Adult, Female, Osteoporotic Fractures/epidemiology, Multiple, Cohort Studies

الوصف: Objective: This study aimed to determine the hazard ratios (HR) for various fracture sites and identify associated risk factors in a cohort of relatively healthy adult people with newly diagnosed type 1 diabetes (T1D). Methods: The study utilized data from the UK Clinical Practice Research Datalink GOLD (1987–2017). Participants included people aged 20 and above with a T1D diagnosis code (n = 3281) and a new prescription for insulin. Controls without diabetes were matched based on sex, year of birth, and practice. Cox regression analysis was conducted to estimate HRs for any fracture, major osteoporotic fractures (MOFs), and peripheral fractures (lower-arm and lower-leg) in people with T1D compared to controls. Risk factors for T1D were examined and included sex, age, diabetic complications, medication usage, Charlson comorbidity index (CCI), hypoglycemia, previous fractures, falls, and alcohol consumption. Furthermore, T1D was stratified by duration of disease and presence of microvascular complications. Results: The proportion of any fracture was higher in T1D (10.8 %) than controls (7.3). Fully adjusted HRs for any fracture (HR: 1.43, CI95%: 1.17–1.74), MOFs (HR: 1.46, CI95%: 1.04–2.05), and lower-leg fractures (HR: 1.37, CI95%: 1.01–1.85) were statistically significantly increased in people with T1D compared to controls. The primary risk factor across all fracture sites in T1D was a previous fracture. Additional risk factors at different sites included previous falls (HR: 1.64, CI95%: 1.17–2.31), antidepressant use (HR: 1.34, CI95%: 1.02–1.76), and anxiolytic use (HR: 1.54, CI95%: 1.08–2.29) for any fracture; being female (HR: 1.65, CI95%: 1.14–2.38) for MOFs; the presence of retinopathy (HR: 1.47, CI95%: 1.02–2.11) and previous falls (HR: 2.04, CI95%: 1.16–3.59) for lower-arm and lower-leg fractures, respectively. Lipid-lowering medication use decreased the risk of MOFs (HR: 0.66, CI95%: 0.44–0.99). Stratification of T1D by disease duration showed that the relative risk of any fracture in T1D did not ...

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/98613c69-60f8-4f4c-bbb3-567226cba96eTest

الإتاحة: https://doi.org/10.1016/j.bone.2023.116977Test
https://portal.findresearcher.sdu.dk/da/publications/98613c69-60f8-4f4c-bbb3-567226cba96eTest

المؤلفون: Deshmukh, H., Adeleke, K., Wilmot, E. G., Folwell, A., Barnes, D., Walker, N., Saunders, S., Ssemmondo, E., Walton, C., Patmore, J., Ryder, R. E. J., Sathyapalan, T.

مصطلحات موضوعية: Humans, Aged, Diabetes Mellitus, Type 1/drug therapy/epidemiology, Blood Glucose, Glycated Hemoglobin, Blood Glucose Self-Monitoring, Continuous Glucose Monitoring, State Medicine, Hypoglycemia/chemically nduced/epidemiology/prevention & control, Insulins, Hypoglycemic Agents/therapeutic use, continuous glucose monitoring (CGM), glycaemic control, real-world evidence, type 1 diabetes

الوصف: AIMS: To evaluate the clinical features and impact of flash glucose monitoring in older adults with type 1 diabetes (T1D) across age groups defined as young-old, middle-old, and old-old. MATERIALS AND METHODS: Clinicians were invited to submit anonymized intermittently scanned continuous glucose monitoring (isCGM) user data to a secure web-based tool within the National Health Service secure network. We collected baseline data before isCGM initiation, such as demographics, glycated haemoglobin (HbA1c) values from the previous 12 months, Gold scores and Diabetes Distress Scale (DDS2) scores. For analysis, people with diabetes were classified as young-old (65-75 years), middle-old (>75-85 years) and old-old (>85 years). We compared baseline clinical characteristics across the age categories using a t test. All the analyses were performed in R 4.1.2. RESULTS: The study involved 1171 people with diabetes in the young-old group, 374 in the middle-old group, and 47 in the old-old group. There were no significant differences in baseline HbA1c and DDS2 scores among the young-old, middle-old, and old-old age groups. However, Gold score increased with age (3.20 [±1.91] in the young-old vs. 3.46 [±1.94] in the middle-old vs. 4.05 [±2.28] in the old-old group; p < 0.0001). This study showed reduced uptake of insulin pumps (p = 0.005) and structured education (Dose Adjustment For Normal Eating [DAFNE] course; p = 0.007) in the middle-old and old-old populations compared to the young-old population with T1D. With median isCGM use of 7 months, there was a significant improvement in HbA1c in the young-old (p < 0.001) and old-old groups, but not in the middle-old group. Diabetes-related distress score (measured by the DDS2) improved in all three age groups (p < 0.001) and Gold score improved (p < 0.001) in the young-old and old-old populations but not in the middle-old population. There was also a significant improvement in resource utilization across the three age categories following the use of is CGM. ...

العلاقة: https://linkinghub.elsevier.com/retrieve/pii/S2352-4642Test(23)00340-1; Deshmukh H, Adeleke K, Wilmot EG, Folwell A, Barnes D, Walker N, et al. Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study. Diabetes Obes Metab. 2024;26(4):1333-9.; Diabetes, obesity & metabolism; https://hdl.handle.net/11287/623190Test

الإتاحة: https://doi.org/10.1111/dom.15434Test
https://hdl.handle.net/11287/623190Test

المؤلفون: Kunke, Madlen, Knöfler, Hannah, Dahlke, Eileen, Zanon Rodriguez, Luis, Böttner, Martina, Larionov, Alexey, Saudenova, Makhabbat, Ohrenschall, Gerrit M, Westermann, Magdalena, Porubsky, Stefan, Bernardes, Joana P, Häsler, Robert, Magnin, Jean-Luc, Koepsell, Hermann, Jouret, François, Theilig, Franziska

المصدر: Cell Death and Disease, 14 (8), 562 (2023-08-26)

مصطلحات موضوعية: Animals, Mice, Kidney, Kidney Tubules, Proximal, Kidney Glomerulus, Diabetic Nephropathies/genetics, Diabetes Mellitus, Type 1/complications, Diabetes Mellitus, Type 1/genetics, Diabetes Mellitus, Experimental/complications, Diabetes Mellitus, Experimental/genetics, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Immunology, Cellular and Molecular Neuroscience, Cell Biology, Cancer Research, Human health sciences, Urology & nephrology, Sciences de la santé humaine, Urologie & néphrologie

الوصف: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Glomerular hyperfiltration and albuminuria subject the proximal tubule (PT) to a subsequent elevation of workload, growth, and hypoxia. Hypoxia plays an ambiguous role in the development and progression of DKD and shall be clarified in our study. PT-von-Hippel-Lindau (Vhl)-deleted mouse model in combination with streptozotocin (STZ)-induced type I diabetes mellitus (DM) was phenotyped. In contrary to PT-Vhl-deleted STZ-induced type 1 DM mice, proteinuria and glomerular hyperfiltration occurred in diabetic control mice the latter due to higher nitric oxide synthase 1 and sodium and glucose transporter expression. PT Vhl deletion and DKD share common alterations in gene expression profiles, including glomerular and tubular morphology, and tubular transport and metabolism. Compared to diabetic control mice, the most significantly altered in PT Vhl-deleted STZ-induced type 1 DM mice were Ldc-1, regulating cellular oxygen consumption rate, and Zbtb16, inhibiting autophagy. Alignment of altered genes in heat maps uncovered that Vhl deletion prior to STZ-induced DM preconditioned the kidney against DKD. HIF-1α stabilization leading to histone modification and chromatin remodeling resets most genes altered upon DKD towards the control level. These data demonstrate that PT HIF-1α stabilization is a hallmark of early DKD and that targeting hypoxia prior to the onset of type 1 DM normalizes renal cell homeostasis and prevents DKD development.

العلاقة: https://www.nature.com/articles/s41419-023-06074-7.pdfTest; urn:issn:2041-4889

الوصول الحر: https://orbi.uliege.be/handle/2268/306245Test

المؤلفون: Arif Atay, Ilknur Kucukosmanoglu, Hande Köksal, Kemal Arslan, Osman Dogru

المصدر: Cirugía y Cirujanos, Vol 90, Iss 6 (2022)

مصطلحات موضوعية: Pilonidal sinus. Etiopathogenesis. Total collagen. Collagen type 1/3 ratio., Surgery, RD1-811

الوصف: Objective: The purpose of this study is to investigate whether there was a difference between the midline skin and the healthy skin in the lateral by means of total amount of collagen and Type I/III ratio which was the indicator of the collagen structure. Material and methods: Fifty patients with pilonidal sinus disease were enrolled. Samples were prepared from the midline skin of the sinus where the holes were located and lateral skin of the resected material. Results: It was determined that the lateral line had significantly more collagen intensity and a higher collagen Type I/III ratio (p < 0.001). Conclusions: One of the reasons why hair mostly pricks into the midline in the intergluteal sulcus in pilonidal sinus disease is the fact that the amount of total collagen and collagen Type I/III ratio of the midline are lower than those of the lateral tissue. Complications are more common in cases with low Type I/III ratio and low total collagen rates.10.24875/CIRU.21000498

وصف الملف: electronic resource

العلاقة: https://www.cirugiaycirujanos.com/frame_esp.php?id=753Test; https://doaj.org/toc/2444-054XTest

الوصول الحر: https://doaj.org/article/6efaeb7e1b94448cad415d478c267dd2Test

المؤلفون: Van Meijel, Lian A., Van Asten, Jack J.A., Grandjean, Joanes, Heerschap, Arend, Tack, Cornelis J., Van Der Graaf, Marinette, Wiegers, Evita C., De Galan, Bastiaan E.

المساهمون: Highfield Research Group, Cancer

مصطلحات موضوعية: awareness, clinical study, diabetes mellitus, type 1, hypoglycemia, Hypoglycemia/chemically induced, Cerebrovascular Circulation/physiology, Humans, Glucose Clamp Technique, Lactic Acid/adverse effects, Type 1/complications, Endocrinology, Diabetes and Metabolism, Research Support, Non-U.S. Gov't, Journal Article

الوصف: Introduction Impaired awareness of hypoglycemia, clinically reflected by the inability to timely detect hypoglycemia, affects approximately 25% of the people with type 1 diabetes. Both altered brain lactate handling and increased cerebral blood flow (CBF) during hypoglycemia appear to be involved in the pathogenesis of impaired awareness of hypoglycemia. Here we examine the effect of lactate on CBF during hypoglycemia. Research design and methods Nine people with type 1 diabetes and normal awareness of hypoglycemia underwent two hyperinsulinemic euglycemic-hypoglycemic (3.0 mmol/L) glucose clamps in a 3T MR system, once with sodium lactate infusion and once with sodium chloride infusion. Global and regional changes in CBF were determined using pseudocontinuous arterial spin labeling. Results Lactate (3.3±0.6 vs 0.9±0.2 mmol/L during lactate infusion vs placebo infusion, respectively) suppressed the counter-regulatory hormone responses to hypoglycemia. Global CBF increased considerably in response to intravenous lactate infusion but did not further increase during hypoglycemia. Lactate also blunted the hypoglycemia-induced regional redistribution of CBF towards the thalamus. Conclusions Elevated lactate levels enhance global CBF and blunt the thalamic CBF response during hypoglycemia in patients with type 1 diabetes, mimicking observations of impaired awareness of hypoglycemia. These findings suggest that alteration of CBF associated with lactate may play a role in some aspects of the development of impaired awareness of hypoglycemia. Trial registration number NCT03730909.

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/447813Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/447813Test

المؤلفون: Pieterman, Carolina R.C., Valk, Gerlof D.

المساهمون: MS Endocriene Oncologie, Cancer

مصطلحات موضوعية: disease management, genetic testing, multiple endocrine neoplasia type 1, neuroendocrine tumours, pituitary neoplasms, primary hyperparathyroidism, review, Humans, Neuroendocrine Tumors/diagnosis, Multiple Endocrine Neoplasia Type 1/genetics, Pancreatic Neoplasms/diagnosis, Quality of Life, Female, Child, Endocrinology, Diabetes and Metabolism, Journal Article

الوصف: This review provides an overview of novel insights in the clinical management of patients with Multiple Endocrine Neoplasia Type 1, focusing on the last decade since the last update of the MEN1 guidelines. With regard to Diagnosis: Mutation-negative patients with 2/3 main manifestations have a different clinical course compared to mutation-positive patients. As for primary hyperparathyroidism: subtotal parathyroidectomy is the initial procedure of choice. Current debate centres around the timing of initial parathyroidectomy as well as the controversial topic of unilateral clearance in young patients. For duodenopancreatic neuroendocrine tumours (NETs), the main challenge is accurate and individualized risk stratification to enable personalized surveillance and treatment. Thymus NETs remain one of the most aggressive MEN1-related tumours. Lung NETs are more frequent than previously thought, generally indolent, but rare aggressive cases do occur. Pituitary adenomas are most often prolactinomas and nonfunctioning microadenomas with an excellent prognosis and good response to therapy. Breast cancer is recognized as part of the MEN1 syndrome in women and periodical screening is advised. Clinically relevant manifestations are already seen at the paediatric age and initiating screening in the second decade is advisable. MEN1 has a significant impact on quality of life and US data show a significant financial burden. In conclusion, patient outcomes have improved, but much is still to be achieved. For care tailored to the needs of the individual patient and improving outcomes on an individual basis, studies are now needed to define predictors of tumour behaviour and effects of more individualized interventions.

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/447802Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/447802Test

المؤلفون: van Beek, Dirk-Jan, Pieterman, Carolina R C, Wessels, Frank J, van de Ven, Annenienke C, de Herder, Wouter W, Dekkers, Olaf M, Zandee, Wouter T, Drent, Madeleine L, Bisschop, Peter H, Havekes, Bas, Borel Rinkes, Inne H M, Vriens, Menno R, Valk, Gerlof D

المساهمون: Heelkunde Opleiding, Cancer, MS CGO, MS Endocriene Oncologie, MS Radiologie, Regenerative Medicine and Stem Cells

مصطلحات موضوعية: Adenocarcinoma, Humans, Multiple Endocrine Neoplasia Type 1/diagnosis, Neuroendocrine Tumors/diagnostic imaging, Pancreatic Neoplasms/diagnostic imaging, multiple endocrine neoplasia type 1, EUS, MRI, diagnosis, imaging, CT, pancreatic neuroendocrine tumor, FNA, Endocrinology, Diabetes and Metabolism, Journal Article

الوصف: BACKGROUND: In multiple endocrine neoplasia type 1 (MEN1), pancreatic neuroendocrine tumors (PanNETs) have a high prevalence and represent the main cause of death. This study aimed to assess the diagnostic accuracy of the currently used conventional pancreatic imaging techniques and the added value of fine needle aspirations (FNAs). METHODS: Patients who had at least one imaging study were included from the population-based MEN1 database of the DutchMEN Study Group from 1990 to 2017. Magnetic resonance imaging (MRI), computed tomography (CT), endoscopic ultrasonography (EUS), FNA, and surgical resection specimens were obtained. The first MRI, CT, or EUS was considered as the index test. For a comparison of the diagnostic accuracy of MRI versus CT, patients with their index test taken between 2010 and 2017 were included. The reference standard consisted of surgical histopathology or radiological follow-up. RESULTS: A total of 413 patients (92.8% of the database) underwent 3,477 imaging studies. The number of imaging studies per patient increased, and a preference for MRI was observed in the last decade. Overall diagnostic accuracy was good with a positive (PPV) and negative predictive value (NPV) of 88.9% (95% confidence interval, 76.0-95.6) and 92.8% (89.4-95.1), respectively, for PanNET in the pancreatic head and 92.0% (85.3-96.0) and 85.3% (80.5-89.1), respectively, in the body/tail. For MRI, PPV and NPV for pancreatic head tumors were 100% (76.1-100) and 87.1% (76.3-93.6) and for CT, 60.0% (22.9-88.4) and 70.4% (51.3-84.3), respectively. For body/tail tumors, PPV and NPV were 91.3% (72.0-98.8) and 87.0% (75.3-93.9), respectively, for MRI and 100% (74.9-100) and 77.8% (54.3-91.5), respectively, for CT. Pathology confirmed a PanNET in 106 out of 110 (96.4%) resection specimens. FNA was performed on 34 lesions in 33 patients and was considered PanNET in 24 [all confirmed PanNET by histology (10) or follow-up (14)], normal/cyst/unrepresentative in 6 (all confirmed PanNET by follow-up), and adenocarcinoma in 4 (2 ...

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/447618Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/447618Test