المؤلفون: Ulusoy A, Turgut N, Cilli F, Unal AM

المصدر: Malaysian Orthopaedic Journal, Vol 18, Iss 1, Pp 99-105 (2024)

مصطلحات موضوعية: acromioclavicular joint, acromioclavicular separation, coracoclavicular ligament reconstruction, acromioclavicular reconstruction, Orthopedic surgery, RD701-811

الوصف: Introduction: This study reports the results of surgical anatomic reconstruction of torn coracoclavicular ligaments with an autogenous semitendinosus graft and temporary Kirschner wires (K-wires) in chronic acromioclavicular (AC) joint dislocations. Materials and methods: Nineteen shoulders underwent surgical anatomic reconstruction of torn coracoclavicular (CC)ligaments with an autogenous semitendinosus tendon graft and temporary K-wires for Rockwood grade III, IV and V chronic AC joint dislocations. Pre-operative data included patients’ demographic characteristics, injury characteristics and surgical histories. The primary outcome measures were the University of California Los Angeles (UCLA) shoulder rating scale and visual analogue pain scoring (VAS), and the complications were noted for each patient. Results: Surgical anatomic reconstruction of torn CC ligaments was performed in 19 patients with a mean age of41.6±16 years (range 21–72 years). All of the patients were satisfied and felt better after CC ligament reconstruction. The average UCLA shoulder rating scale score was good/excellent: 29.4 (range 23–34) out of 35 points. The average pre-operative VAS score was 7.7 points out of 10and improved to 1.1 points post-operatively (p

وصف الملف: electronic resource

العلاقة: https://www.morthoj.org/2024/v18n1/acromioclavicular-joint.pdfTest; https://doaj.org/toc/1985-2533Test; https://doaj.org/toc/2232-111XTest

الوصول الحر: https://doaj.org/article/a5a0d785898c4fb69cfff96dd939919bTest

المؤلفون: Sahin K, Demirel M, Turgut N, Arzu U, Polat G

المصدر: Malaysian Orthopaedic Journal, Vol 13, Iss 1, Pp 45-48 (2019)

مصطلحات موضوعية: aneurysmal bone cyst, bone cyst, bone tissue neoplasm, osteotomy, Orthopedic surgery, RD701-811

الوصف: Aneurysmal bone cysts rather than local aggressive lesions of the bone which may arise in any part of the axial or appendicular skeleton. Although several theories are available in the literature, the pathogenesis is still conflicting. We report an exceptional case of an aneurysmal bone cyst in the distal femur of a female cerebral palsy patient who underwent bilateral distal femoral derotational osteotomy and plate-screw fixation operations when she was 11 years old. Twenty-four months after the operation, radiographs showed a cystic lesion in the distal portion of the right femur around the osteotomy site. The diagnosis of Aneurysmal Bone Cyst (ABC) was made and the lesion was treated by curettage with cement application. After 36 months of follow-up, there was no recurrence. This is the first case reported in literature which raises the possibility that an osteotomy could be a cause in the development of an aneurysmal bone cyst.

وصف الملف: electronic resource

العلاقة: https://www.morthoj.org/2019/v13n1/aneurysmal-bone-cyst.pdfTest; https://doaj.org/toc/1985-2533Test; https://doaj.org/toc/2232-111XTest

الوصول الحر: https://doaj.org/article/a2b4458750634908ac2b66831cd7e9caTest

المؤلفون: Weiss, Raphael, Saadat-Gilani, Khaschayar, Kerschke, Laura, Wempe, Carola, Meersch, Melanie, Zarbock, Alexander, Makhloufi, Hichem, Cherak, Anis, Ghanem, Lamine Lakhel, Gouaglia, Zohier, Guadouri, Dina Nasrine, Hama, Fayrouz Naouel, Kara, Mustafa, Saadi, Omayma, Sakhraoui, Rachida, Bourou, Fadila, Cherifi, Abdelhadi, Sadaoui, Rahmoune Ghania, Ouyahia, Amel, Ouahab, Ilhem, Bouaoud, Souad, Abdoun, Meriem, Tidjane, Anisse, Tabeti, Benali, Boudjenan-Serradj, Nabil, Perez Rivera, Carlos J., Cabrer, Paulo, Corso, Julian, García, Juan Pablo, Idarraga-Ayala, Sharon V., Montoya, Christopher, Figueroa-Casanova, Rafael, Aldana, Eduar, Torrado, María Alejandra, Peng, Ke, Ma, Zhengmin, Yang, Yufan, Zhu, Yajuan, Sklienka, Peter, Frelich, Michal, Jarkulis, Vojtech, Sevcik, Pavel, Vodicka, Vojtech, Elbahnasawy, Mohamed, Elsalhawy, Shady, Motawea, Sara H., Othman, Zeinab, Sahma, Mohamed, Nafea, Ahmed Mahmoud, Ahmed, Nermin, Attia, Doaa Ali, Emara, Moataz Maher, Bonna, Mohamed Mamdouh, Gabr, Mohamed Ahmed, Tarbay, Amany Ismail, Abdehaleem, Ibrahim A., Mohamed, Esraa Elsayed, Eldeeb, Amr Mahmoud, Abbas, Ahmed Mohamed, Magdy, John Ashraf, Hamed, Zyad Hassan, Osman, Hany Mostafa Esmaeil, Abbas, Mostafa Samy, Joannes-Boyau, Oliver, Barraud, Nicolas, Berthelot, Corentin, Camus, Thibault, Dahmi, Anissa, Defaye, Mylène, Derville, Sébastien, El-Boustani, Younes, Deloge, Elsa, Jacob, Hélène, Monziols, Simon, Priem, Fred, Robin, Jean-Jacques, Legros, Vincent, Floch, Therry, Muccio, Salvatore, Geneve, Claire, Legouge, Marie Lim, Mauny, Stéphanie Tao, Mfam, Willy, Pascot, Léa, Aveline, Christophe, Chartier, Mireille, Duteurtre, Benjamin, Gautier, Jean Francois, Cousin, Aidren Le, Vautier, Pierre, Nadaud, Julien, Begel, Nathalie, Chekirine, Claire-Annissa, Derlon, Vincent, Grein, Elodie, Lehair, Marie-Annick, Magazzeni, Laurent, Magazzeni, Philippe, Potter, Carsten, Roth, Catherine, Voivret, Florence, Rimmelé, Thomas, Cerro, Valérie, Suria, Stéphanie, Elmawieh, Jamil, Stoclin, Annabelle, Cirenei, Cédric, Andrieu, Gregoire, Couloumy, Sven, Falcone, Jeremy, Fajardy, Marion, Gagneuil, Arsène, Girardet, Emeline, Mazereeuw, Agnès, Ponsonnard, Sébastien, Egreteau, Pierre-Yves, Bertel, Mélanie, Bocher, Simon, Carn, Vanessa, Guen, Lenaïg Le, Loup, Guillaume Le, Lefevre, Montaine, Ichai, Carole, Diop, Amanita, Jean-Michel, Vanessa, Devlieger, Sylvie, Duthoit, Juliette, El Kadiri, Mohamed, Léger, Maxime, Cassisa, Viviane, Lasocki, Sigismond, Masson, Charline, Rineau, Emmanuel, Verrier, Pierre, Coquerel, Axel, Montravers, Philippe, Atchade, Enora, Rochon, C.E., Delerue, C., Quentin, V., Latry, V., Queixalos, N., Cottenceau, V., Braun, T., Bouzoubaa, S., Christ, B., Geiger, A., Gomille, J., Kieffer, V., Mangeant, S., Prochilo, C., Schmitt, C., Skwirba, S., Grand, H., Boury, F., Mayeur, N., Pasquie, M., Garçon, P., Bruckert, V., Arnould, V., Bonciu, M., Chapelle, T., Facchino, L., Fagot-Gandet, F., Iachim, A., Mannu, E., Perus, O., Plattier, R., Rozier, R., Pradel, G., Boudinaud, M., Hausermann, M.H., Nguyen, M.H., Ramorasata, A., Barreau, A., Boivin, A.H., Ravry, C., Mottard, N., Beuvelot, J., Bossion, F.P., Desebbe, O., Zarbock, A., Dörr, C., von Groote, T.C., Küllmar, M., Massoth, C., Meersch, M., Saadat-Gilani, K., Weiss, R., Wempe, C., Ziemann, S., Grüßer, L., Kowark, A., Wittig, P., Brandenburger, T., Dimski, T., Döhmen, N., Huthmann, L., Kaierle, D., Pelletier, C., Schleß, M., Hohn, A., Cleophas, S., Haunhorst, S., Jansen, M., Schmitt, A., Soisch, J., Sturm, K., Rosenberger, P., Bendig, A., Flohr, L., Häberle, H., Hofmann, P., Kuhle, J., Leser, N.M., Pfister, K., Prohaska, S., Sennholz, F., Stetz, L., Weber, K., Stehr, S., Klaus, S., Sadlo, M., Boschin, M., Sengelhoff, C., Göbel, U.M., Haaker, J.G., Göttker, C.K., Gründel, M., Heringlake, M., Baumgärtel, R., Berggren, A., Gülzow, M., Muras, L., Paarmann, H., Thal, S., Bentley, A., El-Masri, D., Sebastiani, A., Arnaoutoglou, E., Ntalouka, M., Stratigopoulou, P., Analytis, A., Mavrommatis, E., Tzimas, P., Karakosta, A., Pantazi, D., Dimakopoulou, A., Dimitropoulou, K., Ioannidis, O., Jalaawiy, H., Anwar, A., Hashim, H.T., Aldawoody, H.I.R., Cortegiani, Andrea, Catalisano, G., Ingoglia, G., Ippolito, M., De Rosa, S., Cattin, L., Bianchin, A., Barone, M., Paternoster, G., Cutuli, S.L., Russo, A., Sollazzi, L., Cascarano, L., Antonelli, M., Aceto, P., Romanò, B., Spadaro, S., Tripodi, V.F., Rossi, M., Scappatura, R., Vadalà , M.C., Fiume, D., Strano, M.T., Oddo, G., Santorsola, C., Hussain, B.A., Alnaser, A.R., Ghassan, A.H., Hasanein, K., Theab, M., Shin, S., Jung, S., Lee, K., Jung, S.M., Baek, J., Elhadi, M.K., Aldressi, W.W.O., Abuzeid, I., Albaraesi, M., Aldressi, S., Khalel, W., Abdulwahed, E., Abujrad, A.A.A., Almaghrabi, A., Alteleeb, M.M., Alshareea, E.A.A., Biala, M.I., Deeknah, A., Gheddim, D.A., Ghmagh, R., Ikhrays, N.S.A.A., Sinan, M., Soula, E., Bahroun, S.G., Derwish, K., Mohamed, A.M., Younes, E.S., Al Islam Benjouira, R., Aliwa, M., Altashani, N.A., Alteb, M.O., Msherghi, A., Alagelli, F., Albarouni, S., Albishti, A., Aljamal, S., Alsori, M., Ekhuja, T., Elzwai, S., Ghula, M., Mustafa, T., Tuwaib, A., Zriba, H., Agilla, H.M., Rafanomezantsoa, T.A., Podesta, A.M.C., Bonnici, D.M., Pirotta, T., López, G.A.G., Mijovska, M.M., Davitkovska, T., Gavrilovska, A., Lukikj, S., Vesova, M., Zafirova, D., Amro, S., Hajjaj, B.N.F., Alkhazendar, M., Barakat, Y., Elejla, S.A., Elhissi, A., Khader, A., Salem, A., de Freitas Regufe, R., de Oliveira Eloy, A.F., Perdigão, L.M.N.C., Grigoriev, E., Ivkin, A., Kornelyuk, R., Yaroustovsky, M., Abramyan, M., Komardina, E., Lesteva, N., Aybazova, M., Kumykova, E., Lesina, S., Rybakov, G., Shestov, A., Barmou, A.A.A., Ahmed, B.L.A., Eliyas, A.M., Emadeldin, Y., Kaserer, A., Castellucci, C., Rössler, J., Akbas, S., Petrun, A.M., Gregorcic, I., Sok, V., Cicak, Roman, Bárcena, Elizabeth, Guisado, Antonio, Wi, Ismail, Ripollés-Melchor, Javier, Becerra, Angel, Cabrera-Doreste, Sergio, Domínguez-Arbelo, Ancor, Delgado-Alonso, María Candelaria, Muiño-Palomar, Virginia, Rodriguez-Perez, Aurelio, Mata Estévez, Javier, Munoz, Maria Begona Covas, Matas, Juan Mulet, Palao, Sara Perez, Quirós, Maria Dolores Mira, Cezara Teslev, Alisi, Argilaga, Marta, Campos, Maria, Bainac, Albert, Batalla Gonzalez, Astrid Maria, García Ãlvarez, Mercedes, Gine Serven, Marta, Herránz Perez, Gracia, Hinojal, Ignacio, Logroño Ejea, Margarita, de la Rosa Ruiz, Noelia, Abasolo, María Gastaca, Acuna, Carla Rosario Houhton, Zaranton, Ibai Iriarte, Mendigurenmurua, Ana, Sanz, María José Munoz, de la Fuente, Erika Olea, Vaquero, María Pilar Pérez, Iglesias, Ana Soto, Mieres, Ana Ugarte, Urrestizala, Alaitz Urtiaga, Ferreira, Lourdes, Lobato, Félix, Sevilla, Marta Aguado, Erazo, Andres, Miró, Pere, Sabaté, Sergi, Vernetta, Diana, Perez, Anabel Adell, Pagola, Marta Aseguinolaza, Paulis, Berta Castellano, del Val Peciña, Elena, Odriozola, Ainhoa Garmendia, Aizpurua, Amaia Lopetegi, Piquer, Olatz Pavón, Garcia, Pilar Plou, Rezola, P.O., Lopez, A.O., de la Calle Gil, I., Casado, R.N., Adamove, P., Domenge, R.B., Blasco, F.M.B., Villamizar, A.A.R., Llaneras, M.A.P., García-Sánchez, J.I., Téllez, L.F., Zamorano, S.G., Herreros, N.G., Esteve, A.R., Rodríguez, P.M., Trigo, I.G., Alcaraz, A., Jiménez, A.L., Rubio, I., García, N., Callejas, R., Toha, A.M.C., Claros, E., Cobeta, P., Crespo, P., Dorado, T., Elías, E., Felices, J., Gil, D., Gómez, M., Mané, N., Martín, M., Martínez, A., Pereira, L., Samaranch, A.B.N., Serrano, A., Tiscar, C., VillaHoz, J., Menéndez, Patricia Galán, Cardona, E., Conesa, A., Estepa, V., Galán, P., Espí, L.L., Loaiza Aldeán, Yuri, Manrique, Susana, Ariza, Victor Morales, Villarino Villa, Laura V, Suliman, E.S.M.A., Hamid, H., Ibrahim, A.M., Saeed, M.M., Mukadder, O.S., Altun, D., Canbolat, N., Dinçer, M.B., Seyhan, T.Ö., Yildirim, S.A., Iyigün, M., Yapici, D., Özdemir, L., Sagun, A., Boztug, N., Cetintas, Y., Dinc, B., Gündüz, E., Ãœnlügenç, H., Tunay, D.L., Karakaya, D., Dost, B., Komurcu, O., Akcil, E.F., Dilmen, Ö.K., Tunali, Y., Ok, G., Alsina, E.T., Hakli, Ö., Polat, C., Turgut, N., Kizilcik, N., Köner, Ö., Sen, Ö., Aydin, N., Basaran, B., Bingul, E.S., Gürkan, Y., Darcin, K., Ugur, S., Saracoglu, K.T., Demir, A., Aysegül, Ö., Balci, E., Girgin, B., Guler, A., Karadeniz, Ãœ., Özaslan, N., Hülya, Y.Ö., Ozcan, N., Postaci, A., Sahap, M., Salman, N., Sagir, Ö., Atik, B., Bicakcioglu, M., Demir, H.F., Fatih, U., Kocaoglu, N., Toprak, H.i., Aslan, D.D., Colak, Y.Z., Ozcan, M.S., Yilmaz, M., Karaca, U., Sahin, S.H., Karka, Ö.E., Senoglu, G.D., Karadag, S.E., Alkis, N., Baytas, V., Akdogan, A., Besir, A., Erturk, E., Kutanis, D., Saylan, S., Tugcugil, E., Ayvat, P., Günaydin, B., Büyükgebiz, B.M., Boran, O.F., Calisir, F., Orak, Y., Balkan, B.K., Büyükcoban, S., Gökel, E., Günenc, S.F., Özbilgin, S., Göre, S., Akesen, S., Cansabuncu, S., Momot, N., Panchenko, A., Pittet, J.F., Rutledge, K., Universitat Autònoma de Barcelona

مصطلحات موضوعية: Adult intensive & critical care, Acute renal failure, Chronic renal failure, Epidemiology

الوصف: More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369.

وصف الملف: application/pdf

العلاقة: BMJ open; Vol. 11 Núm. 12 (30 2021), p. e055705; https://ddd.uab.cat/record/283286Test; urn:10.1136/bmjopen-2021-055705; urn:oai:ddd.uab.cat:283286; urn:scopus_id:85122637577; urn:articleid:20446055v11n12e055705; urn:pmid:35588372; urn:pmc-uid:8718477; urn:pmcid:PMC8718477; urn:oai:pubmedcentral.nih.gov:8718477

الإتاحة: https://ddd.uab.cat/record/283286Test

المؤلفون: Başaran, N., Adaş, M., Gökden, Y., Turgut, N., Yıldırmak, T., Güntaş, Gülcan

مصطلحات موضوعية: COVID-19, CRP, d-dimer, ferritin, vitamin D

الوصف: AIM: Vitamin D, which has immunomodulatory effect, can reduce risk of infections and concentrations of pro-inflammatory cytokines. The aim of this study was to investigate the relationship between the levels of vitamin D and severity of COVID-19. METHODS: A total of 204 patients with COVID-19 disease were enrolled in the study. All patients had viral pneumonia, which was confirmed with chest computer tomography. All cases were divided in two groups-mild (outpatients); and serious (inpatients)- according to their clinical and laboratory data. Serum vitamin D levels were measured by chemiluminescence method. RESULTS: Vitamin D deficiency was found in 41.7 % (n = 85) of cases and insufficiency was found in 46.0 % (n = 94), while in 12.3 % (n = 25) of cases normal vitamin D levels were found. The odds of having a serious clinical outcome were increased for vitamin D insufficiency patients 5.604 times ( CI:0.633-49.584) and for vitamin D deficiency patients 38.095 times ( CI:2.965-489.50) for each standard deviation decrease in serum 25(OH)D. CONCLUSION: Adequate levels of vitamin D could suppress inflammation and reduce the severity of COVID-19. Vitamin D supplementation may have an important role in decreasing the impact of the pandemic

وصف الملف: application/pdf

العلاقة: Bratislava Medical Journal-Bratislavske Lekarske Listy; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.4149/BLL_2021_034Test; https://hdl.handle.net/20.500.11857/2974Test; 122; 200; 205; WOS:000637613200007; 2-s2.0-85101946377; PubMed: 33618529

الإتاحة: https://doi.org/20.500.11857/2974Test
https://doi.org/10.4149/BLL_2021_034Test
https://hdl.handle.net/20.500.11857/2974Test

المؤلفون: Barman, H.A., Atici, A., Tekin, E.A., Baycan, O.F., Alici, G., Meric, B.K., Turgut, N.

مصطلحات موضوعية: Cardiac injury, COVID-19, Two-dimensional echocardiography

الوصف: COVID-19 patients with cardiac involvement have a high mortality rate. The aim of this study was to investigate the echocardiographic features in COVID-19 patients between severe and non-severe groups.For this single-center study, data from patients who were treated for COVID-19 between March 25, 2020 and April 15, 2020 were collected. Two-dimensional echocardiography (2DE) images were obtained for all patients. Patients were divided into two groups based on the severity of their COVID-19 infections. 2DE parameters indicating right ventricular (RV) and left ventricular (LV) functions were compared between the two groups.A total of 90 patients hospitalized for COVID-19 were included in this study. The mean age of the severe group (n = 44) was 63.3 ± 15.7 years, and 54% were male. The mean age of non-severe group (n = 46) was 49.7 ± 21.4 years, and 47% were male. In the severe group, RV and LV diameters were larger (RV, 36.6 ± 5.9 mm vs. 33.1 ± 4.8 mm, p = 0.003; LV 47.3 ± 5.8 mm vs. 44.9 ± 3.8 mm, p = 0.023), the LE ejection fraction (LVEF) and the RV fractional area change (RV-FAC) were lower (LVEF, 54.0 ± 9.8% vs. 61.9 ± 4.8%, p < 0.001; RV-FAC, 41.4 ± 4.1% vs. 45.5 ± 4.5%, p < 0.001), and pericardial effusions were more frequent (23% vs. 0%) compared to patients in the non-severe group. A multiple linear regression analysis determined that LVEF, right atrial diameter, high-sensitivity troponin I, d-dimer, and systolic pulmonary artery pressure, were independent predictors of RV dilatation.The results demonstrate that both right and left ventricular functions decreased due to COVID-19 infection in the severe group. 2DE is a valuable bedside tool and may yield valuable information about the clinical status of patients and their prognoses. © 2020, Springer Nature B.V.

العلاقة: International Journal of Cardiovascular Imaging; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1007/s10554-020-02051-9Test; https://hdl.handle.net/20.500.12831/7056Test; 37; 825; 834; 2-s2.0-85092381194; PubMed: 33030636

الإتاحة: https://doi.org/10.1007/s10554-020-02051-9Test
https://doi.org/20.500.12831/7056Test
https://hdl.handle.net/20.500.12831/7056Test

المؤلفون: Sungur Z, Ergil J, Karaaslan K, Tomak Y, Turgut N, Kurtipek Ö.

العلاقة: Turk J Anaesthesiol Reanim; https://hdl.handle.net/20.500.12645/37549Test

الإتاحة: https://doi.org/20.500.12645/37549Test
https://doi.org/10.5152/TJAR.2021.1255Test
https://hdl.handle.net/20.500.12645/37549Test

المؤلفون: Turgut, N., Hildebrandt, H.

المصدر: Neurologie & Rehabilitation ; volume 27, issue 4, page 239-254 ; ISSN 1869-7003

مصطلحات موضوعية: Pharmacology (medical)

الوصف: The aim of this paper is to provide an overview of treatment strategies and methods as well as a practical decision support, based on the current version of the guideline on memory rehabilitation [55] and the authorsʼ views. We show that the choice of a method for efficient neuropsychological treatment depends on the type and severity of the memory disorder as well as on the previous therapy experience of the affected person and the defined therapy goal: e.g., what it means to work with implicit »errorless learning« methods; which form of external memory aids can be used with which patients; that methods for improving memory performance are available for persons with moderate to mild memory disorders; and that PC therapy is also likely to help younger and more mildly affected persons. The aim is also to provide a broad overview of current studies on memory rehabilitation, some with very promising results. However, many questions remain unanswered to date, some of which have been highlighted in this paper with the aim of stimulating future research to enable those affected by memory impairment to achieve the best possible rehabilitation and the greatest possible independence

الإتاحة: https://doi.org/10.14624/nr2104005Test
https://www.hippocampus.de/index.php?id=12245%26dimx_gf=288776Test

المؤلفون: Dayan, M. O., Beşoluk, K., Eken, E., Aydoğdu, S., Turgut, N.

المساهمون: Selçuk Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümü, Dayan, M. O., Beşoluk, K., Eken, E., Aydoğdu, S., Turgut, N.

مصطلحات موضوعية: computed tomography, femur, humerus, guinea pig, three-dimensional reconstruction

الوصف: WOS: 000484118100017 ; PubMed: 30644082 ; Background: Guinea pig is a species belonging to the Caviidae family of the Rodentia order and is frequently used in experimental studies. Biomedical imaging methods are used in the diagnosis and treatment of many diseases in medicine. Among these methods, computed tomography (CT) is one of the most important imaging methods. In this study, it was aimed to perform the three-dimensional (3D) modelling of the CT images, obtained from the humerus and femur in the guinea pigs, via the MIMICS programme, and to make some biometric measurements regarding the bones over these models. Materials and methods: In the present study, 12 male adult guinea pigs were used. The soft tissue on the humerus and femur bones of the guinea pigs was removed. After this procedure, CT images at a 0.5 mm-thickness were obtained from the animals. The images were recorded in DICOM format. Then, the reconstruction process was performed from the images by using the 3D modelling programme MIMICS (R) 13.1. On the 3D model of the humerus and femur (right-left), volumes, surface areas and lengths as well as other biometric parameters were measured separately, and the values were recorded. In addition, measurements of the bones were made with the help of a digital calliper. Results: Among the parameters obtained from 3D models, a statistical difference was observed between the right and left cortical thicknesses of the femur from the measurements of calliper and the right and left humerus volumes (p < 0.05); whereas, no statistical difference was found in other parameters of both measurements (p > 0.05). Conclusions: It can be stated that CT and 3D modelling can be used for the measurement of some parameters in the long bones of the guinea pigs. ; SUBAPKSelcuk University [17401095] ; A portion of this study's abstract was presented in "1 st International Health Science and Life Congress". This study was supported by SUBAPK (17401095).

وصف الملف: application/pdf

العلاقة: FOLIA MORPHOLOGICA; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Dayan, M. O., Beşoluk, K., Eken, E., Aydoğdu, S., Turgut, N. (2019). Three-Dimensional Modelling of The Femur and Humerus in Adult Male Guinea Pigs (Guinea Pig) with Computed Tomography and Some Biometric Measurement Values. Folia Morphologica, 78(3), 588-594.; https://dx.doi.org/10.5603/FM.a2019.0002Test; https://hdl.handle.net/20.500.12395/38341Test; 78; 588; 594

الإتاحة: https://doi.org/20.500.12395/38341Test
https://doi.org/10.5603/FM.a2019.0002Test
https://hdl.handle.net/20.500.12395/38341Test

المؤلفون: Turgut, N. H.¹ (AUTHOR), Gungor, H.² (AUTHOR) gungor@cumhuriyet.edu.tr, Ekici, M.³ (AUTHOR), Karayigit, M. O.⁴ (AUTHOR), Kara, H.² (AUTHOR)

المصدر: Journal of Evolutionary Biochemistry & Physiology. Sep2023, Vol. 59 Issue 5, p1577-1593. 17p.

مصطلحات موضوعية: *PULMONARY fibrosis, *CARVACROL, *IDIOPATHIC pulmonary fibrosis, *NITRIC-oxide synthases, *STAINS & staining (Microscopy), *MONOTERPENES, *GLUTATHIONE peroxidase

مستخلص: Idiopathic pulmonary fibrosis (IPF) is a serious progressive pulmonary disease of unknown etiology and high mortality. Carvacrol is a natural phenolic monoterpene with various pharmacological effects, especially antioxidant and anti-inflammatory effects. Hence, the present study aimed to investigate the effect of carvacrol on bleomycin (BLM) induced pulmonary fibrosis (PF) in Wistar-albino rats. Rats were administered a single dose of BLM (5mg/kg, intratracheal) or vehicle and treated with carvacrol (100 mg/kg, p.o. for 14 days following BLM administration). For calculating the lung index, the body and lungs were weighed. The Elisa method was used to assess hydroxyproline content, anti-inflammatory, and antioxidant effects. Fibrosis score, collagen deposition and inflammation were evaluated with Hematoxylin-Eosin (HxE) and Masson's trichrome staining. Inducible nitric oxide synthase (iNOS), transforming growth factor-beta 1 (TGF-β1), and caspase 3 expressions were assessed immunohistochemically. BLM administration significantly diminished glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities and increased malondialdehyde (MDA) levels. BLM also increased tumor necrosis factor alpha (TNF-α) and collagen bundle accumulation. Carvacrol at 100 mg/kg significantly decreased collagen accumulation, MDA, TNF-α levels, iNOS, TGF-1, and caspase 3 expression, while increasing SOD and GPx activity. Histopathological examination supported the findings that carvacrol attenuated the degree of collagen deposition and inflammation. This study revealed that treatment with carvacrol (100 mg/kg) exhibits a potential healing effect on BLM-induced PF by reducing inflammatory and oxidative damages and histopathological alterations, with possible molecular targets being iNOS, TGF-β1 and caspase 3 signaling pathways. [ABSTRACT FROM AUTHOR]

المؤلفون: Scheffels, J. F., Turgut, N., Pape, A. P., Kastrup, A., Hildebrandt, H.

المصدر: Neurologie & Rehabilitation ; volume 25, issue 03, page 165-173 ; ISSN 1869-7003

مصطلحات موضوعية: Pharmacology (medical)

الإتاحة: https://doi.org/10.14624/nr1908003Test