المؤلفون: Letesson, Julien, Goin, Bastien, Trouillet, Jean Louis, Barthez, Paul

المصدر: Vet Med Int

مصطلحات موضوعية: Research Article

الوصف: Traumatic vertebral fracture or luxation often results in spinal instability requiring surgical stabilization. This study describes the long-term outcome of spinal stabilization using a unilateral 5-hole 2-0 UniLock implant in eight dogs and two cats with trauma-induced thoracolumbar vertebral luxation/subluxation and presumed instability, as assessed by a combination of preoperative radiographs and MRI using a 3-compartment method. The UniLock plate was secured with four monocortical locking screws in adjacent vertebral bodies. Additional pins and facet screws were used in several patients. Postoperative radiographs and MRI studies showed restoration of the main spinal axis in all patients and satisfactory implantation of the screws in the vertebral bodies, with no intrusion in the vertebral canal or in the adjacent intervertebral disc spaces. Neurological status improved in nine patients six weeks postoperatively. Partial implant failure was detected in three patients with no long-term consequences. After 12 months, seven patients reached full recovery with no neurological deficit, two patients were euthanized (including one owing to an unrelated condition), and one remained paraparetic. The results of this study demonstrate that using a 2-0 UniLock implant to stabilize the thoracolumbar spine results in satisfactory long-term recovery in most dogs and cats with traumatic spinal luxation/subluxation and presumed instability. Complications may occur but do not require revision surgery and do not affect clinical outcomes.

العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064500Test/; http://dx.doi.org/10.1155/2022/5112274Test

الإتاحة: https://doi.org/10.1155/2022/5112274Test
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064500Test/

المؤلفون: Dupuis, Claire, Le Bihan, Clément, Maubon, Daniele, Calvet, Laure, Ruckly, Stéphane, Schwebel, Carole, Bouadma, Lila, Azoulay, Elie, Cornet, Muriel, Timsit, Jean-Francois, Hamidfar-Roy, Rebecca, Ciroldi, Magalie, Paugam-Burtz, Clichy Catherine, Foucrier, Arnaud, Navellou, Jean Christophe, Wolff, Michel, Mourvillier, Bruno, Sonneville, Romain, Chemam, Sarah, Gruson, Didier, Souweine, Bertrand, Lautrette, Alexandre, Charles, Pierre Emmanuel, Bruyere, Rémi, Hamet, Maël, Allaouchiche, Bernard, Guillaume, Christian, Ber, Charles-Eric, Prothet, Johanne, Rimmele, Thomas, Argaud, Laurent, Simon, Marie, Cour, Martin, Hernu, Romain, Jaber, Samir, Jung, Boris, Conseil, Mathieu, Coisel, Yannael, Belafia, Fouad, Klouche, Kada, Amigues, Laurent, Machado, Sonia, Serveaux, Marianne, Chastre, Jean, Trouillet, Jean-Louis, Cousson, Joël, Raclot, Pascal, Floch, Thierry, Zeni, Fabrice, Darmon, Michael, Pichon, Matthias, Coudrot, Maud, Ninet, Sebastien, Diconne, Eric, Schlemmer, Benoit, Lemiale, Virginie, Maziers, Nicolas, Meziani, Ferhat, Schnell, David, Boisrame-Helms, Julie, Neagu-Anca, Raluca, Delabranche, Xavier, Martinet, Olivier, Garrouste-Orgeas, Maité, Misset, Benoit, Brunee, Fabrice, Laurent, Virginie, Lacave, Guillaume, Bedos, Jean-Pierre, Hammi, Khadija, Styfalova, Lenka, Fritzsch, Joelle, Letrou, Sophie, Estevez, Lucie, Devaux, Therese, Dubien, Celine, Bayarassou, Soumia, Faure, Catherine Jouvene, de La Salle, Sylvie, Prades, Albert, Rodriguez, Annie, Meur, Pierre, Warchol, Magda, El Haouari, Hanane, Theodose, Igor, Fournier, Julien, Cavelot, Sebastien, Kodja, Lilia Bakir, Faure, Marie Joyeux, Tacco, Frédéric, Roos, Sonia, Dupre, Karima, Abazid, Malek, Essert, Michele, Arnaud, Philippe, P., Papy, Emmanuelle, Ghezzoul, Bellabes, Gerbouin, Olivier, Peccoux, Sandrine Corny, Fagnoni, Philippe, Millaret, Anne, Pivot, Christine, Gerard, Cecile, Breuker, Cyril, Castet, Audrey, Charbonnier, Fanny, Legrand, Maryline, Mordini, Julia, Chambrin, Isabelle Madeleine, Clauss, Anne Hutt, Cherifi, Mohamed, Pattyn, Anne, Cornet, Murielle, Benveniste, Eliane, Grenouillet, Frédéric, Chochillon, Christian, Accoberry, Isabelle, Pons, Denis, Mrozek, Natacha, Dalle, Frédéric, Picot, Stephane, Beyerle, Francoise, Bienvenu, Anne-Lise, Bourgeois, Nathalie, Fekkar, Arnaud, Toubas, Dominique, Raberin, Hélène, Candolfi, Ermanno, Bru, Valérie, Kitzis, Marie Dominique, Senghor, Yaye, Palette, Catherine, Vesin, Aurélien, Zahar, Jean-Ralph, Mira, Jean-Paul, Larrey, Dominique, Zarski, Jean-Pierre, Schir, Edith

المساهمون: CHU Clermont-Ferrand, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Université de Montpellier (UM), Centre Hospitalier Universitaire CHU Grenoble (CHUGA), AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hopital Saint-Louis AP-HP (AP-HP), Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 2328-8957.

مصطلحات موضوعية: (1, 3)-β-D-glucan, competing risk models, invasive candidiasis, [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology

الوصف: International audience ; Background. We aimed to assess the prognostic value of repeated measurements of serum (1-3)-β-D-glucan (BDG), mannanantigen (mannan-Ag), and antimannan antibodies (antimannan-Ab) for the occurrence of invasive candidiasis (IC) in a high-risk nonimmunocompromised population. Methods. This was a preplanned ancillary analysis of the EMPIRICUS Randomized Clinical Trial, including nonimmunocompromised critically ill patients with intensive care unit-acquired sepsis, multiple Candida colonization, and multiple organ failure who were exposed to broad-spectrum antibacterial agents. BDG (>80 and >250 pg/mL), mannan-Ag (>125 pg/ mL), and antimannan-Ab (>10 AU) were collected repeatedly. We used cause-specific hazard models. Biomarkers were assessed at baseline in the whole cohort (cohort 1). Baseline covariates and/or repeated measurements and/or increased biomarkers were then studied in the subgroup of patients who were still alive at day 3 and free of IC (cohort 2). Results. Two hundred thirty-four patients were included, and 215 were still alive and free of IC at day 3. IC developed in 27 patients (11.5%), and day 28 mortality was 29.1%. Finally, BDG >80 pg/mL at inclusion was associated with an increased risk of IC (CSHR[IC], 4.67; 95% CI, 1.61-13.5) but not death (CSHR[death], 1.20; 95% CI, 0.71-2.02). Conclusions. Among high-risk patients, a first measurement of BDG >80 pg/mL was strongly associated with the occurrence of IC. Neither a cutoff of 250 pg/mL nor repeated measurements of fungal biomarkers seemed to be useful to predict the occurrence of IC. The cumulative risk of IC in the placebo group if BDG >80 pg/mL was 25.39%, which calls into question the efficacy of empirical therapy in this subgroup.

العلاقة: hal-03190667; https://hal.science/hal-03190667Test; https://hal.science/hal-03190667/documentTest; https://hal.science/hal-03190667/file/2021%20Dupuis%20et%20al.,%20Open%20Forum%20Infect%20Dis.pdfTest

الإتاحة: https://doi.org/10.1093/ofid/ofab080Test
https://hal.science/hal-03190667Test
https://hal.science/hal-03190667/documentTest
https://hal.science/hal-03190667/file/2021%20Dupuis%20et%20al.,%20Open%20Forum%20Infect%20Dis.pdfTest

المؤلفون: Heming, Nicholas, Lamothe, Laure, Jaber, Samir, Trouillet, Jean Louis, Martin, Claude, Chevret, Sylvie, Annane, Djillali

المساهمون: Hôpital Européen Georges Pompidou APHP (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Hôpital Raymond Poincaré AP-HP, Laboratoire d'étude de la réponse neuroendocrine au sepsis (LARENES), Infection et inflammation (2I), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de cardiologie CHU Pitié-Salpêtrière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Étude des Structures, des Processus d’Adaptation et des Changements de l’Espace (ESPACE), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Avignon Université (AU)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA), Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Groupe de Recherche Clinique et Technologique sur le Handicap (GRCTH), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)

المصدر: ISSN: 0003-3022 ; Anesthesiology ; https://hal.umontpellier.fr/hal-01874469Test ; Anesthesiology, 2018, 129, pp.1149-1158. ⟨10.1097/ALN.0000000000002413⟩.

مصطلحات موضوعية: [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie

الوصف: International audience

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30212412; hal-01874469; https://hal.umontpellier.fr/hal-01874469Test; https://hal.umontpellier.fr/hal-01874469/documentTest; https://hal.umontpellier.fr/hal-01874469/file/2018%20Heming%20et%20al.,%20Morbidity%20and%20Mortality.pdfTest; PUBMED: 30212412

الإتاحة: https://doi.org/10.1097/ALN.0000000000002413Test
https://hal.umontpellier.fr/hal-01874469Test
https://hal.umontpellier.fr/hal-01874469/documentTest
https://hal.umontpellier.fr/hal-01874469/file/2018%20Heming%20et%20al.,%20Morbidity%20and%20Mortality.pdfTest

المؤلفون: Trouillet, Jean Louis, Collange, Olivier, Belafia, Fouad, Blot, François, Capellier, Gilles, Cesareo, Eric, Constantin, Jean-Michel, Demoule, Alexandre, Diehl, Jean-Luc, Guinot, Pierre-Grégoire, Jegoux, Franck, L’Her, Erwan, Luyt, Charles-Edouard, Mahjoub, Yazine, Mayaux, Julien, Quintard, Hervé, Ravat, François, Vergez, Sebastien, Amour, Julien, Guillot, Max

مصطلحات موضوعية: Review

الوصف: Tracheotomy is widely used in intensive care units, albeit with great disparities between medical teams in terms of frequency and modality. Indications and techniques are, however, associated with variable levels of evidence based on inhomogeneous or even contradictory literature. Our aim was to conduct a systematic analysis of the published data in order to provide guidelines. We present herein recommendations for the use of tracheotomy in adult critically ill patients developed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. These guidelines were conducted by a group of experts from the French Intensive Care Society (Société de Réanimation de Langue Française) and the French Society of Anesthesia and Intensive Care Medicine (Société Francaise d’Anesthésie Réanimation) with the participation of the French Emergency Medicine Association (Société Française de Médecine d’Urgence), the French Society of Otorhinolaryngology. Sixteen experts and two coordinators agreed to consider questions concerning tracheotomy and its practical implementation. Five topics were defined: indications and contraindications for tracheotomy in intensive care, tracheotomy techniques in intensive care, modalities of tracheotomy in intensive care, management of patients undergoing tracheotomy in intensive care, and decannulation in intensive care. The summary made by the experts and the application of GRADE methodology led to the drawing up of 8 formal guidelines, 10 recommendations, and 3 treatment protocols. Among the 8 formal guidelines, 2 have a high level of proof (Grade 1+/−) and 6 a low level of proof (Grade 2+/−). For the 10 recommendations, GRADE methodology was not applicable and instead 10 expert opinions were produced.

العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854567Test/; http://www.ncbi.nlm.nih.gov/pubmed/29546588Test; http://dx.doi.org/10.1186/s13613-018-0381-yTest

الإتاحة: https://doi.org/10.1186/s13613-018-0381-yTest
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854567Test/
http://www.ncbi.nlm.nih.gov/pubmed/29546588Test

المؤلفون: Trouillet, Jean-Louis, Collange, Olivier, Belafia, Fouad, Blot, François, Capellier, Gilles, Cesareo, Eric, Constantin, Jean-Michel, Demoule, Alexandre, Diehl, Jean-Luc, Guinot, Pierre-Grégoire, Jegoux, Franck, L’Her, Erwan, Luyt, Charles-Edouard, Mahjoub, Yazine, Mayaux, Julien, Quintard, Hervé, Ravat, François, Vergez, Sébastien, Amour, Julien, Guillot, Max, Quillot, Max

المصدر: Anaesthesia Critical Care & Pain Medicine ; volume 37, issue 3, page 281-294 ; ISSN 2352-5568

مصطلحات موضوعية: Anesthesiology and Pain Medicine, Critical Care and Intensive Care Medicine, General Medicine

الإتاحة: https://doi.org/10.1016/j.accpm.2018.02.012Test
https://api.elsevier.com/content/article/PII:S2352556818300651?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2352556818300651?httpAccept=text/plainTest

المؤلفون: Trouillet, Jean-Louis, Collange, Olivier, Belafia, Fouad, Blot, François, Capellier, Gilles, Cesareo, Eric, Constantin, Jean-Michel, Demoule, Alexandre, Diehl, Jean-Luc, Guinot, Pierre-Grégoire, Jegoux, Franck, L’Her, Erwan, Luyt, Charles-Edouard, Mahjoub, Yazine, Mayaux, Julien, Quintard, Hervé, Ravat, François, Vergez, Sébastien, Amour, Julien, Guillot, Max

المصدر: Anesthésie & Réanimation ; volume 4, issue 6, page 508-522 ; ISSN 2352-5800

مصطلحات موضوعية: Anesthesiology and Pain Medicine

الإتاحة: https://doi.org/10.1016/j.anrea.2018.08.003Test
https://api.elsevier.com/content/article/PII:S2352580018301412?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2352580018301412?httpAccept=text/plainTest

المؤلفون: Bretonnière, Cédric, Jozwiak, Mathieu, Girault, Christophe, Beuret, Pascal, Trouillet, Jean-Louis, Anguel, Nadia, Caillon, Jocelyne, Potel, Gilles, Villers, Daniel, Boutoille, David, Guitton, Christophe

مصطلحات موضوعية: Medicine, Microbiology, FOS Biological sciences, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Cancer, Science Policy

الوصف: Bacteria involved in 136 episodes of meningitis. Figure S2. Glasgow Outcome Scale scores for the groups of patients who did or did not receive rifampin for community-acquired meningitis. Figure S3. Glasgow Outcome Scale scores for the groups of patients who did or not receive early rifampin (within the first 24 h of hospitalization) or not for community-acquired meningitis. Table S1. Comparison of patient characteristics, severity at ICU admission, 9pt?>microbiological data, and therapeutic measures between survivors and non-survivors after ICU admission for pneumococcal meningitis (n=76). Table S2. Factors associated with ICU mortality for a cohort of 76 patients admitted for pneumococcal meningitis. (PDF 157 kb) ...

العلاقة: https://dx.doi.org/10.1186/s13054-015-1021-7Test

الإتاحة: https://doi.org/10.6084/m9.figshare.446784810.1186/s13054-015-1021-7Test
https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_Figure_S1_of_Rifampin_use_in_acute_community-acquired_meningitis_in_intensive_care_units_the_French_retrospective_cohort_ACAM-ICU_study/4467848Test

المؤلفون: Heming, Nicholas, Elatrous, Souheil, Jaber, Samir, Dumenil, Anne Sylvie, Cousson, Joel, Forceville, Xavier, Kimmoun, Antoine, Trouillet, Jean Louis, Fichet, Jerome, Anguel, Nadia, Darmon, Michael, Martin, Claude, Chevret, Sylvie, Annane, Djillali

المساهمون: Service médical des soins intensifs CHU Raymond Poincaré, Hôpital Raymond Poincaré AP-HP, Infection et inflammation (2I), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Monastir - University of Monastir (UM), Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Hôpital Antoine Béclère, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital universitaire Robert Debré Reims (CHU Reims), Centre Hospitalier de Meaux, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC), Centre cardiologique du Nord (CCN), Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Hôpital Nord CHU - APHM, Service de biostatistiques et information médicale Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris

المصدر: ISSN: 2044-6055 ; BMJ Open ; https://hal.sorbonne-universite.fr/hal-01700757Test ; BMJ Open, 2017, 7 (10), pp.e016736. ⟨10.1136/bmjopen-2017-016736⟩.

مصطلحات موضوعية: [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

الوصف: for the CRISTAL Investigators ; International audience ; Objective To compare the haemodynamic effect of crystalloids and colloids during acute severe hypovolaemic shock.Design Exploratory subgroup analysis of a multicentre randomised controlled trial (Colloids Versus Crystalloids for the Resuscitation of the Critically Ill, CRISTAL, ClinicalTrials.gov NCT00318942).Setting CRISTAL was conducted in intensive care units in Europe, North Africa and Canada.Participants Current analysis included all patients who had a pulmonary artery catheter in place at randomisation. 220 patients (117 received crystalloids vs 103 colloids) underwent pulmonary artery catheterisation.Intervention Crystalloids versus colloids for fluid resuscitation in hypovolaemic shock.Outcome measures Haemodynamic data were collected at the time of randomisation and subsequently on days 1, 2, 3, 4, 5, 6 and 7.Results Median cumulative volume of fluid administered during the first 7 days was higher in the crystalloids group than in the colloids group (3500 (2000–6000) vs 2500 (1000–4000) mL, p=0.01). Patients in the colloids arm exhibited a lower heart rate over time compared with those allocated to the crystalloids arm (p=0.014). There was no significant difference in Cardiac Index (p=0.053), mean blood pressure (p=0.4), arterial lactates (p=0.9) or global Sequential Organ Failure Assessment score (p=0.3) over time between arms.Conclusions During acute severe hypovolaemic shock, patients monitored by a pulmonary artery catheter achieved broadly similar haemodynamic outcomes, using lower volumes of colloids than crystalloids. The heart rate was lower in the colloids arm.

العلاقة: hal-01700757; https://hal.sorbonne-universite.fr/hal-01700757Test; https://hal.sorbonne-universite.fr/hal-01700757/documentTest; https://hal.sorbonne-universite.fr/hal-01700757/file/e016736.full.pdfTest

الإتاحة: https://doi.org/10.1136/bmjopen-2017-016736Test
https://hal.sorbonne-universite.fr/hal-01700757Test
https://hal.sorbonne-universite.fr/hal-01700757/documentTest
https://hal.sorbonne-universite.fr/hal-01700757/file/e016736.full.pdfTest

المؤلفون: Kamilia, Chtara, Regaieg, Kais, Baccouch, Najeh, Chelly, Hedi, Bahloul, Mabrouk, Bouaziz, Mounir, Jendoubi, Ali, Abbes, Ahmed, Belhaouane, Houda, Nasri, Oussama, Jenzri, Layla, Ghedira, Salma, Houissa, Mohamed, Belkadi, Kamal, Harti, Youness, Nsiri, Afak, Khaleq, Khalid, Hamoudi, Driss, Harrar, Rachid, Thieffry, Camille, Wallet, Frédéric, Parmentier-Decrucq, Erika, Favory, Raphaël, Mathieu, Daniel, Poissy, Julien, Lafon, Thomas, Vignon, Philippe, Begot, Emmanuelle, Appert, Alexandra, Hadj, Mathilde, Claverie, Paul, Matt, Morgan, Barraud, Olivier, François, Bruno, Jamoussi, Amira, Jazia, Amira Ben, Marhbène, Takoua, Lakhdhar, Dhouha, Khelil, Jalila Ben, Besbes, Mohamed, Goutay, Julien, Blazejewski, Caroline, Joly-Durand, Isabelle, Pirlet, Isabelle, Weillaert, Marie Pierre, Beague, Sebastien, Aziz, Soufi, Hafiane, Reda, Hattabi, Khalid, Bouhouri, Mohamed Aziz, Hammoudi, Driss, Fadil, Abdelaziz, Harrar, Rachid Al, Zerouali, Khalid, Medhioub, Fatma Kaaniche, Allela, Rania, Algia, Najla Ben, Cherif, Samar, Slaoui, Mohamed Taoufik, Boubia, Souhail, Hafiani, Y, Khaoudi, A, Cherkab, R, Elallam, W, Elkettani, C, Barrou, L, Ridaii, M, Mehdi, Rihi El, Schimpf, Caroline, Mizrahi, Assaf, Pilmis, Benoît, Le Monnier, Alban, Tiercelet, Kelly, Cherin, Mélanie, Bruel, Cédric, Philippart, Francois, Bailly, Sébastien, Lucet, Jc, Lepape, Alain, L'hériteau, François, Aupée, Martine, Bervas, Caroline, Boussat, Sandrine, Berger-Carbonne, Anne, Machut, Anaïs, Savey, Anne, Timsit, Jean-François, Razazi, Keyvan, Rosman, Jérémy, de Prost, Nicolas, Carteaux, Guillaume, Jansen, Chloe, Decousser, Jean Winoc, Brun-Buisson, Christian, Dessap, Armand Mekontso, M'rad, Aymen, Ouali, Zouhour, Barghouth, Manel, Kouatchet, Achille, Mahieu, Rafael, Weiss, Emmanuel, Schnell, David, Zahar, Jean-Ralph, Artiguenave, Margaux, Sophie, Paktoris-Papine, Espinasse, Florence, Sayed, Faten El, Dinh, Aurélien, Charron, Cyril, Geri, Guillaume, Vieillard-Baron, Antoine, Repessé, Xavier, Kallel, Hatem, Mayence, Claire, Houcke, Stéphanie, Guegueniat, Pascal, Hommel, Didier, Dhifaoui, Kaouther, Hajjej, Zied, Fatnassi, Amira, Sellami, Walid, Labbene, Iheb, Ferjani, Mustapha, Dachraoui, Fahmi, Nakkaa, Sabrine, M'ghirbi, Abdelwaheb, Adhieb, Ali, Braiek, Dhouha Ben, Hraiech, Kmar, Ousji, Ali, Ouanes, Islem, Zaineb, Hammouda, Abdallah, Saousen Ben, Ouanes-Besbes, Lamia, Abroug, Fekri, Klein, Simon, Miquet, Mattéo, Thouret, Jean-Marc, Peigne, Vincent, Daban, Jean-Louis, Boutonnet, Mathieu, Lenoir, Bernard, Merhbene, Takoua, Derreumaux, Celine, Seguin, Thierry, Conil, Jean-Marie, Kelway, Charlotte, Blasco, Valery, Nafati, Cyril, Harti, Karim, Reydellet, Laurent, Albanese, Jacques, Aicha, Narjess Ben, Meddeb, Khaoula, Khedher, Ahmed, Ayachi, Jihene, Fraj, Nesrine, Sma, Nesrine, Chouchene, Imed, Boussarsar, Mohamed, Yedder, Soumaya Ben, Samoud, Walid, Radhouene, Bousselmi, Mariem, Bousselmi, Ammar, Asma, Cheikh, Asma Ben, Lakhal, Hend Ben, Khelfa, Messaouda, Hamdaoui, Yamina, Bouafia, Nabiha, Trampont, Timothée, Daix, Thomas, Legarçon, Vincent, Karam, Henri Hani, Pichon, Nicolas, Essafi, Fatma, Foudhaili, Nasreddine, Thabet, Hafedh, Blel, Youssef, Brahmi, Nozha, Ezzouine, Hanane, Kerrous, Mahmoud, Haoui, Saad El, Ahdil, Soufiane, Benslama, Abdellatif, Abidi, Khalid, Dendane, Tarek, Oussama, Ssouni, Belayachi, Jihane, Madani, Naoufal, Abouqal, Redouane, Zeggwagh, Amine Ali, Ghadhoune, Hatem, Chaari, Anis, Jihene, Guissouma, Allouche, Hend, Trabelsi, Insaf, Brahmi, Habib, Samet, Mohamed, Ghord, Hatem El, Habiba, Ben Sik Ali, Hajer, Nouira, Tilouch, Najla, Yaakoubi, Sondes, Jaoued, Oussama, Gharbi, Rim, Hassen, Mohamed Fekih, Elatrous, Souheil, Arcizet, Julien, Leroy, Bertrand, Abdulmalack, Caroline, Renzullo, Catherine, Hamet, Maël, Doise, Jean-Marc, Coutet, Jérôme, Cheikh, Chaigar Mohammed, Quechar, Zakaria, Joris, Magalie, Beauport, Dimitri Titeca, Kontar, Loay, Lebon, Delphine, Gruson, Bérengère, Slama, Michel, Marolleau, Jean-Pierre, Maizel, Julien, Gorham, Julie, Ameye, Lieveke, 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Jérôme, Deho, Anna, Dauger, Stéphane, Sauthier, Michaël, Bergeron-Gallant, Krystale, Emeriaud, Guillaume, Jouvet, Philippe, Tiebergien, Nicolas, Jacquet-Lagrèze, Matthias, Fellahi, Jean-Luc, Baudin, Florent, Essouri, Sandrine, Javouhey, Etienne, Guérin, Claude, Lampin, Marie, Mamouri, Ouardia, Devos, Patrick, Karaca-Altintas, Yasemin, Vinchon, Matthieu, Brossier, David, Eltaani, Redha, Teyssedre, Sonia, Sabine, Meyet, Bouchut, Jean-Christophe, Peguet, Olivier, Petitdemange, Lucie, Guilbert, Anne Sophie, Aoul, Nabil Tabet, Addou, Zakaria, Aouffen, Nabil, Anas, Benqqa, Kalouch, Samira, Yaqini, Khalid, Chlilek, Aziz, Abdou, Rchi, Gravellier, Perrine, Chantreuil, Julie, Travers, Nadine, Listrat, Antoine, Le Reun, Claire, Favrais, Geraldine, Coppere, Zoe, Blanot, Stéphane, Montmayeur, Juliette, Bronchard, Régis, Rolando, Stephane, Orliaguet, Gilles, Leger, Pierre-Louis, Rambaud, Jérôme, Thueux, Emilie, De Larrard, Alexandra, Berthelot, Véronique, Denot, Julien, Reymond, Marie, Amblard, Alain, Morin-Zorman, Sarah, Lengliné, Etienne, Pichereau, Claire, Mariotte, Eric, Emmanuel, Canet, Poujade, Julien, Trumpff, Guillaume, Janssen-Langenstein, Ralf, Harlay, Marie-Line, Zaid, Noorah, Ait-Ammar, Nawel, Bonnal, Christine, Merle, Jean-Claude, Botterel, Francoise, Levesque, Eric, Riad, Zakaria, Mezidi, Mehdi, Yonis, Hodane, Aublanc, Mylène, Perinel-Ragey, Sophie, Lissonde, Floriane, Louf-Durier, Aurore, Tapponnier, Romain, Louis, Bruno, Forel, Jean-Marie, Bisbal, Magali, Lehingue, Samuel, Rambaud, Romain, Adda, Mélanie, Hraiech, Sami, Marchi, Elisa, Roch, Antoine, Guerin, Vincent, Rozencwajg, Sacha, Schmidt, Matthieu, Hekimian, Guillaume, Bréchot, Nicolas, Trouillet, Jean Louis, Besset, Sébastien, Franchineau, Guillaume, Nieszkowska, Ania, Pascal, Leprince, Loiselle, Maud, Sarah, Chemam, Laurence, Dangers, Guillemette, Thomas, Jacquens, Alice, Kerever, Sebastien, Guidet, Bertrand, Aegerter, Philippe, Das, Vincent, Fartoukh, Muriel, Hayon, Jan, Desmard, Mathieu, Fulgencio, Jean-Pierre, Zuber, Benjamin, Soufi, A, Khaleq, K, Hamoudi, D, Garret, Charlotte, Peron, Matthieu, Coron, Emmanuel, Bretonnière, Cédric, Audureau, Etienne, Audrey, Winters, Christophe, Duvoux, Christian, Jacquelinet, Daniel, Azoulay, Cyrille, Feray, Aissaoui, Wissal, Rghioui, Kawtar, Haddad, Wafae, Barrou, Houcine, Carteaux-Taeib, Anna, Lupinacci, Renato, Manceau, Gilles, Jeune, Florence, Tresallet, Christophe, Habacha, Sahar, Fathallah, Ines, Zoubli, Aymen, Aloui, Rafaa, Kouraichi, Nadia, Jouet, Emilie, Badin, Julie, Fermier, Brice, Feller, Marc, Serie, Mathieu, Pillot, Jérôme, Marie, William, Gisbert-Mora, Chloé, Vinclair, Camille, Lesbordes, Pierre, Mathieu, Pascal, De Brabant, Fabienne, Muller, Emmanuel, Robaux, Marie-Aline, Giabicani, Mikhael, Marchalot, Antoine, Gelinotte, Stéphanie, Declercq, Pierre Louis, Eraldi, Jean-Pierre, Bougerol, François, Meunier-Beillard, Nicolas, Devilliers, Hervé, Rigaud, Jean-Philippe, Verrière, Camille, Ardisson, Fanny, Kentish-Barnes, Nancy, Jacq, Gwenaëlle, Chermak, Akli, Lautrette, Alexandre, Legrand, Matthieu, Soummer, Alexis, Thiery, Guillaume, Cottereau, Alice, Canet, Emmanuel, Caujolle, Marie, Allyn, Jérôme, Valance, Dorothée, Brulliard, Caroline, Martinet, Olivier, Jabot, Julien, Gallas, Thomas, Vandroux, David, Allou, Nicolas, Durand, Arthur, Nevière, Rémi, Delguste, Florian, Boulanger, Eric, Preau, Sebastien, Martin, Ruste, Cochet, Hélène, Ponthus, Jean Pierre, Amilien, Virginie, Tchir, Martial, Barsam, Elise, Ayoub, Mohsen, Georger, Jean Francois, Guillame, Izaute, Assaraf, Julie, Tripon, Simona, Mallet, Maxime, Barbara, Guilaume, Louis, Guillaume, Gaudry, Stéphane, Barbarot, Nicolas, Jamet, Angéline, Outin, Hervé, Gibot, Sébastien, Bollaert, Pierre-Edouard, Holleville, Mathilde, Legriel, Stéphane, Chateauneuf, Anne Laure, Cavelot, Sébastien, Moyer, Jean-Denis, Bedos, Jean Pierre, Merle, Philippe, Laine, Aurelie, Natalie, De Sa, Cornuault, Mathieu, Libot, Jérome, Asehnoune, Karim, Rozec, Bertrand, Dantal, Jacques, Videcoq, Michel, Degroote, Thècle, Jaillette, Emmanuelle, Zerimech, Farid, Malika, Balduyck, Llitjos, Jean-François, Amara, Marlène, Lacave, Guillaume, Pangon, Béatrice, Mavinga, José, Makunza, Joseph Nsiala, Mafuta, M E, Yanga, Yves, Eric, Amisi, Ilunga, Jp, Kilembe, Ma, Alby-Laurent, Fanny, Toubiana, Julie, Mokline, Amel, Laajili, Achraf, Amri, Helmi, Rahmani, Imene, Mensi, Nidhal, Gharsallah, Lazheri, Tlaili, Sofiene, Gasri, Bahija, Hammouda, Rym, Messadi, Amen Allah, Allain, Pierre-Antoine, Gault, Nathallie, Paugam-Burtz, Catherine, Foucrier, Arnaud, Chatbri, Bassem, Bourbiaa, Yousra, Thabet, Lamia, Neuschwander, Arthur, Vincent, Looten, Beck, Jennifer, Vibol, Chhor, Amelie, Yavchitz, Resche-Rigon, Matthieu, Pirracchio, Jean MantzRomain, Bureau, Côme, Decavèle, Maxens, Campion, Sébastien, Ainsouya, Roukia, Niérat, Marie-Cécile, Prodanovic, Hélène, Raux, Mathieu, Similowski, Thomas, Dubé, Bruno-Pierre, Demiri, Suela, Dres, Martin, May, Faten, Quintard, Hervé, Kounis, Ilias, Saliba, Faouzi, André, Stephane, Boudon, Marc, Ichai, Philippe, Younes, Aline, Nakad, Lionel, Coilly, Audrey, Antonini, Teresa, Sobesky, Rodolphe, De Martin, Eleonora, Samuel, Didier, Hubert, Noemie, Nay, Mai-Anh, Auchabie, Johann, Giraudeau, Bruno, Jean, Reignier, Darmon, Michaël, Ruckly, Stephane, Garrouste-Orgeas, Maïté, Gratia, Elisabeth, Goldgran-Toledano, Dany, Jamali, Samir, Dumenil, Anne Sylvie, Schwebel, Carole, Brisard, Laurent, Bizouarn, Philippe, Lepoivre, Thierry, Nicolet, Johanna, Rigal, Jean Christophe, Roussel, Jean Christian, Cheurfa, Cherifa, Abily, Julien, Lescot, Thomas, Page, Isaline, Warnier, Stéphanie, Nys, Monique, Rousseau, Anne-Françoise, Damas, Pierre, Uhel, Fabrice, Lesouhaitier, Mathieu, Grégoire, Murielle, Gaudriot, Baptiste, Gacouin, Arnaud, Le Tulzo, Yves, Flecher, Erwan, Tarte, Karin, Tadié, Jean-Marc, Georges, Quentin, Soares, M, Jeon, Kyeongman, Oeyen, Sandra, Rhee, Chin Kook, Gruber, Pascale, Ostermann, Marlies, Hill, Quentin, Depuydt, Peter, Ferra, Christelle, Muller, Alice, Aurelie, Bourmaud, Niles, Christopher, Herbert, Fabien, Pied, Sylviane, Loridant, Séverine, François, Nadine, Bignon, Anne, Sendid, Boualem, Lemaitre, Caroline, Dupre, Celine, Zayene, Aymen, Portier, Lucie, De Freitas Caires, Nathalie, Lassalle, Philippe, Le Neindre, Aymeric, Selot, Pascal, Ferreiro, Daniel, Bonarek, Maria, Henriot, Stépahen, Rodriguez, Julie, Taddei, Mara, Di Bari, Mauro, Hickmann, Cheryl, Castanares Zapatero, Diego, Deldicque, Louise, Van Den Bergh, Peter, Caty, Gilles, Roeseler, Jean, Francaux, Marc, Laterre, Pierre-François, Dupuis, Bastien, Machayeckhi, Sharam, Sarfati, Celine, Moore, Alex, Mendialdua, Paula, Rodet, Emilie, Pilorge, Catherine, Stephan, Francois, Rezaiguia-Delclaux, Saida, Dugernier, Jonathan, Hesse, Michel, Jumetz, Thibaud, Bialais, Emilie, Depoortere, Virginie, Michotte, Jean Bernard, Wittebole, Xavier, Jamar, François

المساهمون: UCL - (SLuc) Service de médecine physique et de réadaptation motrice

المصدر: Annal Intensive Care, Vol. 7, no.S1, p. 105-207 (2017)

العلاقة: boreal:182725; http://hdl.handle.net/2078.1/182725Test; info:pmid/28074416; urn:ISSN:2110-5820

الإتاحة: https://doi.org/10.1186/s13613-016-0224-7Test
http://hdl.handle.net/2078.1/182725Test

المؤلفون: Jullien, Vincent, Azoulay, Elie, Schwebel, Carole, Le Saux, Thomas, Charles, Pierre Emmanuel, Cornet, Muriel, Souweine, Bertrand, Klouche, Kadda, Jaber, Samir, Trouillet, Jean-Louis, Bruneel, Fabrice, Cour, Martin, Cousson, Joel, Meziani, Ferhat, Gruson, Didier, Paris, Adeline, Darmon, Michael, Garrouste-Orgeas, Maité, Navellou, Jean-Christophe, Foucrier, Arnaud, Allaouchiche, Bernard, Das, Vincent, Gangneux, Jean-Pierre, Ruckly, Stéphane, Wolff, Michel, Timsit, Jean-François

المساهمون: Génétique, pharmacologie et physiopathologie des maladies cardiovasculaires CHU Pitié-Salpétriêre, Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hopital Saint-Louis AP-HP (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Réanimation Médicale Grenoble, Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Hôpital Michallon, Département de Chimie - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL), Université Pierre et Marie Curie - Paris 6 (UPMC), Service de Réanimation Médicale (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Thérapeutique Recombinante Expérimentale (TIMC-IMAG-TheREx), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 )-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 ), Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS), Département d'anesthésie-réanimation Montpellier, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Hôpital Gui de Chauliac CHU Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de réanimation CH Versailles, Centre Hospitalier de Versailles André Mignot (CHV), Centre Hospitalier Lyon Sud CHU - HCL (CHLS), Hospices Civils de Lyon (HCL), Hôpital universitaire Robert Debré Reims, Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS), CHU Bordeaux, Centre Hospitalier Universitaire CHU Grenoble (CHUGA), Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E), Epidémiologie pronostique des cancers et affections graves, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Réanimation médicale CHRU Besançon, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Service de réanimation médicale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Space Science Institute Boulder (SSI), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Grenoble 1/Albert Michallon university hospital, Astellas company

المصدر: ISSN: 0305-7453.

مصطلحات موضوعية: Critically-ill patients, Intensive care unit, Healthy volunteers, Adult patients, Plasma, Echinocandins, Pharmacodynamics, Caspofungin, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology

الوصف: International audience ; Objectives: To identify the factors associated with the interindividual pharmacokinetic (PK) variability of micafungin and to evaluate the probability of reaching the previously determined PK/pharmacodynamic efficacy thresholds (AUC/MIC >5000 for non-parapsilosis Candida sp. and ≥285 for Candida parapsilosis) with the recommended 100 mg daily dose in ICU patients with sepsis and mechanical ventilation.Methods: One hundred patients were included and 436 concentrations were available for PK analysis performed with NONMEM software. PTA was determined by Monte Carlo simulations.Results: Micafungin obeyed a two-compartment model with first-order elimination from the central compartment. Mean parameter estimates (percentage interindividual variability) were 1.34 L/h (34%) for clearance (CL), 11.80 L (38%) and 7.68 L (39%) for central (Vc) and peripheral (Vp) distribution volumes, respectively, and 4.67 L/h (37%) for distribution clearance. CL, Vc and Vp increased by 14% when the albumin level was ≤25 g/L and CL decreased by 25% when SOFA score was ≥10. Body weight was related to CL, Vc and Vp by allometric models. PTA was ≥90% in Candida albicans and Candida glabrata infections, except when the MIC was ≥0.015 mg/L, and ranged between 0% and 40% for C. parapsilosis infections with MIC ≥0.5 mg/L.Conclusions: A possible increase in the dose should be evaluated for infections due to C. parapsilosis and for infections due to C. albicans and C. glabrata with MICs ≥0.015 mg/L.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27609051; hal-01470808; https://hal.science/hal-01470808Test; https://hal.science/hal-01470808/documentTest; https://hal.science/hal-01470808/file/2017%20Julien%20et%20al.,%20Population%20pharmacokinetics.pdfTest; PUBMED: 27609051; WOS: WOS:000394038700023

الإتاحة: https://doi.org/10.1093/jac/dkw352Test
https://hal.science/hal-01470808Test
https://hal.science/hal-01470808/documentTest
https://hal.science/hal-01470808/file/2017%20Julien%20et%20al.,%20Population%20pharmacokinetics.pdfTest