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81Removal of acidic residues of the prodomain of PCSK9 increases its activity towards the LDL receptor
المؤلفون: Øystein L. Holla, Trond P. Leren, Knut Erik Berge, Thea Bismo Strøm, Jon K. Laerdahl, Jamie Cameron, Kristian Tveten
المصدر: Biochemical and Biophysical Research Communications. 406:234-238
مصطلحات موضوعية: Molecular Sequence Data, Biophysics, Peptide, Biochemistry, Cell Line, Protein structure, Animals, Humans, Amino Acid Sequence, Molecular Biology, Peptide sequence, Conserved Sequence, Sequence Deletion, chemistry.chemical_classification, Serine Endopeptidases, Subtilisin, Cell Biology, Proprotein convertase, Protein Structure, Tertiary, Amino acid, Amino Acid Substitution, Receptors, LDL, chemistry, LDL receptor, Kexin, Proprotein Convertases, Proprotein Convertase 9
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f971a8d8de687c7b169e6d3f6a7374bdTest
https://doi.org/10.1016/j.bbrc.2011.02.023Test -
82
المؤلفون: Trond P. Leren, Morten Reier-Nilsen, Erik H. Strøm, Christina Dörje, Ståle Sund
المصدر: Ultrastructural Pathology. 35:139-145
مصطلحات موضوعية: Male, Heterozygote, medicine.medical_specialty, Kidney Glomerulus, Sterol O-acyltransferase, Biology, Kidney, Compound heterozygosity, Pathology and Forensic Medicine, Young Adult, Lecithin Cholesterol Acyltransferase Deficiency, Recurrence, Structural Biology, Internal medicine, medicine, Humans, Lecithin cholesterol acyltransferase deficiency, Proteinuria, medicine.diagnostic_test, medicine.disease, Kidney Transplantation, Transplantation, medicine.anatomical_structure, Endocrinology, Mutation, Female, Kidney Diseases, Renal biopsy, medicine.symptom, Nephrotic syndrome
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d85699970961a95262b810a5b0d324dTest
https://doi.org/10.3109/01913123.2010.551578Test -
83
المؤلفون: Trond P. Leren, Knut Erik Berge
المصدر: Clinica Chimica Acta. 411:2019-2023
مصطلحات موضوعية: Adult, Male, Heterozygote, medicine.medical_specialty, Candidate gene, Apolipoprotein B, DNA Mutational Analysis, Clinical Biochemistry, Mutation, Missense, Myocardial Ischemia, Blood lipids, Single-nucleotide polymorphism, Biochemistry, White People, chemistry.chemical_compound, High-density lipoprotein, Internal medicine, medicine, ABCA1 Gene, Humans, Genetics, Apolipoprotein A-I, biology, Norway, Cholesterol, Cholesterol, HDL, Biochemistry (medical), nutritional and metabolic diseases, General Medicine, Pedigree, Endocrinology, chemistry, Codon, Nonsense, ABCA1, Mutation, biology.protein, ATP-Binding Cassette Transporters, Female, lipids (amino acids, peptides, and proteins), RNA Splice Sites, ATP Binding Cassette Transporter 1
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f733bc22e9260659e05010020a591b4Test
https://doi.org/10.1016/j.cca.2010.08.027Test -
84
المؤلفون: Per Morten Fredriksen, Trond P. Leren, Thomas Möller, Henrik Holmstrøm, Kristin Eiklid, Erik Thaulow
المصدر: Scandinavian Cardiovascular Journal. 44:331-336
مصطلحات موضوعية: Adult, Heart Septal Defects, Ventricular, Male, medicine.medical_specialty, Adolescent, Activin Receptors, Type II, Hypertension, Pulmonary, Population, Receptors, Cell Surface, Bone Morphogenetic Protein Receptors, Type II, Bone morphogenetic protein, Risk Assessment, Heart Septal Defects, Atrial, Ventricular Function, Left, Young Adult, Antigens, CD, Transforming Growth Factor beta, Internal medicine, medicine, Humans, Bone morphogenetic protein receptor, education, Exercise, Heart septal defect, education.field_of_study, Base Sequence, business.industry, Endoglin, Ultrasonography, Doppler, medicine.disease, Pulmonary hypertension, BMPR2, Mutation, Ventricular Function, Right, Ventricular pressure, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f035941a883a82affb1f592e5962f52aTest
https://doi.org/10.3109/14017431.2010.525747Test -
85
المصدر: Journal of Human Genetics. 55:676-680
مصطلحات موضوعية: Male, Hypercholesterolemia, Familial hypercholesterolemia, Biology, medicine.disease_cause, Hyperlipoproteinemia Type II, Exon, Genetics, medicine, Humans, RNA, Messenger, Receptor, Genetics (clinical), Messenger RNA, Mutation, Intron, nutritional and metabolic diseases, RNA, Exons, medicine.disease, Molecular biology, Introns, Pedigree, Receptors, LDL, LDL receptor, Female, lipids (amino acids, peptides, and proteins), RNA Splice Sites
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93dc08ce0801423d73e306b86f370ac3Test
https://doi.org/10.1038/jhg.2010.87Test -
86
المؤلفون: Geir Siem, Sten Harris, Toril Fagerheim, Christoffer Jonsrud, Erik Teig, Ketil Heimdal, Andreas Früh, Claude Laurent, Trond P. Leren
المصدر: International Journal of Audiology. 49:596-605
مصطلحات موضوعية: Male, Proband, Linguistics and Language, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Genetic counseling, DNA Mutational Analysis, Norwegian, Audiology, DNA, Mitochondrial, Severity of Illness Index, Connexins, Language and Linguistics, Young Adult, Speech and Hearing, Cochlear implant, Prevalence, otorhinolaryngologic diseases, medicine, Humans, Profound hearing impairment, Child, Hearing Loss, Cochlear implantation, biology, Norway, business.industry, Infant, language.human_language, Connexin 26, Cochlear Implants, Otorhinolaryngology, Child, Preschool, Mutation, language, biology.protein, Female, business, GJB6
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fa940979cfabca1c260f3bec6e7d6bTest
https://doi.org/10.3109/14992021003743269Test -
87
المؤلفون: Trond P. Leren, Dan Atar, Martin P. Bogsrud, Linn Kristin Lie Øyri, Kirsten B. Holven, Sigrun Halvorsen
المصدر: Journal of the American College of Cardiology. 71:A187
مصطلحات موضوعية: medicine.medical_specialty, business.industry, First myocardial infarction, Mean age, Early death, Norwegian, Disease, Familial hypercholesterolemia, medicine.disease, language.human_language, Increased risk, Internal medicine, language, medicine, Cardiology, lipids (amino acids, peptides, and proteins), Myocardial infarction, Cardiology and Cardiovascular Medicine, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1b8774f638326241c0118c1caa93e4d0Test
https://doi.org/10.1016/s0735-1097Test(18)30728-9 -
88
المصدر: Molecular Genetics and Metabolism. 99:149-156
مصطلحات موضوعية: Low-density lipoprotein receptor gene family, Endosome, Endocrinology, Diabetes and Metabolism, Molecular Sequence Data, Transferrin receptor, CHO Cells, Biology, Transfection, Biochemistry, Cricetulus, Endocrinology, Cricetinae, Receptors, Transferrin, Genetics, Animals, Humans, Amino Acid Sequence, cardiovascular diseases, Receptor, Molecular Biology, Enzyme Assays, Protein Stability, Chinese hamster ovary cell, Cell Membrane, Serine Endopeptidases, food and beverages, nutritional and metabolic diseases, Proprotein convertase, Molecular biology, Endocytosis, Recombinant Proteins, Protein Structure, Tertiary, Protein Transport, Transmembrane domain, Receptors, LDL, LDL receptor, Mutant Proteins, lipids (amino acids, peptides, and proteins), Proprotein Convertases, Proprotein Convertase 9, Protein Processing, Post-Translational
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c50cc3d8d8f9e9f4aac16e55a39056eTest
https://doi.org/10.1016/j.ymgme.2009.09.012Test -
89
المؤلفون: Kristina H. Haugaa, Trond P. Leren, Thor Edvardsen, Jan P. Amlie, Ida S. Leren, Ole-Gunnar Anfinsen, Knut Erik Berge, Erik Kongsgård
المصدر: Tidsskrift for Den norske legeforening. 130:139-142
مصطلحات موضوعية: Tachycardia, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, General Medicine, Disease, Catecholaminergic polymorphic ventricular tachycardia, medicine.disease, Implantable cardioverter-defibrillator, Ryanodine receptor 2, Internal medicine, Cardiology, Medicine, Differential diagnosis, medicine.symptom, business, Electrocardiography, Genetic testing
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4912cb161eadf0e8e1dbb387912f6e31Test
https://doi.org/10.4045/tidsskr.09.0529Test -
90
المؤلفون: Jannicke Igland, Grethe S. Tell, Kjetil Retterstøl, Kirsten B. Holven, Marit Braglien Veierød, Liv Mundal, Trond P. Leren
المصدر: Atherosclerosis. 263:e26
مصطلحات موضوعية: medicine.medical_specialty, business.industry, 030503 health policy & services, Incidence (epidemiology), Atherosclerotic disease, Familial hypercholesterolemia, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Medicine, In patient, 030212 general & internal medicine, 0305 other medical science, Cardiology and Cardiovascular Medicine, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::22be3c6389d0bf65dfafd24bbdeffe75Test
https://doi.org/10.1016/j.atherosclerosis.2017.06.106Test