المؤلفون: Julia H. Littell, Sarah Young, Therese D. Pigott, M. Antonia Biggs, Trine Munk‐Olsen, Julia R. Steinberg

المصدر: Campbell Systematic Reviews, Vol 20, Iss 2, Pp n/a-n/a (2024)

مصطلحات موضوعية: abortion, mental health, meta‐analysis, systematic review, Social Sciences

الوصف: Abstract This is a protocol for a systematic review and meta‐analysis of research on mental health outcomes of abortion. Does abortion increase the risk of adverse mental health outcomes? That is the central question for this review. Our review aims to inform policy and practice by locating, critically appraising, and synthesizing empirical evidence on associations between abortion and subsequent mental health outcomes. Given the controversies surrounding this topic and the complex social, political, legal, and ideological contexts in which research and reviews on abortion are conducted, it is especially important to conduct this systematic review and meta‐analysis with comprehensive, rigorous, unbiased, and transparent methods. We will include a variety of study designs to enhance understanding of studies' methodological strengths and weaknesses and to identify potential explanations for conflicting results. We will follow open science principles, providing access to our methods, measures, and results, and making data available for re‐analysis.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1891-1803Test

الوصول الحر: https://doaj.org/article/d52c5a60649346868a563eca0e9474deTest

المؤلفون: Trine Munk-Olsen, Arianna Di Florio, Kathrine B. Madsen, Clara Albiñana, Merete L. Mægbæk, Veerle Bergink, Vibe G. Frøkjær, Esben Agerbo, Bjarni J. Vilhjálmsson, Thomas Werge, Merete Nordentoft, David M. Hougaard, Anders D. Børglum, Ole Mors, Preben Bo Mortensen, Xiaoqin Liu

المصدر: Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Abstract It remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disorders differ between PPD cases and MDD cases in a nested case-control study of 50,057 women born from 1981 to 1997 in the iPSYCH2015 sample in Demark. We identified 333 women with first-onset postpartum depression (PPD group), who were matched with 993 women with first-onset depression diagnosed outside of postpartum (MDD group), and 999 female population controls. Data on genetics and depressive disorders were retrieved from neonatal biobanks and the Psychiatric Central Research Register. PGSs were calculated from both individual-level genetic data and meta-analysis summary statistics from the Psychiatric Genomics Consortium. Conditional logistic regression was used to calculate the odds ratio (OR), accounting for the selection-related reproductive behavior. After adjustment for covariates, higher PGSs for severe mental disorders were associated with increased ORs of both PPD and MDD. Compared with MDD cases, MDD PGS and attention-deficit/hyperactivity disorder PGS were marginally but not statistically higher for PPD cases, with the OR of PPD versus MDD being 1.12 (95% CI: 0 .97–1.29) and 1.11 (0.97–1.27) per-standard deviation increase, respectively. The ORs of PPD versus MDD did not statistically differ by PGSs of bipolar disorder, schizophrenia, or autism spectrum disorder. Our findings suggest that relying on PGS data, there was no clear evidence of distinct genetic make-up of women with depression occurring during or outside postpartum, after taking the selection-related reproductive behavior into account.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2158-3188Test

الوصول الحر: https://doaj.org/article/55dd8d9090d14f2ea460f664133aba97Test

المؤلفون: Nhung T. H. Trinh, Birgitte Dige Semark, Trine Munk-Olsen, Xiaoqin Liu, Suraj Bahadur Thapa, Zeynep Yilmaz, Liselotte Vogdrup Petersen, Angela Lupattelli

المصدر: Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Abstract The association between antidepressant continuation during pregnancy and postpartum mental health in women with obsessive-compulsive disorder (OCD) is uncertain. We identified 1317 women with live-birth singleton pregnancies and having outpatient/inpatient visits for OCD in the 4 years pre-pregnancy from the Danish registries. We defined three groups based on antidepressant prescriptions filled in the 2 years before pregnancy to delivery: (i) unexposed (n = 449); (ii) discontinuers (n = 346), i.e., with pre-pregnancy antidepressant fills only; (iii) continuers (n = 522), i.e., with antidepressant fills before and during pregnancy. We estimated crude and propensity score weighted hazard ratio (HRs) of postpartum visit for OCD and mood/anxiety disorders using Cox proportional hazard models. In weighted analyses, we found no difference in the probability of a postpartum visit for OCD or MADs with antidepressant continuation compared to unexposed and discontinuers. The likelihood of a postpartum OCD visit was higher in pregnancies having only one prescription fill during pregnancy compared to unexposed (HR = 3.44, 95% CI: 1.24, 9.54) or discontinuers (HR = 2.49, 95% CI: 0.91, 6.83). Continuers in pregnancy without antidepressant fill in the first three months postpartum had higher probability for postpartum visit for mood/anxiety disorders compared to discontinuers (HR = 3.84, 95% CI: 1.49, 9.92). Among pregnant women with pre-existing OCD, we found similar probabilities of a postpartum visit for OCD or mood/anxiety disorders in antidepressant continuers compared to unexposed and discontinuers. Continuers with a single prescription fill during pregnancy or no fill postpartum may have higher risks for these outcomes. Our findings highlight the importance of continuity of treatment throughout the perinatal period.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2158-3188Test

الوصول الحر: https://doaj.org/article/49c5b89acd0a401aa9f1639c9c51b28bTest

المؤلفون: Xiaoqin Liu, Esben Agerbo, Trine Munk-Olsen, Arianna Di Florio, Veerle Bergink, Kathrine Bang Madsen, Liselotte Vogdrup Petersen

المصدر: BMJ Mental Health, Vol 26, Iss 1 (2023)

مصطلحات موضوعية: Psychiatry, RC435-571

وصف الملف: electronic resource

العلاقة: https://ebmh.bmj.com/content/26/1/e300835.fullTest; https://doaj.org/toc/2755-9734Test

الوصول الحر: https://doaj.org/article/f6b179c60d8d41bf94d83310bc8665beTest

المؤلفون: Trine Munk-Olsen, Xiaoqin Liu, Kathrine Bang Madsen, Mette-Marie Zacher Kjeldsen, Liselotte Vogdrup Petersen, Veerle Bergink, Alkistis Skalkidou, Simone N. Vigod, Vibe G. Frokjaer, Carsten B. Pedersen, Merete L. Maegbaek

المصدر: Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Abstract Postpartum depression (PPD) is a serious condition associated with potentially tragic outcomes, and in an ideal world PPDs should be prevented. Risk prediction models have been developed in psychiatry estimating an individual’s probability of developing a specific condition, and recently a few models have also emerged within the field of PPD research, although none are implemented in clinical care. For the present study we aimed to develop and validate a prediction model to assess individualized risk of PPD and provide a tentative template for individualized risk calculation offering opportunities for additional external validation of this tool. Danish population registers served as our data sources and PPD was defined as recorded contact to a psychiatric treatment facility (ICD-10 code DF32-33) or redeemed antidepressant prescriptions (ATC code N06A), resulting in a sample of 6,402 PPD cases (development sample) and 2,379 (validation sample). Candidate predictors covered background information including cohabitating status, age, education, and previous psychiatric episodes in index mother (Core model), additional variables related to pregnancy and childbirth (Extended model), and further health information about the mother and her family (Extended+ model). Results indicated our recalibrated Extended model with 14 variables achieved highest performance with satisfying calibration and discrimination. Previous psychiatric history, maternal age, low education, and hyperemesis gravidarum were the most important predictors. Moving forward, external validation of the model represents the next step, while considering who will benefit from preventive PPD interventions, as well as considering potential consequences from false positive and negative test results, defined through different threshold values.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2158-3188Test

الوصول الحر: https://doaj.org/article/c67d5014762c4458b8e1e980fd3f503aTest

المؤلفون: Mette-Marie Zacher Kjeldsen, Alessio Bricca, Xiaoqin Liu, Vibe G. Frokjaer, Kathrine Bang Madsen, Trine Munk-Olsen

المصدر: Systematic Reviews, Vol 11, Iss 1, Pp 1-7 (2022)

مصطلحات موضوعية: Postpartum depression, Postnatal depression, Family psychiatry, Psychiatric family history, Familial risk, Risk factor, Medicine

الوصف: Abstract Background Postpartum depression (PPD) is the most common postpartum psychiatric disorder, affecting 11–15% of new mothers, and initiatives towards early identification and treatment are essential due to detrimental consequences. Family history of psychiatric disorders is a risk factor for developing psychiatric episodes outside the postpartum period, but evidence of the association between familial risk and PPD is not clear. Hence, the objective of this systematic review is to summarize the current literature on the association between family history of psychiatric disorders and PPD. Methods This protocol has been developed and reported according to the PRISMA-P guidelines for systematic reviews. A comprehensive literature search will be conducted in PubMed, Embase, and PsycINFO from inception of the databases, supplemented with citation tracking and reference screening of the included studies. Two independent authors will examine all retrieved articles for inclusion in two steps: title/abstract screening and full-text screening. Eligible studies are case-control and cohort studies reporting a risk estimate for the association between family history of psychiatric disorders and PPD. Studies will be assessed for risk of bias using the Newcastle-Ottawa Scale. The association between family psychiatry and PPD will be combined in a meta-analysis using a restricted maximum likelihood method (REML). Heterogeneity will be quantified using I2 and investigated through meta-regression, subgroup and sensitivity analyses, and publication bias will be evaluated via visual inspection of a funnel plot. The overall strength and quality of the findings will be evaluated using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. If meta-analysis is not possible, data will be synthesized narratively in text and tables. Discussion This systematic review will be the first to summarize current knowledge and present an overall estimate for the association between family history of psychiatric disorders and PPD. Evaluation of psychiatric family history as a PPD risk factor is essential to assist early identification of women at high risk of PPD in routine perinatal care. Systematic review registration PROSPERO ID: 277998 (registered 10th of September 2021).

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2046-4053Test

الوصول الحر: https://doaj.org/article/49037c9dc6c84920a6dedc6c54ee22c7Test

المؤلفون: Xiaoqin Liu, Nina Molenaar, Esben Agerbo, Natalie C Momen, Anna-Sophie Rommel, Angela Lupattelli, Veerle Bergink, Trine Munk-Olsen

المصدر: PLoS Medicine, Vol 19, Iss 1, p e1003895 (2022)

مصطلحات موضوعية: Medicine

الوصف: BackgroundWomen prescribed antidepressants face the dilemma of whether or not to continue their treatment during pregnancy. Currently, limited evidence is available on the efficacy of continuing versus discontinuing antidepressant treatment during pregnancy to aid their decision. We aimed to estimate whether antidepressant discontinuation before or during pregnancy was associated with an increased risk of psychiatric emergency (ascertained by psychiatric admission or emergency room visit), a proxy measure of severe exacerbation of symptoms/mental health crisis.Methods and findingsWe carried out a propensity score-matched cohort study of women who gave birth to live-born singletons between January 1, 1997 and June 30, 2016 in Denmark and who redeemed an antidepressant prescription in the 90 days before the pregnancy, identified by Anatomical Therapeutic Chemical (ATC) code N06A. We constructed 2 matched cohorts, matching each woman who discontinued antidepressants before pregnancy (N = 2,669) or during pregnancy (N = 5,467) to one who continued antidepressants based on propensity scores. Maternal characteristics and variables related to disease severity were used to generate the propensity scores in logistic regression models. We estimated hazard ratios (HRs) of psychiatric emergency in the perinatal period (pregnancy and 6 months postpartum) using stratified Cox regression. Psychiatric emergencies were observed in 76 women who discontinued antidepressants before pregnancy and 91 women who continued. There was no evidence of higher risk of psychiatric emergency among women who discontinued antidepressants before pregnancy (cumulative incidence: 2.9%, 95% confidence interval [CI]: 2.3% to 3.6% for discontinuation versus 3.4%, 95% CI: 2.8% to 4.2% for continuation; HR = 0.84, 95% CI: 0.61 to 1.16, p = 0.298). Overall, 202 women who discontinued antidepressants during pregnancy and 156 who continued had psychiatric emergencies (cumulative incidence: 5.0%, 95% CI: 4.2% to 5.9% versus 3.7%, 95% CI: 3.1% to 4.5%). Antidepressant discontinuation during pregnancy was associated with increased risk of psychiatric emergency (HR = 1.25, 95% CI: 1.00 to 1.55, p = 0.048). Study limitations include lack of information on indications for antidepressant treatment and reasons for discontinuing antidepressants.ConclusionsIn this study, we found that discontinuing antidepressant medication during pregnancy (but not before) is associated with an apparent increased risk of psychiatric emergency compared to continuing treatment throughout pregnancy.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1549-1277Test; https://doaj.org/toc/1549-1676Test

الوصول الحر: https://doaj.org/article/e64d9798823b4ad692dc6bc2bbc6b436Test

المؤلفون: Bente Kjær Lyngsøe, Trine Munk‐Olsen, Claus Høstrup Vestergaard, Dorte Rytter, Kaj Sparle Christensen, Bodil Hammer Bech

المصدر: Brain and Behavior, Vol 11, Iss 3, Pp n/a-n/a (2021)

مصطلحات موضوعية: Adolescent, Child, Delivery of Health Care, Depressive Disorder, Mother–Child Relations, Wounds and Injuries, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Abstract Aims To assess the association between different stages of maternal depression and injury risk in offspring aged 0–10 years. Methods Population‐based cohort study of all live‐born children in Denmark from 1 January 1997 until 31 December 2013 (n = 1,064,387). Main outcome measure was emergency department contacts with a main diagnosis of injury coded as DS00‐DT98 (chapter XIX) according to the ICD‐10. All information was obtained from Danish national registries. Results Maternal depression was associated with higher injury hazard in the offspring throughout childhood compared to offspring of mothers with no history of depression. The strongest association was seen for the first year of life. First‐time maternal depression was most strongly associated with injury in the child, especially in the first year of life (aHR = 1.70, 95% CI: 1.48–1.96). Children of mothers with relapse depression had 1.57 higher hazard of injury in the first year of life (aHR: 1.57, 95% CI: 1.44–1.70). Children of mothers with previously treated depression (postdepression) had 1.13 higher hazard of injury in the first year of life (aHR: 1.13, 95% CI: 1.09–1.17). Continuous treatment for depression was associated with a nonsignificant higher hazard of injuries in the first year of life (aHR: 1.06, 95% CI: 0.91–1.23). Conclusions Maternal depression was associated with higher injury risk in the offspring, particularly in early childhood. The association persisted in children of mothers with relapse depression. Our results suggest that children of mothers with depression are vulnerable several years after depression onset and treatment cessation.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2162-3279Test

الوصول الحر: https://doaj.org/article/8a77620eb8c6451f8c1c5121fd856600Test

المؤلفون: Kathrine Bang Madsen, Liselotte Vogdrup Petersen, Oleguer Plana-Ripoll, Katherine L. Musliner, Jean-Christophe Philippe Debost, Frederikke Hordam Gronemann, Preben Bo Mortensen, Trine Munk-Olsen

المصدر: Therapeutic Advances in Psychopharmacology, Vol 10 (2020)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950, Psychiatry, RC435-571

الوصف: Background: Depression is one of the leading causes of premature workforce exit in many Western countries, but little is known about the extent to which treatment-resistance reduces number of work-years. We compared the risk of premature workforce exit among patients with treatment-resistant depression (TRD) relative to non-TRD patients and estimated work years lost (WYL) before scheduled retirement age. Methods: The study population, identified in the Danish National Prescription Registry, included all individuals born and living in Denmark who redeemed their first antidepressant (AD) prescription for depression at age 18–60 years between 2005 and 2012. TRD was defined as failure to respond to at least two different treatment trials. Premature workforce exit was measured using disability pension records. We used Cox regression to estimate the hazard ratio (HR) for premature workforce exit in TRD relative to non-TRD patients, adjusting for calendar year, psychiatric and somatic comorbidity, and educational level. Differences in WYL in patients with TRD and all depression patients were estimated through a competing risks model. Results: Out of the total sample of patients with depression ( N = 129,945), 7478 (5.75%) were classified as having TRD. During follow up, 17% of patients with TRD and 8% of non-TRD patients received disability pension, resulting in a greater than three-fold larger risk of premature workforce exit [adjusted HR (aHR) 3.23 95% confidence interval (CI) 3.05–3.43]. The TRD group lost on average six work-years (95% CI 5.64–6.47) more than the total sample due to early labor force exit. The association between TRD and age at premature workforce exit was inversely U-shaped; the hazard rate of premature workforce exit for patients with TRD compared with non-TRD patients was highest in the age groups 31–35, 36–40, and 41–45 years. Conclusion: Patients with TRD constitute a small group within depression patients, but contribute disproportionally to societal costs due to premature workforce exit at a young age.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-1261Test

الوصول الحر: https://doaj.org/article/a33c8280516b4b289d96bbc0279118aeTest

المؤلفون: Clare L. Taylor, Trine Munk-Olsen, Louise M. Howard, Simone N. Vigod

المصدر: BJPsych Open, Vol 6 (2020)

مصطلحات موضوعية: Schizophrenia, pregnancy, information technologies, epidemiology, perinatal psychiatry, Psychiatry, RC435-571

الوصف: BackgroundResearch in schizophrenia and pregnancy has traditionally been conducted in small samples. More recently, secondary analysis of routine healthcare data has facilitated access to data on large numbers of women with schizophrenia.AimsTo discuss four scientific advances using data from Canada, Denmark and the UK from population-level health registers and clinical data sources.MethodNarrative review of research from these three countries to illustrate key advances in the area of schizophrenia and pregnancy.ResultsHealth administrative and clinical data from electronic medical records have been used to identify population-level and clinical cohorts of women with schizophrenia, and follow them longitudinally along with their children. These data have demonstrated that fertility rates in women with schizophrenia have increased over time and have enabled documentation of the course of illness in relation with pregnancy, showing the early postpartum as the time of highest risk. As a result of large sample sizes, we have been able to understand the prevalence of and risk factors for rare outcomes that would be difficult to study in clinical research. Advanced pharmaco-epidemiological methods have been used to address confounding in studies of antipsychotic medications in pregnancy, to provide data about the benefits and risks of treatment for women and their care providers.ConclusionsUse of these data has advanced the field of research in schizophrenia and pregnancy. Future developments in use of electronic health records include access to richer data sources and use of modern technical advances such as machine learning and supporting team science.

وصف الملف: electronic resource

العلاقة: https://www.cambridge.org/core/product/identifier/S2056472420000782/type/journal_articleTest; https://doaj.org/toc/2056-4724Test

الوصول الحر: https://doaj.org/article/820cfe0f79a441e7970a4c21c90855cfTest