المؤلفون: Matricardi P. M., Potapova E., Panetta V., Lidholm J., Mattsson L., Scala E., Bernardini R., Caffarelli C., Casani A., Cervone R., Chini L., Comberiati P., De Castro G., Miraglia del Giudice M., Dello Iacono I., Di Rienzo Businco A., Gallucci M., Giannetti A., Moschese V., Varin E., Bianchi A., Calvani M., Frediani T., Macri F., Maiello N., Paravati F., Pelosi U., Peroni D., Pingitore G., Tosca M., Zicari A. M., Ricci G., Asero R., Tripodi S.

المساهمون: Matricardi, P. M., Potapova, E., Panetta, V., Lidholm, J., Mattsson, L., Scala, E., Bernardini, R., Caffarelli, C., Casani, A., Cervone, R., Chini, L., Comberiati, P., De Castro, G., Miraglia del Giudice, M., Dello Iacono, I., Di Rienzo Businco, A., Gallucci, M., Giannetti, A., Moschese, V., Varin, E., Bianchi, A., Calvani, M., Frediani, T., Macri, F., Maiello, N., Paravati, F., Pelosi, U., Peroni, D., Pingitore, G., Tosca, M., Zicari, A. M., Ricci, G., Asero, R., Tripodi, S.

مصطلحات موضوعية: Allergic rhiniti, allergy, asthma, component resolved diagnostic, cross-reactivity, cyclophilin, diagnosi, immunoglobulin E, oral allergy syndrome, panallergen, pollen, precision medicine

الوصف: Background: Cyclophilins are ubiquitous panallergens whose epidemiologic, diagnostic, and clinical relevance is largely unknown and whose sensitization is rarely examined in routine allergy practice. Objective: We investigated the epidemiologic, diagnostic, and clinical relevance of cyclophilins in seasonal allergic rhinitis and its comorbidities. Methods: We examined a random sample of 253 (25%) of 1263 Italian children with seasonal allergic rhinitis from the Panallergens in Pediatrics (PAN-PED) cohort with characterized disease phenotypes. Nested studies of sensitization prevalence, correlation, and allergen extract inhibition were performed in patients sensitized to birch pollen extract but lacking IgE to Bet v 1/2/4 (74/1263) or with highest serum level of IgE to Bet v 1 (26/1263); and in patients with sensitization to various extracts (ragweed, mugwort, pellitory, Plantago, and plane tree), but not to their respective major allergenic molecule, profilins, and polcalcins. IgE to cyclophilin was detected with recombinant Bet v 7, and extract inhibition tests were performed with the same rBet v 7. Results: IgE to rBet v 7 was detected in 43 (17%) of 253 patients. It was associated with asthma (P < .028) and oral allergy syndrome (P < .017) in univariate but not multivariate analysis adjusted for IgE to profilins (Phl p 12), PR-10s (Bet v 1), and lipid transfer proteins (Pru p 3). IgE to rBet v 7 was also highly prevalent (47/74, 63%) among patients with unexplained sensitization to birch pollen extract. In patients with unexplained sensitization to ragweed, mugwort, pellitory, Plantago and plane tree pollen, the levels of IgE to those extracts correlated with the levels of IgE to rBet v 7, and they were also significantly inhibited by rBet v 7 (inhibition range 45%-74%). Conclusions: IgE sensitization to cyclophilin is frequent in pollen-allergic patients living in temperate areas and can produce “false” positive outcomes in skin prick and IgE tests to pollen extracts. Molecular diagnostic guidelines ...

العلاقة: journal:JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY; https://hdl.handle.net/11568/1231754Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85189977889

الإتاحة: https://doi.org/10.1016/j.jaci.2024.01.030Test
https://hdl.handle.net/11568/1231754Test

المؤلفون: Ciprandi, G., Giuliano, M., Schiavetti, I., Miraglia del Giudice, M., Tosca, M. A.

المساهمون: Ciprandi, G., Giuliano, M., Schiavetti, I., Miraglia del Giudice, M., Tosca, M. A.

العلاقة: volume:56; issue:01; journal:EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY; https://hdl.handle.net/11591/523029Test

الإتاحة: https://doi.org/10.23822/eurannaci.1764-1489.255Test
https://hdl.handle.net/11591/523029Test

المؤلفون: Duse, M, Santamaria, F, Verga, MC, Bergamini, M, Simeone, G, Leonardi, L, Tezza, G, Bianchi, A, Capuano, A, Cardinale, F, Cerimoniale, G, Landi, M, Malventano, M, Tosca, M, Varricchio, A, Zicari, AM, Alfaro, C, Barberi, S, Becherucci, P, Bernardini, R, Biasci, P, Caffarelli, C, Caldarelli, V, Capristo, C, Castronuovo, S, Chiappini, E, Cutrera, R, De Castro, G, De Franciscis, L, Decimo, F, Iacono, ID, Diaferio, L, Di Cicco, ME, Di Mauro, C, Di Mauro, D, Di Mauro, F, Di Mauro, G, Doria, M, Falsaperla, R, Ferraro, V, Fanos, V, Galli, E, Ghiglioni, DG, Indinnimeo, L, Kantar, A, Lamborghini, A, Licari, A, Lubrano, R, Luciani, S, Macri, F, Marseglia, G, Martelli, AG, Masini, L, Midulla, F, Minasi, D, Miniello, VL, Del Giudice, MM, Morandini, SR, Nardini, G, Nocerino, A, Novembre, E, Pajno, GB, Paravati, F, Piacentini, G, Piersantelli, C, Pozzobon, G, Ricci, G, Spanevello, V, Turra, R, Zanconato, S, Borrelli, M, Villani, A, Corsello, G, Peroni, D

المساهمون: Duse, M, Santamaria, F, Verga, M, Bergamini, M, Simeone, G, Leonardi, L, Tezza, G, Bianchi, A, Capuano, A, Cardinale, F, Cerimoniale, G, Landi, M, Malventano, M, Tosca, M, Varricchio, A, Zicari, A, Alfaro, C, Barberi, S, Becherucci, P, Bernardini, R, Biasci, P, Caffarelli, C, Caldarelli, V, Capristo, C, Castronuovo, S, Chiappini, E, Cutrera, R, De Castro, G, De Franciscis, L, Decimo, F, Iacono, I, Diaferio, L, Di Cicco, M, Di Mauro, C, Di Mauro, D, Di Mauro, F, Di Mauro, G, Doria, M, Falsaperla, R, Ferraro, V, Fanos, V, Galli, E, Ghiglioni, D, Indinnimeo, L, Kantar, A, Lamborghini, A, Licari, A, Lubrano, R, Luciani, S, Macri, F, Marseglia, G, Martelli, A, Masini, L, Midulla, F, Minasi, D, Miniello, V, Del Giudice, M, Morandini, S, Nardini, G, Nocerino, A, Novembre, E, Pajno, G, Paravati, F, Piacentini, G, Piersantelli, C, Pozzobon, G, Ricci, G, Spanevello, V, Turra, R, Zanconato, S, Borrelli, M, Villani, A, Corsello, G, Peroni, D

مصطلحات موضوعية: Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35216620; info:eu-repo/semantics/altIdentifier/wos/WOS:000761386000001; volume:48; firstpage:1; lastpage:2; numberofpages:2; journal:THE ITALIAN JOURNAL OF PEDIATRICS; https://hdl.handle.net/2108/317321Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85125527400

الإتاحة: https://doi.org/10.1186/s13052-022-01231-8Test
https://hdl.handle.net/2108/317321Test

المؤلفون: Giuffrida, L., Istokskaia, V., Picciotto, A., Kantarelou, V., Barozzi, M., Dell'Anna, R., Divoky, M., Denk, O., Giubertoni, D., Grepl, F., Hadjikyriacou, A., Hanus, M., Krasa, J., Kucharik, M., Levato, T., Navratil, P., Pilar, J., Schillaci, F., Stancek, S., Tosca, M.

المصدر: Quantum Beam Science (QuBS); Mar2024, Vol. 8 Issue 1, p5, 13p

المؤلفون: Duse M, Santamaria F, Verga MC, Bergamini M, Simeone G, Leonardi L, Tezza G, Bianchi A, Capuano A, Cardinale F, Cerimoniale G, Landi M, Malventano M, Tosca M, Varricchio A, Zicari AM, Alfaro C, Barberi S, Becherucci P, Bernardini R, Biasci P, Caffarelli C, Caldarelli V, Capristo C, Castronuovo S, Chiappini E, Cutrera R, De Castro G, De Franciscis L, Decimo F, Iacono ID, Diaferio L, Di Cicco ME, Di Mauro C, Di Mauro D, Di Mauro F, Di Mauro G, Doria M, Falsaperla R, Ferraro V, Fanos V, Galli E, Ghiglioni DG, Indinnimeo L, Kantar A, Lamborghini A, Licari A, Lubrano R, Luciani S, Macri F, Marseglia G, Martelli AG, Masini L, Midulla F, Minasi D, Miniello VL, del Giudice MM, Morandini SR, Nardini G, Nocerino A, Novembre E, Pajno GB, Paravati F, Piacentini G, Piersantelli C, Pozzobon G, Ricci G, Spanevello V, Turra R, Zanconato S, Borrelli M, Villani A, Corsello G, Peroni D

المساهمون: Duse, M, Santamaria, F, Verga, M, Bergamini, M, Simeone, G, Leonardi, L, Tezza, G, Bianchi, A, Capuano, A, Cardinale, F, Cerimoniale, G, Landi, M, Malventano, M, Tosca, M, Varricchio, A, Zicari, A, Alfaro, C, Barberi, S, Becherucci, P, Bernardini, R, Biasci, P, Caffarelli, C, Caldarelli, V, Capristo, C, Castronuovo, S, Chiappini, E, Cutrera, R, De Castro, G, De Franciscis, L, Decimo, F, Iacono, I, Diaferio, L, Di Cicco, M, Di Mauro, C, Di Mauro, D, Di Mauro, F, Di Mauro, G, Doria, M, Falsaperla, R, Ferraro, V, Fanos, V, Galli, E, Ghiglioni, D, Indinnimeo, L, Kantar, A, Lamborghini, A, Licari, A, Lubrano, R, Luciani, S, Macri, F, Marseglia, G, Martelli, A, Masini, L, Midulla, F, Minasi, D, Miniello, V, del Giudice, M, Morandini, S, Nardini, G, Nocerino, A, Novembre, E, Pajno, G, Paravati, F, Piacentini, G, Piersantelli, C, Pozzobon, G, Ricci, G, Spanevello, V, Turra, R, Zanconato, S, Borrelli, M, Villani, A, Corsello, G, Peroni, D

مصطلحات موضوعية: Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000643901200003; volume:47; firstpage:1; lastpage:24; numberofpages:24; journal:THE ITALIAN JOURNAL OF PEDIATRICS; https://hdl.handle.net/2108/317211Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85104729740

الإتاحة: https://doi.org/10.1186/s13052-021-01013-8Test
https://hdl.handle.net/2108/317211Test

المؤلفون: Tosca M. A., Marseglia G. L., Ciprandi G., Anastasio E., Brambilla I., Caffarelli C., Caricato F., Chini L., Ciprandi R., De Vittori V., Duse M., Di Cicco M. E., Esposito S., Giovinazzo V., Kantar A., Leone M., Licari A., Moschese V., Olcese R., Peroni D. G., Pistorio A., Sgrulletti M., Silvestri M, Talarico V

المساهمون: Tosca, M. A., Marseglia, G. L., Ciprandi, G., Anastasio, E., Brambilla, I., Caffarelli, C., Caricato, F., Chini, L., Ciprandi, R., De Vittori, V., Duse, M., Di Cicco, M. E., Esposito, S., Giovinazzo, V., Kantar, A., Leone, M., Licari, A., Moschese, V., Olcese, R., Peroni, D. G., Pistorio, A., Sgrulletti, M., Silvestri, M, Talarico, V

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000619192200005; volume:49; issue:1; firstpage:32; lastpage:39; numberofpages:8; journal:ALLERGOLOGIA ET IMMUNOPATHOLOGIA; http://hdl.handle.net/11381/2904240Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85101195373

الإتاحة: https://doi.org/10.15586/aei.v49i1.14Test
http://hdl.handle.net/11381/2904240Test

المؤلفون: Bonvalet, J., Nicolaï, Ph, Raffestin, D., D'Humieres, E., Batani, D., Tikhonchuk, V., Kantarelou, V., Giuffrida, L., Tosca, M., Korn, G., Picciotto, A., Morace, A., Abe, Y., Arikawa, Y., Fujioka, S., Fukuda, Y., Kuramitsu, Y., Habara, H., Margarone, D.

المصدر: Bonvalet , J , Nicolaï , P , Raffestin , D , D'Humieres , E , Batani , D , Tikhonchuk , V , Kantarelou , V , Giuffrida , L , Tosca , M , Korn , G , Picciotto , A , Morace , A , Abe , Y , Arikawa , Y , Fujioka , S , Fukuda , Y , Kuramitsu , Y , Habara , H & Margarone , D 2021 , ' Energetic α -particle sources produced through proton-boron reactions by high-energy high-intensity laser beams ' , Physical Review E , vol. 103 ....

مصطلحات موضوعية: /dk/atira/pure/subjectarea/asjc/3100/3109, name=Statistical and Nonlinear Physics, /dk/atira/pure/subjectarea/asjc/2600/2613, name=Statistics and Probability, /dk/atira/pure/subjectarea/asjc/3100/3104, name=Condensed Matter Physics

الوصف: In an experiment performed with a high-intensity and high-energy laser system, α-particle production in proton-boron reaction by using a laser-driven proton beam was measured. α particles were observed from the front and also from the rear side, even after a 2-mm-thick boron target. The data obtained in this experiment have been analyzed using a sequence of numerical simulations. The simulations clarify the mechanisms of α-particle production and transport through the boron targets. α-particle energies observed in the experiment and in the simulation reach 10-20 MeV through energy transfer from 20-30 MeV energy incident protons. Despite the lower cross sections for protons with energy above the sub-MeV resonances in the proton-boron reactions, 108-109α particles per steradian have been detected.

وصف الملف: application/pdf

العلاقة: https://pure.qub.ac.uk/en/publications/f57231e5-3990-498a-a136-86d9304372acTest

الإتاحة: https://doi.org/10.1103/PhysRevE.103.053202Test
https://pure.qub.ac.uk/en/publications/f57231e5-3990-498a-a136-86d9304372acTest
https://pureadmin.qub.ac.uk/ws/files/246479171/ener.pdfTest

المؤلفون: Tosca, M. G, Randerson, J. T, Zender, C. S

المصدر: Atmospheric Chemistry and Physics. 13(10)

مصطلحات موضوعية: Community atmosphere model, biomass burning emissions, tropical expansion, hydrological cycle, radiation budget, equatorial Asia, earth system, forest-fires, black carbon, El-Nino

الوصف: Each year landscape fires across the globe emit black and organic carbon smoke particles that can last in the atmosphere for days to weeks. We characterized the climate response to these aerosols using an Earth system model. We used remote sensing observations of aerosol optical depth (AOD) and simulations from the Community Atmosphere Model, version 5 (CAM5) to optimize satellite-derived smoke emissions for high biomass burning regions. Subsequent global simulations using the adjusted fire emissions produced AODs that were in closer agreement with surface and space-based measurements. We then used CAM5, which included radiative aerosol effects, to evaluate theclimate response to the fire-aerosol forcing. We conducted two 52 yr simulations, one with four sets of monthly cycling 1997-2009 fire emissions and one without. Fire emissions increased global mean annual AOD by 10% (+0.02) and decreased net all-sky surface radiation by 1% (1.3 W m(-2)). Elevated AODs reduced global surface temperatures by 0.13 +/- 0.01 degrees C. Though global precipitation declined only slightly, patterns of precipitation changed, with large reductions near the Equator offset by smaller increases north and south of the intertropical convergence zone (ITCZ). A combination of increased tropospheric heating and reduced surface temperatures increased equatorial subsidence and weakened the Hadley circulation. As a consequence, precipitation decreased over tropical forests in South America, Africa and equatorial Asia. These results are consistent with the observed correlation between global temperatures and the strength of the Hadley circulation and studies linking tropospheric heating from black carbon aerosols with tropical expansion.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7hr4s1jbTest

المؤلفون: Cirillo I., Schiavetti I., Ricciardolo F. L. M., Miraglia Del Giudice M., Tosca M. A., Ciprandi G.

المساهمون: Cirillo, I., Schiavetti, I., Ricciardolo, F. L. M., Miraglia Del Giudice, M., Tosca, M. A., Ciprandi, G.

مصطلحات موضوعية: allergic rhiniti, asthma, bronchial hyperresponsivene, FEF, fractioned exhaled nitric oxide, lung function

الوقت: 25-75

الوصف: Allergic rhinitis (AR) is a relevant risk factor asthma as it may frequently precede asthma onset. There is evidence that lung function may be early impaired in AR patients. In this regard, the forced expiratory flow at 25%–75% of vital capacity (FEF25-75) could be a reliable marker of bronchial impairment in AR. Therefore, the present study investigated the practical role of FEF25-75 in young people with AR. The parameters included history, body mass index (BMI), lung function, bronchial hyperresponsiveness (BHR), and fractional exhaled nitric oxide (FeNO). This cross-sectional study included 759 patients (74 females and 685 males, mean age of 29.2 years) suffering from AR. The study demonstrated a significant association between low FEF25-75 values and BMI (OR 0.80), FEV1 (OR 1.29), FEV1/FVC (OR 1.71), and BHR (OR 0.11). Stratifying the patients on the basis of the presence (or absence) of BHR, sensitization to house dust mites (OR 1.81), AR duration (OR 1.08), FEF25-75 (OR 0.94), and FeNO (OR 1.08) were associated with BHR. Stratifying patients based on high FeNO values (>50 ppb), BHR was associated with high FeNO (OR 39). In conclusion, the present study showed that FEF25-75 was associated with low FEV1 and FEV1/FVC and BHR in AR patients. Therefore, spirometry should be considered in the long-term workup of patients with allergic rhinitis as impaired FEF25-75 might suggest an initial progression toward asthma.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37309103; info:eu-repo/semantics/altIdentifier/wos/WOS:001005340000001; volume:37; issue:5; firstpage:571; lastpage:574; numberofpages:4; journal:AMERICAN JOURNAL OF RHINOLOGY & ALLERGY; https://hdl.handle.net/11591/523188Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85162683668

الإتاحة: https://doi.org/10.1177/19458924231182272Test
https://hdl.handle.net/11591/523188Test

المؤلفون: Tosca M. A., Schiavetti I., Medone E., Miraglia del Giudice M., Ciprandi G.

المساهمون: Tosca, M. A., Schiavetti, I., Medone, E., Miraglia del Giudice, M., Ciprandi, G.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36001059; info:eu-repo/semantics/altIdentifier/wos/WOS:000847221700001; volume:112; issue:1; firstpage:122; lastpage:123; numberofpages:2; journal:ACTA PAEDIATRICA; https://hdl.handle.net/11591/523191Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85137183148

الإتاحة: https://doi.org/10.1111/apa.16524Test
https://hdl.handle.net/11591/523191Test