المؤلفون: Mine Filiz, Hakan Erdem, Handan Ankaralı, Edmond Puca, Yvon Ruch, Lurdes Santos, Nesrin Ghanem‐Zoubi, Xavier Argemi, Yves Hansmann, Rahmet Güner, Gilda Tonziello, Jean‐Philippe Mazzucotelli, N. Çomo, Şükran Köse, Ayşe Batırel, Asuman İnan, Necla Tülek, Abdullah Umut Pekok, Ejaz Ahmed Khan, Atilla İyisoy, Meliha Meriç-Koç, Ayşe Kaya-Kalem, Pedro Palma, İmran Hasanoğlu, André Silva‐Pinto, Nefise Öztoprak, Raquel Duro, Fahad Almajid, Mustafa Doğan, Nicolás Dauby, Jesper Damsgaard Gunst, Recep Tekin, Déborah Konopnicki, Nicola Petrosillo, İlkay Bozkurt, Jamal Wadi Al Ramahi, Corneliu Petru Popescu, İ̇lker İnanç Balkan, Safak Ozer-Balin, Tatjana Lejko Zupanc, Antonio Cascio, Irina Magdalena Dumitru, Aysegul Erdem, Gülden Ersöz, Meltem Taşbakan, Oday Abu Ajamieh, Fatma Sırmatel, Simin Aysel Florescu, Serda Gülsün, Hacer Deniz Özkaya

مصطلحات موضوعية: Management and Epidemiology of Infective Endocarditis, Epidemiology, Medicine, Health Sciences, Methicillin-Resistant Staphylococcus aureus Infections, Infectious Diseases, FOS Health sciences, Global Burden of Group A Streptococcal Diseases, Public Health, Environmental and Occupational Health, Endocarditis, Cardiology, Internal medicine

الوصف: Purpose: Blood culture negative endocarditis (BCNE) presents diagnostic challenges, necessitating precise identification of high-risk patient cohorts. Hence, our objective was to pinpoint high-risk cohorts for BCNE. Methods: The study included adult patients with definite endocarditis. Data was collected via the Infectious Diseases International Research Initiative (ID-IRI). The primary study analysing one of the largest case series ever reported and was published in the European Journal of Clinical Microbiology and Infectious Diseases in 2019, was conducted across 41 centres in 13 countries. We performed a re-analysis of the database to determine the predictors of BCNE. Results: 867 cases with definite endocarditis were included in the study. Blood cultures were negative in 101 (11.65%) patients. We disclosed that as patients age, the likelihood of a negative blood culture significantly decreases (OR 0.975, 95% CI 0.963-0.987, p<0.001). Additionally, factors such as rheumatic heart disease (OR ... : الغرض من الملخص: يمثل التهاب الشغاف السلبي لمزرعة الدم (BCNE) تحديات تشخيصية، مما يستلزم تحديدًا دقيقًا لمجموعات المرضى عالية الخطورة. وبالتالي، كان هدفنا هو تحديد المجموعات عالية المخاطر لـ BCNE. الطرق: شملت الدراسة المرضى البالغين الذين يعانون من التهاب الشغاف المحدد. تم جمع البيانات من خلال مبادرة البحوث الدولية للأمراض المعدية (ID - IRI). أجريت الدراسة الأولية التي تحلل واحدة من أكبر سلاسل الحالات التي تم الإبلاغ عنها على الإطلاق ونشرت في المجلة الأوروبية للميكروبيولوجيا السريرية والأمراض المعدية في عام 2019، عبر 41 مركزًا في 13 دولة. أجرينا إعادة تحليل لقاعدة البيانات لتحديد تنبؤات BCNE. النتائج: تم تضمين 867 حالة مصابة بالتهاب الشغاف المحدد في الدراسة. كانت مزارع الدم سلبية في 101 مريض (11.65 ٪). لقد كشفنا أنه مع تقدم المرضى في العمر، تقل احتمالية حدوث مزرعة دم سلبية بشكل كبير (أو 0.975، 95 ٪ CI 0.963-0.987، p<0.001). بالإضافة إلى ذلك، ترتبط عوامل مثل أمراض القلب الروماتيزمية (OR 2.036، 95 ٪ CI 0.970-4.276، p=0.049)، تضيق الأبهر (OR 3.066، 95 ٪ CI 1.564-6.010، p=0.001)، القلس التاجي (OR 1.693، 95 ٪ ...

العلاقة: https://dx.doi.org/10.60692/05k81-yna93Test

الإتاحة: https://doi.org/10.60692/jr5ma-6qh4810.60692/05k81-yna93Test

المؤلفون: Spaziante M, Venditti C, Butera O, Messina F, Di Caro A, Tonziello G, Lanini S, Cataldo MA, Puro V

المصدر: Infection and Drug Resistance, Vol Volume 14, Pp 3659-3665 (2021)

مصطلحات موضوعية: carbapenem-resistant klebsiella pneumoniae, new delhi metallo-β-lactamase, surveillance, healthcare-associated infections, Infectious and parasitic diseases, RC109-216

الوصف: Martina Spaziante,1 Carolina Venditti,2 Ornella Butera,2 Francesco Messina,2 Antonino Di Caro,2 Gilda Tonziello,1 Simone Lanini,1 Maria Adriana Cataldo,1 Vincenzo Puro1 1Emerging Infection Unit and Regional Service for Surveillance and Control of Infectious Diseases (SeRESMI), National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Rome, Italy; 2Laboratory of Microbiology, National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Rome, ItalyCorrespondence: Maria Adriana Cataldo Tel +39 0655170786Email adriana.cataldo@inmi.itIntroduction: New Delhi metallo-β-lactamase producing Klebsiella pneumoniae (NDM-Kpn) strains have been causing healthcare-associated infections worldwide. The aim of this study was to describe the molecular mechanisms of antimicrobial resistance and to analyze the clonality of NDM-Kpn isolates collected between January 2019 and June 2020 from patients admitted to hospitals from the Lazio region, Italy.Methods: We performed a retrospective cohort study. Whole-genome sequencing (WGS) was performed on all NDM-Kpn strains; clonality and genetic relationships were further investigated.Results: During the surveillance period, 17 NDM-Kpn isolates were obtained from 17 patients admitted to seven different hospitals. Eight different sequence types (STs) were detected: ST147 (n = 4), ST383 (n = 4), ST15 (n = 3), ST11 (n = 2), ST17 (n = 1), ST29 (n = 1), ST307 (n = 1) and the newly identified ST4853 (n = 1). Genetic relationships were further investigated by the WGS-based core genome MLST (cgMLST) scheme, and 5 cluster types (CTs) were identified. Whereas a substantial overall heterogeneity among isolates was detected (8 different STs were identified out of 17 isolates), the strains within each cluster showed a very high level of genome similarity.Discussion: Our study highlights the key role of surveillance, which allowed taking a picture of a part of the NDM-Kpn strains circulating in Italy, adding further insight into their molecular features.Keywords: carbapenem-resistant Klebsiella pneumoniae, New Delhi metallo-β-lactamase, surveillance, healthcare-associated infections

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/importance-of-surveillance-of-new-delhi-metallo-beta-lactamase-klebsie-peer-reviewed-fulltext-article-IDRTest; https://doaj.org/toc/1178-6973Test

الوصول الحر: https://doaj.org/article/903d8e02f1ad4fee9d1d9dde4f0216a5Test

المؤلفون: Acampora, Roberto, Quiroga Subirana, Pablo, Durante, Luana, Tonziello, Rossella, Aversano, Giuseppina, Lieto, Maria, Ripa, Patrizia, Mazzaferro, Maria Pia

مصطلحات موضوعية: Antiepileptic drugs (AED), Epilepsy, FIRES, Immunoglobulin, NORSE, Drug Resistant Epilepsy, Encephalitis, Epileptic Syndromes, Humans, Immune System Diseases, Seizures, Status Epilepticus, Young Adult

الوصف: A new onset of status epilepticus in a previously healthy adult preceded by a recent minor febrile infection represents a diagnostic and therapeutic challenge in clinical practice. Considering the broad spectrum of epileptic encephalopathies caused by autoimmune mechanisms, differential diagnosis for new-onset refractory status epilepticus (NORSE) should include febrile infection-related epilepsy syndrome (FIRES), in order to not underestimate the underlying etiological condition triggering epilepsy in non-epileptic patients (Hon et al. in Recent Pat Inflamm Allergy Drug Discov 12:128-135, 2018). We report a case of acute encephalopathy with refractory seizures after a febrile illness (FIRES) in a young adult with complete remission of symptoms as well as dramatic improvement of EEG abnormalities following intravenous immunoglobulin and proper antiepileptic medications. We conducted an extensive workup including lumbar puncture, blood tests, EEG serial monitoring, MRI brain, total body CT scan, and PET brain with FDG to shed light on the etiology of the disease.

وصف الملف: application/pdf

العلاقة: http://hdl.handle.net/10668/20385Test; PMC9064715; https://link.springer.com/content/pdf/10.1007/s10072-022-06106-8.pdfTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064715/pdfTest

الإتاحة: https://doi.org/10.1007/s10072-022-06106-8Test
http://hdl.handle.net/10668/20385Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064715/pdfTest

المؤلفون: Accogli A., Severino M., Riva A., Madia F., Balagura G., Iacomino M., Carlini B., Baldassari S., Giacomini T., Croci C., Pisciotta L., Messana T., Boni A., Russo A., Bilo L., Tonziello R., Coppola A., Filla A., Mecarelli O., Casalone R., Pisani F., Falsaperla R., Marino S., Parisi P., Ferretti A., Elia M., Luchetti A., Milani D., Vanadia F., Silvestri L., Rebessi E., Parente E., Vatti G., Mancardi M. M., Nobili L., Capra V., Salpietro V., Striano P., Zara F.

المساهمون: Accogli, A., Severino, M., Riva, A., Madia, F., Balagura, G., Iacomino, M., Carlini, B., Baldassari, S., Giacomini, T., Croci, C., Pisciotta, L., Messana, T., Boni, A., Russo, A., Bilo, L., Tonziello, R., Coppola, A., Filla, A., Mecarelli, O., Casalone, R., Pisani, F., Falsaperla, R., Marino, S., Parisi, P., Ferretti, A., Elia, M., Luchetti, A., Milani, D., Vanadia, F., Silvestri, L., Rebessi, E., Parente, E., Vatti, G., Mancardi, M. M., Nobili, L., Capra, V., Salpietro, V., Striano, P., Zara, F.

مصطلحات موضوعية: brain MRI, gene panel, malformations of cortical development, next-generation sequencing

الوصف: Purpose: Malformations of cortical development (MCD) are a phenotypically and genetically heterogeneous group of disorders, for which the diagnostic rate of genetic testing in a clinical setting remains to be clarified. In this study we aimed to assess the diagnostic rate of germline and pathogenic variants using a custom panel in a heterogeneous group of subjects with MCD and explore genotype-phenotype correlations. Methods: A total of 84 subjects with different MCD were enrolled. Genomic DNA was isolated from peripheral blood. Fifty-nine tartget genes were assessed using a custom next-generation sequencing (NGS) panel. Results: Genetic causes were identified in one-fourth of our cohort (21.4 %). Overall, we identified 19 pathogenic or likely pathogenic single-nucleotide variants in 11 genes among 18 subjects, including PAFAH1B1 (LIS1) (n = 3), TUBA1A (n = 3), DYNC1H1 (n = 3), ACTG1 (n = 2), TUBB2B (n = 1), TUBB3 (n = 1), DCX (n = 1), FLNA (n = 1), LAMA2 (n = 1), POMGNT2 (n = 1) and VLDLR (n = 1). The diagnostic yield was higher in patients with lissencephaly/pachygyria (60 %) (p = 0.001), cobblestone malformation (50 %), and subcortical band heterotopia (SBH) (40 %). Furthermore, five out of six subjects with suspect tubulinopathies on imaging harboured pathogenic variants in tubulin genes. Overall, germline pathogenic variants were more likely to be identified if MCD were diffuse (p = 0.002) and associated with other central nervous system malformations (p = 0.029). Moderate to severe intellectual disability was also more commonly associated with pathogenic variants (p = 0.044). Conclusion: Customized gene panels may support the diagnostic work-up for some specific MCD, especially when these are diffuse, bilateral and associated with other brain malformations.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32570172; info:eu-repo/semantics/altIdentifier/wos/WOS:000565178800032; volume:80; firstpage:145; lastpage:152; numberofpages:8; journal:SEIZURE; https://hdl.handle.net/11573/1472360Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85086508127

الإتاحة: https://doi.org/10.1016/j.seizure.2020.05.023Test
https://hdl.handle.net/11573/1472360Test

المؤلفون: Spaziante,Martina, Venditti,Carolina, Butera,Ornella, Messina,Francesco, Di Caro,Antonino, Tonziello,Gilda, Lanini,Simone, Cataldo,Maria Adriana, Puro,Vincenzo

مصطلحات موضوعية: Infection and Drug Resistance

الوصف: Martina Spaziante,1 Carolina Venditti,2 Ornella Butera,2 Francesco Messina,2 Antonino Di Caro,2 Gilda Tonziello,1 Simone Lanini,1 Maria Adriana Cataldo,1 Vincenzo Puro1 1Emerging Infection Unit and Regional Service for Surveillance and Control of Infectious Diseases (SeRESMI), National Institute for Infectious Diseases “Lazzaro Spallanzani†IRCCS, Rome, Italy; 2Laboratory of Microbiology, National Institute for Infectious Diseases “Lazzaro Spallanzani†IRCCS, Rome, ItalyCorrespondence: Maria Adriana Cataldo Tel +39 0655170786Email adriana.cataldo@inmi.itIntroduction: New Delhi metallo-β-lactamase producing Klebsiella pneumoniae (NDM-Kpn) strains have been causing healthcare-associated infections worldwide. The aim of this study was to describe the molecular mechanisms of antimicrobial resistance and to analyze the clonality of NDM-Kpn isolates collected between January 2019 and June 2020 from patients admitted to hospitals from the Lazio region, Italy.Methods: We performed a retrospective cohort study. Whole-genome sequencing (WGS) was performed on all NDM-Kpn strains; clonality and genetic relationships were further investigated.Results: During the surveillance period, 17 NDM-Kpn isolates were obtained from 17 patients admitted to seven different hospitals. Eight different sequence types (STs) were detected: ST147 (n = 4), ST383 (n = 4), ST15 (n = 3), ST11 (n = 2), ST17 (n = 1), ST29 (n = 1), ST307 (n = 1) and the newly identified ST4853 (n = 1). Genetic relationships were further investigated by the WGS-based core genome MLST (cgMLST) scheme, and 5 cluster types (CTs) were identified. Whereas a substantial overall heterogeneity among isolates was detected (8 different STs were identified out of 17 isolates), the strains within each cluster showed a very high level of genome similarity.Discussion: Our study highlights the key role of surveillance, which allowed taking a picture of a part of the NDM-Kpn strains circulating in Italy, adding further insight into their molecular features.Keywords: ...

وصف الملف: text/html

العلاقة: https://www.dovepress.com/importance-of-surveillance-of-new-delhi-metallo-beta-lactamase-klebsie-peer-reviewed-fulltext-article-IDRTest

الإتاحة: https://doi.org/10.2147/IDR.S318717Test
https://www.dovepress.com/importance-of-surveillance-of-new-delhi-metallo-beta-lactamase-klebsie-peer-reviewed-fulltext-article-IDRTest

المؤلفون: M. Tagliabue, J. Tonziello, A. Bottino, G. Capannelli, A. Comite, M. Pagliero, F. Boero, C. Cattaneo

المصدر: Membranes, Vol 11, Iss 610, p 610 (2021)

مصطلحات موضوعية: fertiliser wastewater, ammonium, phosphates, vacuum membrane distillation, reverse osmosis, Chemical technology, TP1-1185, Chemical engineering, TP155-156

الوصف: The incumbent water stress scenario imposes wastewater valorisation to freshwater, promoting technology for its effective treatment. Wastewater from fertiliser factories is quite problematic because of its relevant acidity and solute content. Its treatment through vacuum membrane distillation (VMD) was evaluated through laboratory scale tests at 40 °C and 25 mbar vacuum pressure with polytetrafluoroethylene and polypropylene flat-sheet porous membranes. The wastewater from a partially disused Italian industrial site was considered. VMD distillate fluxes between 22 and 57.4 L m −2 h −1 (LMH), depending on the pore size of the membranes, along with very high retention (R > 99%) for anions (Cl − , NO 3 − , SO 4 2− , PO 4 3− ), NH 4 + , and chemical oxygen demand (COD) were observed. Laboratory scale reverse osmosis (RO) tests at 25 °C and increasing of the operating pressure (from 20 bar to 40 bar) were carried out with a seawater desalination membrane for comparison purposes. Permeability values around 1.1 LMH/bar almost independently of the operating pressure were observed. Lower retentions than those measured from VMD tests were found. Finally, for any given RO operating pressure, the flux recovery ratio (FRR) calculated from permeate fluxes measured with pure water before and after wastewater treatment was always much lower that evaluated for VMD membranes.

العلاقة: https://www.mdpi.com/2077-0375/11/8/610Test; https://doaj.org/toc/2077-0375Test; https://doaj.org/article/2ff00361921543e889247095d8fe3957Test

الإتاحة: https://doi.org/10.3390/membranes11080610Test
https://doaj.org/article/2ff00361921543e889247095d8fe3957Test

المؤلفون: Vocciante, Marco, Finocchi, Antonio, De Folly D′Auris, Alessandra, Conte, Alessandro, Tonziello, Jacopo, Pola, Annalisa, Reverberi, Andrea

المساهمون: Vocciante, Marco, Finocchi, Antonio, De Folly D′Auris, Alessandra, Conte, Alessandro, Tonziello, Jacopo, Pola, Annalisa, Reverberi, Andrea

مصطلحات موضوعية: water remediation, hydrocarbons removal, selective adsorption, innovative adsorbents, super-expanded graphite

الوصف: The performances of an innovative material based on graphene multilayers in a 3D structure similar to expanded graphite, Grafysorber® G+ (Directa Plus), have been tested via in field applications on a real contaminated site. Several experimental tests were performed using Grafysorber® inside adsorbent devices (booms and pillows) to treat waters polluted by oil. The experimental campaign was carried out with the aim of comparing the performances of Grafysorber® with those of polypropylene (PP), which is the material used worldwide in case of water oil spill clean-up activities. The results achieved have confirmed a considerably higher selective adsorption capacity of Grafysorber® compared to PP, and configure the new material as a promising alternative to standard materials in enhancing oil spill remediation by selective adsorption.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31295967; info:eu-repo/semantics/altIdentifier/wos/WOS:000480454300019; volume:12 (14); firstpage:2231-1; lastpage:2231-12; numberofpages:12; journal:MATERIALS; http://hdl.handle.net/11567/960139Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85070454299

الإتاحة: https://doi.org/10.3390/ma12142231Test
http://hdl.handle.net/11567/960139Test

المؤلفون: Gilda Tonziello, Emanuela Caraffa, Biagio Pinchera, Guido Granata, Nicola Petrosillo

المصدر: Infectious Disease Reports, Vol 11, Iss 2 (2019)

مصطلحات موضوعية: iron uptake, siderophores, multidrug-resistant organisms, cefiderocol, Other systems of medicine, RZ201-999

الوصف: Iron is an essential micronutrient required for the growth of almost all aerobic organisms; the iron uptake pathway in bacteria therefore represents a possible target for novel antimicrobials, including hybrids between antimicrobials and siderophores. Siderophores are low molecular weight iron chelators that bind to iron and are actively transported inside the cell through specific binding protein complexes. These binding protein complexes are present both in Gram negative bacteria, in their outer and inner membrane, and in Gram positive bacteria in their cytoplasmic membrane. Most bacteria have the ability to produce siderophores in order to survive in environments with limited concentrations of free iron, however some bacteria synthetize natural siderophore-antibiotic conjugates that exploit the siderophore-iron uptake pathway to deliver antibiotics into competing bacterial cells and gain a competitive advantage. This approach has been referred to as a Trojan Horse Strategy. To overcome the increasing global problem of antibiotic resistance in Gram negative bacteria, which often have reduced outer membrane permeability, siderophore-antibiotic hybrid conjugates have been synthetized in vitro. Cefiderocol is the first siderophore-antibiotic conjugate that progressed to late stage clinical development so far. In studies on murine models the iron-siderophore uptake pathway has been also exploited for diagnostic imaging of infectious diseases, in which labelled siderophores have been used as specific probes. The aim of this review is to describe the research progress in the field of siderophore-based therapeutic and diagnostic approaches in infectious diseases.

وصف الملف: electronic resource

العلاقة: https://pagepress.org/journals/index.php/idr/article/view/8208Test; https://doaj.org/toc/2036-7430Test; https://doaj.org/toc/2036-7449Test

الوصول الحر: https://doaj.org/article/a482ffaa372e4440a218018f532f29faTest

المؤلفون: Roberto Acampora, Pablo Quiroga Subirana, Luana Durante, Rossella Tonziello, Giuseppina Aversano, Maria Lieto, Patrizia Ripa, Maria Pia Mazzaferro

المصدر: Neurological Sciences. 43:4555-4558

مصطلحات موضوعية: Drug Resistant Epilepsy, Epilepsy, NORSE, Dermatology, General Medicine, Young Adult, Psychiatry and Mental health, Status Epilepticus, Immune System Diseases, Seizures, Immunoglobulin, Encephalitis, Humans, Neurology (clinical), Antiepileptic drugs (AED), Epileptic Syndromes, FIRES

الوصف: A new onset of status epilepticus in a previously healthy adult preceded by a recent minor febrile infection represents a diagnostic and therapeutic challenge in clinical practice. Considering the broad spectrum of epileptic encephalopathies caused by autoimmune mechanisms, differential diagnosis for new-onset refractory status epilepticus (NORSE) should include febrile infection-related epilepsy syndrome (FIRES), in order to not underestimate the underlying etiological condition triggering epilepsy in non-epileptic patients (Hon et al. in Recent Pat Inflamm Allergy Drug Discov 12:128-135, 2018). We report a case of acute encephalopathy with refractory seizures after a febrile illness (FIRES) in a young adult with complete remission of symptoms as well as dramatic improvement of EEG abnormalities following intravenous immunoglobulin and proper antiepileptic medications. We conducted an extensive workup including lumbar puncture, blood tests, EEG serial monitoring, MRI brain, total body CT scan, and PET brain with FDG to shed light on the etiology of the disease.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50113bee730ab8cbfa96f070a187992dTest
https://doi.org/10.1007/s10072-022-06106-8Test

المؤلفون: Erdem, Hakan, Puca, Edmond, Ruch, Yvon, Santos, Lurdes, Ghanem-Zoubi, Nesrin, Argemi, Xavier, Hansmann, Yves, Guner, Rahmet, Tonziello, Gilda, Mazzucotelli, Jean-Philippe, Como, Najada, Kose, Sukran, Batirel, Ayse, Inan, Asuman, Tulek, Necla, Pekok, Abdullah Umut, Khan, Ejaz Ahmed, Iyisoy, Atilla, Meric-Koc, Meliha, Kaya-Kalem, Ayse, Martins, Pedro Palma, Hasanoglu, Imran, Silva-Pinto, André, Oztoprak, Nefise, Duro, Raquel, Almajid, Fahad, Dogan, Mustafa, Dauby, Nicolas, Gunst, Jesper Damsgaard, Tekin, Recep, Konopnicki, Deborah, Petrosillo, Nicola, Bozkurt, Ilkay, Wadi, Jamal, Popescu, Corneliu, Balkan, Ilker Inanc, Ozer-Balin, Safak, Zupanc, Tatjana Lejko, Cascio, Antonio, Dumitru, Irina Magdalena, Erdem, Aysegul, Ersoz, Gulden, Tasbakan, Meltem, Ajamieh, Oday Abu, Sirmatel, Fatma, Florescu, S., Gulsun, Serda, Ozkaya, Hacer Deniz, Sari, Sema, Tosun, Selma, Avci, Meltem, Cag, Yasemin, Celebi, Guven, Sagmak-Tartar, Ayse, Karakus, Sumeyra, Sener, Alper, Dedej, Arjeta, Oncu, Serkan, Del Vecchio, Rosa Fontana, Ozturk-Engin, Derya, Agalar, Canan

المصدر: European journal of clinical microbiology & infectious diseases

مصطلحات موضوعية: Sciences bio-médicales et agricoles, Blood culture, Infective endocarditis, Native, Prosthetic, S. aureus

الوصف: Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042). ; SCOPUS: ar.j ; info:eu-repo/semantics/published

وصف الملف: 1 full-text file(s): application/pdf

العلاقة: uri/info:doi/10.1007/s10096-019-03607-x; uri/info:pii/10.1007/s10096-019-03607-x; uri/info:pmid/31187307; uri/info:scp/85067399544; https://dipot.ulb.ac.be/dspace/bitstream/2013/289030/4/Portrayinginfectiveendocarditis.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/289030Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/289030Test
https://dipot.ulb.ac.be/dspace/bitstream/2013/289030/4/Portrayinginfectiveendocarditis.pdfTest