المؤلفون: Gu, Haotian, Azukaitis, Karolis, Doyon, Anke, Erdem, Sevcan, Ranchin, Bruno, Harambat, Jerome, Lugani, Francesca, Boguslavskyi, Andrii, Cansick, Janette, Finlay, Eric, Gilbert, Rodney, Kerecuk, Larissa, Lunn, Andrew, Maxwell, Heather, Morgan, Henry, Shenoy, Mohan, Shroff, Rukshana, Subramaniam, Pushpa, Tizard, Jane, Tse, Yincent, Simpson, John, Chowienczyk, Phil, Schaefer, Franz, Sinha, Manish D.

المساهمون: National Institute for Health and Care Research, British Heart Foundation

المصدر: Journal of the American Society of Echocardiography ; volume 37, issue 3, page 356-363.e1 ; ISSN 0894-7317

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and imaging

الإتاحة: https://doi.org/10.1016/j.echo.2023.11.013Test
https://api.elsevier.com/content/article/PII:S089473172300620X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S089473172300620X?httpAccept=text/plainTest

المؤلفون: Gu, Haotian, Ažukaitis, Karolis, Doyon, Anke, Erdem, Sevcan, Ranchin, Bruno, Harambat, Jerome, Lugani, Francesca, Boguslavskyi, Andrii, Cansick, Janette, Finlay, Eric, Gilbert, Rodney, Kerecuk, Larissa, Lunn, Andrew, Maxwell, Heather, Morgan, Henry, Shenoy, Mohan, Shroff, Rukshana, Subramaniam, Pushpa, Tizard, Jane, Tse, Yincent, Simpson, John, Chowienczyk, Phil, Schaefer, Franz, Sinha, Manish D.

المصدر: Journal of the American Society of Echocardiography., New York : MOSBY-Elsevier, 2024, vol. 37, iss. 3, p. 356-363.e1. ; ISSN 0894-7317

مصطلحات موضوعية: Early systolic function, first-phase ejection fraction, chronic kidney disease

الوصف: Introduction. Adults with childhood-onset chronic kidney disease (CKD) have increased risk of cardiovascular disease. First-phase ejection fraction (EF1) a novel measure of early systolic function may be a more sensitive marker of left ventricular dysfunction than other markers in children with CKD. Objective. To examine whether EF1 is reduced in children with CKD. Methods. Children from 4C and HOT-KID studies were stratified according to estimated glomerular filtration rate (eGFR). EF1 was calculated from the fraction of LV volume ejected up to the time of peak aortic flow velocity. Results. EF1 was measured in children aged 10.9±3.7 (mean±SD) years, 312 with CKD and 63 healthy controls. EF1 was lower, whilst overall EF was similar in those with CKD compared to controls and decreased across stages of CKD (29.3±3.7%, 23.5±4.5%, 19.8±4.0%, 18.5±5.1% and 16.7±6.6% in controls, CKD 1, 2, 3 and ≥4, respectively, p<0.001). The relationship of EF1 to eGFR persisted after adjustment for relevant confounders (p<0.001). The effect size for association of measures of LV structure or function with eGFR (SD change per unit change in eGFR) was greater for EF1 (b=0.365, p<0.001) than other measures: LVMi (β=-0.311), RWT (β=-0.223), E/e’ (β=-0.147), and e’ (β=0.141) after adjustment for confounders in children with CKD. Conclusions. Children with CKD exhibit a marked and progressive decline in EF1 with falling eGFR. This suggests that EF1 is a more sensitive marker of LV dysfunction when compared to other structural or functional measures and early LV systolic function a key feature in the pathophysiology of cardiac dysfunction in CKD.

وصف الملف: application/pdf

العلاقة: https://epublications.vu.lt/object/elaba:181467675/181467675.pdfTest; https://repository.vu.lt/VU:ELABAPDB181467675&prefLang=en_USTest

الإتاحة: https://doi.org/10.1016/j.echo.2023.11.013Test
https://repository.vu.lt/VU:ELABAPDB181467675&prefLang=en_USTest

المؤلفون: GU, Haotian, AZUKAITIS, Karolis, DOYON, Anke, ERDEM, Sevcan, RANCHIN, Bruno, HARAMBAT, Jerome, LUGANI, Francesca, BOGUSLAVSKYI, Andrii, CANSICK, Janette, FINLAY, Eric, GILBERT, Rodney, KERECUK, Larissa, LUNN, Andrew, MAXWELL, Heather, MORGAN, Henry, SHENOY, Mohan, SHROFF, Rukshana, SUBRAMANIAM, Pushpa, TIZARD, Jane, TSE, Yincent, SIMPSON, John, CHOWIENCZYK, Phil, SCHAEFER, Franz, SINHA, Manish D

مصطلحات موضوعية: Chronic kidney disease, Early systolic function, First-phase ejection fraction, Sciences du Vivant [q-bio]/Santé publique et épidémiologie

الوصف: INTRODUCTION: Adults with childhood-onset chronic kidney disease (CKD) have increased risk of cardiovascular disease. First-phase ejection fraction (EF1) a novel measure of early systolic function may be a more sensitive marker of left ventricular dysfunction than other markers in children with CKD. OBJECTIVE: To examine whether EF1 is reduced in children with CKD. METHODS: Children from 4C and HOT-KID studies were stratified according to estimated glomerular filtration rate (eGFR). EF1 was calculated from the fraction of LV volume ejected up to the time of peak aortic flow velocity. RESULTS: EF1 was measured in children aged 10.9±3.7 (mean±SD) years, 312 with CKD and 63 healthy controls. EF1 was lower, whilst overall EF was similar in those with CKD compared to controls and decreased across stages of CKD (29.3±3.7%, 23.5±4.5%, 19.8±4.0%, 18.5±5.1% and 16.7±6.6% in controls, CKD 1, 2, 3 and ≥4, respectively, p<0.001). The relationship of EF1 to eGFR persisted after adjustment for relevant confounders (p<0.001). The effect size for association of measures of LV structure or function with eGFR (SD change per unit change in eGFR) was greater for EF1 (β=0.365, p<0.001) than other measures: LVMi (β=-0.311), RWT (β=-0.223), E/e' (β=-0.147), and e' (β=0.141) after adjustment for confounders in children with CKD. CONCLUSIONS: Children with CKD exhibit a marked and progressive decline in EF1 with falling eGFR. This suggests that EF1 is a more sensitive marker of LV dysfunction when compared to other structural or functional measures and early LV systolic function a key feature in the pathophysiology of cardiac dysfunction in CKD.

العلاقة: https://oskar-bordeaux.fr/handle/20.500.12278/187157Test

الإتاحة: https://doi.org/20.500.12278/187157Test
https://doi.org/10.1016/j.echo.2023.11.013Test
https://oskar-bordeaux.fr/handle/20.500.12278/187157Test
https://hdl.handle.net/20.500.12278/187157Test

المؤلفون: Sinha, Manish D, Gu, Haotian, Douiri, Abdel, Cansick, Janette, Finlay, Eric, Gilbert, Rodney, Kerecuk, Larissa, Lunn, Andrew, Maxwell, Heather, Morgan, Henry, Shenoy, Mohan, Shroff, Rukshana, Subramaniam, Pushpa, Tizard, Jane, Tse, Yincent, Rezavi, Reza, Simpson, John M, Chowienczyk, Phil J

المصدر: Sinha , M D , Gu , H , Douiri , A , Cansick , J , Finlay , E , Gilbert , R , Kerecuk , L , Lunn , A , Maxwell , H , Morgan , H , Shenoy , M , Shroff , R , Subramaniam , P , Tizard , J , Tse , Y , Rezavi , R , Simpson , J M & Chowienczyk , P J 2023 , ' Intensive compared with less intensive blood pressure control to prevent adverse cardiac remodelling in children with chronic kidney disease (HOT-KID): a parallel-group, ....

الوصف: Background: Optimal target blood pressure to reduce adverse cardiac remodelling in children with chronic kidney disease is uncertain. We hypothesised that lower blood pressure would reduce adverse cardiac remodelling. Methods: HOT-KID, a parallel-group, open-label, multicentre, randomised, controlled trial, was done in 14 clinical centres across England and Scotland. We included children aged 2–15 years with stage 1–4 chronic kidney disease—ie, an estimated glomerular filtration rate (eGFR) higher than 15 mL/min per 1·73 m 2 —and who could be followed up for 2 years. Children on antihypertensive medication were eligible as long as it could be changed to angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) if they were not already receiving these therapies. Participants were randomly assigned (1:1) to standard treatment (auscultatory office systolic blood pressure target between the 50th and 75th percentiles) or intensive treatment (systolic target <40th percentile) by the chief investigator using a rapid, secure, web-based randomisation system. ACE inhibitors or ARBs were used as first-line agents, with the dose titrated every 2–4 weeks to achieve the target blood pressure levels. The primary outcome was mean annual difference in left ventricular mass index (LVMI) by echocardiography measured by a masked observer and was assessed in the intention-to-treat population, defined as all the children who underwent randomisation irrespective of the blood pressure reached. Secondary and safety outcomes were the differences between groups in mean left ventricular relative wall thickness, renal function, and adverse effects and were also assessed in the intention-to-treat population. This trial is registered with ISRCTN, ISRCTN25006406. Findings: Between Oct 30, 2012, and Jan 5, 2017, 64 participants were randomly assigned to the intensive treatment group and 60 to the standard treatment group (median age of participants was 10·0 years [IQR 6·8–12·6], 69 [56%] were male and 107 [86%] ...

الإتاحة: https://doi.org/10.1016/S2352-4642Test(22)00302-9
https://kclpure.kcl.ac.uk/portal/en/publications/fba1bf48-e26d-481b-8198-46af9645f72dTest
http://www.scopus.com/inward/record.url?scp=85144049648&partnerID=8YFLogxKTest

المؤلفون: Mumford, Lisa, Maxwell, Heather, Ahmad, Niaz, Marks, Stephen D., Tizard, Jane

المصدر: Transplant International ; volume 32, issue 7, page 751-761 ; ISSN 0934-0874 1432-2277

مصطلحات موضوعية: Transplantation

الإتاحة: https://doi.org/10.1111/tri.13418Test

المؤلفون: Lythgoe, Hanna, Smith, Eve M D, Killeen, Orla G, Murphy, Ruth, Pilkington, Clarissa, Pain, Clare E, Beresford, Michael W, Lynn, Richard, McDonagh, Janet, Tizard, Jane, Ioannou, Yiannis

المساهمون: BPSU Sir Peter Tizard Bursary, LUPUS UK, UK’s Experimental Arthritis Treatment Centre for Children, Versus Arthritis, Alder Hey Children’s National Health Service Foundation Trust, Alder Hey Charity, University of Liverpool

المصدر: Rheumatology ; volume 61, issue 10, page 4097-4106 ; ISSN 1462-0324 1462-0332

مصطلحات موضوعية: Pharmacology (medical), Rheumatology

الوصف: Objectives The primary objective was to define the incidence of JSLE in children <16 years of age in the UK and Republic of Ireland (ROI). The secondary objective was to describe presenting features, classification criteria, initial management and disease damage in newly presenting JSLE patients. Methods A prospective JSLE epidemiological study was undertaken between September 2017 and September 2019 with support of the British Paediatric Surveillance Unit and other professional groups involved in diagnosis and management of JSLE patients. Treating consultants reported all cases of JSLE seen. A follow-up study at 1 year examined management and progression of disease and treatment. Results There were 124 incident cases included in the final analysis. Incidence was estimated using ACR-1997 classification criteria (0.36/100 000), SLICC-2012 classification criteria (0.41/100 000) and clinician expert opinion (0.46/100 000). A high disease burden was seen, with 71.0% of patients requiring ongoing systemic CS treatment at 1 year; 98.2% receiving immunomodulatory treatment; and 20.4% accruing damage in the year following diagnosis (predominantly neuropsychiatric-related), with substantial involvement from multiple speciality teams. Conclusions The minimum UK and ROI incidence of JSLE is between 0.36 and 0.46/100 000, depending on the case definition used. Challenges in classification of patients with JSLE are highlighted, but overall this study supports the use of SLICC-2012 classification criteria. The high levels of disease damage and ongoing CS use 1 year after diagnosis is concerning, highlighting the need for further interventions to improve outcomes in JSLE.

الإتاحة: https://doi.org/10.1093/rheumatology/keac064Test
https://academic.oup.com/rheumatology/article-pdf/61/10/4097/46382723/keac064.pdfTest

المؤلفون: Chiewchengchol, Direkrit, Murphy, Ruth, Morgan, Thomas, Edwards, Steven W., Leone, Valentina, Friswell, Mark, Pilkington, Clarissa, Tullus, Kjell, Rangaraj, Satyapal, McDonagh, Janet E., Gardner-Medwin, Janet, Wilkinson, Nick, Riley, Phil, Tizard, Jane, Armon, Kate, Sinha, Manish D., Ioannou, Yiannis, Mann, Rebecca, Bailey, Kathryn, Davidson, Joyce, Baildam, Eileen M., Pain, Clare E., Cleary, Gavin, McCann, Liza J., Beresford, Michael W., on behalf of the UK JSLE Study Group

مصطلحات موضوعية: CLINICAL SCIENCE

الوصف: Objective. To determine whether mucocutaneous manifestations are associated with major organ involvement in a UK national cohort of juvenile-onset SLE (JSLE) patients. Methods. JSLE patients ( n = 241) from 15 different centres whose diagnosis fulfilled four or more of the ACR criteria were divided into two groups: those with at least one ACR mucocutaneous criterion (ACR skin feature positive) and those without (ACR skin feature negative) at diagnosis. The relative frequency of skin involvement was described by the paediatric adaptation of the 2004 British Isles Lupus Assessment Group (pBILAG-2004) index. Results. One hundred and seventy-nine patients (74%) had ACR-defined skin involvement with no significant demographic differences compared with those without. ACR skin feature negative patients showed greater haematological (84% vs 67%), renal (43% vs 26%) ( P < 0.05) and neurological (16% vs 4%) involvement ( P = 0.001). Forty-two per cent of ACR skin feature negative patients had skin involvement using pBILAG-2004, which included maculopapular rash (17%), non-scaring alopecia (15%), cutaneous vasculitis (12%) and RP (12%). ACR skin feature negative patients with moderate to severe skin involvement by pBILAG-2004 showed greater renal and haematological involvement at diagnosis and over the follow-up period ( P < 0.05). Higher immunosuppressive drug use in the skin feature negative group was demonstrated. Conclusion. Patients who fulfil the ACR criteria but without any of the mucocutaneous criteria at diagnosis have an increased risk of major organ involvement. The pBILAG-2004 index has shown that other skin lesions may go undetected using the ACR criteria alone, and these lesions show a strong correlation with disease severity and major organ involvement.

وصف الملف: text/html

العلاقة: http://rheumatology.oxfordjournals.org/cgi/content/short/53/8/1504Test; http://dx.doi.org/10.1093/rheumatology/keu137Test

الإتاحة: https://doi.org/10.1093/rheumatology/keu137Test
http://rheumatology.oxfordjournals.org/cgi/content/short/53/8/1504Test

المؤلفون: Ding, Wen Y., Koziell, Ania, McCarthy, Hugh J., Bierzynska, Agnieszka, Bhagavatula, Murali K., Dudley, Jan A., Inward, Carol D., Coward, Richard J., Tizard, Jane, Reid, Christopher, Antignac, Corinne, Boyer, Olivia, Saleem, Moin A.

المصدر: Journal of the American Society of Nephrology ; volume 25, issue 6, page 1342-1348 ; ISSN 1046-6673

الإتاحة: https://doi.org/10.1681/asn.2013080852Test
https://journals.lww.com/00001751-201406000-00024Test

المؤلفون: Watson, Louise, Leone, Valentina, Pilkington, Clarissa, Tullus, Kjell, Rangaraj, Satyapal, McDonagh, Janet E., Gardner-Medwin, Janet, Wilkinson, Nick, Riley, Phil, Tizard, Jane, Armon, Kate, Sinha, Manish, Ioannou, Yiannis, Archer, Neil, Bailey, Kathryn, Davidson, Joyce, Baildam, Eileen M., Cleary, Gavin, McCann, Liza J., Beresford, Michael W.

المصدر: Watson , L , Leone , V , Pilkington , C , Tullus , K , Rangaraj , S , McDonagh , J E , Gardner-Medwin , J , Wilkinson , N , Riley , P , Tizard , J , Armon , K , Sinha , M , Ioannou , Y , Archer , N , Bailey , K , Davidson , J , Baildam , E M , Cleary , G , McCann , L J , Beresford , M W 2012 , ' Disease activity, severity, and damage in the UK juvenile-onset systemic lupus erythematosus cohort ....

مصطلحات موضوعية: PEDIATRIC RHEUMATIC-DISEASES, CHILDHOOD-ONSET, ACTIVITY INDEX, ADULT-ONSET, INTRAVENOUS CYCLOPHOSPHAMIDE, INITIAL VALIDATION, CLINICAL-FEATURES, BILAG-2004 INDEX, POPULATION, MORTALITY

الوصف: Objective The UK Juvenile-Onset Systemic Lupus Erythematosus (JSLE) Cohort Study is a multicenter collaborative network established with the aim of improving the understanding of juvenile SLE. The present study was undertaken to describe the clinical manifestations and disease course in patients with juvenile SLE from this large, national inception cohort. Methods Detailed data on clinical phenotype were collected at baseline and at regular clinic reviews and annual followup assessments in 232 patients from 14 centers across the UK over 4.5 years. Patients with SLE were identified according to the American College of Rheumatology (ACR) SLE classification criteria. The present cohort comprised children with juvenile SLE (n = 198) whose diagnosis fulfilled =4 of the ACR criteria for SLE. Results Among patients with juvenile SLE, the female:male sex distribution was 5.6:1 and the median age at diagnosis was 12.6 years (interquartile range 10.414.5 years). Male patients were younger than female patients (P <0.01). Standardized ethnicity data demonstrated a greater risk of juvenile SLE in non-Caucasian UK patients (P <0.05). Scores on the pediatric adaptation of the 2004 British Isles Lupus Assessment Group disease activity index demonstrated significantly increased frequencies of musculoskeletal (82%), renal (80%), hematologic (91%), immunologic (54%), and neurologic (26%) involvement among the patients over time. A large proportion of the patients (93%) were taking steroids and 24% of the patients required treatment with cyclophosphamide. Disease damage was common, with 28% of the patients having a Systemic Lupus International Collaborating Clinics/ACR damage score of =1. Conclusion The data on these patients from the UK JSLE Cohort Study, comprising one of the largest national inception cohorts of patients with juvenile SLE to date, indicate that severe organ involvement and significant disease activity are primary characteristics in children with juvenile SLE. In addition, accumulation of disease-associated ...

الإتاحة: https://doi.org/10.1002/art.34410Test
https://kclpure.kcl.ac.uk/portal/en/publications/5f2abecf-d4c4-4f0a-a467-b8a521543acaTest

المؤلفون: Shi, Hufeng, Wen, Jianguo, LI, Zhenzhen, Elsayed, Maged, Kamal, Khaled, El Shal, Amal, Youssef, Doaa, Caubet, Cécile, Lacroix, Chrystelle, Benjamin, Breuil, Bandin, Flavio, Bascands, Jean-Loup, Monsarrat, Bernard, Decramer, Stéphane, Schanstra, Joost, Laetitia, Delbe-Bertin, Ulinski, Tim, Aoun, Bilal, Ozdemir, Kadriye, Dincel, Nida, Sozeri, Betul, Mir, Sevgi, Berdeli, Afig, Akyigit, Fatma, Mizerska-Wasiak, Malgorzata, Panczyk-Tomaszewska, Malgorzata, Szymanik-Grzelak, Hanna, Roszkowska-Blaim, Maria, Jamin, Agnes, Dehoux, Laurene, Monteiro, Renato C, Deschenes, Georges, Bouts, Antonia, Davin, Jean-Claude, Dorresteijn, Eiske, Schreuder, Michiel, Lilien, Marc, Oosterveld, Michiel, Kramer, Sharon, Gruppen, Mariken, Pintos-Morell, Guillem, Ramaswami, Uma, Parini, Rossella, Rohrbach, Marianne, Kalkum, Gisela, Beck, Michael, Carter, Mary, Antwi, Sampson, Callegari, John, Kotanko, Peter, Levin, Nathan W, Rumjon, Adam, Macdougall, Iain C., Turner, Charles, Booth, Caroline J., Goldsmith, David, Sinha, Manish D., Camilla, Roberta, Loiacono, Elisa, Donadio, Maria Elena, Conrieri, Margherita, Bianciotto, Manuela, Bosetti, Francesca M., Peruzzi, Licia, Conti, Giovanni, Bitto, Alessandra, Amore, Alessandro, Coppo, Rosannna, Maldyk, Jadwiga, Chou, Hsin-Hsu, Chiou, Yuan-Yow, Bochniewska, Violetta, Jobs, Katarzyna, Jung, Anna, Fallahzadeh Abarghooei, Mohammad Hossein, Zare, Javad, Sedighi Goorabi, Vahid, Derakhshan, Ali, Basiratnia, Mitra, Fallahzadeh Abarghooei, Mohammad Amin, Hosseini Al-Hashemi, Ghamar, Fallahzadeh Abarghooei, Fatemeh, Kluska-Jozwiak, Agnieszka, Soltysiak, Jolanta, Lipkowska, Katarzyna, Silska, Magdalena, Fichna, Piotr, Skowronska, Bogda, Stankiewicz, Witold, Ostalska-Nowicka, Danuta, Zachwieja, Jacek, Girisgen, Llknur, Sönmez, Ferah, Yenisey, Çigdem, Kis, Eva, Cseprekal, Orsolya, Kerti, Andrea, Szabo, Attila, Salvi, Paolo, Benetos, Athanase, Tulassay, Tivadar, Reusz, George, Makulska, Irena, Szczepanska, Maria, Drozdz, Dorota, Zwolnska, Danuta, Tolstova, Evgeniya, Anis, Larakeb, Alber, Bensman, Edouard, Bingen, Gérard, Coulibaly, Seni, Kouanda, Dunia Julienne Hadiza, Tountian/Ouedraogo, Christian, Sapo, Benoît, Tiendrébéogo, François, Babinet, Adama, Lengani, Rosenberg, Andrew, Munro, Jane, Murray, Kevin, Wainstein, Brynn, Ziegler, John, Singh-Grewal, Davinder, Boros, Christina, Adib, Navid, Elliot, Elizabeth, Fahy, Rose, Mackie, Fiona, Kainer, Gad, Polak-Jonkisz, Dorota, Zwolinska, Danuta, Laszki-Szczachor, Krystyna, Janocha, Anna, Rusiecki, Leslaw, Sobieszczanska, Malgorzata, Garzotto, Francesco, Ricci, Zaccaria, Clementi, Anna, Cena, Roberto, Kim, Jeong Chul, Zanella, Monica, Ronco, Claudio, Purzyc, Leszek, Peco-Antic, Amira, Kotur-Stevuljevic, Jelena, Paripovic, Dusan, Scekic, Gordana, Milosevski-Lomic, Gordana, Bogicevic, Dragana, Spasojevic-Dimitrijeva, Brankica, Hassan, Rashad, El-Husseini, Amr, Sobh, Mohamed, Ghoneim, Mohamed, Harambat, Jerome, Bonthuis, Marjolein, Van Stralen, Karlijn J., Ariceta, Gema, Battelino, Nina, Jahnukainen, Timo, Sandes, Ana R., Combe, Christian, Jager, Kitty J., Verrina, Enrico, Schaefer, Franz, Espindola, Reynaldo, Bacchetta, Justine, Cochat, Pierre, Stefanis, Constantinos, Leroy, Sandrine, Fernandez-Lopez, Anna, Nikfar, Roya, Romanello, Carla, Bouissou, François, Gervaix, Alain, Gurgoze, Metin, Bressan, Silvia, Smolkin, Vladislav, Tuerlinkx, David, Stefanidis, Constantinos, Vaos, Georgios, Leblond, Pierre, Gungor, Firat, Gendrel, Dominique, Chalumeau, Martin, Rawlins, Debbie, Simpson, John M., Arnaud, Garnier, Anne, Modesto, Stéphanie, Tellier, Flavio, Bandin, Veronique, Fremeaux Bacchi, Stéphane, Decramer, Mumford, Lisa, Marks, Stephen, Ahmad, Niaz, Maxwell, Heather, Tizard, Jane, Vidal, Enrico, Amigoni, Angela, Varagnolo, Mariacristina, Benetti, Elisa, Ghirardo, Giulia, Brugnolaro, Valentina, Murer, Luisa, Christine, Grapin, Dégi, Arianna, Kis, Éva, Cseprekál, Orsolya, Szabó, Attila J., Reusz, György S., Vidoni, Alessandro, Ramondo, Gaetano, Miotto, Diego

مصطلحات موضوعية: Abstracts

الوصف: Introduction and Aims: Congenital obstructive nephropathy is the primary cause of chronic renal failure in children. Rapid diagnosis and initiation of the treatment are vital to preserve function and/or to slow down renal injury. In oxidative stress, heme oxygenase-1 (HO-1) plays a pivotal role in maintaining renal function and protecting renal structure, especially in renal tubular epithelial cells. The aim of our study was to determine whether urinary (u) HO-1 may be a useful biomarker in children with congenital hydronephrosis (HN) caused by ureteropelvic junction obstruction. Methods: The study consisted of 25 children with severe HN who required pyeloplasty (average age: 2.37 ± 0.66 years), 25 children with mild, non-obstructive HN (average age: 7.13 ± 0.65 years) and 30 healthy children (control group, average age: 5.95 ± 0.70 years). Immunoenzymatic ELISA commercial kits were used to measure uHO-1 concentration. Results: The uHO-1 and uHO-1/creatinine (cr) levels before surgery and during surgery were significantly greater in children with severe HN than in both children with mild, non-obstructive HN and control group (P < 0.01). Three months after surgery, uHO-1/cr decreased significantly in children with severe HN compared with that before surgery (1.73 ± 0.25 ng/mg vs. 4.23 ± 0.53 ng/mg; P < 0.01), but was still higher than that in children with mild, non-obstructive HN (1.73 ± 0.25 ng/mg vs. 1.04 ± 0.21 ng/mg; P < 0.05). The uHO-1 and uHO- 1/creatinine (cr) levels were markedly lower in control group than that in children with mild, non-obstructive HN (uHO-1: 0.36 ± 0.06 ng/mg vs. 0.84 ± 0.11 ng/mg, P < 0.01; uHO-1/cr: 0.56 ± 0.10 ng/mg vs. 1.04 ± 0.21 ng/mg, P < 0.05). Moreover, a negative correlation between uHO-1/cr ratio and split renal function was found before surgery (r = −0.593, P = 0.002) and during pyeloplasty (r = −0.452, P = 0.023) in children with severe HN. Receiver operator characteristic analysis revealed that a good diagnostic profile for uHO-1 in terms of identifying a ...

وصف الملف: text/html

العلاقة: http://ndt.oxfordjournals.org/cgi/content/short/27/suppl_2/ii537Test; http://dx.doi.org/10.1093/ndt/gfs250Test

الإتاحة: https://doi.org/10.1093/ndt/gfs250Test
http://ndt.oxfordjournals.org/cgi/content/short/27/suppl_2/ii537Test