المؤلفون: Stefanie Vandevijvere, Wim Coucke, Jean Vanderpas, Caroline Trumpff, Maarten Fauvart, Ann Meulemans, Sandrine Marie, Marie-Françoise Vincent, Roland Schoos, François Boemer, Timothy Vanwynsberghe, Eddy Philips, François Eyskens, Brigitte Wuyts, Valbona Selimaj, Bart Van Overmeire, Christine Kirkpatrick, Herman Van Oyen, Rodrigo Moreno-Reyes

المصدر: PLoS ONE, Vol 7, Iss 10, p e47770 (2012)

مصطلحات موضوعية: Medicine, Science

الوصف: It has been proposed that neonatal thyroid-stimulating hormone (TSH) concentrations are a good indicator of iodine deficiency in the population. A frequency of neonatal TSH concentrations above 5 mU/L below 3% has been proposed as the threshold indicating iodine sufficiency. The objective of the present study was to evaluate feasibility and usefulness of nation-wide neonatal TSH concentration screening results to assess iodine status in Belgium. All newborns born in Belgium during the period 2009-2011 (n = 377713) were included in the study, except those suffering from congenital hypothyroidism and premature neonates. The frequency of neonatal TSH concentrations above 5 mU/L from 2009 to 2011 in Belgium fluctuated between 2.6 and 3.3% in the centres using the same TSH assay. There was a significant inverse association between neonatal TSH level and birth weight. The longer the duration between birth and screening, the lower the TSH level. Neonatal TSH levels were significantly lower in winter than in spring or autumn and significantly lower in spring and summer than in autumn while significantly higher in spring compared to summer. In conclusion, despite that pregnant women in Belgium are mildly iodine deficient, the frequency of neonatal TSH concentrations above 5 mU/L was very low, suggesting that the neonatal TSH threshold proposed for detecting iodine deficiency needs to be re-evaluated. Although neonatal TSH is useful to detect severe iodine deficiency, it should not be recommended presently for the evaluation of iodine status in mildly iodine deficient regions.

وصف الملف: electronic resource

العلاقة: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23112844/?tool=EBITest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/0afcf7c5986f4666bf26c0bfb35da2e4Test

المؤلفون: Hans De Beenhouwer, An Boel, Kristien Van Vaerenbergh, Katia M.C. Verhamme, Reinoud Cartuyvels, M. Raymaekers, Timothy Vanwynsberghe

المصدر: The Open Infectious Diseases Journal. 3:55-60

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, medicine.drug_class, Klebsiella pneumoniae, Cefepime, media_common.quotation_subject, Cephalosporin, Microbiology, Meropenem, law.invention, Hygiene, law, polycyclic compounds, medicine, Infection control, media_common, biology, business.industry, Outbreak, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, biology.organism_classification, Intensive care unit, Infectious Diseases, Parasitology, business, medicine.drug

الوصف: Plasmid-borne ampC � -lactamases are emerging worldwide. There is no gold standard in detecting them so it is presumed their prevalence is underestimated. They may confer resistance to broad-spectrum cephalosporins. In this paper the first outbreak in Europe of a Klebsiella pneumoniae harbouring a plasmid-borne DHA-1 � -lactamase and a SHV-11 � - lactamase is reported. Following CLSI (Clinical Laboratories Standards Institute) guidelines the majority of isolates would have been reported susceptible to third generation cephalosporines in spite of increased MIC values. No failures were observed in patients treated with cefepime or meropenem. Infections were linked to stay on the intensive care unit and/or urological interventions. The outbreak was stopped after a meeting was organised between the department of infection control of the hospital and the complete ICU and urology staff in which the importance of strict hand hygiene to limit transmission was stressed.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::59c8ba6b215337a3d188cbb6dad6e072Test
https://doi.org/10.2174/1874279300903010055Test

المؤلفون: Pieter Vermeersch, Veronique Stove, Lisa Florin, Steven Pauwels, Timothy Vanwynsberghe, Anna Vantilborgh

المصدر: Clinica Chimica Acta. 447:32-33

مصطلحات موضوعية: medicine.diagnostic_test, Chemistry, Biochemistry (medical), Clinical Biochemistry, nutritional and metabolic diseases, General Medicine, Biochemistry, Virology, nervous system diseases, Interference (communication), immune system diseases, hemic and lymphatic diseases, Immunoassay, Immunology, medicine, Vancomycin, cardiovascular diseases, medicine.drug

الوصف: • We describe a case of falsely elevated vancomycin concentration due to IgM paraprotein interference

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a4530c16c9438cae8a9ee27e46fe1c77Test
https://doi.org/10.1016/j.cca.2015.05.006Test

المؤلفون: Jean Vanderpas, Marie-Françoise Vincent, Ann Meulemans, Timothy Vanwynsberghe, Caroline Trumpff, Brigitte Wuyts, Valbona Selimaj, Bart Van Overmeire, Roland Schoos, Stefanie Vandevijvere, François Eyskens, Sandrine Marie, Wim Coucke, Christine Kirkpatrick, Herman Van Oyen, François Boemer, Maarten Fauvart, Eddy Philips, Rodrigo Moreno-Reyes

المساهمون: UCL - (SLuc) Service de biochimie médicale, Nizami, Qamaruddin

المصدر: PLoS One, Vol. 7, no.10, p. e47770 [1-6] (2012)
PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e47770 (2012)
PloS one, 7 (10

مصطلحات موضوعية: endocrine system diseases, Epidemiology, Thyrotropin, Pediatrics, Endocrinology, Pediatric Endocrinology, Belgium, Pregnancy, Congenital Hypothyroidism -- blood -- diagnosis, Pediatric Epidemiology, Thyroid, education.field_of_study, Multidisciplinary, Child Health, Sciences bio-médicales et agricoles, Congenital hypothyroidism, Micronutrient Deficiencies, Medicine, Female, Public Health, Seasons, hormones, hormone substitutes, and hormone antagonists, Research Article, medicine.medical_specialty, endocrine system, Birth weight, Science, Population, chemistry.chemical_element, Iodine, Thyroid-stimulating hormone, Internal medicine, medicine, Congenital Hypothyroidism, Humans, Least-Squares Analysis, education, Thyrotropin -- blood -- diagnostic use, Nutrition, business.industry, Infant, Newborn, medicine.disease, Iodine deficiency, Survey Methods, chemistry, Preventive Medicine, Neonatology, business, Hormone

الوصف: It has been proposed that neonatal thyroid-stimulating hormone (TSH) concentrations are a good indicator of iodine deficiency in the population. A frequency of neonatal TSH concentrations above 5 mU/L below 3% has been proposed as the threshold indicating iodine sufficiency. The objective of the present study was to evaluate feasibility and usefulness of nation-wide neonatal TSH concentration screening results to assess iodine status in Belgium. All newborns born in Belgium during the period 2009-2011 (n = 377713) were included in the study, except those suffering from congenital hypothyroidism and premature neonates. The frequency of neonatal TSH concentrations above 5 mU/L from 2009 to 2011 in Belgium fluctuated between 2.6 and 3.3% in the centres using the same TSH assay. There was a significant inverse association between neonatal TSH level and birth weight. The longer the duration between birth and screening, the lower the TSH level. Neonatal TSH levels were significantly lower in winter than in spring or autumn and significantly lower in spring and summer than in autumn while significantly higher in spring compared to summer. In conclusion, despite that pregnant women in Belgium are mildly iodine deficient, the frequency of neonatal TSH concentrations above 5 mU/L was very low, suggesting that the neonatal TSH threshold proposed for detecting iodine deficiency needs to be re-evaluated. Although neonatal TSH is useful to detect severe iodine deficiency, it should not be recommended presently for the evaluation of iodine status in mildly iodine deficient regions.
Journal Article
SCOPUS: ar.j
info:eu-repo/semantics/published

وصف الملف: 1 full-text file(s): application/pdf; Print-Electronic; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11240d559d8c9426fc7bb4913890dbeTest
https://hdl.handle.net/2078.1/158473Test