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1دورية أكاديمية
المؤلفون: Trong Duc Le, Tien Cong Nguyen, Thi Kim Dung Hoang, Minh Khoi Huynh, Quang Thang Phan, Luc Van Meervelt
المصدر: Acta Crystallographica Section E: Crystallographic Communications, Vol 80, Iss 2, Pp 218-222 (2024)
مصطلحات موضوعية: crystal structure, 1,2,4-triazole, hirshfeld surface, Crystallography, QD901-999
الوصف: The title compound, C27H20N4O3S, crystallizes in the monoclinic system, space group P21/n, with Z = 4. The global shape of the molecule is determined by the orientation of the substituents on the central 4H-1,2,4-triazole ring. The nitrophenyl ring, phenyl ring, and naphthalene ring system are oriented at dihedral angles of 82.95 (17), 77.14 (18) and 89.46 (15)°, respectively, with respect to the triazole ring. The crystal packing features chain formation in the b-axis direction by S...O interactions. A Hirshfeld surface analysis indicates that the highest contributions to surface contacts arise from contacts in which H atoms are involved.
وصف الملف: electronic resource
العلاقة: http://scripts.iucr.org/cgi-bin/paper?S2056989024000859Test; https://doaj.org/toc/2056-9890Test
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2دورية أكاديمية
المؤلفون: Tien Cong Nguyen, Duc Dung Pham, Thi Minh Dinh Tran, Thi Thuy Linh Bui
المصدر: Vietnam Journal of Science, Technology and Engineering, Vol 64, Iss 2 (2022)
مصطلحات موضوعية: acetamide, hydrazide, quinazolin-4(3H)-one, thiocarbonyl-bis-thioglycolic, 2-thioxothiazolidin-4- one, Science
الوصف: Five new derivatives of N-(4-oxo-2-thioxothiazolidin-3-yl)-2-((3-aryl-4-oxo-3,4-dihydroquinazolin-2-yl)thio) acetamides have been synthesized successfully through a four-step process from anthranilic acid and aryl isothiocyanates as starting materials. The total yields ranged from 29 to 31% and these structures were determined by IR, 1H-NMR, 13C-NMR, and HR-MS spectra.
وصف الملف: electronic resource
العلاقة: https://vietnamscience.vjst.vn/index.php/vjste/article/view/329Test; https://doaj.org/toc/2525-2461Test; https://doaj.org/toc/2615-9937Test
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3دورية أكاديمية
المؤلفون: Trong Duc Le, Ngoc Nam Pham, Tien Cong Nguyen
المصدر: Journal of Chemistry, Vol 2018 (2018)
الوصف: N-(4-Substituted phenyl)acetamides, which were prepared from acetic anhydride and p-substituted anilines, were utilized as precursors for reactions to Vilsmeier-Haack reagent to form 6-substituted-2-chloroquinoline-3-carbaldehydes 3a–c. Meanwhile, a similar reagent was applied to 1-[1-(4-substituted phenyl)ethylidene]-2-phenylhydrazines as substrates, which were synthesized from phenylhydrazine hydrochloride and p-substituted acetophenones, and 1,3-diarylpyrazole-4-carbaldehydes 3d–f were observed as a result. Reactions between the aldehydes 3a–f and 7-chloro-4-hydrazinylquinoline 2, obtained from reaction of 4,7-dichloroquinoline 1 and hydrazine hydrate, formed six new hydrazone compounds, namely, 4-{2-[(6-substituted-2-chloroquinolin-3-yl)methylidene]hydrazinyl}-7-chloroquinolines 4a–c and 4-(2-{[3-(4-substituted phenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}hydrazinyl)-7-chloroquinolines 4d–f. The chemical structures of all synthesized compounds were elucidated by the analysis of IR, 1H, 13C-NMR, and HRMS spectral data. Additionally, all of the synthesized hydrazones were evaluated in terms of cytotoxic activity against four strains of bacteria and four strains of fungus at several concentrations of substrates. As a result, three of them, 4a–c, possess the good ability as growth inhibitor of Bacillus subtilis and Aspergillus niger at the concentration of 25 μg/mL and 50 μg/mL, respectively, while compound 4e only shows a cytotoxic activity against Aspergillus niger at the concentration of 25 μg/mL.
وصف الملف: electronic resource
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4دورية أكاديمية
المصدر: Vietnam Journal of Chemistry; Nov2023 Supplement 1, Vol. 61, p131-136, 6p
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المؤلفون: Anh Tuan Vo, Thanh Van Nguyen, Son Minh Kieu, An Quang Kieu, Kha Tan Huynh, Quynh Ngoc Hoa Nguyen, Truc T. T. Nguyen, Tien Cong Nguyen
المصدر: Journal for Vascular Ultrasound. 46:160-164
الوصف: Background: The global prevalence of chronic kidney disease (CKD) continues to increase, with the arteriovenous fistula (AVF) as the most preferred vascular access for hemodialysis. Whether routine preoperative ultrasound mapping improves the outcome of AVF formation compared with clinical examination alone remains controversial. Methods: This retrospective study included patients undergoing AVF surgery with and without preoperative ultrasound at our center between September 2017 and August 2020. Outcome measures included AVF early and mid-term outcome. Cox regression analysis was performed to identify independent predictors of favorable AVF outcome. Results: A total of 158 patients received an AVF during the study period. Both groups with (n = 79) and without (n = 79) ultrasound mapping were similar regarding baseline characteristics (age, sex, comorbidities). Patency rates were comparable between the 2 groups at 30 days, 3 months, and 6 months after AVF surgery, although there was a trend toward more favorable outcome for the mapping group ( P = .07). Kaplan-Meier analysis showed that at the end of study, the ultrasound mapping group had a higher mid-term patency rate; however, the improvement was not significant ( P = .07). Cox regression analysis did not reveal age, gender, comorbidities, and ultrasound as predictors of AVF survival. Conclusion: Our study did not find a significant benefit from routine preoperative ultrasound mapping in creating AVFs for hemodialysis. Further well-designed and adequately powered trials are needed to demonstrate the beneficial role of routine preoperative ultrasound mapping for vascular access in CKD coupled with clinical evaluation in short- and long-term AVF outcome.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2451cadc3f944422f8d383856f012225Test
https://doi.org/10.1177/15443167221113867Test -
6دورية أكاديمية
المصدر: Vietnam Journal of Chemistry ; volume 61, issue S2, page 131-136 ; ISSN 2572-8288 2572-8288
الوصف: Two series of novel hybrid compounds, in which a variety of 2‐mercapto‐3‐arylquinazolin‐4(3 H )‐ones ( 3a‐d )/6‐bromo‐2‐mercapto‐3‐phenylquinazolin‐4(3 H )‐one ( 9 ) act as fundamental moieties are incorporated in particular 3‐(2‐bromoacetyl)‐2 H ‐chromen‐2‐one ( 4 ) or 2‐chloro‐ N ‐(2‐oxo‐2 H ‐chromen‐3‐yl)acetamide ( 5 ) via alkylation of the thiol group in quinazolin‐4(3 H )‐one ring, were synthesized. The key intermediates ( 3a‐d ) and ( 9 ) were prepared by the reaction of anthranilic acid ( 1 )/2‐amino‐5‐bromobenzoic acid ( 8 ) with carbon disulfide and appropriate aromatic amines in an alkaline medium. These compounds’ structures were confirmed by comparing their physical characteristics and spectral data to the earlier ones. Ten novel products ( 6a‐d , 7a‐d , 10 , 11 ) were synthesized and the structures were determined by their IR, 1 H‐NMR, 13 C‐NMR and HR‐MS spectral data. Subsequently, their antimicrobial activities were estimated in vitro test against four bacterial strains including P. aeruginosa NRRL B‐14781 and E. coli NRRL B‐409 (Gram‐negative), B. cereus ATCC 10876 and L. monocytogenes ATCC 13932 (Gram‐positive), by agar well diffusion assay. The outcome showed that all hybrid compounds have potential inhibition of tested Gram‐negative bacteria. Compound ( 6d ) revealed remarkable antibacterial effects on P. aeruginosa and E. coli growth. Besides, compounds ( 6a ), ( 7a ), ( 7d ) and ( 10 ) have also inhibitory effects on B. cereus strain at tested concentrations. The compounds mentioned above contain the 3‐chlorophenyl/phenyl substituent at position 3 in the quinazoline ring.
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المؤلفون: Trong Duc Le, Tien Cong Nguyen, Thi My Nuong Bui, Thi Kim Dung Hoang, Quoc Trung Vu, Chien Thang Pham, Chau Phi Dinh, Jibril Abdullahi Alhaji, Luc Van Meervelt
المصدر: Journal of Molecular Structure. 1284:135321
مصطلحات موضوعية: Inorganic Chemistry, Organic Chemistry, Spectroscopy, Analytical Chemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d069959740ff3025bb7ab971da5a6ef0Test
https://doi.org/10.1016/j.molstruc.2023.135321Test -
8دورية أكاديمية
المؤلفون: Trương Tiến Công*, Nguyễn Minh Chơn, Nguyễn Hữu Thanh, Nguyễn Phú Thọ, Trịnh Thị Lan, Nguyễn Hữu Yến Nhi, Nguyễn Thị Thúy Hằng
المصدر: Vietnam Journal of Science and Technology; Vol. 64 No. 7B (2022): Tập 64 - Số 7 - Tháng 7 năm 2022; 49 ; Tạp chí Khoa học và Công nghệ Việt Nam- B; Tập. 64 Số. 7B (2022): Tập 64 - Số 7 - Tháng 7 năm 2022; 49 ; 1859-4794
مصطلحات موضوعية: Bifidobacterium bifidum, Black tiger shrimp, lactic acid, Lactobacillus plantarum, prebiotic, Vibrio parahaemolyticus, lactic, tôm Sú
الوصف: Extracellular polymeric substances (EPS) are known as prebiotic-like compounds that promote the growth of beneficial bacteria in the intestinal tract of humans and animals. To demonstrate the prebiotic potential of EPSs produced from lactic acid bacteria, Lactobacillus plantarum and Bifidobacterium bifidum, this study demonstrated the influence of these bacteria on the immune response in shrimp to infection with pathogenic bacteria. Vibrio parahaemolyticus disease. ; Các hợp chất cao phân tử ngoại bào (EPS - Extracellular polymeric substances) được biết đến là một hợp chất có khả năng như prebiotic để thúc đẩy sự phát triển của vi khuẩn có lợi trong đường ruột của người và động vật. Để chứng minh tiềm năng prebiotic của các EPS được sản xuất từ vi khuẩn lactic, Lactobacillus plantarum và Bifidobacterium bifidum, nghiên cứu này đã đánh gia ảnh hưởng của các vi khuẩn trên với đáp ứng miễn dịch ở tôm khi lây nhiễm với vi khuẩn gây bệnh Vibrio parahaemolyticus.
وصف الملف: application/pdf
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المؤلفون: Thanh-Tran Le Thi, Thi-Thuy Luu, Trong-Vu Tran, Tien-Cong Nguyen, Quang Hieu Tran, Quang-Tri Le, Van-Phuc Dinh
المصدر: Journal of Food Processing and Preservation. 45
مصطلحات موضوعية: Antioxidant, Chemistry, General Chemical Engineering, medicine.medical_treatment, medicine, General Chemistry, Phase inversion, Food Science, Characterization (materials science), Nuclear chemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a3cfb78ade4c5407bcc8b4402c90d40cTest
https://doi.org/10.1111/jfpp.15402Test -
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المؤلفون: Nguyen-Minh-An Tran, Asshaima Paramita Devi, Mahboob Alam, Thuc-Huy Duong, Hoang-Vinh-Truong Phan, Ngoc-Vinh Huynh, Hoai-Duc Tran, Huu-Hung Nguyen, Jirapast Sichaem, Tien-Cong Nguyen, Thi-Phuong Nguyen, Warinthorn Chavasiri
المصدر: Bioorganicmedicinal chemistry letters. 30(17)
مصطلحات موضوعية: Cell Survival, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Hydrazide, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Molecular dynamics, Structure-Activity Relationship, Catalytic Domain, Drug Discovery, Hydroxybenzoates, Molecule, Humans, Hypoglycemic Agents, Glycoside Hydrolase Inhibitors, Cytotoxicity, Molecular Biology, Antidiabetic agents, Natural product, Binding Sites, 010405 organic chemistry, Organic Chemistry, alpha-Glucosidases, Combinatorial chemistry, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Hydrazines, chemistry, Docking (molecular), Molecular Medicine, Depside
الوصف: A series of novel N-substituted hydrazide derivatives were synthesized by reacting atranorin, a compound with a natural depside structure (1), with a range of hydrazines. The natural product and 12 new analogues (2–13) were investigated for inhibition of α-glucosidase. The N-substituted hydrazide derivatives showed more potent inhibition than the original. The experimental results were confirmed by docking analysis. This study suggests that these compounds are promising molecules for diabetes therapy. Molecular dynamics simulations were carried out with compound 2 demonstrating the best docking model using Gromac during simulation up to 20 ns to explore the stability of the complex ligand-protein. Furthermore, the activity of all synthetic compounds 2–13 against a normal cell line HEK293, used for assessing their cytotoxicity, was evaluated.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7dbb48718c11db390c0382bce74ede9Test
https://pubmed.ncbi.nlm.nih.gov/32738998Test
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