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1دورية أكاديمية
المؤلفون: Mouterde, Timothée, Keerthi, A., Poggioli, Anthony, Dar, S., Siria, A., Geim, A., Bocquet, Lydéric, Radha, B.
المساهمون: Micromegas : Nano-Fluidique, Laboratoire de physique de l'ENS - ENS Paris (LPENS (UMR_8023)), École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), School of Physics and Astronomy Manchester, University of Manchester Manchester, ANR-17-CE09-0046,NEPTUNE,Transport hors equilibre de fluides aux échelles nanométriques(2017)
المصدر: ISSN: 0028-0836.
مصطلحات موضوعية: KSK campus, Lahore, Pakistan † these authors contributed equally to the work, [PHYS]Physics [physics], [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph]
الوصف: International audience ; The field of nanofluidics has shown considerable progress over the past decade thanks to key instrumental advances, leading to the discovery of a number of exotic transport phenomena for fluids and ions under extreme confinement. Recently, van der Waals assembly of 2D materials 1 allowed fabrication of artificial channels with ångström-scale precision 2. This ultimate confinement to the true molecular scale revealed unforeseen behaviour for both mass 2 and ionic 3 transport. In this work, we explore pressure-driven streaming in such molecular-size slits and report a new electro-hydrodynamic effect under coupled pressure and electric force. It takes the form of a transistor-like response of the pressure induced ionic streaming: an applied bias of a fraction of a volt results in an enhancement of the streaming mobility by up to 20 times. The gating effect is observed with both graphite and boron nitride channels but exhibits marked material-dependent features. Our observations are rationalized by a theoretical framework for the flow dynamics, including the frictional interaction of water, ions and the confining surfaces as a key ingredient. The material dependence of the voltage modulation can be traced back to a contrasting molecular friction on graphene and boron nitride. The highly nonlinear transport under molecular-scale confinement offers new routes to actively control molecular and ion transport and design elementary building blocks for artificial ionic machinery, such as ion pumps. Furthermore, it provides a versatile platform to explore electro-mechanical couplings potentially at play in recently discovered mechanosensitive ionic channels 4 .
العلاقة: hal-02125601; https://hal.science/hal-02125601Test; https://hal.science/hal-02125601/documentTest; https://hal.science/hal-02125601/file/Nature-Mouterde-2019.pdfTest
الإتاحة: https://doi.org/10.1038/s41586-019-0961-5Test
https://hal.science/hal-02125601Test
https://hal.science/hal-02125601/documentTest
https://hal.science/hal-02125601/file/Nature-Mouterde-2019.pdfTest -
2
المؤلفون: Ju Hwan, Kim, Chang Yell, Shin, Sun Woo, Jang, Dong-Seok, Kim, Wonae, Lee, Hyung-Gun, Kim, Hak Rim, Kim
المصدر: The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
مصطلحات موضوعية: Inflammation, #These authors contributed equally to this work, NSAIDs, T cell, Original Article, Small intestine, DA-9601
الوصف: DA-9601 is an extract obtained from Artemisia asiatica, which has been reported to have anti-inflammatory effects on gastrointestinal lesions; however, its possible anti-inflammatory effects on the small intestine have not been studied yet. Therefore, in this study, we investigated the protective effects of DA-9601 against the ACF-induced small intestinal inflammation. Inflammation of the small intestine was confirmed by histological studies and the changes in the CD4+ T cell fraction induced by the inflammation-related cytokines, and the inflammatory reactions were analyzed. Multifocal discrete small necrotic ulcers with intervening normal mucosa were frequently observed after treatment with ACF. The expression of IL-6, IL-17, and TNF-α genes was increased in the ACF group; however, it was found to have been significantly decreased in the DA-9601 treated group. In addition, DA-9601 significantly decreased the levels of proinflammatory mediators such as IL-1β, GM-CSF, IFN-γ, and TNF-α; the anti-inflammatory cytokine IL-10, on the other hand, was observed to have increased. It is known that inflammatory mediators related to T cell imbalance and dysfunction continuously activate the inflammatory response, causing chronic tissue damage. The fractions of IFN-γ+ Th1 cells, IL-4+ Th2 cells, IL-9+ Th9 cells, IL-17+ Th17 cells, and Foxp3+ Treg cells were significantly decreased upon DA-9601 treatment. These data suggest that the inflammatory response induced by ACF is reduced by DA-9601 via lowering of the expression of genes encoding the inflammatory cytokines and the concentration of inflammatory mediators. Furthermore, DA-9601 inhibited the acute inflammatory response mediated by T cells, resulting in an improvement in ACF-induced enteritis.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::4b33d5a6bcae423ed366d605a081f2f9Test
https://pubmed.ncbi.nlm.nih.gov/34448461Test -
3دورية أكاديمية
المؤلفون: Grégory Caignard, Megan M. Eva, Rebekah Van Bruggen, Robert Eveleigh, Guillaume Bourque, Danielle Malo, Silvia M. Vidal
المساهمون: The Pennsylvania State University CiteSeerX Archives
مصطلحات موضوعية: † These authors contributed equally to this work
الوصف: www.mdpi.com/journal/genes
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4دورية أكاديمية
المؤلفون: Tzu-rong Su, Jen-jie Lin, Chi-chu Tsai, Tsu-kei Huang, Zih-yan Yang, Ming-o Wu
المساهمون: The Pennsylvania State University CiteSeerX Archives
مصطلحات موضوعية: † These authors contributed equally to this work
الوصف: Gallic acid is one of the major flavonoids found in plants. It acts as an antioxidant, and seems to have anti-inflammatory, anti-viral, and anti-cancer properties. In this study, we investigated the effects of gallic acid on melanogenesis, including the activation of melanogenesis signaling pathways. Gallic acid significantly inhibited both melanin synthesis and tyrosinase activity in a dose- and time-dependent manner, and decreased the expression of melanogenesis-related proteins, such as microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein-1 (TRP1), and dopachrome tautomerase OPEN ACCESS Int. J. Mol. Sci. 2013, 14 20444 (Dct). In addition, gallic acid also acts by phosphorylating and activating melanogenesis
وصف الملف: application/pdf
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5دورية أكاديمية
المؤلفون: Sung Jean Park, Woo Sung Son, Bong-jin Lee
المساهمون: The Pennsylvania State University CiteSeerX Archives
مصطلحات موضوعية: These authors contributed equally to this work
الوصف: Helicobacter pylori (H. pylori) have a unique ability to survive in extreme acidic environments and to colonize the gastric mucosa. It can cause diverse gastric diseases such as peptic ulcers, chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, gastric cancer, etc. Based on genomic research of H. pylori, over 1600 genes have been functionally identified so far. However, H. pylori possess some genes that are uncharacterized since: (i) the gene sequences are quite new; (ii) the function of genes have not been characterized in any other bacterial systems; and (iii) sometimes, the protein that is classified into a known protein based on the sequence homology shows some functional ambiguity, which raises questions about the function of the protein produced in H. pylori. Thus, there are still a lot of genes to be biologically or biochemically characterized to understand the whole picture of gene functions in the bacteria. In this regard, knowledge on the 3D structure of a protein, especially unknown or hypothetical protein, is frequently useful to elucidate the structure-function relationship of the uncharacterized gene product. That is, a structural comparison with known proteins provides valuable information to help predict the cellular functions of hypothetical proteins. Here, we show the 3D structures ofInt. J. Mol. Sci. 2012, 13 7110
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6دورية أكاديمية
المؤلفون: Artem Blagodatski, Vera Batrak, Sabine Schmidl, Ulrike Schoetz, Olph B. Caldwell, Jean-marie Buerstedde
المساهمون: The Pennsylvania State University CiteSeerX Archives
المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/44/ce/PLoS_Genet_2009_Jan_9_5(1)_e1000332.tar.gz
مصطلحات موضوعية: These authors contributed equally to this work
الوصف: Hypermutation of the immunoglobulin (Ig) genes requires Activation Induced cytidine Deaminase (AID) and transcription, but it remains unclear why other transcribed genes of B cells do not mutate. We describe a reporter transgene crippled by hypermutation when inserted into or near the Ig light chain (IgL) locus of the DT40 B cell line yet stably expressed when inserted into other chromosomal positions. Step-wise deletions of the IgL locus revealed that a sequence extending for 9.8 kilobases downstream of the IgL transcription start site confers the hypermutation activity. This sequence, named DIVAC for diversification activator, efficiently activates hypermutation when inserted at non-Ig loci. The results significantly extend previously reported findings on AID-mediated gene diversification. They show by both deletion and insertion analyses that
وصف الملف: application/zip
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7دورية أكاديمية
المؤلفون: Rine Daubeuf, Divyendu Singh, Yaohong Tan, Hongiu Liu, Howard J Federoff, William J Bowers, Khaled Tolba, Immunobiology Articles, Howard J, William J. Bowers
المساهمون: The Pennsylvania State University CiteSeerX Archives
المصدر: http://bloodjournal.hematologylibrary.org/content/early/2008/10/24/blood-2008-07-168203.full.pdfTest.
مصطلحات موضوعية: § These authors contributed equally to this work
الوصف: only.
وصف الملف: application/pdf
العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.312.7092Test; http://bloodjournal.hematologylibrary.org/content/early/2008/10/24/blood-2008-07-168203.full.pdfTest
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8دورية أكاديمية
المؤلفون: Roberta Martinelli, Matthew Gegg, Rebecca Longbottom, Peter Adamson, Patric Turowski, John Greenwood, Martin A. Schwartz
المساهمون: The Pennsylvania State University CiteSeerX Archives
مصطلحات موضوعية: These authors contributed equally to this work
الوصف: As a gatekeeper of leukocyte trafficking the vasculature fulfills an essential immune function. We have recently shown that paracellular transendothelial lymphocyte migration is controlled by intercellular adhesion molecule 1 (ICAM-1)mediated vascular endothelial cadherin (VEC) phosphorylation [Turowski et al., J. Cell Sci. 121, 29–37 (2008)]. Here we show that endothelial nitric oxide synthase (eNOS) is a critical regulator of this pathway. ICAM-1 stimulated eNOS by a mechanism that was clearly distinct from that utilized by insulin. In particular, phosphorylation of eNOS on S1177 in response to ICAM-1 activation was regulated by src family protein kinase, rho GTPase, Ca 2 � , CaMKK, and AMPK, but not Akt/PI3K. Functional neutralization of any component of this pathway or its downstream effector guanylyl cyclase significantly reduced lymphocyte diapedesis across the endothelial monolayer. In turn, activation of NO signaling promoted lymphocyte transmigration. The eNOS signaling pathway was required for T-cell transmigration across primary rat and human microvascular endothelial cells and also when shear flow was applied, suggesting that this pathway is ubiquitously used. These data reveal a novel and essential role of eNOS in basic immune function and provide a key link in the molecular network governing endothelial cell compliance to diapedesis. This article was published online ahead of print in MBC in Press
وصف الملف: application/pdf
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9دورية أكاديمية
المؤلفون: Sarah A. Tishkoff, Mary Katherine Gonder, Brenna M. Henn, Holly Mortensen, Christopher Gignoux, Godfrey Lema, Thomas B. Nyambo, Peter A, Uma Ramakrishnan, Floyd A. Reed, Joanna L. Mountain, Ph. D
المساهمون: The Pennsylvania State University CiteSeerX Archives
مصطلحات موضوعية: These authors contributed equally to this work Key Words, mtDNA evolution, Y chromosome evolution, human evolution, genetic variation, African diversity, language evolution Downloaded from
الوصف: This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License
وصف الملف: application/pdf
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10دورية أكاديمية
المؤلفون: Eun-kyung Yoon, Won-kil Lee, Sang-gu Hwang, Song-ja Kim
المساهمون: The Pennsylvania State University CiteSeerX Archives
المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c3/09/J_Korean_Med_Sci_2007_Dec_20_22(6)_1015-1021.tar.gz
مصطلحات موضوعية: These authors contributed equally to this work
الوصف: Peroxisome proliferator-activated receptor gamma (PPAR-) is a ligand-activated transcription factor and plays an important role in growth, differentiation, and inflammation in different tissues. In this study, we investigated the effects of 15d-PGJ2, a high-affinity ligand of PPAR-, on dedifferentiation and on inflammatory responses such as COX-2 expression and PGE2 production in rabbit articular chondrocytes with a focus on ERK-1/-2, p38 kinase, and PPAR- activation. We report here that 15d-PGJ2 induced dedifferentiation and/or COX-2 expression and subsequent PGE2 production. 15d-PGJ2 treatment stimulated activation of ERK-1/-2, p38 kinase, and PPAR-. Inhibition of ERK-1/-2 with PD98059 recovered 15d-PGJ2-induced dedifferentiation and enhanced PPAR- activation, whereas inhibition of p38 kinase with SB203580 potentiated dedifferentiation and partially blocked PPAR- activation. Inhibition of ERK-1/-2 and p38 kinase abolished 15d-PGJ2-induced COX-2 expression and subsequent PGE2 production. Our findings collectively suggest that ERK-1/-2 and p38 kinase oppositely regulate 15d-PGJ2-induced dedifferentiation through a PPAR--dependent mechanism, whereas COX-2 expression and PGE2
وصف الملف: application/zip
