المؤلفون: Starita, Francesca, Stussi, Yoann, Garofalo, Sara, Terenzi, Damiano

المصدر: ISSN: 1662-5153 ; Frontiers in behavioral neuroscience, vol. 18 (2024) 1383393.

مصطلحات موضوعية: info:eu-repo/classification/ddc/128.37, info:eu-repo/classification/ddc/150

العلاقة: info:eu-repo/grantAgreement/EC/H2020/948671/EU/Characterizing information integration in reinforcement learning: a neuro-computational investigation/INFORL; https://archive-ouverte.unige.ch/unige:175472Test; unige:175472

الإتاحة: https://doi.org/10.3389/fnbeh.2024.1383393Test
https://archive-ouverte.unige.ch/unige:175472Test

المؤلفون: Keweloh, Beatrix, Terenzi, Damiano, Froehlich, Eva, Coricelli, Carol, Stürmer, Paula, Rohmann, Nathalie, Wietzke-Braun, Perdita, Beckmann, Alexia, Laudes, Matthias, Park, Soyoung Q.

المساهمون: Else Kröner-Fresenius-Stiftung

المصدر: Clinical Nutrition ; volume 43, issue 6, page 1270-1277 ; ISSN 0261-5614

الإتاحة: https://doi.org/10.1016/j.clnu.2024.04.002Test
https://api.elsevier.com/content/article/PII:S0261561424001080?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0261561424001080?httpAccept=text/plainTest

المؤلفون: Terenzi, Damiano, Catalan, Mauro, Polverino, Paola, Bertolotti, Claudio, Manganotti, Paolo, Rumiati, Raffaella I, Aiello, Marilena

المساهمون: Terenzi, Damiano, Catalan, Mauro, Polverino, Paola, Bertolotti, Claudio, Manganotti, Paolo, Rumiati, Raffaella I, Aiello, Marilena

مصطلحات موضوعية: Disease, Liking, Parkinson’, Prefrontal cortex, Temporal discounting, Wanting, Human, Reward, Delay Discounting, Disruptive, Impulse Control, and Conduct Disorder, Parkinson Disease, Transcranial Direct Current Stimulation

الوصف: Parkinson's disease (PD) patients with impulse control disorders (ICD) frequently report hypersensitivity to rewards. However, a few studies have explored the effectiveness of modulation techniques on symptoms experienced by these patients. In this study, we assessed the effect of anodal tDCS over the DLPFC on reward responsiveness and valuation in PD patients with ICD. 43 participants (15 PD patients with ICD, 13 PD without ICD, and 15 healthy matched controls) were asked to perform a reward-craving test employing both explicit (self-ratings of liking and wanting) and implicit (heart rate and skin conductance response) measures, as well as two temporal discounting tasks with food and money rewards. Each participant performed the experimental tasks during active anodal tDCS of the left dorsolateral prefrontal cortex (DLPFC), anodal tDCS of the primary motor cortex (M1), and sham tDCS. Results showed increased wanting and a steeper temporal discounting of rewards in PD with ICD compared to the other groups. Moreover, we found that PD without ICD exhibit reduced liking for rewards. tDCS results capable to modulate the altered intensity of PD patients' liking, but not wanting and temporal discounting of rewards in PD patients with ICD. These findings confirm that alterations in reward responsiveness and valuation are characteristics of impulse control disorders in patients with PD but suggest that anodal tDCS over the left DLPFC is not capable to influence these processes. At the same time, they provide new insight into affective experience of rewards in PD.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34333702; info:eu-repo/semantics/altIdentifier/wos/WOS:000679777600002; volume:269; issue:3; firstpage:1557; lastpage:1565; numberofpages:9; journal:JOURNAL OF NEUROLOGY; https://hdl.handle.net/11585/962611Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85111597885; https://link.springer.com/article/10.1007/s00415-021-10733-0Test

الإتاحة: https://doi.org/10.1007/s00415-021-10733-0Test
https://hdl.handle.net/11585/962611Test

المؤلفون: Terenzi, Damiano, Simon, Nicolas, Gachomba, Michael Joe Munyua, de Peretti, Jeanne Laure, Nazarian, Bruno, Sein, Julien, Anton, Jean-Luc, Grandjean, Didier, Baunez, Christelle, Chaminade, Thierry

المساهمون: Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), A*Midex foundation, IRESP

المصدر: https://hal.science/hal-04262807Test ; 2023.

مصطلحات موضوعية: Brain imaging/neuroimaging, Addiction, Inhibition control, Subthalamic Nucleus, [SDV]Life Sciences [q-bio], [SCCO]Cognitive science

الوصف: Background Addictions often develop in a social context, although the influence of social factors did not receive much attention in the neuroscience of addiction. Recent animal studies suggest that peer presence can reduce cocaine intake, an influence potentially mediated, among others, by the subthalamic nucleus (STN). However, there is to date no such neurobiological study in humans. Methods This study investigated the impact of social context and drug cues on brain correlates of inhibitory control in individuals with and without cocaine use disorder (CUD) using functional Magnetic Resonance Imaging (fMRI). Seventeen CUD participants and 17 healthy controls (HC) performed a novel fMRI Stop-Signal task in the presence and absence of an observer while being exposed to cocaine-related and neutral pictures as cues. Results The results showed that CUD participants, while slower at stopping with neutral cues, recovered control level stopping abilities with cocaine cues, while HC did not show any difference. Neuroimaging revealed the involvement of frontal cortical regions and of the subthalamic nucleus (STN) in inhibitory control, which was modulated by both social context and drug cues in CUD participants but not in HC. Conclusions These findings highlight the impact of social context and drug cues on inhibitory control in CUD and suggest potential targets for intervention such as the STN, also emphasizing the importance of considering the social context in addiction research and treatment.

العلاقة: hal-04262807; https://hal.science/hal-04262807Test; https://hal.science/hal-04262807/documentTest; https://hal.science/hal-04262807/fileTest/Terenzi%20et%20al-2023-BioRxiv.pdf; BIORXIV: 2023.09.06.556336

الإتاحة: https://doi.org/10.1101/2023.09.06.556336Test
https://hal.science/hal-04262807Test
https://hal.science/hal-04262807/documentTest
https://hal.science/hal-04262807/fileTest/Terenzi%20et%20al-2023-BioRxiv.pdf

المؤلفون: Terenzi, Damiano, Simon, Nicolas, Gachomba, Michael Joe Munyua, de Peretti, Jeanne-Laure, Nazarian, Bruno, Sein, Julien, Anton, Jean-Luc, Grandjean, Didier, Baunez, Christelle, Chaminade, Thierry

المصدر: Mol Psychiatry ; ISSN:1476-5578

الوصف: Addictions often develop in a social context, although the influence of social factors did not receive much attention in the neuroscience of addiction. Recent animal studies suggest that peer presence can reduce cocaine intake, an influence potentially mediated, among others, by the subthalamic nucleus (STN). However, there is to date no neurobiological study investigating this mediation in humans. This study investigated the impact of social context and drug cues on brain correlates of inhibitory control in individuals with and without cocaine use disorder (CUD) using functional Magnetic Resonance Imaging (fMRI). Seventeen CUD participants and 17 healthy controls (HC) performed a novel fMRI "Social" Stop-Signal Task (SSST) in the presence or absence of an observer while being exposed to cocaine-related (vs. neutral) cues eliciting craving in drug users. The results showed that CUD participants, while slower at stopping with neutral cues, recovered control level stopping abilities with cocaine cues, while HC did not show any difference. During inhibition (Stop Correct vs Stop Incorrect), activity in the right STN, right inferior frontal gyrus (IFG), and bilateral orbitofrontal cortex (OFC) varied according to the type of cue. Notably, the presence of an observer reversed this effect in most areas for CUD participants. These findings highlight the impact of social context and drug cues on inhibitory control in CUD and the mediation of these effects by the right STN and bilateral OFC, emphasizing the importance of considering the social context in addiction research. They also comfort the STN as a potential addiction treatment target.

العلاقة: https://doi.org/10.1038/s41380-024-02637-yTest; https://pubmed.ncbi.nlm.nih.gov/38926543Test

الإتاحة: https://doi.org/10.1038/s41380-024-02637-yTest
https://pubmed.ncbi.nlm.nih.gov/38926543Test

المؤلفون: Terenzi, Damiano, Muth, Anne-Katrin, Vermeer Losecaat, Annabel, Park, Soyoung Q.

المصدر: Frontiers in nutrition, 9:1006043

الوصف: The COVID-19 pandemic has increased the occurrence of conspiracy theories. It has been suggested that a greater endorsement of these theories may be associated with psychotic-like experiences (PLEs), as well as with social isolation. In this preregistered study, we investigated whether both PLEs and measures of social isolation (e.g., loneliness) can predict conspiratorial beliefs and, if so, which of these variables can mediate the association with conspiratorial beliefs. Furthermore, based on previous studies on schizophrenia, we explored whether the diet is associated with PLEs and conspiratorial beliefs. Participants (N = 142) completed online questionnaires measuring PLEs, social isolation, mental well-being, and conspiratorial beliefs. They also submitted their daily food intake for a week using a smartphone app. We found that loneliness predicted the endorsement of conspiracy theories during the COVID-19 lockdown. Strikingly, the proneness to experience subclinical psychotic symptoms played an underlying mediating role. In addition, these subclinical symptoms were associated with lower fruit, carbohydrate, and iron intakes, as well as with higher fat intake. Our results add insights into how conspiratorial beliefs can affect individuals’ mental health and relationships. Moreover, these results open the avenue for potential novel intervention strategies to optimize food intake in individuals with PLEs.

العلاقة: https://repository.publisso.de/resource/frl:6438613Test; https://doi.org/10.3389/fnut.2022.1006043Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650276Test/; https://www.frontiersin.org/articles/10.3389/fnut.2022.1006043/full#h13Test

الإتاحة: https://doi.org/10.3389/fnut.2022.1006043Test
https://repository.publisso.de/resource/frl:6438613Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650276Test/

المؤلفون: Terenzi, Damiano, Madipakkam, Apoorva R., Molter, Felix, Mohr, Peter N. C., Losecaat Vermeer, Annabel B., Liu, Lu, Park, Soyoung Q.

المصدر: The journal of neuroscience, 42(32):6276-6284

مصطلحات موضوعية: behavioral modification, value processing, fMRI, social cue, gaze

الوصف: As humans are social beings, human behavior and cognition are fundamentally shaped by information provided by peers, making human subjective value for rewards prone to be manipulated by perceived social information. Even subtle nonverbal social information, such as others' eye gazes, can influence value assignment, such as food value. In this study, we investigate the neural underpinnings of how gaze cues modify participants' food value (both genders) by means of functional magnetic resonance imaging. During the gaze-cuing task, food items were repeatedly presented either while others looked at them or while they were ignored by others. We determined participants' food values by assessing their willingness to pay before and after a standard gaze-cuing training. Results revealed that participants were willing to pay significantly more for food items that were attended to by others compared with the unattended to food items. Neural data showed that differences in subjective values between the two conditions were accompanied by enhanced activity in the inferior frontal gyrus, middle temporal gyrus, and caudate after food items were attended to. Furthermore, the functional connectivity between the caudate and the angular gyrus precisely predicted the individual differences in the preference shift. Our results unveil the key neural mechanism underlying the influence of social cues on the subjective value of food and highlight the crucial role of social context in shaping subjective value for food rewards in human.

العلاقة: https://repository.publisso.de/resource/frl:6438611Test; https://doi.org/10.1523/JNEUROSCI.2405-21.2022Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374136Test/; https://www.jneurosci.org/content/42/32/6276/tab-figures-dataTest

الإتاحة: https://doi.org/10.1523/JNEUROSCI.2405-21.2022Test
https://repository.publisso.de/resource/frl:6438611Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374136Test/
https://www.jneurosci.org/content/42/32/6276/tab-figures-dataTest

المؤلفون: Terenzi, Damiano, Muth, Anne-Katrin, Park, Soyoung

المصدر: Nutrients, 14(14):2781

مصطلحات موضوعية: biomarker, inflammation, nutrition, prevention, Parkinson’s disease

الوصف: An emerging body of literature suggests that long-term gut inflammation may be a silent driver of Parkinson’s disease (PD) pathogenesis. Importantly, specific nutritive patterns might improve gut health for PD risk reduction. Here, we review the current literature on the nutritive patterns and inflammatory markers as a predictor for early detection of PD. This knowledge might be used to foster the detection of early nutritive patterns and preclinical biomarkers to potentially alter PD development and progression.

العلاقة: https://repository.publisso.de/resource/frl:6434430Test; https://doi.org/10.3390/nu14142781Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323908Test/

الإتاحة: https://doi.org/10.3390/nu14142781Test
https://repository.publisso.de/resource/frl:6434430Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323908Test/

المؤلفون: Muth, Anne-Katrin, Vermeer, Annabel Losecaat, Terenzi, Damiano, Park, Soyoung Q.

المصدر: Frontiers in nutrition, 9:993180

مصطلحات موضوعية: COVID-19, gender, mental health, activity, eating behavior

الوصف: A healthy diet and lifestyle may protect against adverse mental health outcomes, which is especially crucial during stressful times, such as the COVID-19 pandemic. This preregistered longitudinal online study explored whether diet and lifestyle (physical activity, sleep, and social interactions) were associated with wellbeing and mood during a light lockdown in Germany. Participants (N = 117, 72 males; 28 ± 9 years old) answered mental health and lifestyle questionnaires (social connections, sleep, activity) followed by submitting 1 week of food and mood-lifestyle diary (food intake, positive and negative mood, mental wellbeing, sleep quality, physical activity level, quantity and quality of social interactions) via a smartphone app. We used multivariate linear and mixed-effects models to associate mood and wellbeing with dietary components and lifestyle factors. Interindividual analyses revealed that sleep and social interaction significantly impacted mood and wellbeing. Interestingly, fruit and vegetable intake correlated with wellbeing, even when controlling for all lifestyle factors. Fruit and vegetable intake also significantly correlated with daily fluctuations in wellbeing within individuals next to sleep, physical activity, and social interactions. We observed gender differences in fruit and vegetable intake and anxiety levels. Our results emphasize the importance of diet contributing to individual wellbeing, even in the challenging times of a pandemic. Future research is necessary to test if our findings could extend to other populations.

العلاقة: https://repository.publisso.de/resource/frl:6438587Test; https://doi.org/10.3389/fnut.2022.993180Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582278Test/; https://www.frontiersin.org/articles/10.3389/fnut.2022.993180/full#S10Test

الإتاحة: https://doi.org/10.3389/fnut.2022.993180Test
https://repository.publisso.de/resource/frl:6438587Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582278Test/

المؤلفون: Terenzi, Damiano, Liu, Lu, Bellucci, Gabriele, Park, Soyoung Q.

المصدر: Neuroscience & biobehavioral reviews, 128:383-393

مصطلحات موضوعية: Neuromodulators, Neuroimaging, Social interaction, Generosity, Neural activity, Trust, Social decision

الوصف: Social decision making is a highly complex process that involves diverse cognitive mechanisms, and it is driven by the precise processing of information from both the environment and from the internal state. On the one hand, successful social decisions require close monitoring of others’ behavior, in order to track their intentions; this can guide not only decisions involving other people, but also one’s own choices and preferences. On the other hand, internal states such as own reward or changes in hormonal and neurotransmitter states shape social decisions and their underlying neural function. Here, we review the current literature on modulators and determinants of human social decisions.

العلاقة: https://repository.publisso.de/resource/frl:6432640Test; https://doi.org/10.1016/j.neubiorev.2021.06.041Test

الإتاحة: https://doi.org/10.1016/j.neubiorev.2021.06.041Test
https://repository.publisso.de/resource/frl:6432640Test