المؤلفون: Atsushi Kanamori, Yuji Nadatani, Nahoko Kushiyama, Akinobu Nakata, Akira Higashimori, Masaki Ominami, Tatsuo Kimura, Shinya Fukumoto, Yasuhiro Fujiwara, Toshio Watanabe

المصدر: DEN Open, Vol 4, Iss 1, Pp n/a-n/a (2024)

مصطلحات موضوعية: endoscopy, esophageal hematoma, esophageal intramural hematoma, esophageal submucosal hematoma, vomiting, Diseases of the digestive system. Gastroenterology, RC799-869

الوصف: Abstract Esophageal submucosal hematoma is a rare, often incidental complication of therapeutic endoscopic procedures marked by disrupted blood vessels beneath the esophageal mucosa, forming a hematoma. We report the unique case of a severely thin and alcoholic 38‐year‐old woman with a history of reflux esophagitis who developed an esophageal submucosal hematoma during an unsedated transnasal endoscopy for health check‐up. During the procedure, the patient experienced strong vomiting reflexes and vomited blood, leading to the initial suspicion of either Mallory‐Weiss syndrome or epistaxis. However, subsequent sedated endoscopy revealed an esophageal submucosal tumor‐like lesion and a mucosal laceration with blood clots, prompting a dual diagnosis of esophageal submucosal hematoma and Mallory‐Weiss syndrome. The bleeding was not severe enough to require hemostatic intervention. The patient opted for conservative treatment with vonoprazan, which resulted in the improvement and healing of the hematoma within 28 days. This is the first report of an esophageal submucosal hematoma during transnasal endoscopy and emphasizes the importance of including an esophageal submucosal hematoma and Mallory‐Weiss syndrome in the differential diagnosis of hematemesis encountered in similar scenarios. Factors such as severe thinness, daily alcohol consumption, and reflux esophagitis may have possibly contributed to the development of the esophageal submucosal hematoma in this patient.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2692-4609Test

الوصول الحر: https://doaj.org/article/05390d895fc74337a3eec034d73ef570Test

المؤلفون: Chieko Tanaka, Koji Otani, Mitsuhiro Tamoto, Hisako Yoshida, Yuji Nadatani, Masaki Ominami, Shusei Fukunaga, Shuhei Hosomi, Noriko Kamata, Fumio Tanaka, Koichi Taira, Tatsuo Kimura, Shinya Fukumoto, Toshio Watanabe, Yasuhiro Fujiwara

المصدر: Journal of Clinical Biochemistry and Nutrition. 2024, 74(3):253-260

المؤلفون: Koji Otani, Toshio Watanabe, Kanae Takahashi, Yuji Nadatani, Masaki Ominami, Shusei Fukunaga, Shuhei Hosomi, Noriko Kamata, Fumio Tanaka, Yasuaki Nagami, Koichi Taira, Tatsuo Kimura, Shinya Fukumoto, Yasuhiro Fujiwara

المصدر: BMC Gastroenterology, Vol 23, Iss 1, Pp 1-11 (2023)

مصطلحات موضوعية: Rome IV, Disorders of gut–brain interaction, Functional constipation, Irritable bowel syndrome, Kyoto Classification of Gastritis, Diseases of the digestive system. Gastroenterology, RC799-869

الوصف: Abstract Background The Rome IV criteria have been established as an international standard for diagnosing disorders of gut–brain interaction. In this study, we aimed to examine the upper gastrointestinal (GI) endoscopic findings and symptoms of subjects with functional constipation (FC) and irritable bowel syndrome (IBS) of individuals undergoing a medical check-up. Methods A total of 13,729 subjects underwent a medical check-up at Osaka City University-affiliated clinic, MedCity21, between April 2018 and March 2019. Among the 5,840 subjects who underwent screening upper GI endoscopy and completed a questionnaire based on the Rome IV criteria, 5,402 subjects were consecutively enrolled after excluding subjects with a large amount of gastric residue (n = 6), those who had previously undergone partial or total gastrectomy (n = 40), or those with daily use of low-dose aspirin (n = 82), nonsteroidal anti-inflammatory drugs (n = 63), or acid secretion inhibitors (n = 308). Results Robust Poisson regression analyses adjusted for age, sex, Helicobacter pylori infection status, alcohol intake, and smoking habits showed a significant association between FC and corpus erosion (adjusted prevalence ratio [aPR], 2.93; 95% confidence interval [CI], 1.51–5.67; p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-230XTest

الوصول الحر: https://doaj.org/article/e85c6764a9e7498ca4fde7455df969f3Test

المؤلفون: Yuji Matsumoto, Yuji Nadatani, Koji Otani, Akira Higashimori, Masaki Ominami, Shusei Fukunaga, Shuhei Hosomi, Noriko Kamata, Tatsuo Kimura, Shinya Fukumoto, Fumio Tanaka, Koichi Taira, Yasuaki Nagami, Toshio Watanabe, Yasuhiro Fujiwara

المصدر: JGH Open, Vol 6, Iss 1, Pp 69-75 (2022)

مصطلحات موضوعية: chronic diarrhea, gastroenterology, medical checkup, Diseases of the digestive system. Gastroenterology, RC799-869

الوصف: Abstract Background and Aim Although chronic diarrhea is a major digestive disorder, it has not been well studied. The aims of this study were to investigate the prevalence and risk factors of chronic diarrhea in the Japanese population and to assess the relationship between stool type and frequency and symptoms related to chronic diarrhea. Method A total of 13 668 adults who underwent a medical checkup at MedCity21 were enrolled, and 9540 who met the inclusion criteria participated in the study. Participants with chronic diarrhea were defined as those who typically had a Bristol Stool Form Scale of type 6 or 7. Results The prevalence of chronic diarrhea was 3.0%. The risk factors for chronic diarrhea were younger age (odds ratio [OR] 0.984, 95% confidence interval [CI] 0.972–0.996), male sex (OR = 2.270, CI = 1.730–2.960), alcohol intake on ≥5 days per week (OR = 2.390, CI = 1.860–3.060), not getting adequate sleep (OR = 0.712, CI = 0.559–0.907), skipping breakfast ≥3 times a week (OR = 1.490, CI = 1.120–1.980), and absence of diabetes mellitus (OR = 0.384, CI = 0.179–0.824). Only 23.5% of the participants in the diarrhea group had ≥3 bowel movements per day. Chronic diarrhea was significantly associated with heartburn, nausea, stomach ache, abdominal bloating and distension, and feeling of stress. Conclusions Our study shows that chronic diarrhea is common in Japan with a prevalence of 3.0%; unique risk factors related to gender, age, and irregular lifestyle were identified. An understanding of bowel habit in the healthy population is helpful for the assessment of change in bowel habit associated with gastrointestinal disorders.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2397-9070Test

الوصول الحر: https://doaj.org/article/423e21fed18647218cc805fb68d8074dTest

المؤلفون: Hideki Fujii, Masaru Enomoto, Shinya Fukumoto, Tatsuo Kimura, Yuji Nadatani, Shingo Takashima, Atsushi Hagihara, Sawako Uchida‐Kobayashi, Akihiro Tamori, Naoki Nishimoto, Norifumi Kawada

المصدر: JGH Open, Vol 5, Iss 7, Pp 801-808 (2021)

مصطلحات موضوعية: hepatic fibrosis, non‐alcoholic fatty liver disease, noninvasive fibrosis test, transient elastography, Diseases of the digestive system. Gastroenterology, RC799-869

الوصف: Abstract Background and Aim The Gut and Obesity in Asia Workgroup recently reported that a two‐step approach using fibrosis scores followed by liver stiffness measurement (LSM) could accurately detect patients with non‐alcoholic fatty liver disease (NAFLD) having advanced fibrosis in low‐risk fibrosis populations. This study aimed to validate the utility of this approach using a Japanese health checkup registry. Methods This cross‐sectional study included subjects who underwent a health checkup from 2014 to 2019. Using estimated fibrosis stage measured by LSM as a standard, we calculated the percentage of misclassification from assessments made based on fibrosis scores (NAFLD fibrosis score [NFS] or Fibrosis‐4 score [FIB‐4]) and LSM, alone or in combination. Results Of 630 subjects with NAFLD, 4 (0.8%) had advanced fibrosis. In the first‐step evaluation, only 21.4–38.0% of subjects needed further testing. This approach was associated with a high specificity of approximately 100% and a negative predictive value of 99.7%. The percentage of misclassification based on NFS or FIB‐4 values followed by LSM in all subjects and using LSM after NFS or FIB‐4 determination only in subjects with indeterminate/high NFS or FIB‐4 values (two‐step approach) was 0% and 0.3% and 0.16% and 0.3%, respectively. In addition, very few false negatives occurred for both NFS and FIB‐4. Conclusion The two‐step approach helps to identify the subjects with NAFLD who have advanced fibrosis during a routine health checkup and is associated with only a few false negatives.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2397-9070Test

الوصول الحر: https://doaj.org/article/cc009334cc0947659dad4152cf9a3d15Test

المؤلفون: Hideki Fujii, Shinya Fukumoto, Masaru Enomoto, Sawako Uchida-Kobayashi, Tatsuo Kimura, Akihiro Tamori, Yuji Nadatani, Shingo Takashima, Naoki Nishimoto, Norifumi Kawada

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract This study aimed to prove that the FibroScan-aspartate aminotransferase (FAST) scores can be used to stratify disease severity in a Japanese cohort with fatty liver diseases [metabolic dysfunction-associated fatty liver disease (MAFLD) and nonalcoholic fatty liver disease (NAFLD)]. All the participants (n = 2254) underwent liver stiffness measurements and controlled attenuation parameter assessments. We compared the clinical characteristics of the patients with MAFLD and NAFLD using the FAST scores and explored the independent determinants of FAST scores ≥ 0.35, which indicated possible progressive disease. Overall, MAFLD was diagnosed in 789 patients (35.0%), while NAFLD was diagnosed in 618 (27.4%). The proportion of patients that had a condition that suggested progressive liver disease was higher in those with MAFLD than in those with NAFLD [68 (8.6%) vs 48 (7.7%)]. The area under the receiver-operating characteristic curve of the FAST score for diagnosing advanced fibrosis was 0.969 in MAFLD and 0.965 in NAFLD. Multivariate analyses determined that diabetes mellitus, alanine aminotransferase (ALT) levels, fatty liver index, and Fibrosis-4 index independently predict FAST scores ≥ 0.35 in patients with MAFLD. ALT levels had the strongest correlation with the FAST scores (p = 0.7817). The FAST score could stratify the disease severity in the Japanese cohort with fatty liver diseases.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/e1ed949c073c40da8db5b7808859e73eTest

المؤلفون: Fumio Tanaka, Kanae Takahashi, Koichi Taira, Koji Otani, Masaki Ominami, Noriko Kamata, Shinya Fukumoto, Shuhei Hosomi, Shusei Fukunaga, Tatsuo Kimura, Toshio Watanabe, Yasuaki Nagami, Yasuhiro Fujiwara, Yuji Nadatani

المصدر: Journal of Clinical Biochemistry and Nutrition. 2022, 70(2):205

المؤلفون: Yuji Nadatani, Akira Higashimori, Shingo Takashima, Hirotsugu Maruyama, Koji Otani, Shusei Fukunaga, Shuhei Hosomi, Fumio Tanaka, Hideki Fujii, Akemi Nakano, Koichi Taira, Noriko Kamata, Yasuaki Nagami, Tatsuo Kimura, Shinya Fukumoto, Toshio Watanabe, Norifumi Kawada, Yasuhiro Fujiwara

المصدر: SAGE Open Medicine, Vol 9 (2021)

مصطلحات موضوعية: Medicine (General), R5-920

الوصف: Objectives: Endoscopy confers high risk for acquiring coronavirus disease 2019. Although guidelines recommend that medical staff use personal protective equipment, no infection control equipment have been established for patients. This study aimed to clarify the usefulness of two face masks we had designed for transnasal and transoral endoscopy. Methods: The efficacy of the masks was evaluated by simulating coughing in a mannequin with fluorescent dyes and mapping the droplet trajectory and number. The number of aerosols generated during endoscopy was clinically evaluated in the endoscopy room. Overall, 4356 screening endoscopies were performed with the patients wearing our masks at Medcity21, a health checkup facility, between June and December 2020; the effects of the masks on the patient’s condition were evaluated retrospectively. An 11-item paper-based survey was performed by the endoscopy staff 6 months after the adoption of the mask-based infection control method. Results: Use of both masks reduced the number of droplets released during the simulation. Clinically, the use of both masks did not affect the patients’ conditions during endoscopy and prevented an increase in the aerosols in the endoscopy room. This mask-based infection control method was favorably received, and all staff indicated that understanding the efficacy of our mask-based infection control reduced their anxiety regarding infection. Until December 2020, none of our staff had contracted SARS-CoV-2. Conclusion: Our mask-based infection control method is easy to adopt, inexpensive, and effective; understanding its effectiveness may help ease the fear of infection among endoscopy staff.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2050-3121Test

الوصول الحر: https://doaj.org/article/6a0bd4938fe142d7b40547bc6d3df93bTest

المؤلفون: Akemi Nakano, Fumio Tanaka, Hideki Fujii, Koji Otani, Shingo Takashima, Shinya Fukumoto, Tatsuo Kimura, Toshio Watanabe, Yasuhiro Fujiwara, Yuji Nadatani, Yukie Tauchi, Yuko Nishii, 中野 朱美, 大谷 恒史, 木村 達郎, 渡邉 俊雄, 灘谷 祐二, 田中 史生, 田内 幸枝, 福本 真也, 藤井 英樹, 藤原 靖弘, 西居 由布子, 高嶋 信吾

المصدر: 人間ドック (Ningen Dock) / Official Journal of Japan Society of Ningen Dock. 2021, 36(4):545

المؤلفون: Akinobu Nakata, Fumio Tanaka, Koichi Taira, Koji Otani, Norifumi Kawada, Noriko Kamata, Satoshi Kosaka, Shinya Fukumoto, Shuhei Hosomi, Shusei Fukunaga, Tatsuo Kimura, Tetsuya Tanigawa, Toshio Watanabe, Yasuaki Nagami, Yasuhiro Fujiwara, Yuji Matsumoto, Yuji Nadatani

المصدر: Journal of Clinical Biochemistry and Nutrition. 2020, 67(3):317