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1رسالة جامعية
المؤلفون: Tanner, Elizabeth Ann
مرشدي الرسالة: McFarlin, Brian K., Vingren, Jakob L., Hill, David W.
مصطلحات موضوعية: VAT, DXA, Body Composition, Nanostring, MegaDuo
الوصف: Probiotics/prebiotic supplementation represents a viable option for addressing systemic inflammation and chronic disease risk resulting from excessive body weight. The purpose of this feasibility study was to determine if 90-d of supplementation with prebiotic and probiotic could alter mRNA responsible for inflammation and subsequently metabolic health in weight stable overweight adults. Participants were advised to not change their diet or exercise habits during the study. All protocols were approved by the University IRB and participants gave written informed consent. Participants were randomly assigned to either placebo (N=7; rice flour) or combined (N=8) prebiotic (PreticX® Xylooligosaccharide; 0.8 g/d; ADIP) and probiotic (MegaDuo® Bacillus subtilis HU58 and Bacillus coagulans SC-208; 3 Billion CFU/d) and measurements were made at baseline, 30, 60, and 90-d. Whole body DXA scans (GE iDXA®) and blood 574-plex mRNA analysis (Nanostring®) were used to generate primary outcomes. Compared to placebo, supplementation was associated with a 36% reduction in visceral adipose tissue (p = 0.001). Supplement resulted in significant, differential expression of 15 mRNA associated with adipose tissue inflammation, systemic inflammation, and/or chronic disease risk. The key findings support that 90-d prebiotic/probiotic supplementation may be associated with an improved metabolic health, reduced adipose tissue inflammation, reduced systemic inflammation, and reduced chronic disease risk. Collectively these findings demonstrate the potential of a prebiotic/probiotic supplement to impact metabolic health risk independent of weight loss in free-living individuals.
وصف الملف: Text
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2دورية أكاديمية
المؤلفون: Tanner, Elizabeth, Cîrstocea, Ioana
المصدر: Clio. Femmes, Genre, Histoire. 2023, 57(1), p. 261-275.
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3دورية أكاديمية
المؤلفون: Tanner, Elizabeth, Cîrstocea, Ioana
المصدر: Clio. Femmes, Genre, Histoire. 2023, 57(1), p. 261-275.
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4دورية أكاديمية
المؤلفون: Chaturvedi, Sonali, Vasen, Gustavo, Pablo, Michael, Chen, Xinyue, Beutler, Nathan, Kumar, Arjun, Tanner, Elizabeth, Illouz, Sylvia, Rahgoshay, Donna, Burnett, John, Holguin, Leo, Chen, Pei-Yi, Ndjamen, Blaise, Ott, Melanie, Rodick, Robert, Rogers, Thomas, Smith, Davey M, Weinberger, Leor S
المصدر: Cell. 184(25)
مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Pneumonia & Influenza, Pneumonia, Emerging Infectious Diseases, Prevention, Infectious Diseases, Biodefense, Lung, Vaccine Related, Infection, Good Health and Well Being, Animals, Antiviral Agents, COVID-19, Cell Line, Chlorocebus aethiops, Culture Media, Conditioned, Defective Interfering Viruses, Drug Delivery Systems, Epithelial Cells, Humans, Male, Mesocricetus, Nanoparticles, SARS-CoV-2, Vero Cells, Virus Replication, COVID-19 Drug Treatment, RNA, coronavirus, defective interfering particles, evolution, intranasal, lipid nanoparticle, therapeutic interfering particles, variants, virus-like particle, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
الوصف: Viral-deletion mutants that conditionally replicate and inhibit the wild-type virus (i.e., defective interfering particles, DIPs) have long been proposed as single-administration interventions with high genetic barriers to resistance. However, theories predict that robust, therapeutic DIPs (i.e., therapeutic interfering particles, TIPs) must conditionally spread between cells with R0 >1. Here, we report engineering of TIPs that conditionally replicate with SARS-CoV-2, exhibit R0 >1, and inhibit viral replication 10- to 100-fold. Inhibition occurs via competition for viral replication machinery, and a single administration of TIP RNA inhibits SARS-CoV-2 sustainably in continuous cultures. Strikingly, TIPs maintain efficacy against neutralization-resistant variants (e.g., B.1.351). In hamsters, both prophylactic and therapeutic intranasal administration of lipid-nanoparticle TIPs durably suppressed SARS-CoV-2 by 100-fold in the lungs, reduced pro-inflammatory cytokine expression, and prevented severe pulmonary edema. These data provide proof of concept for a class of single-administration antivirals that may circumvent current requirements to continually update medical countermeasures against new variants.
الوصول الحر: https://escholarship.org/uc/item/8m59r1qwTest
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5دورية أكاديمية
المؤلفون: McWhinnie, Kirsty, Negi, Deepti, Tanner, Elizabeth, Parsons, Kevin J.
الوصف: Phenotypic plasticity enables development to produce multiple phenotypes in response to environmental conditions. Plasticity driven variation has been suggested to play a key role in adaptive divergence, and plasticity itself can evolve. However, the interaction of plasticity with the multiple levels involved with adaptive divergence is less understood. For example, sexual dimorphism can contribute adaptive variation through ecological sexual dimorphism (ESD), but the contribution of plasticity to this phenomenon is unknown. Therefore, to determine the potential contribution of plasticity to ESD, we used the adaptive radiation of Malawi cichlids. Two mouthbrooding species (Labeotropheus fuelleborni and Tropheops “Red Cheek”) with differences in foraging tactics underwent foraging experiments using benthic and limnetic treatments while accounting for sex. Plasticity in craniofacial shape and three functionally important traits were measured. Plasticity was shown, but without any sex-based differences in shape. However, for mechanical advantage traits of the mandible sex by diet interactions were found. This suggests that ESD, may be influenced by phenotypic plasticity that diverges between sexes. Given the involvement of the mandible in parental care in cichlids this may indicate that sexual divergence in plasticity may trade-off against maternal care tactics.
وصف الملف: text
العلاقة: https://eprints.gla.ac.uk/285113/1/285113.pdfTest; McWhinnie, K. , Negi, D. , Tanner, E. and Parsons, K. J. (2023) Functional trait plasticity diverges between sexes in African cichlids: A contribution toward ecological sexual dimorphism? Ecology and Evolution , 13(11), e10702. (doi:10.1002/ece3.10702 ) (PMID:38034329) (PMCID:PMC10682861)
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6دورية أكاديمية
المؤلفون: Mendez, Kyra Jennifer Waligora, Labrique, Alain Bernard, Budhathoki, Chakra, Sadak, Tatiana, Tanner, Elizabeth K., Cotter, Valerie T., Han, Hae-Ra
المساهمون: National Institute of Nursing Research, National Cancer Institute, National Center for Advancing Translational Sciences, Scholl Foundation, Sigma Foundation for Nursing
المصدر: DIGITAL HEALTH ; volume 9 ; ISSN 2055-2076 2055-2076
مصطلحات موضوعية: Health Information Management, Computer Science Applications, Health Informatics, Health Policy
الوصف: Objective Almost 80% of people, who are caring for someone with dementia, have one or more chronic conditions and require self-management support. New technologies offer promising solutions; however, little is known about what technologies caregivers use for their health or in general. This study aimed to describe the prevalence of mobile application (app) and health-related technology use among caregivers who have chronic conditions and care for someone with dementia. Methods A cross-sectional study was conducted with 122 caregivers recruited online and from communities in the Baltimore-metropolitan area. Data were collected with online surveys and computer-assisted telephone interviews. Descriptive and inferential statistics were used to analyze survey data. Results Study participants were primarily female (95 of 122, 77.9%), middle-aged (average 53 years, standard deviation (SD) 17), well educated (average 16 years, SD 3.3), an adult child of the person with dementia (53 of 122, 43.4%), and had 4 chronic conditions on average (SD 2.6). Over 90% of caregivers used mobile apps (116 of 122), spending a range of 9 to 82 min on each app. Most caregivers reported using social media apps (96 of 116, 82.8%), weather apps (96 of 116, 82.8%), and/or music or entertainment apps (89 of 116, 76.7%). Among caregivers using each app type, more than half of caregivers used social media (66 of 96, 69%), games (49 of 74, 66%), weather (62 of 96, 65%), and/or music or entertainment apps (51 of 89, 57%) daily. Caregivers also used several technologies to support their own health—the most common being websites, mobile devices, and health-related mobile apps. Conclusion This study supports the feasibility of using technologies to promote health behavior change and support self-management among caregivers.
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7دورية أكاديمية
المؤلفون: Blakeney, Erin Abu-Rish, Chu, Frances, White, Andrew A., Smith Jr., G. Randy, Woodward, Kyla, Lavallee, Danielle C., Salas, Rachel Marie E., Beaird, Genevieve, Willgerodt, Mayumi A., Dang, Deborah, Dent, John M., Tanner, Elizabeth Ibby, Summerside, Nicole, Zierler, Brenda K., O'Brien, Kevin D., Weiner, Bryan J.
المصدر: Journal of Interprofessional Care; May/Jun2024, Vol. 38 Issue 3, p411-426, 16p
مصطلحات موضوعية: TEAMS in the workplace, MEDICAL information storage & retrieval systems, MEDICAL quality control, INTERPROFESSIONAL relations, EVIDENCE gaps, RESEARCH funding, CINAHL database, HOSPITAL patients, PATIENT care, HOSPITALS, HOSPITAL rounds, SYSTEMATIC reviews, MEDLINE, ROOMS, LITERATURE reviews, QUALITY assurance, HEALTH outcome assessment, ONLINE information services, PSYCHOLOGY information storage & retrieval systems
مستخلص: Poor communication within healthcare teams occurs commonly, contributing to inefficiency, medical errors, conflict, and other adverse outcomes. Interprofessional bedside rounds (IBR) are a promising model that brings two or more health professions together with patients and families as part of a consistent, team-based routine to share information and collaboratively arrive at a daily plan of care. The purpose of this systematic scoping review was to investigate the breadth and quality of IBR literature to identify and describe gaps and opportunities for future research. We followed an adapted Arksey and O'Malley Framework and PRISMA scoping review guidelines. PubMed, CINAHL, PsycINFO, and Embase were systematically searched for key IBR words and concepts through June 2020. Seventy-nine articles met inclusion criteria and underwent data abstraction. Study quality was assessed using the Mixed Methods Assessment Tool. Publications in this field have increased since 2014, and the majority of studies reported positive impacts of IBR implementation across an array of team, patient, and care quality/delivery outcomes. Despite the preponderance of positive findings, great heterogeneity, and a reliance on quantitative non-randomized study designs remain in the extant research. A growing number of interventions to improve safety, quality, and care experiences in hospital settings focus on redesigning daily inpatient rounds. Limited information on IBR characteristics and implementation strategies coupled with widespread variation in terminology, study quality, and design create challenges in assessing the effectiveness of models of rounds and optimal implementation strategies. This scoping review highlights the need for additional studies of rounding models, implementation strategies, and outcomes that facilitate comparative research. [ABSTRACT FROM AUTHOR]
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8دورية أكاديمية
المصدر: Journal of Gerontology Series B: Psychological Sciences and Social Sciences. 72(5)
مصطلحات موضوعية: Beliefs, Friendship, Social networks, Social psychology of aging, Social support, Stereotypes, Aged, Aged, 80 and over, Aging, Baltimore, Culture, Emotional Adjustment, Female, Friends, Humans, Male, Middle Aged, Optimism, Social Adjustment, Social Support, Statistics as Topic, Stereotyping, Surveys and Questionnaires, Volunteers
الوصف: OBJECTIVES: Negative perceptions of aging can be self-fulfilling prophecies, predicting worse cognitive and physical outcomes. Although older adults are portrayed as either lonely curmudgeons or perfect grandparents, little research addresses how perceptions of aging relate to social outcomes. We considered whether more positive expectations about aging encourage older adults to maintain or bolster their social network connections and support. METHOD: This study examined baseline, 12-, and 24-month questionnaire data from the Baltimore Experience Corps Trial, a longitudinal randomized volunteer intervention for adults aged 60 years and older. The associations between expectations regarding aging and different types of social support were tested using negative binomial and multiple regression models controlling for relevant covariates such as baseline levels of perceived support availability. RESULTS: Participants with more positive expectations at baseline made more new friends 2 years later and had greater overall perceived support availability 12 months later. Notably, only participants with at least average perceived support availability at baseline showed an association between expectations and later support availability. DISCUSSION: These results are the first to link overall expectations regarding aging to the social domain and suggest that the influence of perceptions of aging is not limited to physical or cognitive function.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/1527g59rTest
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9دورية أكاديمية
المؤلفون: Menkin, Josephine A, Robles, Theodore F, Gruenewald, Tara L, Tanner, Elizabeth K, Seeman, Teresa E
المصدر: The Journals of Gerontology Series B. 72(5)
مصطلحات موضوعية: Clinical Research, Mental Health, Clinical Trials and Supportive Activities, Aging, Behavioral and Social Science, Basic Behavioral and Social Science, Aged, Aged, 80 and over, Baltimore, Culture, Emotional Adjustment, Female, Friends, Humans, Male, Middle Aged, Optimism, Social Adjustment, Social Support, Statistics as Topic, Stereotyping, Surveys and Questionnaires, Volunteers, Beliefs, Friendship, Social networks, Social psychology of aging, Social support, Stereotypes, Clinical Sciences, Sociology, Psychology, Gerontology
الوصف: ObjectivesNegative perceptions of aging can be self-fulfilling prophecies, predicting worse cognitive and physical outcomes. Although older adults are portrayed as either lonely curmudgeons or perfect grandparents, little research addresses how perceptions of aging relate to social outcomes. We considered whether more positive expectations about aging encourage older adults to maintain or bolster their social network connections and support.MethodThis study examined baseline, 12-, and 24-month questionnaire data from the Baltimore Experience Corps Trial, a longitudinal randomized volunteer intervention for adults aged 60 years and older. The associations between expectations regarding aging and different types of social support were tested using negative binomial and multiple regression models controlling for relevant covariates such as baseline levels of perceived support availability.ResultsParticipants with more positive expectations at baseline made more new friends 2 years later and had greater overall perceived support availability 12 months later. Notably, only participants with at least average perceived support availability at baseline showed an association between expectations and later support availability.DiscussionThese results are the first to link overall expectations regarding aging to the social domain and suggest that the influence of perceptions of aging is not limited to physical or cognitive function.
الوصول الحر: https://escholarship.org/uc/item/1gn4z55tTest
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10دورية أكاديميةPositive Aging Expectations Are Associated With Physical Activity Among Urban-Dwelling Older Adults.
المؤلفون: Andrews, Ryan M, Tan, Erwin J, Varma, Vijay R, Rebok, George W, Romani, William A, Seeman, Teresa E, Gruenewald, Tara L, Tanner, Elizabeth K, Carlson, Michelle C
المصدر: The Gerontologist. 57(suppl_2)
مصطلحات موضوعية: Behavioral and Social Science, Aging, Clinical Research, Basic Behavioral and Social Science, Prevention of disease and conditions, and promotion of well-being, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Cancer, Black or African American, Aged, Attitude to Health, Baltimore, Exercise, Female, Humans, Linear Models, Longitudinal Studies, Male, Middle Aged, Surveys and Questionnaires, Urban Population, African American older adults, Attitudes & perception toward aging, Epidemiology, Analysis-hierarchical linear modeling, Clinical Sciences, Gerontology
الوصف: PurposeRegular physical activity is a key component of healthy aging, but few older adults meet physical activity guidelines. Poor aging expectations can contribute to this lack of activity, since negative stereotypes about the aging process can be internalized and affect physical performance. Although prior cross-sectional studies have shown that physical activity and aging expectations are associated, less is known about this association longitudinally, particularly among traditionally underrepresented groups. It is also unclear whether different domains of aging expectations are differentially associated with physical activity.Design and methodsThe number of minutes/week of physical activity in which Baltimore Experience Corps Trial participants (N = 446; 92.6% African American) engaged were measured using the CHAMPS questionnaire, while their aging expectations were measured using the ERA-12 survey. Linear mixed effects models assessed the association between physical activity and aging expectations over 2 years, both in full and sex-stratified samples. Separate models were also fit for different ERA-12 domains.ResultsWe found that higher overall expectations regarding aging are associated with higher engagement in moderate- to high-intensity physical activity over a 2-year period of time for women only. When the ERA-12 domains were examined separately, only the physical domain was associated with physical activity, both in women and overall.ImplicationsLow expectations regarding physical aging may represent a barrier to physical activity for older adults. Given that most older adults do not meet recommended physical activity guidelines, identifying factors that improve aging expectations may be a way to increase physical activity levels in aging populations.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/2q8863v4Test
