المؤلفون: Torigoe, Misako, Takahashi, Tsutomu, Takayanagi, Yoichiro, Sasabayahi, Daiki, Kobayashi, Haruko, Sakamoto, Kazumi, Yuasa, Yusuke, Tsujii, Noa, Noguchi, Kyo, Suzuki, Michio

المساهمون: Japan Society for the Promotion of Science, Japan Agency for Medical Research and Development, SENSHIN Medical Research Foundation

المصدر: Frontiers in Psychiatry ; volume 15 ; ISSN 1664-0640

الوصف: Introduction The findings of epidemiological studies suggest that a relationship exists between the risk of schizophrenia and winter births in the Northern Hemisphere, which may affect the process of fetal neurodevelopment. However, it remains unclear whether birth seasons are associated with the brain morphological characteristics of patients within the schizophrenia spectrum. Methods The present magnetic resonance imaging study using FreeSurfer software examined the effects of birth seasons (i.e., summer-born vs. winter-born) on the comprehensive brain surface characteristics of 101 patients with schizophrenia (48 summer- and 53 winter-born), 46 with schizotypal disorder (20 summer- and 26 winter-born), and 76 healthy control subjects (28 summer- and 48 winter-born). Results In comparisons with summer-born patients, winter-born patients, particularly those with schizophrenia, showed significantly increased gyrification mainly in the left lateral occipital and inferior temporal regions and right fronto-parietal region as well as cortical thinning in the right superior frontal region. Birth seasons did not significantly affect the local gyrification index or cortical thickness in healthy controls. Discussion The present whole-brain surface-based analysis demonstrated that brain morphological characteristics reported in the schizophrenia spectrum were more pronounced in winter-born patients than in summer-born patients, suggesting the contribution of early neurodevelopmental factors associated with birth seasons to the pathophysiology of the schizophrenia spectrum.

الإتاحة: https://doi.org/10.3389/fpsyt.2024.1368681Test

المؤلفون: Takayanagi, Yoichiro, Sasabayashi, Daiki, Takahashi, Tsutomu, Higuchi, Yuko, Nishiyama, Shimako, Tateno, Takahiro, Mizukami, Yuko, Akasaki, Yukiko, Furuichi, Atsushi, Kobayashi, Haruko, Takayanagi, Mizuho, Noguchi, Kyo, Tsujii, Noa, Suzuki, Michio

المساهمون: Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science

المصدر: Biomarkers in Neuropsychiatry ; volume 10, page 100089 ; ISSN 2666-1446

مصطلحات موضوعية: Biochemistry (medical), Psychiatry and Mental health, Clinical Biochemistry, Neurology (clinical)

الإتاحة: https://doi.org/10.1016/j.bionps.2024.100089Test
https://api.elsevier.com/content/article/PII:S2666144624000078?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666144624000078?httpAccept=text/plainTest

المؤلفون: Radua, Joaquim, Vieta, Eduard, Shinohara, Russell, Kochunov, Peter, Quidé, Yann, Green, Melissa J, Weickert, Cynthia S, Weickert, Thomas, Bruggemann, Jason, Kircher, Tilo, Nenadić, Igor, Cairns, Murray J, Seal, Marc, Schall, Ulrich, Henskens, Frans, Fullerton, Janice M, Mowry, Bryan, Pantelis, Christos, Lenroot, Rhoshel, Cropley, Vanessa, Loughland, Carmel, Scott, Rodney, Wolf, Daniel, Satterthwaite, Theodore D, Tan, Yunlong, Sim, Kang, Piras, Fabrizio, Spalletta, Gianfranco, Banaj, Nerisa, Pomarol-Clotet, Edith, Solanes, Aleix, Albajes-Eizagirre, Anton, Canales-Rodríguez, Erick J, Sarro, Salvador, Di Giorgio, Annabella, Bertolino, Alessandro, Stäblein, Michael, Oertel, Viola, Knöchel, Christian, Borgwardt, Stefan, du Plessis, Stefan, Yun, Je-Yeon, Kwon, Jun Soo, Dannlowski, Udo, Hahn, Tim, Grotegerd, Dominik, Alloza, Clara, Arango, Celso, Janssen, Joost, Díaz-Caneja, Covadonga, Jiang, Wenhao, Calhoun, Vince, Ehrlich, Stefan, Yang, Kun, Cascella, Nicola G, Takayanagi, Yoichiro, Sawa, Akira, Tomyshev, Alexander, Lebedeva, Irina, Kaleda, Vasily, Kirschner, Matthias, Hoschl, Cyril, Tomecek, David, Skoch, Antonin, van Amelsvoort, Therese, Bakker, Geor, James, Anthony, Preda, Adrian, Weideman, Andrea, Stein, Dan J, Howells, Fleur, Uhlmann, Anne, Temmingh, Henk, López-Jaramillo, Carlos, Díaz-Zuluaga, Ana, Fortea, Lydia, Martinez-Heras, Eloy, Solana, Elisabeth, Llufriu, Sara, Jahanshad, Neda, Thompson, Paul, Turner, Jessica, van Erp, Theo, collaborators, ENIGMA Consortium, Glahn, David, Pearlson, Godfrey, Hong, Elliot, Krug, Axel, Carr, Vaughan, Tooney, Paul, Cooper, Gavin, Rasser, Paul, Michie, Patricia, Catts, Stanley, Gur, Raquel, Gur, Ruben, Yang, Fude, Fan, Fengmei, Chen, Jingxu, Guo, Hua

مصطلحات موضوعية: Brain Disorders, Biomedical Imaging, Mental Health, Schizophrenia, Neurosciences, Mental health, Adult, Algorithms, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Meta-Analysis as Topic, Middle Aged, Neuroimaging, Young Adult, Brain, Cortical thickness, Gray matter, Mega-analysis, Volume, ENIGMA Consortium collaborators, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery

الوصف: A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium combines neuroimaging data from many institutions worldwide. However, this introduces heterogeneity due to different scanning devices and sequences. ENIGMA projects commonly address this heterogeneity with random-effects meta-analysis or mixed-effects mega-analysis. Here we tested whether the batch adjustment method, ComBat, can further reduce site-related heterogeneity and thus increase statistical power. We conducted random-effects meta-analyses, mixed-effects mega-analyses and ComBat mega-analyses to compare cortical thickness, surface area and subcortical volumes between 2897 individuals with a diagnosis of schizophrenia and 3141 healthy controls from 33 sites. Specifically, we compared the imaging data between individuals with schizophrenia and healthy controls, covarying for age and sex. The use of ComBat substantially increased the statistical significance of the findings as compared to random-effects meta-analyses. The findings were more similar when comparing ComBat with mixed-effects mega-analysis, although ComBat still slightly increased the statistical significance. ComBat also showed increased statistical power when we repeated the analyses with fewer sites. Results were nearly identical when we applied the ComBat harmonization separately for cortical thickness, cortical surface area and subcortical volumes. Therefore, we recommend applying the ComBat function to attenuate potential effects of site in ENIGMA projects and other multi-site structural imaging work. We provide easy-to-use functions in R that work even if imaging data are partially missing in some brain regions, and they can be trained with one data set and then applied to another (a requirement for some analyses such as machine learning).

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2bc1b6zpTest

المؤلفون: Takahashi, Tsutomu, Sasabayashi, Daiki, Takayanagi, Yoichiro, Higuchi, Yuko, Mizukami, Yuko, Akasaki, Yukiko, Nishiyama, Shimako, Furuichi, Atsushi, Kobayashi, Haruko, Yuasa, Yusuke, Tsujii, Noa, Noguchi, Kyo, Suzuki, Michio

المصدر: Frontiers in Psychiatry ; volume 14 ; ISSN 1664-0640

مصطلحات موضوعية: Psychiatry and Mental health

الوصف: Introduction Since the number of insular gyri is higher in schizophrenia patients, it has potential as a marker of early neurodevelopmental deviations. However, it currently remains unknown whether the features of the insular gross anatomy are similar between schizophrenia patients and individuals at risk of psychosis. Furthermore, the relationship between anatomical variations in the insular cortex and cognitive function has not yet been clarified. Methods The gross anatomical features (i.e., the number of gyri and development pattern of each gyrus) of the insular cortex were examined using magnetic resonance imaging, and their relationships with clinical characteristics were investigated in 57 subjects with an at-risk mental state (ARMS) and 63 schizophrenia patients in comparison with 61 healthy controls. Results The number of insular gyri bilaterally in the anterior subdivision was higher in the ARMS and schizophrenia groups than in the control group. The schizophrenia group was also characterized by a higher number of insular gyri in the left posterior subdivision. A well-developed right middle short insular gyrus was associated with symptom severity in first-episode schizophrenia patients, whereas chronic schizophrenia patients with a well-developed left accessory gyrus were characterized by less severe cognitive impairments in motor and executive functions. The features of the insular gross anatomy were not associated with clinical characteristics in the ARMS group. Discussion The features of the insular gross anatomy that were shared in the ARMS and schizophrenia groups may reflect a vulnerability to psychosis that may be attributed to anomalies in the early stages of neurodevelopment. However, the contribution of the insular gross anatomy to the clinical characteristics of schizophrenia may differ according to illness stages.

الإتاحة: https://doi.org/10.3389/fpsyt.2023.1192854Test

المؤلفون: Takahashi, Tsutomu, Sasabayashi, Daiki, Takayanagi, Yoichiro, Kobayashi, Haruko, Torigoe, Misako, Sakamoto, Kazumi, Yuasa, Yusuke, Tsujii, Noa, Noguchi, Kyo, Suzuki, Michio

المساهمون: Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science

المصدر: Psychiatry Research: Neuroimaging ; volume 335, page 111714 ; ISSN 0925-4927

مصطلحات موضوعية: Psychiatry and Mental health, Radiology, Nuclear Medicine and imaging, Neuroscience (miscellaneous)

الإتاحة: https://doi.org/10.1016/j.pscychresns.2023.111714Test
https://api.elsevier.com/content/article/PII:S0925492723001245?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0925492723001245?httpAccept=text/plainTest

المؤلفون: Takahashi, Tsutomu, Sasabayashi, Daiki, Takayanagi, Yoichiro, Furuichi, Atsushi, Kobayashi, Haruko, Yuasa, Yusuke, Noguchi, Kyo, Suzuki, Michio

المساهمون: Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science

المصدر: Schizophrenia Research ; volume 260, page 23-29 ; ISSN 0920-9964

مصطلحات موضوعية: Biological Psychiatry, Psychiatry and Mental health

الإتاحة: https://doi.org/10.1016/j.schres.2023.07.032Test
https://api.elsevier.com/content/article/PII:S092099642300258X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S092099642300258X?httpAccept=text/plainTest

المؤلفون: Kobayashi, Haruko, Sasabayashi, Daiki, Takahashi, Tsutomu, Furuichi, Atsushi, Kido, Mikio, Takayanagi, Yoichiro, Noguchi, Kyo, Suzuki, Michio

المساهمون: JSPS KAKENHI, Health and Labour Science Research Grants for Comprehensive Research, Japan Agency for Medical Research and Development

المصدر: Cerebral Cortex ; volume 34, issue 2 ; ISSN 1047-3211 1460-2199

مصطلحات موضوعية: Cellular and Molecular Neuroscience, Cognitive Neuroscience

الوصف: Previous postmortem brain studies have revealed disturbed myelination in the intracortical regions in patients with schizophrenia, possibly reflecting anomalous brain maturational processes. However, it currently remains unclear whether this anomalous myelination is already present in early illness stages and/or progresses during the course of the illness. In this magnetic resonance imaging study, we examined gray/white matter contrast (GWC) as a potential marker of intracortical myelination in 63 first-episode schizophrenia (FESz) patients and 77 healthy controls (HC). Furthermore, we investigated the relationships between GWC findings and clinical/cognitive variables in FESz patients. GWC in the bilateral temporal, parietal, occipital, and insular regions was significantly higher in FESz patients than in HC, which was partly associated with the durations of illness and medication, the onset age, and lower executive and verbal learning performances. Because higher GWC implicates lower myelin in the deeper layers of the cortex, these results suggest that schizophrenia patients have less intracortical myelin at the time of their first psychotic episode, which underlies lower cognitive performance in early illness stages.

الإتاحة: https://doi.org/10.1093/cercor/bhae009Test
https://academic.oup.com/cercor/article-pdf/34/2/bhae009/56572909/bhae009.pdfTest

المؤلفون: Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A., Arango, Celso, Arolt, Volker, Auzias, Guillaume, Ayesa-Arriola, Rosa, Banaj, Nerisa, Banaschewski, Tobias, Bandeira, Cibele, Başgöze, Zeynep, Cupertino, Renata Basso, Bau, Claiton H.D., Bauer, Jochen, Baumeister, Sarah, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina del Mar, Brandeis, Daniel, Brem, Silvia, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R., Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J., Cannon, Dara M., Carmona, Susanna, Carr, Vaughan J., Catts, Stanley V., Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G., Conzelmann, Annette, Craven, Alexander R., Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Dannlowski, Udo, Davey, Christopher G., Deruelle, Christine, Díaz-Caneja, Covadonga M., Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T., Fedor, Jennifer, Fitzgerald, Jacqueline, Foran, William, Ford, Judith M., Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Gao, Bingchen, Gao, Si, Goikolea, Jose M., Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J., Green, Melissa, Grevet, Eugenio H., Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Haavik, Jan, Hahn, Tim, Harrison, Ben J., Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J., Hilland, Eva, Hoekstra, Pieter J., Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M., Ipser, Jonathan C., Jahanshad, Neda, Jakobi, Babette, Jansen, Andreas, Janssen, Joost, Jonassen, Rune, Kaiser, Anna, Kaleda, Vasiliy, Karantonis, James, King, Joseph A., Kircher, Tilo, Kochunov, Peter, Koopowitz, Sheri Michelle, Landén, Mikael, Landrø, Nils Inge, Lawrie, Stephen, Lebedeva, Irina, Luna, Beatriz, Lundervold, Astri J., MacMaster, Frank P., Maglanoc, Luigi A., Mathalon, Daniel H., McDonald, Colm, McIntosh, Andrew, Meinert, Susanne, Michie, Patricia T., Mitchell, Philip, Moreno-Alcázar, Ana, Mowry, Bryan, Muratori, Filippo, Nabulsi, Leila, Nenadić, Igor, O'Gorman Tuura, Ruth, Oosterlaan, Jaap, Overs, Bronwyn, Pantelis, Christos, Parellada, Mara, Pariente, Jose C., Pauli, Paul, Pergola, Giulio, Piarulli, Francesco Maria, Picon, Felipe, Piras, Fabrizio, Pomarol-Clotet, Edith, Pretus, Clara, Quidé, Yann, Radua, Joaquim, Ramos-Quiroga, J. Antoni, Rasser, Paul E., Reif, Andreas, Retico, Alessandra, Roberts, Gloria, Rossell, Susan, Rovaris, Diego Luiz, Rubia, Katya, Sacchet, Matthew, Salavert, Josep, Salvador, Raymond, Sarró, Salvador, Sawa, Akira, Schall, Ulrich, Scott, Rodney, Selvaggi, Pierluigi, Silk, Tim, Sim, Kang, Skoch, Antonin, Spalletta, Gianfranco, Spaniel, Filip, Stein, Dan J., Steinsträter, Olaf, Stolicyn, Aleks, Takayanagi, Yoichiro, Tamm, Leanne, Tavares, Maria, Teumer, Alexander, Thiel, Katharina, Thomopoulos, Sophia I., Tomecek, David, Tomyshev, Alexander S., Tordesillas-Gutiérrez, Diana, Tosetti, Michela, Uhlmann, Anne, Van Rheenen, Tamsyn, Vazquez-Bourgón, Javier, Vernooij, Meike W., Vieta, Eduard, Vilarroya, Oscar, Weickert, Cynthia, Weickert, Thomas, Westlye, Lars T., Whalley, Heather, Willinger, David, Winter, Alexandra, Wittfeld, Katharina, Yang, Tony T., Yoncheva, Yuliya, Zijlmans, Jendé L., Hoogman, Martine, Franke, Barbara, van Rooij, Daan, Buitelaar, Jan, Ching, Christopher R.K., Andreassen, Ole A., Pozzi, Elena, Veltman, Dick, Schmaal, Lianne, van Erp, Theo G.M., Turner, Jessica, Castellanos, F. Xavier, Pausova, Zdenka, Thompson, Paul, Paus, Tomas

المصدر: Patel , Y , Shin , J , Abé , C , Agartz , I , Alloza , C , Alnæs , D , Ambrogi , S , Antonucci , L A , Arango , C , Arolt , V , Auzias , G , Ayesa-Arriola , R , Banaj , N , Banaschewski , T , Bandeira , C , Başgöze , Z , Cupertino , R B , Bau , C H D , Bauer , J , Baumeister , S , Bernardoni , F , Bertolino , A , Bonnin , C D M , Brandeis ....

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الوصف: Background: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life. Methods: Interregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed. Results: Across the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth. Conclusions: Our findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.

العلاقة: https://pure.eur.nl/en/publications/239622ba-a558-4ee8-891f-22a824ea830cTest

الإتاحة: https://doi.org/10.1016/j.biopsych.2022.02.959Test
https://pure.eur.nl/en/publications/239622ba-a558-4ee8-891f-22a824ea830cTest
http://www.scopus.com/inward/record.url?scp=85129809360&partnerID=8YFLogxKTest
https://hdl.handle.net/11370/fd5c3e6e-c003-4751-abab-8ed415f7f7a6Test

المؤلفون: Takahashi, Tsutomu, Sasabayashi, Daiki, Takayanagi, Yoichiro, Furuichi, Atsushi, Kobayashi, Haruko, Yuasa, Yusuke, Noguchi, Kyo, Suzuki, Michio

المساهمون: Japan Society for the Promotion of Science, Japan Agency for Medical Research and Development

المصدر: Frontiers in Psychiatry ; volume 13 ; ISSN 1664-0640

الوصف: Introduction Patients with schizophrenia have a higher number of insular gyri; however, it currently remains unclear whether the brain characteristics of patients with schizotypal personality disorder (SPD), a mild form of schizophrenia, are similar. It is also unknown whether insular gross anatomical features are associated with the illness stages and clinical subtypes of schizophrenia. Materials and methods This magnetic resonance imaging study examined gross anatomical variations in the insular cortex of 133 patients with schizophrenia, 47 with SPD, and 88 healthy controls. The relationships between the insular gross anatomy and schizophrenia subgroups (71 first-episode and 58 chronic groups, 38 deficit and 37 non-deficit subtype groups) were also investigated. Results The number of insular gyri was higher in the schizophrenia and SPD patients than in the controls, where the patients were characterized by well-developed accessory, middle short, and posterior long insular gyri. The insular gross anatomy did not significantly differ between the first-episode and chronic schizophrenia subgroups; however, the relationship between the developed accessory gyrus and more severe positive symptoms was specific to the first-episode group. The prevalence of a right middle short gyrus was higher in the deficit schizophrenia group than in the non-deficit group. Discussion These findings suggest that schizophrenia and SPD patients may share an altered insular gross morphology as a vulnerability factor associated with early neurodevelopmental anomalies, which may also contribute to positive symptomatology in the early illness stages and clinical subtypes of schizophrenia.

الإتاحة: https://doi.org/10.3389/fpsyt.2022.1050712Test

المؤلفون: Takahashi, Tsutomu, Sasabayashi, Daiki, Takayanagi, Yoichiro, Furuichi, Atsushi, Kobayashi, Haruko, Noguchi, Kyo, Suzuki, Michio

المساهمون: Japan Society for the Promotion of Science, Japan Agency for Medical Research and Development

المصدر: Frontiers in Psychiatry ; volume 13 ; ISSN 1664-0640

مصطلحات موضوعية: Psychiatry and Mental health

الوصف: Deficit syndrome schizophrenia is a characteristic subtype defined by persistent negative symptoms and poor functional outcomes; however, the biological mechanisms underlying this specific subtype have not yet been elucidated in detail. The present magnetic resonance imaging study examined the prevalence of duplicated Heschl’s gyrus (HG), a potential neurodevelopmental marker, in schizophrenia patients with ( N = 38) and without ( N = 37) the deficit syndrome. The prevalence of the HG duplication pattern bilaterally was higher in the whole schizophrenia group than in 59 matched healthy controls. Furthermore, the prevalence of right HG duplication was significantly higher in the deficit schizophrenia group than in the non-deficit schizophrenia group. The HG pattern in schizophrenia was not associated with clinical variables, including illness duration, medication, and symptom severity, while right HG duplication correlated with higher scores for Proxy for the Deficit Syndrome. The present results suggest that the prominent neurodevelopmental pathology associated with gyral formation of HG may contribute to enduring negative symptomatology in schizophrenia.

الإتاحة: https://doi.org/10.3389/fpsyt.2022.867461Test