المؤلفون: Martumpal Hamonangan, Wahyu, Lee, Sangmin, Hun Choi, Ye, Li, Wanzhao, Tai, Meiling, Kim, Shin-Hyun

المصدر: Journal of Colloid and Interface Science ; ISSN 0021-9797

الإتاحة: https://doi.org/10.1016/j.jcis.2024.04.146Test
https://api.elsevier.com/content/article/PII:S0021979724008749?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021979724008749?httpAccept=text/plainTest

المؤلفون: Tai, Meiling¹ (AUTHOR), Chen, Jieli² (AUTHOR), Chen, Jiawen¹ (AUTHOR), Shen, Xiaoyan² (AUTHOR) shxiaoy@fudan.edu.cn, Ni, Jiahui² (AUTHOR) 19111030058@fudan.edu.cn

المصدر: Experimental Dermatology. Jan2024, Vol. 33 Issue 1, p1-8. 8p.

مصطلحات موضوعية: *SKIN aging, *ENDOPLASMIC reticulum, *UNFOLDED protein response, *CALCIUM ions, *ULTRAVIOLET radiation

مستخلص: Aging is a normal and complex biological process. Skin is located in the most superficial layer of the body, and its degree of aging directly reflects the aging level of the body. Endoplasmic reticulum stress refers to the aggregation of unfolded or misfolded proteins in the endoplasmic reticulum and the disruption of the calcium ion balance when cells are stimulated by external stimuli. Mild endoplasmic reticulum stress can cause a series of protective mechanisms, including the unfolded protein response, while sustained high intensity stimulation leads to endoplasmic reticulum stress and eventually apoptosis. Photoaging caused by ultraviolet radiation is an important stimulus in skin aging. Many studies have focused on oxidative stress, but increasing evidence shows that endoplasmic reticulum stress plays an important role in photoaging. This paper reviews the development and mechanism of endoplasmic reticulum stress (ERS) in skin photoaging, and provides research directions for targeting the ERS pathway to slow aging. [ABSTRACT FROM AUTHOR]

المؤلفون: Tai, Meiling, Chen, Jieli, Chen, Jiawen, Shen, Xiaoyan, Ni, Jiahui

المصدر: Experimental Dermatology ; volume 33, issue 1 ; ISSN 0906-6705 1600-0625

الوصف: Aging is a normal and complex biological process. Skin is located in the most superficial layer of the body, and its degree of aging directly reflects the aging level of the body. Endoplasmic reticulum stress refers to the aggregation of unfolded or misfolded proteins in the endoplasmic reticulum and the disruption of the calcium ion balance when cells are stimulated by external stimuli. Mild endoplasmic reticulum stress can cause a series of protective mechanisms, including the unfolded protein response, while sustained high intensity stimulation leads to endoplasmic reticulum stress and eventually apoptosis. Photoaging caused by ultraviolet radiation is an important stimulus in skin aging. Many studies have focused on oxidative stress, but increasing evidence shows that endoplasmic reticulum stress plays an important role in photoaging. This paper reviews the development and mechanism of endoplasmic reticulum stress (ERS) in skin photoaging, and provides research directions for targeting the ERS pathway to slow aging.

الإتاحة: https://doi.org/10.1111/exd.14956Test

المؤلفون: Tai, Meiling, Zhang, Chenggong, Ma, Yonghao, Yang, Jian, Mai, Zhuoxian, Li, Chengguo, Leng, Gang

المصدر: Journal of Cosmetic Dermatology ; volume 21, issue 12, page 6913-6919 ; ISSN 1473-2130 1473-2165

الوصف: Objective Acne is a significant problem in young people. At present, most acne treatment products are topically applied cosmetics, whose efficacy is limited by the stratum corneum. The dissolving microneedle technique can effectively deliver drug molecules into the body. In this study, dissolving microneedles containing anti‐acne ingredients were tested for human efficacy and safety. Methods We conducted a 28‐day clinical efficacy and safety trial on 30 individuals with visible facial acne. During the trial, anti‐acne microneedle (AA‐DMN) patches were applied to designated skin areas once daily for 28 consecutive days. Skin pigmentation was measured using a Courage + Khazaka skin melanin and hemoglobin test probe Mexameter MX18. Acne volume was measured using a Canfieldsci skin rapid optical imaging system PRIMOS. In addition, skin irritation was evaluated via self‐report and dermatologist's examination. Results The AA‐DMN patches showed good efficacy including improvement of skin pigmentation and reduced acne volume. Acne volume was reduced by 12.34% after 3 days of patch use and further reduced by 10.01% after 7 continuous days of use. After 28 days of treatment, skin melanin decreased by 5.88% and heme decreased by 7.83%. No adverse reactions were observed in any of the participants. Conclusions Anti‐acne microneedle patches showed an excellent effect in reducing acne and post‐inflammatory hyperpigmentation (PIH), without adverse skin reactions. The novel AA‐DMN patch is a safe and effective anti‐acne treatment.

الإتاحة: https://doi.org/10.1111/jocd.15352Test

المؤلفون: Hamonangan, Wahyu Martumpal, Lee, Sangmin, Choi, Ye Hun, Li, Wanzhao, Tai, Meiling, Kim, Shin-Hyun

المساهمون: National Research Foundation of Korea, Infinitus (China) Company Ltd

المصدر: ACS Applied Materials & Interfaces ; volume 14, issue 16, page 18159-18169 ; ISSN 1944-8244 1944-8252

الإتاحة: https://doi.org/10.1021/acsami.2c01319Test

المؤلفون: Ma, Yonghao, Li, Chengguo, Mai, Zhuoxian, Yang, Jian, Tai, Meiling, Leng, Gang

المصدر: Journal of Cosmetic Dermatology; Aug2022, Vol. 21 Issue 8, p3496-3502, 7p

مصطلحات موضوعية: WRINKLES (Skin), SKIN aging, CHINESE people, HYALURONIC acid, MARKETING research

مستخلص: Objectives: There is a lack of clinical research in the Chinese market concerning dissolving microarray (DMA) patches in cosmetic applications. In this study, the clinical efficacy and safety tests of DMA patch technology were performed on Chinese consumers. Methods: A 4‐week clinical efficacy and safety evaluation was conducted on 30 Chinese female subjects with crow's feet and eye bags. DMA patches loaded with hyaluronic acid (HA‐DMA) were applied under the eyes and corners of the eyes of the subjects three times a week over four consecutive weeks. Skin firmness and dermal layer strength were measured using ultrasound, and changes in skin wrinkles were detected using VISIA‐CR and Primos Lite. Eye bag ratings were evaluated by professional dermatologists based on the 0–6 grades of eye bags in the "Skin Aging Atlas Volume 2: Asian Type." Results: HA‐DMA patches produced good clinical improvements on both crow's feet and eye bags in the study participants. HA‐DMA effectively increased skin firmness while reducing the number, area, and volume of crow's feet, along with reducing eye bag ratings. The reductions in all metrics were statistically significant with positive effects evident in as little as 1 week of treatment. There were no adverse effects related to the treatments observed during the test period. Conclusions: In a clinical efficacy trial of 30 Chinese female subjects, HA‐DMA showed excellent therapeutic benefits without adverse effects while reducing crow's feet and eye bags. HA‐DMA is expected to be a safe, effective, and novel cosmetic for improving the appearance of aging skin. [ABSTRACT FROM AUTHOR]

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المؤلفون: Liu, Guan‐Ting, Li, Yong‐Liang, Wang, Jing, Dong, Chang‐Zhi, Deng, Minggao, Tai, Meiling, Deng, Lili, Che, Biao, Lin, Li, Du, Zhi‐Yun, Chen, Hui‐Xiong

المصدر: Photochemistry and Photobiology ; volume 98, issue 1, page 262-272 ; ISSN 0031-8655 1751-1097

الوصف: Lycium barbarum have received an increasing popularity due to its powerful biological activity and medicinal use. However, the effect of Lycium barbarum on skin remains largely uncharacterized. The general purpose of this paper was to characterize the phenolic compounds in Lycium barbarum extract (LBE) using LC‐HRMS/QTOF method and to investigate whether topical administration of LBE can repair skin barrier dysfunction in mice. Our data demonstrated that LBE could not only decrease ROS level and matrix metalloproteinase expression, but also strengthen intrinsic antioxidant defense system including SOD, GSH‐Px and CAT, thereby resulting in increased skin collagen content and an improvement of UV‐induced skin erythema, thickness and wrinkles. Improved skin barrier functions were highly correlated with increased expression of filaggrin, involucrin and loricrin as well as antioxidant proteins such as Nrf2 and HO‐1 in UV‐irradiated mice, suggesting that LBE may be promising natural products at a lower cost for the topical application in the treatment of skin diseases with defective barrier function.

الإتاحة: https://doi.org/10.1111/php.13498Test

المؤلفون: Lee, Sangmin, Che, Biao, Tai, Meiling, Li, Wanzhao, Kim, Shin‐Hyun

المساهمون: National Research Foundation of Korea

المصدر: Advanced Functional Materials ; volume 31, issue 42 ; ISSN 1616-301X 1616-3028

الوصف: Hydrogel shells that compartmentalize the water core from the aqueous surrounding provide molecular selectivity on size and charge in transmembrane transport. It is highly demanding to produce thin hydrogel shells to minimize diffusion length and maximize core volume. Here, internal osmosis in water‐in‐oil‐in‐water‐in‐oil (W/O/W/O) triple‐emulsion droplets is used to produce thin hydrogel shells enclosing a large water core. The triple‐emulsion droplets are prepared to have an ultrathin middle oil layer using a capillary microfluidic device. The innermost water droplet has a higher osmolarity than the outer water layer containing photopolymerizable hydrogel precursors, which pumps water from the outer layer to the core through the ultrathin oil layer by the osmosis. Therefore, the outer layer gets thinner and hydrogel precursors are enriched while the size of the triple‐emulsion droplets remains unchanged. Through photopolymerization of precursors and phase transfer from oil to water, hydrogel shells enclosing water core are produced in the water environment; the oil layer is ruptured for molecular exchange through the shells. The thickness and composition of the hydrogel shells are precisely controllable by the osmotic conditions. The shells show a high permeation rate due to the thinness as well as controlled cut‐off threshold of permeation for neutral and charged molecules.

الإتاحة: https://doi.org/10.1002/adfm.202105477Test

المؤلفون: Deng, Minggao, Wang, Jing, Li, Yong‐Liang, Chen, Hui‐Xiong, Tai, Meiling, Deng, Lili, Che, Biao, Du, Zhi‐Yun, Dong, Chang‐Zhi, Lin, Li

المصدر: Journal of Cosmetic Dermatology ; volume 21, issue 2, page 781-793 ; ISSN 1473-2130 1473-2165

الوصف: Background Despite Tricholoma matsutake has been used as natural health products with multiple medicinal properties, detailed information about its polyphenolic composition as sources of anti‐photoaging agents remains to be determined. Objective To investigate the impact of polyphenols extracted from Tricholoma matsutake (TME) on Ultraviolet B (UVB)‐induced skin photoaging. Materials and Methods Various factors of oxidative stress and inflammation as well as histological and immunohistochemical analysis in the mouse dorsal skin were determined after UVB radiation. Results Topical administration with TME suppressed the UVB‐induced skin thickness, wrinkles and erythema, and increased skin collagen content. Furthermore, TME decreased reactive oxygen species (ROS) level, upregulated glutathione peroxidase (GSH‐Px), superoxide dismutase (SOD), catalase (CAT), and glucose‐6‐phosphate dehydrogenase (G6PDH) activities and inhibited the expression of IL‐1, IL‐6, IL‐8, and TNF‐α in mice irradiated with UVB. TME could reduce UVB‐induced p 38 mitogen‐activated protein kinase ( p 38 MAPK) phosphorylation and effectively inhibited the activity of the transcriptional factor nuclear factor‐kappa B (NF‐ κ B), thereby reducing the cyclooxygenase‐2 (COX‐2) expression, which is an important mediator of inflammatory cascade leading to the inflammatory response. Conclusion Our data demonstrated that TME had various beneficial effects on UVB‐induced skin photoaging due to its antioxidant and anti‐inflammatory activities, and it might be exploited as a promising natural product in skin care, anti‐photoaging and the therapeutic intervention of skin disorders related to both oxidative stress and inflammation.

الإتاحة: https://doi.org/10.1111/jocd.14127Test

المؤلفون: Ma, Yonghao, Li, Chengguo, Mai, Zhuoxian, Yang, Jian, Tai, Meiling, Leng, Gang

المصدر: Journal of Cosmetic Dermatology ; volume 21, issue 8, page 3496-3502 ; ISSN 1473-2130 1473-2165

الوصف: Objectives There is a lack of clinical research in the Chinese market concerning dissolving microarray (DMA) patches in cosmetic applications. In this study, the clinical efficacy and safety tests of DMA patch technology were performed on Chinese consumers. Methods A 4‐week clinical efficacy and safety evaluation was conducted on 30 Chinese female subjects with crow's feet and eye bags. DMA patches loaded with hyaluronic acid (HA‐DMA) were applied under the eyes and corners of the eyes of the subjects three times a week over four consecutive weeks. Skin firmness and dermal layer strength were measured using ultrasound, and changes in skin wrinkles were detected using VISIA‐CR and Primos Lite. Eye bag ratings were evaluated by professional dermatologists based on the 0–6 grades of eye bags in the “Skin Aging Atlas Volume 2: Asian Type.” Results HA‐DMA patches produced good clinical improvements on both crow's feet and eye bags in the study participants. HA‐DMA effectively increased skin firmness while reducing the number, area, and volume of crow's feet, along with reducing eye bag ratings. The reductions in all metrics were statistically significant with positive effects evident in as little as 1 week of treatment. There were no adverse effects related to the treatments observed during the test period. Conclusions In a clinical efficacy trial of 30 Chinese female subjects, HA‐DMA showed excellent therapeutic benefits without adverse effects while reducing crow's feet and eye bags. HA‐DMA is expected to be a safe, effective, and novel cosmetic for improving the appearance of aging skin.

الإتاحة: https://doi.org/10.1111/jocd.14594Test