المؤلفون: Kazuna Matsutani, Yasuto Kinose, Mayuko Kato, Michiko Kodama, Kenjiro Sawada, Tadashi Kimura

المصدر: Case Reports in Women's Health, Vol 41, Iss , Pp e00589- (2024)

مصطلحات موضوعية: Pancreatic fistula, Fallopian tube cancer, Diagnostic laparoscopy, Metal colonic stent, Case report, Surgery, RD1-811, Gynecology and obstetrics, RG1-991

الوصف: Pancreatic fistulas are rare after gynecologic surgeries but are sometimes difficult to manage. A 62-year-old woman was admitted to a local hospital with acute abdominal pain. Computed tomography (CT) images showed subileus and an obstruction site in the transverse/descending colon, with invasion of peritoneal metastasis. A metal stent was placed in the bowel through colonoscopy. Suspecting advanced-stage ovarian cancer, the patient was referred to a tertiary hospital. Diagnostic laparoscopy was performed prior to neoadjuvant chemotherapy. Due to concerns raised by gastrointestinal surgeons regarding the high risk of stent perforation during chemotherapy, an abdominal colectomy of the transverse/descending colon was performed along with the removal of the disseminated tumor and the stent. Post-surgery, the patient was histologically diagnosed with stage IVB left fallopian tube carcinosarcoma. On postoperative day 3, the patient developed a fever, and CT images showed an abscess around the pancreas/spleen, prompting the placement of a drainage tube. The amylase level in the drained fluid was 258,111 U/L, leading to a diagnosis of a pancreatic fistula. Conservative management was undertaken, with drainage, fasting, and octreotide administration. After two months, the drainage tube was removed as the volume of drained fluid had decreased. After four cycles of carboplatin/paclitaxel chemotherapy, CT images showed partial response to chemotherapy, and interval debulking surgery was performed. The necessity of metallic stent placement should be carefully considered as the subileus caused by peritoneal metastasis might be alleviated by the induction of chemotherapy for gynecologic cancer.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2214911224000109Test; https://doaj.org/toc/2214-9112Test

الوصول الحر: https://doaj.org/article/2dd85b5efaa24bceb7cdf69c26ac518dTest

المؤلفون: Emiko Oka, Yutaka Ueda, Asami Yagi, Yuri Ito, Yoshihiko Hosokawa, Takahiro Tabuchi, Tadashi Kimura

المصدر: Vaccine: X, Vol 17, Iss , Pp 100441- (2024)

مصطلحات موضوعية: HPV vaccine, COVID-19 vaccine, Parental intention, Gender, Fear, Vaccine hesitancy, Immunologic diseases. Allergy, RC581-607

الوصف: Purpose: The coronavirus disease of 2019 (COVID-19) pandemic has increased public awareness of infectious diseases and interest in vaccines, including the human papilloma virus (HPV) vaccine. We investigated differences between parental gender and intentions to vaccinate their child for HPV and COVID-19. Methods: We analyzed data from Japan’s COVID-19 and Society Internet Survey (JACSIS), a web-based cross-sectional survey of 2,444 respondents in 2021. Results: Females were more knowledgeable and more afraid of HPV and COVID-19 than males. The proportions of females in favor of, or against, HPV vaccination was higher than among males. The fathers’ intention for HPV vaccination was significantly associated with the child’s gender, knowledge regarding HPV, and intention to inoculate with the COVID-19 vaccine. The mothers’ intention was also associated with her knowledge of HPV and her intention to seek the COVID-19 vaccine, but it included a greater fear of HPV infection. Both male and female parents favored the COVID-19 vaccine over the HPV vaccine. Parents approving of COVID-19 vaccination believed in the overall efficacy of vaccines and were more receptive to opinions from the administration and physicians, even if the parent was currently against HPV vaccination. Conclusions: Mothers were more knowledgeable about HPV and more favorable to vaccinate their child for HPV than fathers. The intention to have children COVID-19 vaccinated was also higher than for HPV vaccination. During this period of heightened public interest in vaccines due to the COVID-19 pandemic, this is a good time to educate and inform the public about HPV.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2590136224000147Test; https://doaj.org/toc/2590-1362Test

الوصول الحر: https://doaj.org/article/3d8de36fc6b442af81da7299b70d7058Test

المؤلفون: Akiko Hanai, Tetsuo Ishikawa, Shoko Sugao, Makoto Fujii, Kei Hirai, Hiroko Watanabe, Masayo Matsuzaki, Goji Nakamoto, Toshihiro Takeda, Yasuji Kitabatake, Yuichi Itoh, Masayuki Endo, Tadashi Kimura, Eiryo Kawakami

المصدر: JMIR Formative Research, Vol 8, p e47372 (2024)

مصطلحات موضوعية: Medicine

الوصف: BackgroundOne life event that requires extensive resilience and adaptation is parenting. However, resilience and perceived support in child-rearing vary, making the real-world situation unclear, even with postpartum checkups. ObjectiveThis study aimed to explore the psychosocial status of mothers during the child-rearing period from newborn to toddler, with a classifier based on data on the resilience and adaptation characteristics of mothers with newborns. MethodsA web-based cross-sectional survey was conducted. Mothers with newborns aged approximately 1 month (newborn cohort) were analyzed to construct an explainable machine learning classifier to stratify parenting-related resilience and adaptation characteristics and identify vulnerable populations. Explainable k-means clustering was used because of its high explanatory power and applicability. The classifier was applied to mothers with infants aged 2 months to 1 year (infant cohort) and mothers with toddlers aged >1 year to 2 years (toddler cohort). Psychosocial status, including depressed mood assessed by the Edinburgh Postnatal Depression Scale (EPDS), bonding assessed by the Postpartum Bonding Questionnaire (PBQ), and sleep quality assessed by the Pittsburgh Sleep Quality Index (PSQI) between the classified groups, was compared. ResultsA total of 1559 participants completed the survey. They were split into 3 cohorts, comprising populations of various characteristics, including parenting difficulties and psychosocial measures. The classifier, which stratified participants into 5 groups, was generated from the self-reported scores of resilience and adaptation in the newborn cohort (n=310). The classifier identified that the group with the greatest difficulties in resilience and adaptation to a child’s temperament and perceived support had higher incidences of problems with depressed mood (relative prevalence [RP] 5.87, 95% CI 2.77-12.45), bonding (RP 5.38, 95% CI 2.53-11.45), and sleep quality (RP 1.70, 95% CI 1.20-2.40) compared to the group with no difficulties in perceived support. In the infant cohort (n=619) and toddler cohort (n=461), the stratified group with the greatest difficulties had higher incidences of problems with depressed mood (RP 9.05, 95% CI 4.36-18.80 and RP 4.63, 95% CI 2.38-9.02, respectively), bonding (RP 1.63, 95% CI 1.29-2.06 and RP 3.19, 95% CI 2.03-5.01, respectively), and sleep quality (RP 8.09, 95% CI 4.62-16.37 and RP 1.72, 95% CI 1.23-2.42, respectively) compared to the group with no difficulties. ConclusionsThe classifier, based on a combination of resilience and adaptation to the child’s temperament and perceived support, was able identify psychosocial vulnerable groups in the newborn cohort, the start-up stage of childcare. Psychosocially vulnerable groups were also identified in qualitatively different infant and toddler cohorts, depending on their classifier. The vulnerable group identified in the infant cohort showed particularly high RP for depressed mood and poor sleep quality.

وصف الملف: electronic resource

العلاقة: https://formative.jmir.org/2024/1/e47372Test; https://doaj.org/toc/2561-326XTest

الوصول الحر: https://doaj.org/article/d192c49a96bb4064b34cb4dc78ff9168Test

المؤلفون: Takumi Kihara MD, Makoto Kubota MD, PhD, Tadashi Kimura MD, PhD, Naoki Suzuki PhD, Asaki Hattori PhD, Mitsuru Saito MD, PhD

المصدر: Foot & Ankle Orthopaedics, Vol 8 (2023)

مصطلحات موضوعية: Orthopedic surgery, RD701-811

الوصف: Category: Midfoot/Forefoot; Basic Sciences/Biologics Introduction/Purpose: The windlass mechanism (WM) increases the height of the medial longitudinal arch (MLA) of the foot by tensing the plantar aponeurosis during dorsiflexion of the metatarsophalangeal (MTP) joint. We speculated that this mechanism may be deeply involved in the pathogenesis of forefoot diseases such as hallux rigidus (HR). These conditions are three- dimensional (3D) deformities including rotational deformity, but the role of the WM has been evaluated only two-dimensionally by measuring the height of the navicular on lateral plain radiographs. The purpose of this study was to analyze in detail the WM of normal and HR feet in 3D. Methods: Participants were 14 patients with HR (17 feet) and 13 volunteers (21 feet). The volunteers had no history of foot disease or trauma, whereas the patients with HR had Coughlin and Shurnas classification I or II. Computed tomography (CT) of the foot with a load equivalent to the participant’s body weight was performed. Imaging was performed with the 1st MTP joint in the neutral position and dorsiflexed 30 degrees. 3D models were created using the software Mimics Research 17.0. Next, we used the iterative closest point (ICP) algorithm, which allows 3D objects to be superimposed without specifying anatomical feature points. Then, we performed 3D measurements of the (1) rotation of each bone in the MLA with respect to the tibia, (2) rotation of the distal bone in each joint of the MLA, and (3) changes in the height of the geometric center of the navicular. Results: At the calcaneus, navicular and medial cuneiform, the HR group showed less inversion, adduction than healthy group. (P < 0.05) At the talonavicular joint, the navicular was 3.7° inversion, 2.9° adduction in the healthy group and 2.4°inversion, 1.3° adduction in the HR group. At the talocalcaneal joint, the calcaneus was 1.7° inversion, 1.5° adduction in the healthy group and 0.9°inversion, 0.6° adduction in the HR group. In the talonavicular and talocalcaneal joint, the HR group showed less inversion and adduction than control. (P < 0.05) With dorsiflexion of the hallux, the height of the navicular increased by 2.1 mm in the healthy group and 1.3 mm in the HR group. There was a significant difference (P < 0.05) between the two groups. Conclusion: In both groups, the calcaneus, navicular, and medial cuneiform bones moved not only in the sagittal plane but also in the frontal plane. But the movement of the talonavicular and talocalcaneal joints and the change in height of the navicular were significantly reduced compared with the healthy group. In other words, in the HR group, the motion of the midfoot and hindfoot was limited, suggesting that there may be a close relationship between WM dysfunction and midfoot and hindfoot motion. This study indicates that the dysfunction of the WM may have been a clue to the cause of HR.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2473-0114Test

الوصول الحر: https://doaj.org/article/7eadbfda455b47a5845965ed961ce221Test

المؤلفون: Tadashi Kimura MD, PhD, Makoto Kubota MD, PhD, Takumi Kihara MD, Asaki Hattori PhD, Naoki Suzuki PhD, Mitsuru Saito MD, PhD

المصدر: Foot & Ankle Orthopaedics, Vol 8 (2023)

مصطلحات موضوعية: Orthopedic surgery, RD701-811

الوصف: Category: Midfoot/Forefoot; Bunion Introduction/Purpose: Both hallux rigidus (HR) and hallux valgus (HV) are conditions that occur in the first ray. Although both are believed to originate from hypermobility of the first ray, they each ultimately result in different clinical feature. Hypermobility of the first ray is strongly involved in the pathogenesis of HV. In contrast, several studies have reported an association between HR and hypermobility of the first ray but few have actually analyzed the nature of that association. We hypothesized that in HR, there would be little rotational movement despite the presence of hypermobility of the first ray. The purpose of this study was to evaluate the first ray mobility in feet with HR, HV, and in healthy feet by using weightbearing and non-weightbearing CT and 3D analysis. Methods: In this case-control study, we examined 17 feet of 11 healthy volunteers with no history of foot disorders and no symptoms such as pain in the foot (control group), 16 feet of 16 patients with HV and 16 feet of 11 patients with HR. First, non- weightbearing foot CT imaging was performed with the participant supine on our original loading device, with the legs extended and the ankle in a neutral position, and then weightbearing CT imaging was performed by applying a load equivalent to body weight. Using an iterative closest point algorithm, each joint in the first ray—the talonavicular joint, the medial cuneonavicular joint, and the first tarsometatarsal (TMT) joint—was aligned using its respective proximal bone. Displacement of the distal bone relative to the proximal bone was quantified in 3D under both weightbearing and non-weightbearing conditions. Results: In the talonavicular joint, the HV group showed significantly greater eversion (p = 0.011) than the control group, and greater dorsiflexion (p = 0.027) and eversion (p < 0.01) than the HR group. In the medial cuneiform joint, the HV group showed significantly greater eversion (p < 0.01) and abduction (p = 0.011) than the control group. In the first TMTl joint, the HV group showed significantly greater dorsiflexion (p = 0.014), inversion (p = 0.028), and adduction (p < 0.01) than the control group, and greater inversion (p < 0.01) and adduction (p < 0.01) than the HR group. The HR group showed significantly greater dorsiflexion (p = 0.026) than the control group. Conclusion: In the present study, hypermobility was observed at the first TMT in both HV and HR. However, the changes in HR were mainly in the sagittal plane, whereas those in HV were in all three planes. This difference may explain the different clinical feature ultimately observed in each condition. Future studies involving comparison of various severity levels and postoperative analysis should elucidate the pathophysiology and contribute to selection of appropriate treatment as well as the development of new treatments for HV and HR.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2473-0114Test

الوصول الحر: https://doaj.org/article/d181b4c7d646489090925df5d3530c4fTest

المؤلفون: Tadashi Oride, Kenjiro Sawada, Aasa Shimizu, Yasuto Kinose, Tsuyoshi Takiuchi, Michiko Kodama, Kae Hashimoto, Eiji Kobayashi, Eiji Nakatani, Tadashi Kimura

المصدر: Thrombosis Journal, Vol 21, Iss 1, Pp 1-11 (2023)

مصطلحات موضوعية: Cancer associated thrombosis, Edoxaban, DOAC, Gynecological cancer, Trough concentration, Diseases of the blood and blood-forming organs, RC633-647.5

الوصف: Abstract Background Gynecological cancer is one of the highest risk factors for cancer-associated thrombosis (CAT). Although low-molecular-weight heparin (LMWH) is recommended as an anticoagulant for treating CAT, recent studies have shown that direct oral anticoagulants (DOACs) are an acceptable alternative. Patients with cancer require a series of chemotherapies concomitantly with DOAC administration; however, the extent to which these drugs influence DOAC blood concentrations is unknown. In this study, we measured the plasma concentration of edoxaban during chemotherapy for gynecological cancers to determine its safety. Methods Patients histologically diagnosed with ovarian or uterine corpus cancer and CAT were recruited after primary surgery and before the initiation of postoperative adjuvant chemotherapy, including paclitaxel. Patients were administered edoxaban (30 or 60 mg) orally for CAT. The plasma concentrations of edoxaban and active factor Xa were determined and their percentage change before and after chemotherapy was calculated. Additionally, blood coagulation tests were analyzed. Results Sixteen patients with gynecological cancer (12 with ovarian cancer and 4 with uterine corpus cancer) were enrolled. Among these, 15 samples were collected one day after chemotherapy initiation. During chemotherapy, the trough concentration of edoxaban changed from 17.6 ± 10.6 to 20.0 ± 15.6 ng/ml, and the mean percentage change in edoxaban concentration was 14.5%. Therefore, the trough concentrations of edoxaban, which represent excretion capacity, were not significantly increased by chemotherapy with paclitaxel. The area under the plasma edoxaban concentration–time curve and the active factor Xa concentration were also unaffected. Conclusion Patients with CAT and ovarian or uterine corpus cancer administered edoxaban orally showed no significant increase in the trough concentration of edoxaban while undergoing chemotherapy. This suggests the safety of edoxaban use during the treatment of gynecological cancers. Trial registration EGCAT study; Japan Registry of Clinical Trials, jRCTs051190024.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1477-9560Test

الوصول الحر: https://doaj.org/article/ed32d9cc77024ec1b9f2a2efcc52fcddTest

المؤلفون: Sachiko Baba, Satoyo Ikehara, Ehab S. Eshak, Kimiko Ueda, Tadashi Kimura, Hiroyasu Iso

المصدر: Journal of Epidemiology, Vol 33, Iss 5, Pp 209-216 (2023)

مصطلحات موضوعية: cesarean section, postpartum depression, psychological distress, breastfeeding, prospective study, Medicine (General), R5-920

الوصف: Background: Postpartum depression (PPD) has been associated with adverse health outcomes, including maternal suicide. Mode of delivery has been suggested to be a risk factor for PPD, but no large cohort study has examined the association between mode of delivery and PPD. We aimed to examine the association between mode of delivery and risks of PPD at 1 and 6 months after childbirth. Methods: In a nationwide study of 89,954 mothers with a live singleton birth, we examined the association between mode of delivery and risks of PPD. PPD was evaluated using the Edinburgh Postnatal Depression Scale (≥13) at 1 and 6 months after childbirth. Odds ratios (ORs) with 95% confidence intervals (CIs) of PPD were calculated using multivariable logistic regression analyses after adjustment of antenatal physical, socioeconomic, and mental factors. Results: Among 89,954 women, 3.7% and 2.8% had PPD at 1 and 6 months after childbirth, respectively. Compared with unassisted vaginal delivery, cesarean section (CS) was marginally associated with PPD at 1 month but not at 6 months; adjusted ORs were 1.10 (95% CI, 1.00–1.21) and 1.01 (95% CI, 0.90–1.13), respectively. The association with PPD at 1 month was evident in women with antenatal psychological distress (adjusted OR 1.15; 95% CI, 1.03–1.28). The observed associations were attenuated after adjusting for infant feeding method. Conclusion: Women who had antenatal psychological distress and underwent CS delivery may be regarded as a target for monitoring PPD.

وصف الملف: electronic resource

العلاقة: https://www.jstage.jst.go.jp/article/jea/33/5/33_JE20210117/_pdfTest; https://doaj.org/toc/0917-5040Test; https://doaj.org/toc/1349-9092Test

الوصول الحر: https://doaj.org/article/9ee7842116894a9493e94ab484c99e48Test

المؤلفون: Aya Tanaka, Kanal Koum, Kyna Uy, Linka Koun, Lumpiny Kim, Maryan Chhit, Noriko Fujita, Rei Haruyama, Tadashi Kimura, Yutaka Osuga

المصدر: GHM Open. 2023, 3(1):42

المؤلفون: Aasa Shimizu, Kenjiro Sawada, Masaki Kobayashi, Yukako Oi, Tadashi Oride, Yasuto Kinose, Michiko Kodama, Kae Hashimoto, Tadashi Kimura

المصدر: Cancers, Vol 16, Iss 8, p 1482 (2024)

مصطلحات موضوعية: siRNAs, exosomes, ovarian cancer, omentum, fibroblasts, peritoneal dissemination, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: RNA interference is a powerful gene-silencing tool with potential clinical applications. However, its therapeutic use is challenging because suitable carriers are unavailable. Exosomes are stable small endogenous vesicles that can transport functional molecules to target cells, making them ideal small interfering RNA (siRNA) carriers. Herein, we elucidated the therapeutic potential of patient-derived exosomes as an siRNA carrier for ovarian cancer (OC) treatment. The exosomes were extracted from the culture medium of primary fibroblasts collected from the omentum of patients with OC during surgery. MET proto-oncogene, receptor tyrosine kinase (MET) was selected for gene silencing, c-Met siRNAs were synthesized and loaded into the exosomes (Met-siExosomes) via electroporation, and the treatment effect of the Met-siExosomes was assessed in vitro and in vivo. The Met-siExosomes downregulated the c-Met protein levels and inhibited OC cell proliferation, migration, and invasion. In xenograft experiments using SKOV3-13 and ES-2 cells, Met-siExosomes were selectively extracted from peritoneally disseminated tumors. Intraperitoneal treatment suppressed the c-Met downstream targets in cancer cells and prolonged mouse survival. The synthesized siRNAs were successfully and selectively delivered via the exosomes to intraperitoneally disseminated tumors. As patients with OC routinely undergo omentectomy and abundant fibroblasts can be easily collected from the omentum, patient-derived exosomes may represent a promising therapeutic siRNA carrier to treat OC.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2072-6694/16/8/1482Test; https://doaj.org/toc/2072-6694Test

الوصول الحر: https://doaj.org/article/e083098dd4694f01b790e470e16aa7c3Test

المؤلفون: Kanami Tanigawa, Satoyo Ikehara, Meishan Cui, Yoko Kawanishi, Tadashi Kimura, Kimiko Ueda, Kazumasa Yamagishi, Hiroyasu Iso

المصدر: Journal of Epidemiology, Vol 33, Iss 3, Pp 113-119 (2023)

مصطلحات موضوعية: interpregnancy interval, preterm birth, folate, folic acid, prospective studies, Medicine (General), R5-920

الوصف: Background: Both short and long interpregnancy intervals (IPIs) have been associated with risk of preterm birth, but the evidence is limited in Asians. It is also uncertain whether the association is modified by dietary folate intake or folic acid supplementation during pregnancy. Thus, we examined associations between IPI and risk of preterm birth and effect modification of those associations by dietary intake of folate and supplementation with folic acid on the basis of a nationwide birth cohort study. Methods: Among 103,062 pregnancies registered in the Japan Environment and Children’s Study, 55,203 singleton live-birth pregnancies were included in the analysis. We calculated IPI using birth date, gestational age at birth of offspring, and birth data of the latest offspring. Odds ratios (ORs) and 95% confidence intervals (CIs) of the risk of preterm birth were estimated according to IPI categories. Results: Both

وصف الملف: electronic resource

العلاقة: https://www.jstage.jst.go.jp/article/jea/33/3/33_JE20210031/_pdfTest; https://doaj.org/toc/0917-5040Test; https://doaj.org/toc/1349-9092Test

الوصول الحر: https://doaj.org/article/425b9bc69987415282385fefc8dc6706Test