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1دورية أكاديمية
المؤلفون: Hofmann, Felix Martin, Rambeau, Claire M. C., Gegg, Lukas, Schulz, Melanie, Steiner, Martin, Fülling, Alexander, Léanni, Laëtitia, Preusser, Frank, Aster Team, Study Group
المصدر: Geochronology. - 6 , 147-174, ISSN: 2628-3697
مصطلحات موضوعية: Beryllium-10, Radiokarbonmethode, Lumineszenzdatierung, Tephra, Tephrochronologie, Geomorphologie, Glazialgeologie, Glaziallandschaft, Moräne, Kar, Gletscher, Gletscherrückzug, Sedimentologie, Seesediment
الوصف: Beryllium-10 cosmic-ray exposure (CRE) dating has revolutionized our understanding of glacier fluctuations around the globe. A key prerequisite for the successful application of this dating method is the determination of regional production rates of in situ accumulated 10Be, usually inferred at independently dated calibration sites. Until now, no calibration site has been available for the mid-elevation mountain ranges of central Europe. We fill this gap by determining in situ 10Be concentrations in large boulders on moraines and by applying radiocarbon and infrared-stimulated luminescence (IRSL) dating to stratigraphically younger lake sediments in the southern Black Forest, SW Germany. The dating methods yielded concordant results, and, based on age–depth modelling with 14C ages, the age of a cryptotephra, and IRSL ages, we deduced a regional 10Be production rate in quartz. Calibrating the Black Forest production rate (BFPR) in the Cosmic-Ray Exposure program (CREp) resulted in a spallogenic sea-level and high-latitude (SLHL) production rate of 3.64±0.11 atoms 10Be g−1 quartz a−1 when referring to time-dependent Lal–Stone scaling, the European Reanalysis (ERA)-40 atmosphere model, and the atmospheric 10Be-based geomagnetic database in CREp. The BFPR turned out to be ∼11 % lower than both those at the nearest calibration site in the Alps (4.10±0.10 atoms 10Be g−1 quartz a−1 at SLHL) and the canonical global 10Be production rate (4.11±0.19 atoms 10Be g−1 quartz a−1 at SLHL) in CREp. A stronger weathering and snow cover bias and a higher impact of forest, soil, moss, and shrub cover at the study site likely explain this discrepancy.
وصف الملف: pdf
الإتاحة: https://doi.org/10.5194/gchron-6-147-2024Test
https://freidok.uni-freiburg.de/data/248906Test
https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2489062Test
https://freidok.uni-freiburg.de/dnb/download/248906Test -
2دورية أكاديمية
المؤلفون: Gianpaola Monti, Emanuele Rezoagli, Angelo Calini, Alice Nova, Silvia Marchesi, Giovanni Nattino, Greta Carrara, Sergio Morra, Francesca Cortellaro, Monica Savioli, Federico Capra Marzani, Moreno Tresoldi, Paolo Villa, Stefano Greco, Paolo Bonfanti, Maria Grazia Spitoni, Sergio Vesconi, Pietro Caironi, Roberto Fumagalli, “Lotta alla Sepsi” Team Study Group, M. Aceti, M. Alborghetti, E. Beck, W. Bonalume, M. Bornaghi, S. Bosisio, E. Brusa, V. Canegrati, R. Capra, A. Cecchin, S. Ciccone, M. De Lucia, G. Erhan, C. Fabbri, L. Ferrante, N. Ferrari, S. Franchini, G. Gallotta, P. Galotti, P. Gavazzi, D. Grassi, M. Lattuada, C. Lorini, L. Manin, G. Marchesi, F. Margarito, F. Martini, M. Meo, G. Minoja, M. Ortolan, M. Padovani, M. Pecorino, A. Quaini, S. Quarteroni, D. Radrizzani, M. Ranzini, T. Santambrogio, V. Savojardo, A. Sciascera, G. Serra, M. Tajè, F. Tengattin, T. Tira, B. Tonolli, R. Traficante, M. Tresoldi, E. Varisco, M. Zarienato, C. Zeroli
المصدر: Frontiers in Medicine, Vol 10 (2023)
مصطلحات موضوعية: quality improvement program, Sepsis, medical ward, emergency department, mortality, Medicine (General), R5-920
الوصف: ObjectiveSepsis and septic shock are major challenges and economic burdens to healthcare, impacting millions of people globally and representing significant causes of mortality. Recently, a large number of quality improvement programs focused on sepsis resuscitation bundles have been instituted worldwide. These educational initiatives have been shown to be associated with improvements in clinical outcomes. We aimed to evaluate the impact of a multi-faceted quality implementing program (QIP) on the compliance of a “simplified 1-h bundle” (Sepsis 6) and hospital mortality of severe sepsis and septic shock patients out of the intensive care unit (ICU).MethodsEmergency departments (EDs) and medical wards (MWs) of 12 academic and non-academic hospitals in the Lombardy region (Northern Italy) were involved in a multi-faceted QIP, which included educational and organizational interventions. Patients with a clinical diagnosis of severe sepsis or septic shock according to the Sepsis-2 criteria were enrolled in two different periods: from May 2011 to November 2011 (before-QIP cohort) and from August 2012 to June 2013 (after-QIP cohort).Measurements and main resultsThe effect of QIP on bundle compliance and hospital mortality was evaluated in a before–after analysis. We enrolled 467 patients in the before-QIP group and 656 in the after-QIP group. At the time of enrollment, septic shock was diagnosed in 50% of patients, similarly between the two periods. In the after-QIP group, we observed increased compliance to the “simplified rapid (1 h) intervention bundle” (the Sepsis 6 bundle – S6) at three time-points evaluated (1 h, 13.7 to 18.7%, p = 0.018, 3 h, 37.1 to 48.0%, p = 0.013, overall study period, 46.2 to 57.9%, p
وصف الملف: electronic resource
العلاقة: https://www.frontiersin.org/articles/10.3389/fmed.2023.1215341/fullTest; https://doaj.org/toc/2296-858XTest
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3تقرير
المؤلفون: Hofmann, Felix Martin, Rambeau, Claire M. C., Gegg, Lukas, Schulz, Melanie, Steiner, Martin, Fülling, Alexander, Léanni, Laëtitia, Preusser, Frank, Aster Team, Study Group
المصدر: Geochronology discussions. - (2024) , 27, ISSN: 2628-3735
مصطلحات موضوعية: Moräne, Kosmogenes Radionuklid, Seesediment, Gletscher, Radiokarbonmethode, Lumineszenzdatierung, Glazialgeologie, Sedimentologie, Glazialmorphologie, Beryllium-10
الوصف: Beryllium-10 cosmic-ray (CRE) exposure dating has revolutionised our understanding of glacier fluctuations around the globe. A key prerequisite for the successful application of this dating method is a thorough understanding of local production rates of in-situ accumulated 10Be, usually inferred from independently dated regional reference sites. For the mid-elevation (Variscan) mountain ranges of central Europe, no production rate reference site has been available so far. We fill this gap by determining in-situ 10Be concentrations in large boulders on moraines and by applying radiocarbon and luminescence dating to stratigraphically younger lake sediments in the southern Black Forest, SW Germany. The dating methods yielded concordant results and, based on age-depth modelling with 14C ages, we deduced a local 10Be production rate. The resulting Black Forest (BF) production rate is ~11 % lower than both those at the nearest reference site in the Alps and the canonical global 10Be production rate. A stronger weathering and snow cover bias and a higher impact of soil, moss and shrub cover at the stud site likely explain this discrepancy. Due to its internal robustness, we suggest applying the BF production rate in future CRE dating studies in Central Europe and for revising existing age estimates which will have crucial implications for understanding past atmospheric circulation patterns.
وصف الملف: pdf
الإتاحة: https://doi.org/10.5194/gchron-2023-27Test
https://freidok.uni-freiburg.de/data/245710Test
https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2457100Test
https://freidok.uni-freiburg.de/dnb/download/245710Test -
4دورية أكاديمية
المؤلفون: Troeman, Darren P. R., Hazard, Derek, Wolkewitz, Martin, Kluytmans, Jan A. J. W., Weber, Susanne, ASPIRE-SSI Study Team, Study group
المصدر: JAMA network open. - 6, 10 (2023) , e2339793, ISSN: 2574-3805
الوصف: Question What is the cumulative incidence of Staphylococcus aureus surgical site infections (SSIs) and bloodstream infections (BSIs) in Europe, and what factors are associated with an increased risk of SSIs and BSIs? Findings In a cohort study of 5004 surgical patients, the weighted cumulative incidence of S aureus SSIs and BSIs was 1.23%. Preoperative S aureus carriage, mastectomy or neurosurgery, higher body mass index, and having nonremovable implants in the body were independently associated with S aureus SSIs and BSIs. Meaning Staphylococcus aureus SSIs and BSIs are important postoperative complications, and future interventions aimed at prevention of these infections should focus on at-risk surgical patient groups to achieve a higher efficacy.
وصف الملف: pdf
الإتاحة: https://doi.org/10.1001/jamanetworkopen.2023.39793Test
https://freidok.uni-freiburg.de/data/241002Test
https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2410029Test
https://freidok.uni-freiburg.de/dnb/download/241002Test -
5دورية أكاديمية
المؤلفون: Anselmetti, Flavio S., Bavec, Miloš, Crouzet, Christian, Fiebig, Markus, Gabriel, Gerald, Preusser, Frank, Ravazzi, Cesare, DOVE scientific team, Study group
المصدر: ISSN: 1816-3459.
الوصف: The sedimentary infill of glacially overdeepened valleys (i.e., structures eroded below the fluvial base level) is an excellent but yet underexplored archive with regard to the age, extent, and nature of past glaciations. The ICDP project DOVE (Drilling Overdeepened Alpine Valleys) Phase 1 investigates a series of drill cores from glacially overdeepened troughs at several locations along the northern front of the Alps. All sites will be investigated with regard to several aspects of environmental dynamics during the Quaternary, with focus on the glaciation, vegetation, and landscape history. Geophysical methods (e.g., seismic surveys), for example, will explore the geometry of overdeepened structures to better understand the process of overdeepening. Sedimentological analyses combined with downhole logging, analysis of biological remains, and state-of-the-art geochronological methods, will enable us to reconstruct the erosion and sedimentation history of the overdeepened troughs. This approach is expected to yield significant novel data quantifying the extent and timing of Middle and Late Pleistocene glaciations of the Alps. In a first phase, two sites were drilled in late 2021 into filled overdeepenings below the paleolobe of the Rhine Glacier, and both recovered a trough filling composed of multiphase glacial sequences. Fully cored Hole 5068_1_C reached a depth of 165 m and recovered 10 m molasse bedrock at the base. This hole will be used together with two flush holes (5068_1_A, 5068_1_B) for further geophysical cross-well experiments. Site 5068_2 reached a depth of 255 m and bottomed out near the soft rock–bedrock contact. These two sites are complemented by three legacy drill sites that previously recovered filled overdeepenings below the more eastern Alpine Isar-Loisach, Salzach, and Traun paleoglacier lobes (5068_3, 5068_4, 5068_5). All analysis and interpretations of this DOVE Phase 1 will eventually lay the ground for an upcoming Phase 2 that will complete the pan-Alpine approach. This follow-up phase ...
وصف الملف: pdf
الإتاحة: https://doi.org/10.5194/sd-31-51-2022Test
https://freidok.uni-freiburg.de/data/240793Test
https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2407938Test
https://freidok.uni-freiburg.de/dnb/download/240793Test -
6مؤتمر
المؤلفون: Hofmann, Felix Martin, Schimmelpfennig, Irene, Preusser, Frank, Léanni, Laëtitia, Aster Team, Study group
الوصف: The Black Forest temporarily hosted a 1000 km2 large ice cap and its outlet glaciers during the Late Pleistocene. Multiple groups of moraines inside the last glaciation maximum extent document highly dynamic deglaciation. However, the chronology of periods of moraine formation remains largely unknown. To fill this gap, moraines in Sankt Wilhelmer Tal, a well-developed trough valley north-west of the Feldberg were mapped with a high-resolution digital terrain model (DTM) and raster files derived from the DTM. This was complemented with geomorphological field mapping. Moraines with suitable boulders were sampled for 10Be cosmic-ray exposure (CRE) to establish a regional glacier chronology. Previously published 10Be CRE ages from the mountain regions of Central Europe and their forelands were recalculated for suitable comparison. Equilibrium line altitudes (ELAs) during moraine formation were reconstructed to assess whether palaeo-ELAs can be used as a tool for relative dating of moraines. Geomorphological mapping reveals moraines of 18 ice-marginal positions in the main valley and moraines of multiple ice-marginal positions in two tributary valleys. The CRE ages suggest that the deglaciation of the study area occurred during the last termination and provide evidence for two distinct periods of moraine formation. ELA reconstructions show that the ELA varied considerably across the study area during the second phase of glacier fluctuations. Differing ELAs impede the use of palaeo-ELAs as a tool for relative dating of moraines. The CRE age-based glacier chronology significantly increases the knowledge of glacier variations in the mountain regions of Central Europe and provides important data for future palaeoclimatic reconstructions. As it could not be answered whether the outermost sampled moraine formed during the last glaciation maximum, 10Be CRE dating and other suitable dating methods should be applied to moraines in other parts of the southern Black Forest to determine the timing of this event.
وصف الملف: pdf
الإتاحة: https://doi.org/10.6094/UNIFR/224475Test
https://freidok.uni-freiburg.de/data/224475Test
https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2244751Test
https://freidok.uni-freiburg.de/dnb/download/224475Test -
7دورية أكاديمية
المصدر: Trials. - 22, 1 (2021) , 343, ISSN: 1745-6215
الوصف: PurposeTo evaluate the clinical outcomes of patients with a minimum 2-year follow-up following contemporary patel-lofemoral inlay arthroplasty (PFIA) and to identify potential risk factors for failure in a multi-center study.MethodsAll patients who underwent implantation of PFIA between 09/2009 and 11/2016 at 11 specialized orthopedic refer-ral centers were enrolled in the study and were evaluated retrospectively at a minimum 2-year follow-up. Clinical outcomes included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, the Knee Injury and Osteo-arthritis Outcome Score (KOOS), the Tegner Scale, the visual analogue scale (VAS) for pain, and subjective patient satisfac-tion. Pre- and perioperative risk factors were compared among failures and non-failures to determine potential risk factors.ResultsA total of 263 patients (85% follow-up rate) could be enrolled. The mean age at the time of index surgery was 49±12 years with a mean postoperative follow-up of 45±18 months. The overall failure rate was 11% (28 patients), of which 18% (5 patients) were patients with patella resurfacing at index surgery and 82% (23 patients) were patients without initial patella resurfacing. At final follow-up, 93% of the patients who did not fail were satisfied with the procedure with a mean transformed WOMAC Score of 84.5±14.5 points, a mean KOOS Score of 73.3±17.1 points, a mean Tegner Score of 3.4±1.4 points and a mean VAS pain of 2.4±2.0 points. An increased BMI was significantly correlated with a worse postoperative outcome. Concomitant procedures addressing patellofemoral instability or malalignment, the lack of patel-lofemoral resurfacing at the index surgery and a high BMI were significantly correlated with failure in our patient cohort.ConclusionPatellofemoral inlay arthroplasty shows high patient satisfaction with good functional outcomes at short-term follow-up and thus can be considered a viable treatment option in young patients suffering from isolated patellofemoral arthritis. Patellar ...
وصف الملف: pdf
الإتاحة: https://doi.org/10.1186/s13063-021-05181-0Test
https://freidok.uni-freiburg.de/data/218872Test
https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2188723Test
https://freidok.uni-freiburg.de/dnb/download/218872Test -
8دورية أكاديمية
المؤلفون: Giannakopoulou, Olga, Kuchenbaecker, Karoline, Domschke, Katharina, 23andMe Research Team, Study group, China Kadoorie Biobank Collaborative Group, Study group, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Study group
المصدر: JAMA psychiatry. - 78, 11 (2021) , 1258, ISSN: 2168-622X
الوصف: Importance: Most previous genome-wide association studies (GWAS) of depression have used data from individuals of European descent. This limits the understanding of the underlying biology of depression and raises questions about the transferability of findings between populations. Objective: To investigate the genetics of depression among individuals of East Asian and European descent living in different geographic locations, and with different outcome definitions for depression. Design, Setting, and Participants: Genome-wide association analyses followed by meta-analysis, which included data from 9 cohort and case-control data sets comprising individuals with depression and control individuals of East Asian descent. This study was conducted between January 2019 and May 2021. Exposures: Associations of genetic variants with depression risk were assessed using generalized linear mixed models and logistic regression. The results were combined across studies using fixed-effects meta-analyses. These were subsequently also meta-analyzed with the largest published GWAS for depression among individuals of European descent. Additional meta-analyses were carried out separately by outcome definition (clinical depression vs symptom-based depression) and region (East Asian countries vs Western countries) for East Asian ancestry cohorts. Main Outcomes and Measures: Depression status was defined based on health records and self-report questionnaires. Results: There were a total of 194 548 study participants (approximate mean age, 51.3 years; 62.8% women). Participants included 15 771 individuals with depression and 178 777 control individuals of East Asian descent. Five novel associations were identified, including 1 in the meta-analysis for broad depression among those of East Asian descent: rs4656484 (β = −0.018, SE = 0.003, P = 4.43x10−8) at 1q24.1. Another locus at 7p21.2 was associated in a meta-analysis restricted to geographically East Asian studies (β = 0.028, SE = 0.005, P = 6.48x10−9 for rs10240457). The lead ...
وصف الملف: pdf
الإتاحة: https://doi.org/10.1001/jamapsychiatry.2021.2099Test
https://freidok.uni-freiburg.de/data/224274Test
https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2242747Test
https://freidok.uni-freiburg.de/dnb/download/224274Test -
9دورية أكاديمية
المؤلفون: Nguyen, Van Thu, Rivière, Philippe, Ripoll, Pierre, Barnier, Julien, Vuillemot, Romain, Ferrand, Gabriel, Cohen-Boulakia, Sarah, Ravaud, Philippe, Boutron, Isabelle, Bollig, Claudia, Meerpohl, Jörg J., Schmucker, Christine, The COVID-NMA Consortium Team, Study Group
المصدر: Journal of clinical epidemiology. - 130 (2021) , 107-116, ISSN: 1878-5921
الوصف: Objectives Researchers worldwide are actively engaging in research activities to search for preventive and therapeutic interventions against coronavirus disease 2019 (COVID-19). Our aim was to describe the planning of randomized controlled trials (RCTs) in terms of timing related to the course of the COVID-19 epidemic and research question evaluated. Study Design and Setting We performed a living mapping of RCTs registered in the WHO International Clinical Trials Registry Platform. We systematically search the platform every week for all RCTs evaluating preventive interventions and treatments for COVID-19 and created a publicly available interactive mapping tool at https://covid-nma.comTest to visualize all trials registered. Results By August 12, 2020, 1,568 trials for COVID-19 were registered worldwide. Overall, the median ([Q1–Q3]; range) delay between the first case recorded in each country and the first RCT registered was 47 days ([33–67]; 15–163). For the 9 countries with the highest number of trials registered, most trials were registered after the peak of the epidemic (from 100% trials in Italy to 38% in the United States). Most trials evaluated treatments (1,333 trials; 85%); only 223 (14%) evaluated preventive strategies and 12 postacute period intervention. A total of 254 trials were planned to assess different regimens of hydroxychloroquine with an expected sample size of 110,883 patients. Conclusion This living mapping analysis showed that COVID-19 trials have relatively small sample size with certain redundancy in research questions. Most trials were registered when the first peak of the pandemic has passed.
وصف الملف: pdf
الإتاحة: https://doi.org/10.1016/j.jclinepi.2020.10.010Test
https://freidok.uni-freiburg.de/data/176069Test
https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-1760690Test
https://freidok.uni-freiburg.de/dnb/download/176069Test -
10سمعي
المؤلفون: Preusser, Frank, Anselmetti, Flavio S., Bavec, Miloš, Crouzet, Christian, Fiebig, Markus, Gabriel, Gerald, Ravazzi, Cesare, DOVE scientific team, Study group
الوصف: The sedimentary infill of glacially overdeepened valleys and basins is an excellent but yet poorly investigated archive with regard to reconstructing the age, extent, and nature of past glaciations. The already available geological information and infrastructure make the Alps an ideal area to study overdeepened structures. The International Continental Scientific Drilling Program (ICDP) project DOVE investigates a series of drill cores from formerly glacially overdeepened troughs at several locations around the Alps. All sites will be investigated with regard to environmental dynamics during the Quaternary, with focus on the glaciation, vegetation, and landscape history. Geophysical methods will explore the geometry of overdeepened structures to better understand the process of overdeepening. Sedimentological analyses combined with downhole logging, analysis of biological remains, and geochronological methods will enable us to reconstruct the erosion and sedimentation history of the overdeepened troughs. This approach will yield data quantifying the extent and timing of Middle and Late Pleistocene glaciations of the Alps. In a first phase, two sites have been drilled in late 2021 into filled overdeepenings below the past lobe of the Rhine Glacier in Switzerland and Germany, and both recovered a trough filling composed of multiphase glacial sequences. These two sites are complemented by three legacy drill sites that previously recovered filled overdeepenings below the eastern Alpine Isar-Loisach, Salzach and Traun palaeoglacier areas (Germany and Austria). All analysis and interpretations of this DOVE Phase-1 will eventually lay the ground for an upcoming DOVE Phase-2 that will complete the panalpine approach. This follow-up phase will investigate overdeepenings and their connected forelands and foredeeps in the formerly ice-covered areas from the western and southern Alpine margins through drilling sites in France, Italy, and Slovenia.
النص الكامل