المؤلفون: Zielonka TM, Demkow U, Zycinska K, Filewska M, Bialas B, Kus J, Radzikowska E, Remiszewski P, Szopinski J, Soszka A, Wardyn KA, Skopinska-Rozewska E

المصدر: European Journal of Medical Research, Vol 14, Iss Suppl 4, Pp 259-264 (2009)

مصطلحات موضوعية: angiogenesis, interstitial lung diseases, clinical symptoms, radiological changes, Medicine

الوصف: Abstract Objective Clinical symptoms and radiological changes are useful in monitoring patients with interstitial lung diseases (ILD). Neovascularization participates in the pathogenesis of idiopathic pulmonary fibrosis and other ILD. The objective of the study was to examine the relationships between angiogenic activity of sera from ILD patients and clinical or radiological status. Material and methods Serum samples were obtained from 83 patients with sarcoidosis, 31 with idiopathic pulmonary fibrosis (IPF), 29 with hypersensitivity pneumonitis (HP), 16 with collagen diseases with pulmonary manifestation (CD), 13 with scleroderma (SCL), 14 with Wegener's granulomatosis (WG), 12 with pulmonary Langerhans cell histiocytosis (HIS), 12 with pneumoconiosis (PNC), 10 with drug-induced lung disease (DLD), 5 with cryptogenic organizing pneumonia (COP), and from 36 healthy volunteers. As an angiogenic test we used a cutaneous angiogenesis assay according to Sidky and Auerbach. Clinical status was evaluated using a special questionnaire. In all patients chest radiographs were performed. Results The angiogenic properties of sera from ILD differed depending on the clinical diagnosis. The strongest proangiogenic effect was induced by sera from patients with HP (mean number of new vessels 16.8), CD (16.6), sarcoidosis (16.3), IPF (16.2), and PNC (15.7). In the case of DLD (13.2), the effect was comparable to healthy controls (13.5). In contrast, sera from SCL (mean number of the vessels 10.5) and HIS patients (10.8) significantly inhibited angiogenesis compared with controls. The angiogenic activity of sera from patients with hilar or mediastinal lymph nodes involvement was higher than that of sera from patients with lung fibrosis. There were also differences in the serum angiogenic activity in relation to the severity of dyspnea. Conclusions The data showed that sera from ILD patients constitute a source of mediators modulating angiogenesis, but the pattern of reaction is different in various diseases. Sera from HP, sarcoidosis, IPF, and CD patients demonstrated the strongest proangiogenic activity. However, sera from SCL and HIS inhibit angiogenesis. Angiogenic activity of examined sera was related to the clinical and radiological changes.

وصف الملف: electronic resource

العلاقة: http://www.eurjmedres.com/content/14/S4/259Test; https://doaj.org/toc/2047-783XTest

الوصول الحر: https://doaj.org/article/d760525d8b3848e1a4c599db0c0a01c5Test

المؤلفون: Klarkowska, A., Jakubczyk, M., Szopiński, J., Baranowski, P., Michalska, M., Jakubczyk, P.

المصدر: Clinical Nutrition ESPEN ; volume 54, page 544 ; ISSN 2405-4577

مصطلحات موضوعية: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism

الإتاحة: https://doi.org/10.1016Test/j.clnesp.2022.09.256
https://api.elsevier.com/content/article/PII:S2405457722007562?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2405457722007562?httpAccept=text/plainTest

المؤلفون: Szopinski, J Z, Pantanowitz, D, Lochner, G P

المصدر: South African Medical Journal; Vol 94, No 7 (2004); 547 ; 2078-5135 ; 0256-9574

وصف الملف: application/pdf

العلاقة: http://samj.org.za/index.php/samj/article/view/2643/1874Test; http://samj.org.za/index.php/samj/article/view/2643Test

الإتاحة: https://doi.org/10.7196/SAMJ.2643Test
http://samj.org.za/index.php/samj/article/view/2643Test

المؤلفون: Zielonka, TM, Demkow, U, Zycinska, K, Filewska, M, Bialas, B, Kus, J, Radzikowska, E, Remiszewski, P, Szopinski, J, Soszka, A, Wardyn, KA, Skopinska-Rozewska, E

مصطلحات موضوعية: angiogenesis, interstitial lung diseases, clinical symptoms, radiological changes

الوصف: Objective Clinical symptoms and radiological changes are useful in monitoring patients with interstitial lung diseases (ILD). Neovascularization participates in the pathogenesis of idiopathic pulmonary fibrosis and other ILD. The objective of the study was to examine the relationships between angiogenic activity of sera from ILD patients and clinical or radiological status. Material and methods Serum samples were obtained from 83 patients with sarcoidosis, 31 with idiopathic pulmonary fibrosis (IPF), 29 with hypersensitivity pneumonitis (HP), 16 with collagen diseases with pulmonary manifestation (CD), 13 with scleroderma (SCL), 14 with Wegener's granulomatosis (WG), 12 with pulmonary Langerhans cell histiocytosis (HIS), 12 with pneumoconiosis (PNC), 10 with drug-induced lung disease (DLD), 5 with cryptogenic organizing pneumonia (COP), and from 36 healthy volunteers. As an angiogenic test we used a cutaneous angiogenesis assay according to Sidky and Auerbach. Clinical status was evaluated using a special questionnaire. In all patients chest radiographs were performed. Results The angiogenic properties of sera from ILD differed depending on the clinical diagnosis. The strongest proangiogenic effect was induced by sera from patients with HP (mean number of new vessels 16.8), CD (16.6), sarcoidosis (16.3), IPF (16.2), and PNC (15.7). In the case of DLD (13.2), the effect was comparable to healthy controls (13.5). In contrast, sera from SCL (mean number of the vessels 10.5) and HIS patients (10.8) significantly inhibited angiogenesis compared with controls. The angiogenic activity of sera from patients with hilar or mediastinal lymph nodes involvement was higher than that of sera from patients with lung fibrosis. There were also differences in the serum angiogenic activity in relation to the severity of dyspnea. Conclusions The data showed that sera from ILD patients constitute a source of mediators modulating angiogenesis, but the pattern of reaction is different in various diseases. Sera from HP, ...

العلاقة: http://www.eurjmedres.com/content/14/S4/259Test

الإتاحة: http://www.eurjmedres.com/content/14/S4/259Test

المؤلفون: Szopinski, J, Pantanowitz, D, Jaros, G G

المصدر: South African Medical Journal; Vol 88, No 2 (1998); 146-149

الوصف: Objective. To estimate the diagnostic accuracy as well as the scope of utilisation of a new bio-electronic method of organ diagnostics.Design. Double-blind comparative study of the diagnostic results obtained by means of organ electrodermal diagnostics (OED) and clinical diagnoses, as a criterion standard.Setting. Department of Surgery, Helen Joseph Hospital, Johannesburg.Patients. 70 pre-selected inpatients of mean age 36 (SD =7) years with suspected pathology of one (or more) of the following organs: oesophagus, stomach, duodenum, biliary tract, pancreas, colon, kidneys and urinary tract. In total, 276 of the above mentioned internal organs were selected for statistical consideration. Main outcome measures. The difference between the so-called basic electrical impedance of the skin and the impedance value established for a particular organ projection area (the skin zone corresponding to a particular internal organ).Results. In total 250 true OED results were obtained from the 276 subjects considered: detection rate 90.6% (95% Cl 87.1 - 94.1 %). Established OED sensitivity was 91.8% (95% Cl 88.6 - 95.0%) and OED specificity equalled 89.9% (95% Cl 86.4 - 93.4%). The predictive value for positive OED results was 83.3% (95% Cl 78.9 - 87.7%) and for negative OED results 95.2% (95% Cl 92.0 - 98.4%). The OED results were affected neither by the type nor the aetiology of disease, i.e. OED estimates the actual extent of the pathological process within particular organs but does not explain the cause of pathology directly. No sideeffects of the OED examinations were observed.Conclusions. So-called organ projection areas do exist on the skin surface. The electrical impedance of the projection areas corresponding to diseased organs is increased, relative to that of healthy organ-related skin zones. The difference in impedance is proportional to the intensity of the pathological process. OED, which utilises these electrical phenomena of the skin, may detect diseased organs and estimate the extent of pathological process activity within these organs.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=78975075580c::1b7704c988285ed6e10b1c3e21831c74Test
https://www.ajol.info/index.php/samj/article/view/148873Test

المؤلفون: Jakubczyk, M., Szopinski, J., Kupczyk, K., Lis, K., Pater, A., Baranowski, P., Jakubczyk, P., Wawrzyniak, K., Kusza, K.

المصدر: Clinical Nutrition ; volume 35, page S139 ; ISSN 0261-5614

مصطلحات موضوعية: Critical Care and Intensive Care Medicine, Nutrition and Dietetics

الإتاحة: https://doi.org/10.1016/s0261-5614Test(16)30599-4
https://api.elsevier.com/content/article/PII:S0261561416305994?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0261561416305994?httpAccept=text/plainTest

المؤلفون: Szopinski, J, Lochner, G, Szopinska, H

المصدر: Southern African Journal of Anaesthesia and Analgesia; Vol 8, No 4 (2002); 12-18

الوصف: Objective: To investigate the usefulness of transcutaneous electrical nerve stimulation (TENS) and electroacupuncture in managing the pain associated with diabetic neuropathy.Research Design and Methods: A randomized, comparative, placebo controlled study was performed on a group of 100 patients diagnosed with diabetic neuropathy, at the 4th Department of Internal Medicine, Silesian Medical Academy, Katowice, Poland and the Pain Clinic, Mayo Medical Centre of South Africa, Johannesburg. The change in pain perceived was assessed after a course of analgesic electrotherapy using a visual analogue scale as well as changes in use of analgesics and walking ability.Results: The level of pain reported and use of analgesics dropped significantly after the electrotherapy course, compared to the control group. Walking ability improved significantly in patients reporting pain relief. There was no statistically significant difference between the results obtained in the Type 1 and Type 2 patients. Electrotherapy did not produce any side effects.Conclusions: Analgesic electrotherapy, which includes electroacupuncture and TENS, is an effective, affordable and convenient treatment of pain associated with diabetic neuropathy. If correctly applied, analgesic electrotherapy does not produce any side effects.

وصف الملف: application/pdf

العلاقة: http://www.ajol.info/index.php/sajaa/article/view/96046/85397Test; http://www.ajol.info/index.php/sajaa/article/view/96046Test

الإتاحة: http://www.ajol.info/index.php/sajaa/article/view/96046Test

المؤلفون: Madajka, Maria, Ozturk, C, Lukaszuk, M, Szopinski, J, Siemionow, V, Siemionow, M, Kwiecien, G

المصدر: Plastic and Reconstructive Surgery ; volume 131, page 160 ; ISSN 0032-1052

الإتاحة: https://doi.org/10.1097/01.prs.0000430160.05268.38Test

المؤلفون: Jakubczyk, M., Szopinski, J., Rzepka, A., Lis, K., Pater, A., Baranowski, P., Rozowicz, A., Kupczyk, K., Kusza, K.

المصدر: Clinical Nutrition ; volume 32, page S120 ; ISSN 0261-5614

مصطلحات موضوعية: Critical Care and Intensive Care Medicine, Nutrition and Dietetics

الإتاحة: https://doi.org/10.1016/s0261-5614Test(13)60302-7
https://api.elsevier.com/content/article/PII:S0261561413603027?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0261561413603027?httpAccept=text/plainTest

المؤلفون: Madajka, M., Oztürk, C., Siemionow, M., Szopinski, J., Siemionow, V., Lukaszuk, M.

المصدر: Transplantation Journal ; volume 94, issue 10S, page 1009 ; ISSN 0041-1337

الإتاحة: https://doi.org/10.1097/00007890-201211271-01993Test
https://journals.lww.com/00007890-201211271-01993Test