المؤلفون: Muller, S, Ackloo, S, Al Chawaf, A, Al-Lazikani, B, Antolin, A, Baell, JB, Beck, H, Beedie, S, Betz, UAK, Bezerra, GA, Brennan, PE, Brown, D, Brown, PJ, Bullock, AN, Carter, AJ, Chaikuad, A, Chaineau, M, Ciulli, A, Collins, I, Dreher, J, Drewry, D, Edfeldt, K, Edwards, AM, Egner, U, Frye, S, Fuchs, SM, Hall, MD, Hartung, I, Hillisch, A, Hitchcock, SH, Homan, E, Kannan, N, Kiefer, JR, Knapp, S, Kostic, M, Kubicek, S, Leach, AR, Lindemann, S, Marsden, BD, Matsui, H, Meier, JL, Merk, D, Michel, M, Morgan, MR, Mueller-Fahrnow, A, Owen, DR, Perry, BG, Rosenberg, SH, Saikatendu, KS, Schapira, M, Scholten, C, Sharma, S, Simeonov, A, Sundstrom, M, Superti-Furga, G, Todd, MH, Tredup, C, Vedadi, M, von Delft, F, Willson, TM, Winter, GE, Workman, P, Arrowsmith, CH

المصدر: RSC medicinal chemistry. 13(1):13-21

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:148250012Test

المؤلفون: Cikes, D, Elsayad, K, Sezgin, E, Koitai, E, Ferenc, T, Orthofer, M, Yarwood, R, Heinz, LX, Sedlyarov, V, Miranda, ND, Taylor, A, Grapentine, S, al-Murshedi, F, Abot, A, Weidinger, A, Kutchukian, C, Sanchez, C, Cronin, SJF, Novatchkova, M, Kavirayani, A, Schuetz, T, Haubner, B, Haas, L, Hagelkruys, A, Jackowski, S, Kozlov, A, Jacquemond, V, Knauf, C, Superti-Furga, G, Rullman, E, Gustafsson, T, McDermot, J, Lowe, M, Radak, Z, Chamberlain, JS, Bakovic, M, Banka, S, Penninger, JM

المصدر: Nature metabolism. 5(3):495-515

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:152951104Test

المؤلفون: Arrowsmith, CH, Audia, JE, Austin, C, Baell, J, Bennett, J, Blagg, J, Bountra, C, Brennan, PE, Brown, PJ, Bunnage, ME, Buser-Doepner, C, Campbell, RM, Carter, AJ, Cohen, P, Copeland, RA, Cravatt, B, Dahlin, JL, Dhanak, D, Edwards, AM, Frye, SV, Gray, N, Grimshaw, CE, Hepworth, D, Howe, T, Huber, KVM, Jin, J, Knapp, S, Kotz, JD, Kruger, RG, Lowe, D, Mader, MM, Marsden, B, Mueller-Fahrnow, A, Muller, S, O'Hagan, RC, Overington, JP, Owen, DR, Rosenberg, SH, Roth, B, Ross, R, Schapira, M, Schreiber, SL, Shoichet, B, Sundstrom, M, Superti-Furga, G, Taunton, J, Toledo-Sherman, L, Walpole, C, Walters, MA, Willson, TM, Workman, P, Young, RN, Zuercher, WJ

المصدر: Nature chemical biology. 11(8):536-541

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:131668584Test

المؤلفون: Unger, S, Gorna, MW, Le Bechec, A, Do Vale-Pereira, S, Bedeschi, MF, Geiberger, S, Grigelioniene, G, Horemuzova, E, Lalatta, F, Lausch, E, Magnan, C, Nampoothiri, S, Nishimura, G, Petrella, D, Rojas-Ringeling, F, Utsunomiya, A, Zabel, B, Pradervand, S, Harshman, K, Campos-Xavier, B, Bonafe, L, Superti-Furga, G, Stevenson, B, Superti-Furga, A

المصدر: American journal of human genetics. 92(6):990-995

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:126853150Test

المؤلفون: Negri, S, Superti-Furga, G, Tironi, E

المساهمون: Negri, S, Superti-Furga, G, Tironi, E

مصطلحات موضوعية: Power Quality, Smart Grid, Voltage Unbalance Mitigation, Distributed Generation

الوصف: In this paper a voltage unbalance mitigation technique for low-voltage microgrids or feeders in presence of large single-phase loads is introduced. In order to take maximum advantage of the existing hardware, the proposed solution consists of a sequence-based decentralized voltage control to be embedded in three-phase VSC connecting distributed generation to the considered system. Furthermore, a centralized controller is proposed to define optimal negative and zero sequence voltage reference. Control effectiveness is numerically verified considering a low-voltage feeder case study.

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/978-1-6654-1639-9; info:eu-repo/semantics/altIdentifier/wos/WOS:000844604500122; ispartofbook:Proceedings of International Conference on Harmonics and Quality of Power, ICHQP; 20th International Conference on Harmonics and Quality of Power, ICHQP 2022; firstpage:1; lastpage:6; numberofpages:6; https://hdl.handle.net/11311/1232759Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85133739495

الإتاحة: https://doi.org/10.1109/ICHQP53011.2022.9808832Test
https://hdl.handle.net/11311/1232759Test

المؤلفون: Davis, B, Backus, K, Winter, G, Chica, R, Li, D, Lee, SY, He, C, Weeks, A, Overall, C, Hagihara, S, Thuronyi, B, Kamat, S, Chen, LL, Guerrero, RH, Yao, S, Mahal, LK, Voigt, C, Woo, C, Strauss, E, Kikuchi, K, Dore, T, Radford, S, Li, XD, Heo, WD, Superti-Furga, G, Deans, T, Belousov, V, Matthews, M, Jackson, C, Malek, S, Waldmann, H, Rising, A, Jewett, M, Stamou, D, Parker, E, Murakami, M, Polizzi, K, Hamachi, I, Erb, T, Joo, C, Uesugi, M, Prinjha, R, Rechavi, G, Solano, R, Schulman, B, David, Y, Oslund, R

المصدر: Nature chemical biology. 17(1):1-4

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:145357793Test

المؤلفون: Kartnig, F., Bonelli, M., Goldmann, U., Mészáros, N., Krall, N., Aletaha, D., Heinz, L., Superti-Furga, G.

المصدر: Scientific Abstracts

الإتاحة: https://doi.org/10.1136/annrheumdis-2024-eular.5620Test

المؤلفون: Smit, P., Buehring-Uhle, C., Nather, C., Negraschus, A., Goldmann, U., Papadopoulou, Alkmini A., Riviere, J., Morath, V., Henkel, E., Bromberger, T., Goetze, K., Heinz, L., Fluhrer, Regina, Moser, M., Superti-Furga, G., Bassermann, F., Eichner, R.

العلاقة: https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/110913Test; https://doi.org/10.1159/000533576Test

الإتاحة: https://doi.org/10.1159/000533576Test
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/110913Test

المؤلفون: Sedlyarov, V., Scorzoni, S., Papakostas, K., Vollert, M., Konecka, J., Guertl, B., Klavins, K., Wiedmer, T., Superti-Furga, G.

المصدر: Life science alliance, vol. 5, no. 11, pp. e202201404

مصطلحات موضوعية: Amino Acid Transport Systems, Basic/genetics, Amino Acids/metabolism, Arginine, Aspartic Acid, Gain of Function Mutation, Glutamates, Glutamine, Humans, Large Neutral Amino Acid-Transporter 1, Lysine, Membrane Transport Proteins/metabolism, Nutrients

الوصف: Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. Because of substantial functional overlap, the interplay and relative contributions of SLCs in response to environmental stresses remain poorly elucidated. To infer functional relationships between SLCs and metabolites, we developed a strategy to identify SLCs able to sustain cell viability and proliferation under growth-limiting concentrations of essential nutrients. One-by-one depletion of 13 amino acids required for cell proliferation enabled gain-of-function genetic screens using a SLC-focused CRISPR/Cas9-based transcriptional activation approach to uncover transporters relieving cells from growth-limiting metabolic bottlenecks. Among the transporters identified, we characterized the cationic amino acid transporter SLC7A3 as a gene that, when up-regulated, overcame low availability of arginine and lysine by increasing their uptake, whereas SLC7A5 was able to sustain cellular fitness upon deprivation of several neutral amino acids. Moreover, we identified metabolic compensation mediated by the glutamate/aspartate transporters SLC1A2 and SLC1A3 under glutamine-limiting conditions. Overall, this gain-of-function approach using human cells uncovered functional transporter-nutrient relationships and revealed that transport activity up-regulation may be sufficient to overcome environmental metabolic restrictions.

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36114003; info:eu-repo/semantics/altIdentifier/eissn/2575-1077; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_ECC63CD3FA4B6; https://serval.unil.ch/notice/serval:BIB_ECC63CD3FA4BTest; urn:issn:2575-1077; https://serval.unil.ch/resource/serval:BIB_ECC63CD3FA4B.P002/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_ECC63CD3FA4B6Test

الإتاحة: https://doi.org/10.26508/lsa.202201404Test
https://serval.unil.ch/notice/serval:BIB_ECC63CD3FA4BTest
https://serval.unil.ch/resource/serval:BIB_ECC63CD3FA4B.P002/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_ECC63CD3FA4B6Test

المؤلفون: Bühring-Uhle, C., Smit, P., Negraschus, A., Morath, V., Goldmann, U., Papadopoulou, Alkmini A., Heider, M., Riviere, J., Götze, K., Heinz, L., Fluhrer, Regina, Moser, M., Superti-Furga, G., Bassermann, F., Eichner, R.

مصطلحات موضوعية: ddc:610

وصف الملف: application/pdf

العلاقة: https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/100475Test; urn:nbn:de:bvb:384-opus4-1004754; https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1004754Test; https://doi.org/10.1159/000526456Test; https://opus.bibliothek.uni-augsburg.de/opus4/files/100475/100475.pdfTest

الإتاحة: https://doi.org/10.1159/000526456Test
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/100475Test
https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1004754Test
https://opus.bibliothek.uni-augsburg.de/opus4/files/100475/100475.pdfTest