المؤلفون: Xianhua Han, Ping Wu, Ian Alberts, Hucheng Zhou, Huan Yu, Panagiotis Bargiotas, Igor Yakushev, Jian Wang, Guenter Höglinger, Stefan Förster, Claudio Bassetti, Wolfgang Oertel, Markus Schwaiger, Sung-Cheng Huang, Paul Cumming, Axel Rominger, Jiehui Jiang, Chuantao Zuo, Kuangyu Shi

المصدر: NeuroImage: Clinical, Vol 27, Iss , Pp 102294- (2020)

مصطلحات موضوعية: REM sleep behavior disorder, Parkinson’s disease, PET, FDG, Conversion, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

الوصف: Objective: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal stage of synucleinopathies such as Parkinson’s disease (PD). Positron emission tomography (PET) with 18F-FDG reveals metabolic perturbations, which are scored by spatial covariance analysis. However, the resultant pattern scores do not capture the spatially heterogeneous trajectories of metabolic changes between individual brain regions. Assuming metabolic progression occurs as a continuum from the healthy control (HC) condition to iRBD and then PD, we investigated spatial dynamics of progressively perturbed glucose metabolism in a cross-sectional study. Methods: 19 iRBD patients, 38 PD patients and 19 HC subjects underwent 18F-FDG PET. The images were spatially normalized, scaled to the global mean uptake, and automatically parcellated. We contrasted regional metabolism by group, and allocated the inferred progression to one of several possible trajectories. We further investigated the correlations between 18F-FDG uptake and the disease duration in the iRBD and PD groups, respectively. We also explored relationships between 18F-FDG uptake and the Unified Parkinson’s Disease Rating Scale motor (UPDRS III) scores in the PD group. Results: PD patients exhibited more extensive relative hyper- and hypo-metabolism than iRBD patients. We identified three dynamic metabolic trajectories, cross-sectional hypo- or hypermetabolism, cross-sectionally unchanged hypo- or hypermetabolism, cross-sectionally late hypo- or hypermetabolism, appearing only in the contrast of PD with iRBD. No correlation was found between relative 18F-FDG metabolism and disease duration in the iRBD group. Regional hyper- and hypo-metabolism in the PD patients correlated with disease duration or clinical UPDRS III scores. Conclusion: Cerebral metabolism changes heterogeneously in a continuum extending from HC to iRBD and PD groups in this preliminary study. The distinctive metabolic trajectories point towards a potential neuroimaging biomarker for conversion of iRBD to frank PD, which should be amenable to advanced pattern recognition analysis in future longitudinal studies.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2213158220301315Test; https://doaj.org/toc/2213-1582Test

الوصول الحر: https://doaj.org/article/cf45928cdb0d4da385f7c2688f49c13dTest

المؤلفون: Lirong Yan, Collin Y. Liu, Koon-Pong Wong, Sung-Cheng Huang, Wendy J. Mack, Kay Jann, Giovanni Coppola, John M. Ringman, Danny J.J. Wang

المصدر: NeuroImage: Clinical, Vol 17, Iss , Pp 751-760 (2018)

مصطلحات موضوعية: Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

الوصف: Autosomal dominant Alzheimer's disease (ADAD) is a small subset of Alzheimer's disease that is genetically determined with 100% penetrance. It provides a valuable window into studying the course of pathologic processes that leads to dementia. Arterial spin labeling (ASL) MRI is a potential AD imaging marker that non-invasively measures cerebral perfusion. In this study, we investigated the relationship of cerebral blood flow measured by pseudo-continuous ASL (pCASL) MRI with measures of cerebral metabolism (FDG PET) and amyloid deposition (Pittsburgh Compound B (PiB) PET). Thirty-one participants at risk for ADAD (age 39±13years, 19 females) were recruited into this study, and 21 of them received both MRI and FDG and PiB PET scans. Considerable variability was observed in regional correlations between ASL-CBF and FDG across subjects. Both regional hypo-perfusion and hypo-metabolism were associated with amyloid deposition. Cross-sectional analyses of each biomarker as a function of the estimated years to expected dementia diagnosis indicated an inverse relationship of both perfusion and glucose metabolism with amyloid deposition during AD development. These findings indicate that neurovascular dysfunction is associated with amyloid pathology, and also indicate that ASL CBF may serve as a sensitive early biomarker for AD. The direct comparison among the three biomarkers provides complementary information for understanding the pathophysiological process of AD. Keywords: Autosomal dominant Alzheimer's disease, Arterial spin labeling, MRI, FDG pet, PiB PET, Cerebral perfusion, Glucose metabolism, Amyloid deposition

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S221315821730308XTest; https://doaj.org/toc/2213-1582Test

الوصول الحر: https://doaj.org/article/c0eb4ce08f2b4289b342f5b0e28ea1a9Test

المؤلفون: Edmond Teng, Vladimir Kepe, Sally A. Frautschy, Jie Liu, Nagichettiar Satyamurthy, Fusheng Yang, Ping-Ping Chen, Graham B. Cole, Mychica R. Jones, Sung-Cheng Huang, Dorothy G. Flood, Stephen P. Trusko, Gary W. Small, Gregory M. Cole, Jorge R. Barrio

المصدر: Neurobiology of Disease, Vol 43, Iss 3, Pp 565-575 (2011)

مصطلحات موضوعية: [F-18]FDDNP, Positron emission tomography, Amyloid, Transgenic rat, Naproxen, Immunotherapy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: In vivo detection of Alzheimer's disease (AD) neuropathology in living patients using positron emission tomography (PET) in conjunction with high affinity molecular imaging probes for β-amyloid (Aβ) and tau has the potential to assist with early diagnosis, evaluation of disease progression, and assessment of therapeutic interventions. Animal models of AD are valuable for exploring the in vivo binding of these probes, particularly their selectivity for specific neuropathologies, but prior PET experiments in transgenic mice have yielded conflicting results. In this work, we utilized microPET imaging in a transgenic rat model of brain Aβ deposition to assess [F-18]FDDNP binding profiles in relation to age-associated accumulation of neuropathology. Cross-sectional and longitudinal imaging demonstrated that [F-18]FDDNP binding in the hippocampus and frontal cortex progressively increases from 9 to 18 months of age and parallels age-associated Aβ accumulation. Specificity of in vivo [F-18]FDDNP binding was assessed by naproxen pretreatment, which reversibly blocked [F-18]FDDNP binding to Aβ aggregrates. Both [F-18]FDDNP microPET imaging and neuropathological analyses revealed decreased Aβ burden after intracranial anti-Aβ antibody administration. The combination of this non-invasive imaging method and robust animal model of brain Aβ accumulation allows for future longitudinal in vivo assessments of potential therapeutics for AD that target Aβ production, aggregation, and/or clearance. These results corroborate previous analyses of [F-18]FDDNP PET imaging in clinical populations.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S0969996111001574Test; https://doaj.org/toc/1095-953XTest

الوصول الحر: https://doaj.org/article/eda7aa183a7f4f13948348dcbfe53217Test

المؤلفون: Hu Ye, Koon-Pong Wong, Mirwais Wardak, Magnus Dahlbom, Vladimir Kepe, Jorge R Barrio, Linda D Nelson, Gary W Small, Sung-Cheng Huang

المصدر: PLoS ONE, Vol 9, Iss 8, p e103745 (2014)

مصطلحات موضوعية: Medicine, Science

الوصف: Head movement during a dynamic brain PET/CT imaging results in mismatch between CT and dynamic PET images. It can cause artifacts in CT-based attenuation corrected PET images, thus affecting both the qualitative and quantitative aspects of the dynamic PET images and the derived parametric images. In this study, we developed an automated retrospective image-based movement correction (MC) procedure. The MC method first registered the CT image to each dynamic PET frames, then re-reconstructed the PET frames with CT-based attenuation correction, and finally re-aligned all the PET frames to the same position. We evaluated the MC method's performance on the Hoffman phantom and dynamic FDDNP and FDG PET/CT images of patients with neurodegenerative disease or with poor compliance. Dynamic FDDNP PET/CT images (65 min) were obtained from 12 patients and dynamic FDG PET/CT images (60 min) were obtained from 6 patients. Logan analysis with cerebellum as the reference region was used to generate regional distribution volume ratio (DVR) for FDDNP scan before and after MC. For FDG studies, the image derived input function was used to generate parametric image of FDG uptake constant (Ki) before and after MC. Phantom study showed high accuracy of registration between PET and CT and improved PET images after MC. In patient study, head movement was observed in all subjects, especially in late PET frames with an average displacement of 6.92 mm. The z-direction translation (average maximum = 5.32 mm) and x-axis rotation (average maximum = 5.19 degrees) occurred most frequently. Image artifacts were significantly diminished after MC. There were significant differences (P

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC4128781?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/e9e69304c94c4495a8f5995c3725ec9bTest

المؤلفون: Kenji Hirata, Kentaro Kobayashi, Koon-Pong Wong, Osamu Manabe, Andrew Surmak, Nagara Tamaki, Sung-Cheng Huang

المصدر: PLoS ONE, Vol 9, Iss 8, p e105682 (2014)

مصطلحات موضوعية: Medicine, Science

الوصف: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) has been an essential modality in oncology. We propose a semi-automated algorithm to objectively determine liver standardized uptake value (SUV), which is used as a threshold for tumor delineation.A large spherical volume of interest (VOI) was placed manually to roughly enclose the right lobe (RL) of the liver. For each voxel in this VOI, a coefficient of variation of voxel values (CVv) was calculated for neighboring voxels within a radius of d/2. The voxel with the minimum CVv was then selected, where a 30-mm spherical VOI was placed at that voxel in accordance with PERCIST criteria. Two nuclear medicine physicians independently defined 30-mm VOIs manually on 124 studies in 62 patients to generate the standard values, against which the results from the new method were compared.The semi-automated method was successful in determining the liver SUV that was consistent between the two physicians in all the studies (d = 80 mm). The liver SUV threshold (mean +3 SD within 30-mm VOI) determined by the new semi-automated method (3.12±0.61) was not statistically different from those determined by the manual method (Physician-1: 3.14±0.58, Physician-2: 3.15±0.58). The semi-automated method produced tumor volumes that were not statistically different from those by experts' manual operation. Furthermore, the volume change in the two sequential studies had no statistical difference between semi-automated and manual methods.Our semi-automated method could define the liver SUV robustly as the threshold value used for tumor volume measurements according to PERCIST. The method could avoid possible subjective bias of manual liver VOI placement and is thus expected to improve clinical performance of volume-based parameters for prediction of cancer treatment response.

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC4146536?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/1ea0399aba114424ad7fe060139a588aTest

المؤلفون: Moses Q. Wilks, Hillary Protas, Mirwais Wardak, Vladimir Kepe, Gary W. Small, Jorge R. Barrio, Sung-Cheng Huang

المصدر: International Journal of Alzheimer's Disease, Vol 2012 (2012)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Geriatrics, RC952-954.6

الوصف: We evaluate an automated approach to the cortical surface mapping (CSM) method of VOI analysis in PET. Although CSM has been previously shown to be successful, the process can be long and tedious. Here, we present an approach that removes these difficulties through the use of 3D image warping to a common space. We test this automated method using studies of FDDNP PET in Alzheimer's disease and mild cognitive impairment. For each subject, VOIs were created, through CSM, to extract regional PET data. After warping to the common space, a single set of CSM-generated VOIs was used to extract PET data from all subjects. The data extracted using a single set of VOIs outperformed the manual approach in classifying AD patients from MCIs and controls. This suggests that this automated method can remove variance in measurements of PET data and can facilitate accurate, high-throughput image analysis.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2090-8024Test; https://doaj.org/toc/2090-0252Test

الوصول الحر: https://doaj.org/article/7edec9c5cf944fba9e872d2e07c56e17Test

المؤلفون: Xinrui Huang, Yun Zhou, Shangliang Bao, Sung-Cheng Huang

المصدر: International Journal of Biomedical Imaging, Vol 2007 (2007)

مصطلحات موضوعية: Medical physics. Medical radiology. Nuclear medicine, R895-920, Medical technology, R855-855.5

الوصف: Parametric images generated from dynamic positron emission tomography (PET) studies are useful for presenting functional/biological information in the 3-dimensional space, but usually suffer from their high sensitivity to image noise. To improve the quality of these images, we proposed in this study a modified linear least square (LLS) fitting method named cLLS that incorporates a clustering-based spatial constraint for generation of parametric images from dynamic PET data of high noise levels. In this method, the combination of K-means and hierarchical cluster analysis was used to classify dynamic PET data. Compared with conventional LLS, cLLS can achieve high statistical reliability in the generated parametric images without incurring a high computational burden. The effectiveness of the method was demonstrated both with computer simulation and with a human brain dynamic FDG PET study. The cLLS method is expected to be useful for generation of parametric images from dynamic FDG PET study.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1687-4188Test; https://doaj.org/toc/1687-4196Test

الوصول الحر: https://doaj.org/article/b12f2e773bb84ba8b3e456ca8d55a92bTest

المؤلفون: Sung-Cheng Huang, 黃松成

مرشدي الرسالة: Chris Lee, Ying-Maw Twng, 李建德, 鄧穎懋

الوصف: 96
Kaohsiung Export Processing Zone was established for over forty years, it witnessed the prosperity of Taiwan. Under the export-oriented policy, it indeed provided lots of contribution on importing the newest industrial technology, attracting the investment of foreign tradesmen, providing mass opportunity to get a job. From the present, the industrial construction has passed the transition and transformation of the export-oriented industrialization period, the export ampliation climax period, the export labor denseness industry period, the Hsin Chu technology district period. From the 80th to now, it has passed another chance of transformation, it has all been becoming capital, technique, labor “Three density” industry. It has become the OEM center of those high value added industry such as high-tech semiconductor industry and LCD (liquid crystal monitor). The district co-defense rescue system is still be aim at excising jurisdiction over Kauhsiung district, in order to amplify the aggregative fire fighting power, take rapid and effective reaction rescue action on the key moment the emergency accident has first occurred. This research processes on multiple aspects from collecting related study reference, arranging the document of passed years, survey research, and interviewing professional person. This research is aim at the analysis of the present development of Kaohsiung Export Processing Zone, based on the trends of gathering high-tech industry, and on the government’s formulation on industry policy, intending to compare directly the change and effect of the whole Kaohsiung Export Processing Zone industrial environment. Secondary, based on the research and estimation of the real environment of Kaohsiung Export Processing Zone, this research proposes practical disaster defense and rescue operation system structure, having analysis through interviewing experts and having surveys, proposing practical draft on environmental development arrangement. This is to become a consultation of the development of Kaohsiung Export Processing Zone’s disaster defense and rescue policy.

وصف الملف: 130

الإتاحة: http://ndltd.ncl.edu.tw/handle/10453578848036451380Test

المؤلفون: Sung-Cheng Huang, Michael E. Phelps, Johannes Czernin, Nagichettiar Satyamurthy, Wei Chen, Timothy Cloughesy, Magnus Dahlbom, Christiaan Schiepers, Mirwais Wardak

الوصف: MOV file - 330KB

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176ef72a26e178e93078197fd17fb792Test
https://doi.org/10.1158/1078-0432.22445016Test

المؤلفون: Sung-Cheng Huang, Michael E. Phelps, Johannes Czernin, Nagichettiar Satyamurthy, Wei Chen, Timothy Cloughesy, Magnus Dahlbom, Christiaan Schiepers, Mirwais Wardak

الوصف: Purpose: The primary objective of this study was to investigate whether changes in 3′-deoxy-3′-[18F]fluorothymidine (18F-FLT) kinetic parameters, taken early after the start of therapy, could predict overall survival (OS) and progression-free survival (PFS) in patients with recurrent malignant glioma undergoing treatment with bevacizumab and irinotecan.Experimental Design: High-grade recurrent brain tumors were investigated in 18 patients (8 male and 10 female), ages 26 to 76 years. Each had 3 dynamic positron emission tomography (PET) studies as follows: at baseline and after 2 and 6 weeks from the start of treatment, 18F-FLT (2.0 MBq/kg) was injected intravenously, and dynamic PET images were acquired for 1 hour. Factor analysis generated factor images from which blood and tumor uptake curves were derived. A three-compartment, two-tissue model was applied to estimate tumor 18F-FLT kinetic rate constants using a metabolite- and partial volume–corrected input function. Different combinations of predictor variables were exhaustively searched in a discriminant function to accurately classify patients into their known OS and PFS groups. A leave-one-out cross-validation technique was used to assess the generalizability of the model predictions.Results: In this study population, changes in single parameters such as standardized uptake value or influx rate constant did not accurately classify patients into their respective OS groups (18F-FLT kinetic parameters could perfectly separate these two groups of patients (hit ratio = 100%) and were also able to correctly classify patients into their respective PFS groups (Conclusions: Discriminant analysis using changes in 18F-FLT kinetic parameters early during treatment seems to be a powerful method for evaluating the efficacy of therapeutic regimens. Clin Cancer Res; 17(20); 6553–62. ©2011 AACR.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad61e623522de3f2f69c84fbf8125314Test
https://doi.org/10.1158/1078-0432.c.6520359.v1Test