المؤلفون: Athavale A, Gooch K, Walker D, Suh M, Scaife J, Haber A, Hadker N, Dmochowski R

المصدر: Patient Preference and Adherence, Vol Volume 12, Pp 2139-2152 (2018)

مصطلحات موضوعية: Overactive bladder, Discrete choice experiment, Treatment preferences, Medicine (General), R5-920

الوصف: Amod Athavale,1 Katherine Gooch,2 David Walker,2 Marissa Suh,1 Jillian Scaife,1 Ali Haber,1 Nandini Hadker,1 Roger Dmochowski3 1Trinity Partners LLC, Waltham, MA, USA; 2Astellas Pharma Global Development, Inc., Northbrook, IL, USA; 3Urologic Surgery, Vanderbilt University, Nashville, TN, USA Purpose: Many pharmacotherapeutic treatment options are available for the symptoms of overactive bladder (OAB), each offering varying efficacy, safety, and tolerability profiles that must be carefully considered when selecting treatment. The objective of the present study was to characterize pharmacotherapy treatment preferences of individuals with symptoms of OAB and to examine how preferences differ by both patient characteristics and disease burden metrics.Patients and methods: Patient preferences for OAB treatment attributes were examined using a discrete choice experiment (DCE). Attributes were identified through literature review, clinical relevance, and input from patients. Eligible respondents were required to be ≥18 years of age, have a self-reported physician OAB diagnosis or have self-reported symptoms of OAB, and be naïve to pharmacotherapy or invasive OAB treatments. A hierarchical Bayesian random-effects-only model was used to estimate the mean relative preference weights and mean relative importance scores of treatment attributes. Multivariable linear regression models with backward selection were used to analyze the differences in relative importance scores by demographic characteristics and disease burden-related metrics.Results: In total, 514 individuals participated in the study. Most respondents were

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/a-patient-reported-non-interventional-cross-sectional-discrete-choice--peer-reviewed-article-PPATest; https://doaj.org/toc/1177-889XTest

الوصول الحر: https://doaj.org/article/d01fc059bf214a91bd6cc3ab4d7b9aa5Test

المؤلفون: Park B, Cho HM, Lee EH, Song S, Suh M, Choi KS, Kang BJ, Ko K, Yi A, Jung HK, Cha JH, Jun JK

المصدر: Clinical Epidemiology, Vol Volume 10, Pp 61-70 (2017)

مصطلحات موضوعية: Breast density, Breast Imaging Reporting and Data System, Breast cancer, nationwide mammography screening program, Infectious and parasitic diseases, RC109-216

الوصف: Boyoung Park,1,2 Hye Mi Cho,2 Eun Hye Lee,3 Seunghoon Song,2 Mina Suh,2 Kui Son Choi,1,2 Bong Joo Kang,4 Kyungran Ko,5 Ann Yi,6 Hae Kyoung Jung,7 Joo Hee Cha,8 Jae Kwan Jun,1,2 1National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea; 2National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea; 3Department of Radiology, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea; 4Department of Radiology, Seoul St Mary’s Hospital, Catholic University of Korea College of Medicine, Seoul, Republic of Korea; 5Center for Breast Cancer, National Cancer Center Hospital, National Cancer Center, Goyang, Republic of Korea; 6Department of Radiology, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea; 7Department of Radiology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea; 8Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea Purpose: The purpose of this study was to investigate the effects of breast density on breast cancer risk among women screened via a nationwide mammographic screening program. Patients and methods: We conducted a nested case–control study for a randomly selected population of 1,561 breast cancer patients and 6,002 matched controls from the National Cancer Screening Program. Breast density was measured and recorded by two independent radiologists using the Breast Imaging Reporting and Data System (BI-RADS). Associations between BI-RADS density and breast cancer risk were evaluated according to screening results, time elapsed since receiving non-recall results, age, and menopausal status after adjusting for possible covariates. Results: Breast cancer risk for women with extremely dense breasts was five times higher (adjusted odds ratio [aOR] =5.0; 95% confidence interval [CI]) =3.7–6.7) than that for women with an almost entirely fatty breast, although the risk differed between recalled women (aOR =3.3, 95% CI =2.3–3.6) and women with non-recalled results (aOR =12.1, 95% CI =6.3–23.3, P-heterogeneity =0.001). aORs for BI-RADS categories of breast density were similar when subjects who developed cancer after showing non-recall findings during initial screening were grouped according to time until cancer diagnosis thereafter (

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/does-breast-density-measured-through-population-based-screening-indepe-peer-reviewed-article-CLEPTest; https://doaj.org/toc/1179-1349Test

الوصول الحر: https://doaj.org/article/196acc4988cf4da9a97390c3be3f1a5cTest

المؤلفون: Newman, Z. L., Maurice, V., Drake, T. E., Stone, J. R., Briles, T. C., Spencer, D. T., Fredrick, C., Li, Q., Westly, D., Ilic, B. R., Shen, B., Suh, M. -G., Yang, K. Y., Johnson, C., Johnson, D. M. S., Hollberg, L., Vahala, K., Srinivasan, K., Diddams, S. A., Kitching, J., Papp, S. B., Hummon, M. T

مصطلحات موضوعية: Physics - Optics, Physics - Atomic Physics

الوصف: Laboratory optical atomic clocks achieve remarkable accuracy (now counted to 18 digits or more), opening possibilities to explore fundamental physics and enable new measurements. However, their size and use of bulk components prevent them from being more widely adopted in applications that require precision timing. By leveraging silicon-chip photonics for integration and to reduce component size and complexity, we demonstrate a compact optical-clock architecture. Here a semiconductor laser is stabilized to an optical transition in a microfabricated rubidium vapor cell, and a pair of interlocked Kerr-microresonator frequency combs provide fully coherent optical division of the clock laser to generate an electronic 22 GHz clock signal with a fractional frequency instability of one part in 10^13. These results demonstrate key concepts of how to use silicon-chip devices in future portable and ultraprecise optical clocks.
Comment: 11 pages, 4 figures

الوصول الحر: http://arxiv.org/abs/1811.00616Test

المؤلفون: Couzens, CA, Kim, H, Kim, N, Lee, Y, Suh, M

الوصف: We construct a consistent truncation of six-dimensional matter coupled F(4) gauged supergravity on a cornucopia of two-dimensional surfaces including a spindle, disc, domain wall and other novel backgrounds to four-dimensional minimal gauged supergravity. Using our consistent truncation we uplift known AdS2 × Σ1 solutions giving rise to four-dimensional orbifold solutions, AdS2 × Σ1 ⋉ Σ2. We further uplift our solutions to massive type IIA supergravity by constructing the full uplift formulae for six-dimensional U(1)2-gauged supergravity including all fields and arbitrary Romans mass and gauge coupling. The solutions we construct are naturally interpreted as the near-horizon geometries of asymptotically AdS6 black holes with a four-dimensional orbifold horizon. Alternatively, one may view them as the holographic duals of superconformal quantum mechanical theories constructed by compactifying five-dimensional USp(2N) theory living on a stack of D4-D8 branes on the four-dimensional orbifolds. As a first step to identifying these quantum mechanical theories we compute the Bekenstein-Hawking entropy holographically.

العلاقة: https://ora.ox.ac.uk/objects/uuid:2f0e662a-0594-40f2-90cf-117c07917c66Test; https://doi.org/10.1007/JHEP02Test(2023)025

الإتاحة: https://doi.org/10.1007/JHEP02Test(2023)025
https://ora.ox.ac.uk/objects/uuid:2f0e662a-0594-40f2-90cf-117c07917c66Test

المؤلفون: Lee, D, Min, S-K, Ahn, J-B, Cha, D-H, Shin, S-W, Chang, E-C, Suh, M-S, Byun, Y-H, Kim, J-U

الوصف: This study examines the spatiotemporal characteristics of the summer monsoon rainy season over East Asia using six regional climate models (RCMs) participating in the Coordinated Regional Domain Experiment (CORDEX) East Asia Phase II project. The framework combining multiple global climate models (GCMs) with multiple RCMs produces a larger spread in summer monsoon characteristics than driving GCMs only, enabling a better quantification of uncertainty factors. On average, the RCM simulations reproduce the observed summer monsoon duration and area better than the corresponding boundary GCMs, implying the added values of downscaling. Both the area and duration of the East Asian summer monsoon are projected to increase by the late 21st century, more strongly in high emission scenarios than in low emission scenarios, particularly in China. Different responses between scenarios, which indicate warming mitigation benefits, only become significant in the late 21st century due to large intersimulation uncertainties. Analysis of variance results show that uncertainty in future monsoon area and duration is larger between boundary GCMs than between RCMs over East Asia and its coastal subregions. A strong intersimulation relationship between RCMs and GCMs supports that boundary GCMs substantially diversify downscaled RCM projections through different climate sensitivities. Furthermore, the distinct subregional responses in future monsoon area and duration emphasize the importance of fine-resolution projections with appropriate uncertainty measures for better preparing region-specific adaptation plans.

العلاقة: https://ora.ox.ac.uk/objects/uuid:2427ee56-83bc-4a36-824f-9efbccd5666aTest; https://doi.org/10.1088/1748-9326/acd208Test

الإتاحة: https://doi.org/10.1088/1748-9326/acd208Test
https://ora.ox.ac.uk/objects/uuid:2427ee56-83bc-4a36-824f-9efbccd5666aTest

المؤلفون: Park, J., Baek, S., Suh, M., Choi, J., Kim, S., Lim, Y.

المصدر: Hearing Research

الوصف: Selective auditory attention has been shown to modulate the cortical representation of speech. This effect has been well documented in acoustically more challenging environments. However, the influence of top-down factors, in particular topic familiarity, on this process remains unclear, despite evidence that semantic information can promote speech-in-noise perception. Apart from individual features forming a static listening condition, dynamic and irregular changes of auditory scenes—volatile listening environments—have been less studied. To address these gaps, we explored the influence of topic familiarity and volatile listening on the selective auditory attention process during dichotic listening using electroencephalography. When stories with unfamiliar topics were presented, participants’ comprehension was severely degraded. However, their cortical activity selectively tracked the speech of the target story well. This implies that topic familiarity hardly influences the speech tracking neural index, possibly when the bottom-up information is sufficient. However, when the listening environment was volatile and the listeners had to re-engage in new speech whenever auditory scenes altered, the neural correlates of the attended speech were degraded. In particular, the cortical response to the attended speech and the spatial asymmetry of the response to the left and right attention were significantly attenuated around 100–200 ms after the speech onset. These findings suggest that volatile listening environments could adversely affect the modulation effect of selective attention, possibly by hampering proper attention due to increased perceptual load.

وصف الملف: application/pdf

العلاقة: http://hdl.handle.net/21.11116/0000-000D-5824-8Test; http://hdl.handle.net/21.11116/0000-000D-5826-6Test

الإتاحة: https://doi.org/10.1016/j.heares.2023.108770Test
http://hdl.handle.net/21.11116/0000-000D-5824-8Test
http://hdl.handle.net/21.11116/0000-000D-5826-6Test

المؤلفون: Kim, E., Kang, H., Noh, T.-S., Oh, S.-H., Suh, M.-W.

المصدر: Neurología ; volume 38, issue 7, page 475-485 ; ISSN 0213-4853

مصطلحات موضوعية: Neurology (clinical)

الإتاحة: https://doi.org/10.1016/j.nrl.2021.01.007Test
https://api.elsevier.com/content/article/PII:S0213485321000232?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0213485321000232?httpAccept=text/plainTest

المؤلفون: Hamilton, I, Suh, M, Bailey, J, Bradley, DDC, Kim, J-S

المصدر: 24680 ; 24668

الوصف: Modification of the π-conjugated backbone structure of conjugated polyelectrolytes (CPEs) for use as electron injection layers (EILs) in polymer light emitting diodes (PLEDs) has previously brought conflicted results in the literature in terms of device efficiency and turn-on response time. Herein, we determine the energetics at the CPE and the light emitting polymer (LEP) interface as a key factor for PLED device performance. By varying the conjugated backbone structure of both the LEP and CPE, we control the nature of the CPE/LEP interface in terms of optical energy gap offset, interfacial energy level offset, and location of the electron–hole recombination zone. We use a wide gap CPE with a shallow LUMO (F8im-Br) and one with a smaller gap and deeper LUMO (F8imBT-Br), in combination with three different LEPs. We find that the formation of a type II heterojunction at the CPE/LEP interfaces causes interfacial luminance quenching, which is responsible for poor efficiency in PLED devices. The effect is exacerbated with increased energy level offset from ionic rearrangement and hole accumulation occurring near the CPE/LEP interface. However, a deep CPE LUMO is found to be beneficial for fast current and luminance turn-on times of devices. This work provides important CPE molecular design rules for EIL use, offering progress toward a universal PLED-compatible CPE that can simultaneously deliver high efficiency and fast response times. In particular, engineering the LUMO position to be deep enough for fast device turn-on while avoiding the creation of a large energy level offset at the CPE/LEP interface is shown to be highly desirable.

العلاقة: ACS Applied Materials and Interfaces; http://hdl.handle.net/10044/1/104175Test

الإتاحة: https://doi.org/10.1021/acsami.2c05640Test
http://hdl.handle.net/10044/1/104175Test

المؤلفون: Wang, H., Lai, Y.-H., Yuan, Z., Suh, M.-G., Vahala, K.

المصدر: 2020 Conference on Lasers and Electro-Optics (CLEO), San Jose, CA, 10-15 May 2020

الوصف: We show that enhanced responsivity of a laser gyroscope operating near an exceptional point is accompanied by laser linewidth broadening related to the Petermann factor. The broadening imposes a fundamental sensitivity limit. ; © 2020 The Author(s). This work was supported by DARPA (N66001-16-1-4046) and the Kavli Nanoscience Institute. ; Published - 09192538.pdf

العلاقة: https://ieeexplore.ieee.org/abstract/document/9192538Test; https://resolver.caltech.edu/CaltechAUTHORS:20191218-102042495Test; https://doi.org/10.1364/cleo_qels.2020.ftu3a.4Test; oai:authors.library.caltech.edu:762af-0hz10; eprintid:105580; resolverid:CaltechAUTHORS:20200928-102723779

الإتاحة: https://doi.org/10.1364/cleo_qels.2020.ftu3a.4Test

المؤلفون: Vahala, K., Lai, Y. H., Suh, M. G.

المصدر: CLEO: QELS_Fundamental Science 2019, San Jose, CA, 5-10 May 2019

الوصف: A chip-based gyroscope is demonstrated that uses counter-propagating Brillouin lasers to measure rotation as a Sagnac-induced frequency shift. Demonstration of rotation measurement below the Earth rotation rate is presented. Prospects for improved performance are discussed. ; © 2019 The Author(s). The authors gratefully acknowledge the Defense Advanced Research Projects Agency (DARPA) under the PRIGM:AIMS program (grant no. N66001-16-1-4046) and the Kavli Nanoscience Institute. ; Published - 08749909.pdf

العلاقة: https://doi.org/10.1364/cleo_qels.2019.ftu3b.1Test; oai:authors.library.caltech.edu:5qyqc-yyp03; eprintid:97077; resolverid:CaltechAUTHORS:20190712-075835713

الإتاحة: https://doi.org/10.1364/cleo_qels.2019.ftu3b.1Test