نتائج البحث - "Stanisław Góźdź"

81

Did Introducing a New Category of Thyroid Tumors (Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features) Decrease the Risk of Malignancy for the Diagnostic Categories in the Bethesda System for Reporting Thyroid Cytopathology?

المؤلفون: Iwona Pałyga, Artur Kowalik, Kornelia Niemyska, Aldona Kowalska, Agnieszka Walczyk, Agnieszka Suligowska, Janusz Kopczyński, Danuta Gąsior-Perczak, Ryszard Mężyk, Kinga Hińcza, Stanisław Góźdź

المصدر: Endocrine Pathology. 31:143-149

مصطلحات موضوعية: Adult, Male, Thyroid nodules, medicine.medical_specialty, Cytodiagnosis, Endocrinology, Diabetes and Metabolism, Biopsy, Fine-Needle, Bethesda system, 030209 endocrinology & metabolism, medicine.disease_cause, Pathology and Forensic Medicine, Papillary thyroid cancer, Thyroid carcinoma, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Adenocarcinoma, Follicular, medicine, Humans, Thyroid Neoplasms, Thyroid cancer, Thyroid neoplasm, Aged, Retrospective Studies, Suspicious for Malignancy, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, medicine.disease, Bethesda system for reporting thyroid cytopathology, Thyroid Cancer, Papillary, 030220 oncology & carcinogenesis, Female, Radiology, business

الوصف: In 2016, Nikiforov et al. (JAMA Oncol 2:1023-1029, 2016) proposed replacing the term "non-invasive encapsulated follicular variant of papillary thyroid carcinoma" (FVPTC) with the term "non-invasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP). In 2018, to avoid the misdiagnosis of papillary thyroid cancer as NIFTP, the authors proposed changes to the criteria for NIFTP classification. Some previous studies evaluated the impact of NIFTP on the risk of malignancy (ROM) in the fine-needle aspiration cytology (FNAC) diagnostic categories according to the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). However, little is known about the influence of an NIFTP diagnosis on ROM on the basis of the revised criteria. The aim of this study was to assess the influence of NIFTP on ROM using the revised diagnostic criteria. The present study included 998 thyroid nodules that were diagnosed and resected at the same medical center. All specimens with a diagnosis of cancer were reviewed to identify NIFTP according to the revised 2018 criteria. Additionally, molecular diagnostics were performed to detect the BRAF p.V600E mutation and TERT promoter mutations in all the NIFTP cases. The number of cases that met the revised criteria was determined, and the ROM was calculated in each of the FNAC diagnostic categories. Only five cases (2.3% of all papillary thyroid carcinoma diagnoses) were considered NIFTP, according to the 2018 criteria. With respect to the FNAC category, one case was a follicular neoplasm or suspicious for a follicular neoplasm (FN/SFN), three cases were suspicious for malignancy (SM), and one case was malignant (M). The ROM decreased in each of the Bethesda categories (0.7% in FN/SFN, 4.3% in SM, and 0.5% in M) when a diagnosis of NIFTP was taken into account. These reductions were not statistically significant. These data indicate that the NIFTP entity has very little impact on ROM for the diagnostic categories of the Bethesda system.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ee7354d340158685bbc0c1aca02da9Test
https://doi.org/10.1007/s12022-020-09619-0Test

82

The role of the rs1421085 polymorphism in the pathogenesis of obesity

المؤلفون: Marek Żak, Paweł Macek, Halina Król, Małgorzata Biskup, Stanisław Góźdź, Łukasz Madej, Artur Kowalik

المصدر: Studia Medyczne, Vol 36, Iss 2, Pp 110-115 (2020)

مصطلحات موضوعية: obesity, business.industry, body mass index, General Medicine, medicine.disease, Bioinformatics, Obesity, polymorphism, Pathogenesis, Polymorphism (materials science), medicine, Medicine, business, fto, Body mass index

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2565d4f0480176030a6811fc021f729cTest
https://doi.org/10.5114/ms.2020.96790Test

83

Analysis of mutations of PARP1, RNF213, PAX8, KMT2C, MTRR in malignant mesothelioma of testicular tunica vaginalis testis

المؤلفون: Andrzej Wincewicz, Sebastian Zięba, Mariusz Koda, Janusz Kopczyński, Stanislaw Sulkowski, Stanisław Góźdź, Wojciech Baran, Artur Kowalik

المصدر: Polish Journal of Pathology, Vol 71, Iss 1, Pp 69-74 (2020)

الوصف: Molecular next gene sequencing was used to evaluate mutations in 409 common mutated cancer-related genes in malignant mesothelioma of tunica vaginalis testis (MMTVT) of 81-year-old man. Multifocal papillary-solid areas contained necrosis among highly cellular fields with multiple mitoses. It was positive for WT1, CKAE1/AE3, calretinin, CK7 with negativity for CK5, PSA, TTF-1. Following mutations were revealed in PARP1 (NM_001618: c.2285TC p.V762A), RNF213 (NM_001256071: c.3121GA, p.A1041T), PAX8 (NM_013992: c.404AG, p.K135R), MTRR (NM_024010: c.147AG, p.I49M) and two sorts of mutations in structure of KMT2C gene (NM_170606: c.2447_2448insA (c.2447dupA), p.Y816fs and NM_170606: c.1042GA, p.D348N) for the first time in MMTVT.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e69534574ce2513faa7983b0cb293d7Test
https://doi.org/10.5114/pjp.2020.95418Test

84

Realizacja pakietu onkologicznego w Polsce a działalność publicznych instytutów i centrów onkologii

المؤلفون: Bartosz Maleszczuk, Stanisław Góźdź, Michał Chrobot, Adam Maciejczyk

المصدر: Polski Przegląd Nauk o Zdrowiu. 59:93-97

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cd4e03fd93ff3a6bb0395891b7ece4dbTest
https://doi.org/10.20883/ppnoz.2019.15Test

85

Assessment of Ceragenins in Prevention of Damage to Voice Prostheses Caused by Candida Biofilm Formation

المؤلفون: Bonita Durnaś, Adrian Godlewski, Tamara Daniluk, Adam Kretowski, Dominika M. Ziembicka, Mateusz Cieśluk, Robert Bucki, Piotr Deptuła, Stanisław Góźdź, Michal Ciborowski, Jakub Spałek, Urszula Wnorowska, Paul B. Savage, Krzysztof Fiedoruk, Sławomir Okła

المصدر: Pathogens
Volume 10
Issue 11
Pathogens, Vol 10, Iss 1371, p 1371 (2021)

الوصف: This study aimed to investigate the potential application of ceragenins (CSAs) as new candidacidal agents to prevent biofilm formation on voice prostheses (VPs). The deterioration of the silicone material of VPs is caused by biofilm growth on the device which leads to frequent replacement procedures and sometimes serious complications. A significant proportion of these failures is caused by Candida species. We found that CSAs have significant candidacidal activities in vitro (MIC
MFC
MBIC), and they effectively eradicate species of yeast responsible for VP failure. Additionally, in our in vitro experimental setting, when different Candida species were subjected to CSA-13 and CSA-131 during 25 passages, no tested Candida strain showed the significant development of resistance. Using liquid chromatography–mass spectrometry (LC-MS), we found that VP immersion in an ethanol solution containing CSA-131 results in silicon impregnation with CSA-131 molecules, and in vitro testing revealed that fungal biofilm formation on such VP surfaces was inhibited by embedded ceragenins. Future in vivo studies will validate the use of ceragenin-coated VP for improvement in the life quality and safety of patients after a total laryngectomy.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbcef1b09ad6bb067d08b60f2c5a019Test

86

New β-Lactam Antibiotics and Ceragenins - A Study to Assess Their Potential in Treatment of Infections Caused by Multidrug-Resistant Strains of

المؤلفون: Paulina Paprocka, Bonita Durnaś, Angelika Mańkowska, Karol Skłodowski, Grzegorz Król, Magdalena Zakrzewska, Michał Czarnowski, Patrycja Kot, Kamila Fortunka, Stanisław Góźdź, Paul B Savage, Robert Bucki

المصدر: Infection and Drug Resistance

مصطلحات موضوعية: Pharmacology, Infectious Diseases, ceragenin, Infection and Drug Resistance, Pseudomonas aeruginosa, antibiotic resistant bacteria, antibacterial agents, new antibiotics, Pharmacology (medical), Original Research

الوصف: Paulina Paprocka,1 Bonita Durnaś,1,2 Angelika Mańkowska,1 Karol Skłodowski,3 Grzegorz KrÃ³l,1 Magdalena Zakrzewska,3 Michał Czarnowski,3 Patrycja Kot,1 Kamila Fortunka,1 Stanisław GÃ³źdź,2 Paul B Savage,4 Robert Bucki1,3 1Department of Microbiology and Immunology, Institute of Medical Science, Collegium Medicum, Jan Kochanowski University in Kielce, Kielce, Poland; 2Holy Cross Oncology Center of Kielce, Kielce, Poland; 3Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Białystok, Białystok, Poland; 4Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USACorrespondence: Robert Bucki Tel +48-85-7485493Fax +48-85 748 54 16Email buckirobert@gmail.comBackground: The increasing number of infections caused by antibiotic resistant strains of Pseudomonas aeruginosa posed a very serious challenge for clinical practice. This standing is driving scientists to develop new antibiotics against these microorganisms.Methods: In this study, we measured the MIC/MBC values and estimated the ability of tested molecules to prevent bacterial biofilm formation to explore the effectiveness of Î²-lactam antibiotics ceftolozane/tazobactam, ceftazidime/avibactam, meropenem/vaborbactam, and ceragenins CSA-13, CSA-44, and CSA-131 against 150 clinical isolates of Pseudomonas aeruginosa that were divided into five groups, based on their antibiotic resistance profiles to beta-lactams. Selected strains of microorganisms from each group were also subjected to prolonged incubations (20 passages) with ceragenins to probe the development of resistance towards those molecules. Cytotoxicity of tested ceragenins was evaluated using human red blood cell (RBCs) hemolysis and microscopy observations of human lung epithelial A549 cells after ceragenin treatment. Poloxamer 407 (pluronic F-127) at concentrations ranging from 0.5% to 5% was tested as a potential drug delivery substrate to reduce ceragenin toxicity.Results: Collected data proved that ceragenins at low concentrations are highly active against clinical strains of Pseudomonas aeruginosa regardless of their resistance mechanisms to conventional antibiotics. Ceragenins also show low potential for resistance development, high antibiofilm activity, and controlled toxicity when used together with poloxamer 407.Conclusion: This data strongly supports the need for further study directed to develop this group of molecules as new antibiotics to fighting infections caused by antibiotic resistant strains of Pseudomonas aeruginosa.Keywords: ceragenin, antibacterial agents, Pseudomonas aeruginosa, antibiotic resistant bacteria, new antibiotics

وصف الملف: text/html

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f8ab1745ac6989c3e0c94f9e3792c7Test
https://pubmed.ncbi.nlm.nih.gov/34992394Test

87

Circulating Hsa-miR-431-5p as Potential Biomarker for Squamous Cell Vulvar Carcinoma and Its Premalignant Lesions

المؤلفون: Martyna Szczyrek, Joanna Boresowicz, Magdalena Kowalewska, Mateusz Bujko, Artur Kowalik, Angelika Długosz, Kamil Zalewski, Stanisław Góźdź, Krzysztof Goryca

المصدر: Diagnostics
Diagnostics, Vol 11, Iss 1706, p 1706 (2021)
Volume 11
Issue 9

الوصف: Vulvar squamous cell carcinoma (VSCC) develops from high-grade squamous intraepithelial lesions (HSIL) and differentiated vulvar intraepithelial neoplasia (dVIN). This study aimed to assess the diagnostic value of circulating hsa-miR-431-5p in vulvar precancers and VSCC. Expression levels of hsa-miR-431-5p were analyzed by quantitative RT-PCR in plasma samples of 29 patients with vulvar precancers (HSIL or dVIN), 107 with VSCC as well as 15 healthy blood donors. We used hsa-miR-93-5p and hsa-miR-425-5p as normalizers. The levels of miR-431-5p were increased in the blood of patients with VSCC compared to those with vulvar precancers. Statistically significant differences in the survival rates (time to progression) were revealed for VSCC patients categorized by miR-431-5p levels. Low levels of circulating miR-431-5p were found to be indicative of unfavorable survival rates. In summary, our data reveal the diagnostic potential of circulating miR-431-5p in patients with vulvar precancers and VSCC.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffdee19171c1d49e6898f7d36bb190bTest
http://europepmc.org/articles/PMC8465739Test

88

Toll-like Receptor 2 as a Marker Molecule of Advanced Ovarian Cancer

المؤلفون: Jolanta Smok-Kalwat, Dominika Bębnowska, Rafał Hrynkiewicz, Ewelina Grywalska, Jacek Roliński, Izabela Korona-Glowniak, Małgorzata Sobstyl, Paulina Niedźwiedzka-Rystwej, Marcin Pasiarski, Stanisław Góźdź, Wojciech Polkowski, Anna Sobstyl, Barbara Sosnowska-Pasiarska

المصدر: Biomolecules
Volume 11
Issue 8
Biomolecules, Vol 11, Iss 1205, p 1205 (2021)

الوصف: Ovarian cancer is a global problem that affects women of all ages. Due to the lack of effective screening tests and the usually asymptomatic course of the disease in the early stages, the diagnosis is too late, with the result that less than half of the patients diagnosed with ovarian cancer (OC) survive more than five years after their diagnosis. In this study, we examined the expression of TLR2 in the peripheral blood of 50 previously untreated patients with newly diagnosed OC at various stages of the disease using flow cytometry. The studies aimed at demonstrating the usefulness of TLR2 as a biomarker in the advanced stage of ovarian cancer. In this study, we showed that TLR2 expression levels were significantly higher in women with more advanced OC than in women in the control group. Our research sheds light on the prognostic potential of TLR2 in developing new diagnostic approaches and thus in increasing survival in patients with confirmed ovarian cancer.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f017f7e8f37def180a6a6d85e274063Test

89

Is Male Sex A Prognostic Factor in Papillary Thyroid Cancer?

المؤلفون: Agnieszka Walczyk, Danuta Gąsior-Perczak, Kinga Furga, Klaudia Gadawska-Juszczyk, Magdalena Chrapek, Aldona Kowalska, Jarosław Jaskulski, Artur Kuchareczko, Agnieszka Suligowska, Aleksandra Gajowiec, Estera Mikina, Anna Chromik, Alicja Skuza, Iwona Pałyga, Stanisław Góźdź, Monika Szymonek, Paweł Orłowski, Tomasz Trybek

المصدر: Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 10, Iss 2438, p 2438 (2021)
Volume 10
Issue 11

الوصف: Identifying risk factors is crucial for predicting papillary thyroid cancer (PTC) with severe course, which causes a clinical problem. The purpose of this study was to assess whether male sex can be such a predictive factor and to verify whether including it as a predictive factor of high initial risk of recurrence/persistence would help to enhance the value of the American Thyroid Association initial risk stratification system (ATA). We retrospectively analyzed 1547 PTC patients (1358 females and 189 males), treated from 1986 to 2018. The relationship between sex and clinicopathological features, response to therapy, and disease status was assessed. Men with PTC showed some adverse clinicopathological features more often than women, including angioinvasion, lymph node metastases, and tumor size >
40 mm. There were sex-related disparities with respect to response to initial therapy and final follow-up. Male sex is associated with some unfavorable clinicopathological features of PTC, which may affect response to initial therapy or final disease status. In our study, modification of the ATA system by including male sex as a risk factor does not enhance its value. Thus, further studies are needed to assess whether males require treatment modalities or oncological follow-up protocols that are different from those of females.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b04eeae63b2d5ca9cf279855265a5aTest
https://pubmed.ncbi.nlm.nih.gov/34072690Test

90

Immunological Prognostic Factors in Multiple Myeloma

المؤلفون: Barbara Sosnowska-Pasiarska, Paulina Niedźwiedzka-Rystwej, Ewelina Grywalska, Dominika Bębnowska, Marcin Pasiarski, Stanisław Góźdź, Rafał Hrynkiewicz, Jacek Roliński, Iwona Smarz-Widelska

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 3587, p 3587 (2021)

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, markers, Review, Catalysis, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, Interferon-gamma, 0302 clinical medicine, Risk groups, Immune system, immune cells, Internal medicine, medicine, Biomarkers, Tumor, Humans, Immunologic Factors, Physical and Theoretical Chemistry, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, Immune Factors, Multiple myeloma, business.industry, Optimal treatment, Organic Chemistry, prognostic factors, General Medicine, Plasma cell neoplasm, medicine.disease, Prognosis, cytokines, Computer Science Applications, multiple myeloma, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, 030220 oncology & carcinogenesis, Tumor Necrosis Factors, Intercellular Signaling Peptides and Proteins, Chemokines, business

الوصف: Multiple myeloma (MM) is a plasma cell neoplasm characterized by an abnormal proliferation of clonal, terminally differentiated B lymphocytes. Current approaches for the treatment of MM focus on developing new diagnostic techniques; however, the search for prognostic markers is also crucial. This enables the classification of patients into risk groups and, thus, the selection of the most optimal treatment method. Particular attention should be paid to the possible use of immune factors, as the immune system plays a key role in the formation and course of MM. In this review, we focus on characterizing the components of the immune system that are of prognostic value in MM patients, in order to facilitate the development of new diagnostic and therapeutic directions.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09d2eb9deefab953511586105244e4cTest
https://pubmed.ncbi.nlm.nih.gov/33808304Test

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