المؤلفون: Dmytriw, Adam A, Dibas, Mahmoud, Phan, Kevin, Efendizade, Aslan, Johanna, Ospel, Schirmer, Clemens, Settecase, Fabio, Heran, Manraj KS, Kühn, Anna Luisa, Puri, Ajit S, Menon, Bijoy K, Sivakumar, Sanjeev, Mowla, Askan, Vela-Duarte, Daniel, Linfante, Italo, Dabus, Guilherme C, Regenhardt, Robert W, D'Amato, Salvatore, Rosenthal, Joseph A, Zha, Alicia, Talukder, Nafee, Sheth, Sunil A, Hassan, Ameer E, Cooke, Daniel L, Leung, Lester Y, Malek, Adel M, Voetsch, Barbara, Sehgal, Siddharth, Wakhloo, Ajay K, Goyal, Mayank, Wu, Hannah, Cohen, Jake, Ghozy, Sherief, Turkel-Parella, David, Farooq, Zerwa, Vranic, Justin, Rabinov, James D, Stapleton, Christopher J, Minhas, Ramandeep, Velayudhan, Vinodkumar, Chaudhry, Zeshan Ahmed, Xavier, Andrew, Bullrich, Maria Bres, Pandey, Sachin, Sposato, Luciano A, Johnson, Stephen A, Gupta, Gaurav, Khandelwal, Priyank, Ali, Latisha, Liebeskind, David S, Farooqui, Mudassir, Ortega-Gutierrez, Santiago, Nahab, Fadi, Jillella, Dinesh V, Chen, Karen, Aziz-Sultan, Mohammad Ali, Abdalkader, Mohamad, Kaliaev, Artem, Nguyen, Thanh N, Haussen, Diogo C, Nogueira, Raul G, Haq, Israr Ul, Zaidat, Osama O, Sanborn, Emma, Leslie-Mazwi, Thabele M, Patel, Aman B, Siegler, James E, Tiwari, Ambooj

المصدر: Journal of Neurology Neurosurgery & Psychiatry. 93(4)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Stroke, Clinical Research, Neurosciences, Good Health and Well Being, Brain Ischemia, COVID-19, Humans, Ischemic Stroke, Middle Aged, Retrospective Studies, SARS-CoV-2, Thrombectomy, Treatment Outcome, stroke, interventional, North American Neurovascular COVID-19 (NAN-C) Consortium & Society of Vascular and Interventional Neurology (SVIN) Investigators, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences

الوصف: BackgroundTo analyse the clinical characteristics of COVID-19 with acute ischaemic stroke (AIS) and identify factors predicting functional outcome.MethodsMulticentre retrospective cohort study of COVID-19 patients with AIS who presented to 30 stroke centres in the USA and Canada between 14 March and 30 August 2020. The primary endpoint was poor functional outcome, defined as a modified Rankin Scale (mRS) of 5 or 6 at discharge. Secondary endpoints include favourable outcome (mRS ≤2) and mortality at discharge, ordinal mRS (shift analysis), symptomatic intracranial haemorrhage (sICH) and occurrence of in-hospital complications.ResultsA total of 216 COVID-19 patients with AIS were included. 68.1% (147/216) were older than 60 years, while 31.9% (69/216) were younger. Median [IQR] National Institutes of Health Stroke Scale (NIHSS) at presentation was 12.5 (15.8), and 44.2% (87/197) presented with large vessel occlusion (LVO). Approximately 51.3% (98/191) of the patients had poor outcomes with an observed mortality rate of 39.1% (81/207). Age >60 years (aOR: 5.11, 95% CI 2.08 to 12.56, p

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/99s7449nTest

المؤلفون: Kamel, Hooman, Farrant, Mary, Easton, J Donald, Sposato, Luciano A, Elm, Jordan J, Underwood, Ellen, Johnston, S Claiborne

المصدر: Journal of the American Heart Association. 10(6)

مصطلحات موضوعية: Stroke, Neurosciences, Brain Disorders, Clinical Research, Prevention, Heart Disease, Cardiovascular, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Aged, Atrial Fibrillation, Female, Follow-Up Studies, Humans, Ischemic Attack, Transient, Ischemic Stroke, Male, Middle Aged, Platelet Aggregation Inhibitors, Retrospective Studies, Risk Factors, Time Factors, arrhythmia, atrial fibrillation, atrial flutter, ischemic stroke, transient ischemic attack, Cardiorespiratory Medicine and Haematology

الوصف: Background Atrial fibrillation/flutter (AF) after transient ischemic attack (TIA) has not been well studied. We compared the likelihood of new AF diagnosis after ischemic stroke versus TIA. Methods and Results The POINT (Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke) trial enrolled adults within 12 hours of minor ischemic stroke or high-risk TIA. Our exposure was index event type (ischemic stroke versus TIA). The primary analysis used the original trial definition of TIA (resolution of symptoms/signs). In secondary analyses, TIA cases with infarction on neuroimaging were reclassified as strokes. Our primary outcome was a new AF diagnosis, ascertained from adverse event and treatment interruption/discontinuation reports. We calculated C-statistics for variables associated with newly diagnosed AF. We used Kaplan-Meier survival statistics and Cox models adjusted for demographics and vascular risk factors. Excluding 49 subjects with baseline AF, 2746 patients had index stroke and 2086 patients had index TIA. During the 90-day follow-up, 106 patients had newly diagnosed AF. Cumulative risks of AF were 2.7% (95% CI, 2.1%-3.4%) after stroke and 2.0% (95% CI, 1.5%-2.7%) after TIA (P=0.15). After reclassifying index events by neuroimaging, cumulative AF risk was higher after stroke (2.7%; 95% CI, 2.2%-3.4%) than TIA (1.8%; 95% CI, 1.3%-2.5%) (P=0.04). Index event type had negligible predictive utility (C-statistic, 0.54). Conclusions Among patients with cerebral ischemia, the distinction between TIA versus minor stroke did not stratify the risk of subsequent AF diagnosis, implying that patients with TIA should undergo similar heart-rhythm monitoring strategies as patients with ischemic stroke.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9932p77gTest

المؤلفون: Sposato, Luciano A, Field, Thalia S, Schnabel, Renate B, Wachter, Rolf, Andrade, Jason G, Hill, Michael D

المساهمون: Sposato, Luciano A, Field, Thalia S, Schnabel, Renate B, Wachter, Rolf, Andrade, Jason G, Hill, Michael D

العلاقة: https://resolver.sub.uni-goettingen.de/purl?gro-2/138642Test; S1474442223003265

الإتاحة: https://doi.org/10.1016/S1474-4422Test(23)00326-5
https://resolver.sub.uni-goettingen.de/purl?gro-2/138642Test

المؤلفون: Mead, Gillian E., Sposato, Luciano A., Sampaio Silva, Gisele, Yperzeele, Laetitia, Wu, Simiao, Kutlubaev, Mansur, Cheyne, Joshua, Wahab, Kolawole, Urrutia, Victor C., Sharma, Vijay K., Sylaja, P.N., Hill, Kelvin, Steiner, Thorsten, Liebeskind, David S., Rabinstein, Alejandro A.

المصدر: 1747-4930 ; International Journal of Stroke

مصطلحات موضوعية: Human medicine

الوصف: Background: There are multiple stroke guidelines globally. To synthesize these and summarize what existing stroke guidelines recommend about the management of people with stroke, the World Stroke Organization (WSO) Guideline committee, under the auspices of the WSO, reviewed available guidelines. Aims: To systematically review the literature to identify stroke guidelines (excluding primary stroke prevention and subarachnoid hemorrhage) since 1 January 2011, evaluate quality (The international Appraisal of Guidelines, Research and Evaluation (AGREE II)), tabulate strong recommendations, and judge applicability according to stroke care available (minimal, essential, advanced). Summary of review: Searches identified 15,400 titles; 911 texts were retrieved, 200 publications scrutinized by the three subgroups (acute, secondary prevention, rehabilitation), and recommendations extracted from most recent version of relevant guidelines. For acute treatment, there were more guidelines about ischemic stroke than intracerebral hemorrhage; recommendations addressed pre-hospital, emergency, and acute hospital care. Strong recommendations were made for reperfusion therapies for acute ischemic stroke. For secondary prevention, strong recommendations included establishing etiological diagnosis; management of hypertension, weight, diabetes, lipids, and lifestyle modification; and for ischemic stroke, management of atrial fibrillation, valvular heart disease, left ventricular and atrial thrombi, patent foramen ovale, atherosclerotic extracranial large vessel disease, intracranial atherosclerotic disease, and antithrombotics in non-cardioembolic stroke. For rehabilitation, there were strong recommendations for organized stroke unit care, multidisciplinary rehabilitation, task-specific training, fitness training, and specific interventions for post-stroke impairments. Most recommendations were from high-income countries, and most did not consider comorbidity, resource implications, and implementation. Patient and public ...

العلاقة: info:eu-repo/semantics/altIdentifier/isi/000941842300001

الإتاحة: https://doi.org/10.1177/17474930231156753Test
https://hdl.handle.net/10067/1946160151162165141Test
https://repository.uantwerpen.be/docstore/d:irua:16768Test

المؤلفون: Jensen, Märit, Al-Shahi Salman, Rustam, Ng, G. Andre, van der Worp, H. Bart, Loh, Peter, Campbell, Bruce C. V., Kalman, Jonathan M., Hill, Michael D., Sposato, Luciano A., Andrade, Jason G., Metzner, Andreas, Kirchhof, Paulus, Thomalla, Götz

المصدر: Neurological Research and Practice ; volume 5, issue 1 ; ISSN 2524-3489

مصطلحات موضوعية: Neurology (clinical), Neurology

الوصف: Background Patients with ischemic stroke and atrial fibrillation (AF) are at particularly high risk for recurrent stroke and cardiovascular events. Early rhythm control has been shown to be superior to usual care for the prevention of stroke and cardiovascular events for people with early AF. There are no data on the willingness to use rhythm control for patients with AF and acute ischemic stroke in clinical practice. Methods An online survey was carried out among stroke physicians to assess current practice and attitudes toward rhythm control in patients with AF and acute ischemic stroke between December 22nd 2021 and March 24th 2022. Results The survey was completed by 277 physicians including 237 from 15 known countries and 40 from unspecified countries. 79% (210/266) reported that they do not regularly apply treatment for rhythm control by ablation or antiarrhythmic drugs at all or only in small numbers (≤ 10%) of patients with AF and acute ischemic stroke. In those patients treated with rhythm-control therapy, antiarrhythmic drugs were used by the majority of respondents (89%), while only a minority reported using AF ablation (11%). 88% of respondents (221/250) stated that they would be willing to randomize patients with AF after acute ischemic stroke to either early rhythm control or usual care in a clinical trial. Conclusion Despite its potential benefit, few patients with AF and acute ischemic stroke appear to be treated with rhythm control, which may result from uncertainty regarding potential complications of antiarrhythmic therapy in patients with acute stroke. Together with recent data on the effectiveness of early rhythm control in patients with a history of stroke, these results call for a randomized clinical trial to assess the efficacy of early rhythm control in patients with acute ischemic stroke and AF.

الإتاحة: https://doi.org/10.1186/s42466-023-00255-7Test

المؤلفون: Mead, Gillian E, Sposato, Luciano A, Sampaio Silva, Gisele, Yperzeele, Laetitia, Wu, Simiao, Kutlubaev, Mansur, Cheyne, Joshua, Wahab, Kolawole, Urrutia, Victor C, Sharma, Vijay K, Sylaja, PN, Hill, Kelvin, Steiner, Thorsten, Liebeskind, David S, Rabinstein, Alejandro A

المصدر: International Journal of Stroke ; volume 18, issue 5, page 499-531 ; ISSN 1747-4930 1747-4949

الوصف: Background: There are multiple stroke guidelines globally. To synthesize these and summarize what existing stroke guidelines recommend about the management of people with stroke, the World Stroke Organization (WSO) Guideline committee, under the auspices of the WSO, reviewed available guidelines. Aims: To systematically review the literature to identify stroke guidelines (excluding primary stroke prevention and subarachnoid hemorrhage) since 1 January 2011, evaluate quality (The international Appraisal of Guidelines, Research and Evaluation (AGREE II)), tabulate strong recommendations, and judge applicability according to stroke care available (minimal, essential, advanced). Summary of review: Searches identified 15,400 titles; 911 texts were retrieved, 200 publications scrutinized by the three subgroups (acute, secondary prevention, rehabilitation), and recommendations extracted from most recent version of relevant guidelines. For acute treatment, there were more guidelines about ischemic stroke than intracerebral hemorrhage; recommendations addressed pre-hospital, emergency, and acute hospital care. Strong recommendations were made for reperfusion therapies for acute ischemic stroke. For secondary prevention, strong recommendations included establishing etiological diagnosis; management of hypertension, weight, diabetes, lipids, and lifestyle modification; and for ischemic stroke, management of atrial fibrillation, valvular heart disease, left ventricular and atrial thrombi, patent foramen ovale, atherosclerotic extracranial large vessel disease, intracranial atherosclerotic disease, and antithrombotics in non-cardioembolic stroke. For rehabilitation, there were strong recommendations for organized stroke unit care, multidisciplinary rehabilitation, task-specific training, fitness training, and specific interventions for post-stroke impairments. Most recommendations were from high-income countries, and most did not consider comorbidity, resource implications, and implementation. Patient and public involvement ...

الإتاحة: https://doi.org/10.1177/17474930231156753Test

المؤلفون: Sparrow, Robert T., Sposato, Luciano A., Alkhouli, Mohamad A., García, Santiago, Elgendy, Islam Y., Kuchtaruk, Adrian A., Jneid, Hani, Alraies, M. Chadi, Tzemos, Nikolaos, Mamas, Mamas A., Bagur, Rodrigo

المصدر: CJC Open ; volume 5, issue 12, page 950-964 ; ISSN 2589-790X

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.cjco.2023.09.009Test
https://api.elsevier.com/content/article/PII:S2589790X23002536?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2589790X23002536?httpAccept=text/plainTest

المؤلفون: Feigin, Valery L., Nichols, Emma, Alam, Tahiya, Bannick, Marlena S., Beghi, Ettore, Blake, Natacha, Culpepper, William J., Dorsey, E. Ray, Elbaz, Alexis, Ellenbogen, Richard G., Fisher, James L., Fitzmaurice, Christina, Giussani, Giorgia, Glennie, Linda, James, Spencer L., Johnson, Catherine Owens, Kassebaum, Nicholas J., Logroscino, Giancarlo, Marin, Benoit, Mountjoy-Venning, W. Cliff, Nguyen, Minh, Ofori-Asenso, Richard, Patel, Anoop P., Piccininni, Marco, Roth, Gregory A., Steiner, Timothy J., Stovner, Lars Jacob, Szoeke, Cassandra E. I., Theadom, Alice, Vollset, Stein Emil, Wallin, Mitchell Taylor, Wright, Claire, Zunt, Joseph Raymond, Abbasi, Nooshin, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahpour, Ibrahim, Aboyans, Victor, Abraha, Haftom Niguse, Acharya, Dilaram, Adamu, Abdu A., Adebayo, Oladimeji M., Adeoye, Abiodun Moshood, Adsuar, Jose C., Afarideh, Mohsen, Agrawal, Sutapa, Ahmadi, Alireza, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Akinyemi, Rufus Olusola, Akseer, Nadia, Al-Eyadhy, Ayman, Salman, Rustam Al-Shahi, Alahdab, Fares, Alene, Kefyalew Addis, Aljunid, Syed Mohamed, Altirkawi, Khalid, Alvis-Guzman, Nelson, Anber, Nahla Hamed, Antonio, Carl Abelardo T., Arabloo, Jalal, Aremu, Olatunde, Arnlov, Johan, Asayesh, Hamid, Asghar, Rana Jawad, Atalay, Hagos Tasew, Awasthi, Ashish, Ayala Quintanilla, Beatriz Paulina, Ayuk, Tambe B., Badawi, Alaa, Banach, Maciej, Banoub, Joseph Adel Mattar, Barboza, Miguel A., Barker-Collo, Suzanne Lyn, Barnighausen, Till Winfried, Baune, Bernhard T., Bedi, Neeraj, Behzadifar, Masoud, Behzadifar, Meysam, Bejot, Yannick, Bekele, Bayu Begashaw, Belachew, Abate Bekele, Bennett, Derrick A., Bensenor, Isabela M., Berhane, Adugnaw, Beuran, Mircea, Bhattacharyya, Krittika, Bhutta, Zulfiqar A., Biadgo, Belete, Bijani, Ali, Bililign, Nigus, Bin Sayeed, Muhammad Shahdaat, Blazes, Christopher Kynrint, Brayne, Carol, Butt, Zahid A., Campos-Nonato, Ismael R., Cantu-Brito, Carlos, Car, Mate, Cardenas, Rosario, Carrero, Juan J., Carvalho, Felix, Castaneda-Orjuela, Carlos A., Castro, Franz, Catala-Lopez, Ferran, Cerin, Ester, Chaiah, Yazan, Chang, Jung-Chen, Chatziralli, Irini, Chiang, Peggy Pei-Chia, Christensen, Hanne, Christopher, Devasahayam J., Cooper, Cyrus, Cortesi, Paolo Angelo, Costa, Vera M., Criqui, Michael H., Crowe, Christopher Stephen, Damasceno, Albertino Antonio Moura, Daryani, Ahmad, De la Cruz-Gongora, Vanessa, Pio De la Hoz, Fernando, De Leo, Diego, Degefa, Meaza Girma, Demoz, Gebre Teklemariam, Deribe, Kebede, Dharmaratne, Samath Dhamminda, Diaz, Daniel, Dinberu, Mesfin Tadese, Djalalinia, Shirin, Doku, David Teye, Dubey, Manisha, Dubljanin, Eleonora, Duken, Eyasu Ejeta, Edvardsson, David, El-Khatib, Ziad, Endres, Matthias, Endries, Aman Yesuf, Eskandarieh, Sharareh, Esteghamati, Alireza, Esteghamati, Sadaf, Farhadi, Farzaneh, Faro, Andre, Farzadfar, Farshad, Farzaei, Mohammad Hosein, Fatima, Batool, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Feyissa, Garumma Tolu, Filip, Irina, Fischer, Florian, Fukumoto, Takeshi, Ganji, Morsaleh, Gankpe, Fortune Gbetoho, Garcia-Gordillo, Miguel A., Gebre, Abadi Kahsu, Gebremichael, Teklu Gebrehiwo, Gelaw, Belayneh K., Geleijnse, Johanna M., Geremew, Demeke, Gezae, Kebede Embaye, Ghasemi-Kasman, Maryam, Gidey, Mahari Y., Gill, Paramjit Singh, Gill, Tiffany K., Gnedovskaya, Elena V., Goulart, Alessandra C., Grada, Ayman, Grosso, Giuseppe, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Haagsma, Juanita A., Hagos, Tekleberhan B., Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hamadeh, Randah R., Hamidi, Samer, Hankey, Graeme J., Hao, Yuantao, Haro, Josep Maria, Hassankhani, Hadi, Hassen, Hamid Yimam, Havmoeller, Rasmus, Hay, Simon I., Hegazy, Mohamed I., Heidari, Behnam, Henok, Andualem, Heydarpour, Fatemeh, Hoang, Chi Linh, Hole, Michael K., Rad, Enayatollah Homaie, Hosseini, Seyed Mostafa, Hu, Guoqing, Igumbor, Ehimario U., Ilesanmi, Olayinka Stephen, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Jakovljevic, Mihajlo, Javanbakht, Mehdi, Jha, Ravi Prakash, Jobanputra, Yash B., Jonas, Jost B., Jozwiak, Jacek Jerzy, Jurisson, Mikk, Kahsay, Amaha, Kalani, Rizwan, Kalkonde, Yogeshwar, Kamil, Teshome Abegaz, Kanchan, Tanuj, Karami, Manoochehr, Karch, Andre, Karimi, Narges, Kasaeian, Amir, Kassa, Tesfaye Dessale, Kassa, Zemenu Yohannes, Kaul, Anil, Kefale, Adane Teshome, Keiyoro, Peter Njenga, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khalil, Ibrahim A., Khan, Ejaz Ahmad, Khang, Young-Ho, Khazaie, Habibolah, Kiadaliri, Aliasghar A., Kiirithio, Daniel N., Kim, Anthony S., Kim, Daniel, Kim, Young-Eun, Kim, Yun Jin, Kisa, Adnan, Kokubo, Yoshihiro, Koyanagi, Ai, Krishnamurthi, Rita V., Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kumar, Manasi, Lacey, Ben, Lafranconi, Alessandra, Lansingh, Van C., Latifi, Arman, Leshargie, Cheru Tesema, Li, Shanshan, Liao, Yu, Linn, Shai, Lo, Warren David, Lopez, Jaifred Christian F., Lorkowski, Stefan, Lotufo, Paulo A., Lucas, Robyn M., Lunevicius, Raimundas, Mackay, Mark T., Mahotra, Narayan Bahadur, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Manafi, Navid, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Marz, Winfried, Mashamba-Thompson, Tivani Phosa, Massenburg, Benjamin Ballard, Mate, Kedar K. V., McAlinden, Colm, McGrath, John J., Mehta, Varshil, Meier, Toni, Meles, Hagazi Gebre, Melese, Addisu, Memiah, Peter T. N., Memish, Ziad A., Mendoza, Walter, Mengistu, Desalegn Tadese, Mengistu, Getnet, Meretoja, Atte, Meretoja, Tuomo J., Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Miller, Ted R., Mini, G. K., Mirrakhimov, Erkin M., Moazen, Babak, Mohajer, Bahram, Mezerji, Naser Mohammad Gholi, Mohammadi, Moslem, Mohammadi-Khanaposhtani, Maryam, Mohammadibakhsh, Roghayeh, Mohammadnia-Afrouzi, Mousa, Mohammed, Shafiu, Mohebi, Farnam, Mokdad, Ali H., Monasta, Lorenzo, Mondello, Stefania, Moodley, Yoshan, Moosazadeh, Mahmood, Moradi, Ghobad, Moradi-Lakeh, Maziar, Moradinazar, Mehdi, Moraga, Paula, Velasquez, Ilais Moreno, Morrison, Shane Douglas, Mousavi, Seyyed Meysam, Muhammed, Oumer Sada, Muruet, Walter, Musa, Kamarul Imran, Mustafa, Ghulam, Naderi, Mehdi, Nagel, Gabriele, Naheed, Aliya, Naik, Gurudatta, Najafi, Farid, Nangia, Vinay, Negoi, Ionut, Negoi, Ruxandra Irina, Newton, Charles Richard James, Ngunjiri, Josephine W., Nguyen, Cuong Tat, Nguyen, Long Hoang, Ningrum, Dina Nur Anggraini, Nirayo, Yirga Legesse, Nixon, Molly R., Norrving, Bo, Noubiap, Jean Jacques, Shiadeh, Malihe Nourollahpour, Nyasulu, Peter S., Ogbo, Felix Akpojene, Oh, In-Hwan, Olagunju, Andrew T., Olagunju, Tinuke O., Olivares, Pedro R., Onwujekwe, Obinna E., Oren, Eyal, Owolabi, Mayowa Ojo, Mahesh, P. A., Pakpour, Amir H., Pan, Wen-Harn, Panda-Jonas, Songhomitra, Pandian, Jeyaraj Durai, Patel, Sangram Kishor, Pereira, David M., Petzold, Max, Pillay, Julian David, Piradov, Michael A., Polanczyk, Guilherme V., Polinder, Suzanne, Postma, Maarten J., Poulton, Richie, Poustchi, Hossein, Prakash, Swayam, Prakash, V., Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Muhammad Aziz, Rajati, Fatemeh, Ram, Usha, Ranta, Anna, Rawaf, David Laith, Rawaf, Salman, Reinig, Nickolas, Reis, Cesar, Renzaho, Andre M. N., Resnikoff, Serge, Rezaeian, Shahab, Rezai, Mohammad Sadegh, Gonzalez, Carlos Miguel Rios, Roberts, Nicholas L. S., Roever, Leonardo, Ronfani, Luca, Roro, Elias Merdassa, Roshandel, Gholamreza, Rostami, Ali, Sabbagh, Parisa, Sacco, Ralph L., Sachdev, Perminder S., Saddik, Basema, Safari, Hosein, Safari-Faramani, Roya, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Salamati, Payman, Zahabi, Saleh Salehi, Salimi, Yahya, Samy, Abdallah M., Sanabria, Juan, Santos, Itamar S., Milicevic, Milena M. Santric, Sarrafzadegan, Nizal, Sartorius, Benn, Sarvi, Shahabeddin, Sathian, Brijesh, Satpathy, Maheswar, Sawant, Arundhati R., Sawhney, Monika, Schneider, Ione J. C., Schottker, Ben, Schwebel, David C., Seedat, Soraya, Sepanlou, Sadaf G., Shabaninejad, Hosein, Shafieesabet, Azadeh, Shaikh, Masood Ali, Shakir, Raad A., Shams-Beyranvand, Mehran, Shamsizadeh, Morteza, Sharif, Mehdi, Sharif-Alhoseini, Mahdi, She, Jun, Sheikh, Aziz, Sheth, Kevin N., Shigematsu, Mika, Shiri, Rahman, Shirkoohi, Reza, Shiue, Ivy, Siabani, Soraya, Siddiqi, Tariq J., Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silberberg, Donald H., Silva, Joao Pedro, Silveira, Dayane Gabriele Alves, Singh, Jasvinder A., Sinha, Dhirendra Narain, Skiadaresi, Eirini, Smith, Mari, Sobaih, Badr Hasan, Sobhani, Soheila, Soofi, Moslem, Soyiri, Ireneous N., Sposato, Luciano A., Stein, Dan J., Stein, Murray B., Stokes, Mark A., Sufiyan, Mu'awiyyah Babale, Sykes, Bryan L., Sylaja, Pn, Tabares-Seisdedos, Rafael, Ao, Braden James Te, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Temsah, Omar, Thakur, Jarnail Singh, Thrift, Amanda G., Topor-Madry, Roman, Tortajada-Girbes, Miguel, Tovani-Palone, Marcos Roberto, Tran, Bach Xuan, Tran, Khanh Bao, Truelsen, Thomas Clement, Tsadik, Afewerki Gebremeskel, Car, Lorainne Tudor, Ukwaja, Kingsley Nnanna, Ullah, Irfan, Usman, Muhammad Shariq, Uthman, Olalekan A., Valdez, Pascual R., Vasankari, Tommi Juhani, Vasanthan, Rajagopalan, Veisani, Yousef, Venketasubramanian, Narayanaswamy, Violante, Francesco S., Vlassov, Vasily, Vosoughi, Kia, Vu, Giang Thu, Vujcic, Isidora S., Wagnew, Fasil Shiferaw, Waheed, Yasir, Wang, Yuan-Pang, Weiderpass, Elisabete, Weiss, Jordan, Whiteford, Harvey A., Wijeratne, Tissa, Winkler, Andrea Sylvia, Wiysonge, Charles Shey, Wolfe, Charles D. A., Xu, Gelin, Yadollahpour, Ali, Yamada, Tomohide, Yano, Yuichiro, Yaseri, Mehdi, Yatsuya, Hiroshi, Yimer, Ebrahim M., Yip, Paul, Yisma, Engida, Yonemoto, Naohiro, Yousefifard, Mahmoud, Yu, Chuanhua, Zaidi, Zoubida, Bin Zaman, Sojib, Zamani, Mohammad, Zandian, Hamed, Zare, Zohreh, Zhang, Yunquan, Zodpey, Sanjay, Naghavi, Mohsen, Murray, Christopher J. L., Vos, Theo

المصدر: Lancet Neurology. 18(5):459-480

الوصف: Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach.Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer's and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable).Interpretation: Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies.Funding: Bill & Melinda Gates Foundation.

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-166425Test
https://doi.org/10.1016/S1474-4422Test(18)30499-X
https://umu.diva-portal.org/smash/get/diva2:1379152/FULLTEXT01.pdfTest

المؤلفون: Fullman, Nancy, Yearwood, Jamal, Abay, Solomon M., Abbafati, Cristiana, Abd-Allah, Foad, Abdela, Jemal, Abdelalim, Ahmed, Abebe, Zegeye, Abebo, Teshome Abuka, Aboyans, Victor, Abraha, Haftom Niguse, Abreu, Daisy M. X., Abu-Raddad, Laith J., Adane, Akilew Awoke, Adedoyin, Rufus Adesoji, Adetokunboh, Olatunji, Adhikari, Tara Ballav, Afarideh, Mohsen, Afshin, Ashkan, Agarwal, Gina, Agius, Dominic, Agrawal, Anurag, Agrawal, Sutapa, Kiadaliri, Aliasghar Ahmad, Aichour, Miloud Taki Eddine, Akibu, Mohammed, Akinyemi, Rufus Olusola, Akinyemiju, Tomi F., Akseer, Nadia, Al Lami, Faris Hasan, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Tahiya, Alasfoor, Deena, Albittar, Mohammed I., Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Ali, Syed Danish, Alijanzadeh, Mehran, Aljunid, Syed M., Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Allen, Christine, Alomari, Mahmoud A., Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Amare, Azmeraw T., Amenu, Kebede, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andrei, Catalina Liliana, Androudi, Sofia, Antonio, Carl Abelardo T., Araujo, Valdelaine E. 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المصدر: The Lancet. 391(10136):2236-2271

الوصف: Background: A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Examining where gains have occurred or progress has faltered across and within countries is crucial to guiding decisions and strategies for future improvement. We used the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) to assess personal health-care access and quality with the Healthcare Access and Quality (HAQ) Index for 195 countries and territories, as well as subnational locations in seven countries, from 1990 to 2016.Methods: Drawing from established methods and updated estimates from GBD 2016, we used 32 causes from which death should not occur in the presence of effective care to approximate personal health-care access and quality by location and over time. To better isolate potential effects of personal health-care access and quality from underlying risk factor patterns, we risk-standardised cause-specific deaths due to non-cancers by location-year, replacing the local joint exposure of environmental and behavioural risks with the global level of exposure. Supported by the expansion of cancer registry data in GBD 2016, we used mortality-to-incidence ratios for cancers instead of risk-standardised death rates to provide a stronger signal of the effects of personal health care and access on cancer survival. We transformed each cause to a scale of 0–100, with 0 as the first percentile (worst) observed between 1990 and 2016, and 100 as the 99th percentile (best); we set these thresholds at the country level, and then applied them to subnational locations. We applied a principal components analysis to construct the HAQ Index using all scaled cause values, providing an overall score of 0–100 of personal health-care access and quality by location over time. We then compared HAQ Index levels and trends by quintiles on the Socio-demographic Index (SDI), a summary measure of overall development. As derived from the broader GBD study and other data sources, we examined relationships between national HAQ Index scores and potential correlates of performance, such as total health spending per capita.Findings: In 2016, HAQ Index performance spanned from a high of 97·1 (95% UI 95·8–98·1) in Iceland, followed by 96·6 (94·9–97·9) in Norway and 96·1 (94·5–97·3) in the Netherlands, to values as low as 18·6 (13·1–24·4) in the Central African Republic, 19·0 (14·3–23·7) in Somalia, and 23·4 (20·2–26·8) in Guinea-Bissau. The pace of progress achieved between 1990 and 2016 varied, with markedly faster improvements occurring between 2000 and 2016 for many countries in sub-Saharan Africa and southeast Asia, whereas several countries in Latin America and elsewhere saw progress stagnate after experiencing considerable advances in the HAQ Index between 1990 and 2000. Striking subnational disparities emerged in personal health-care access and quality, with China and India having particularly large gaps between locations with the highest and lowest scores in 2016. In China, performance ranged from 91·5 (89·1–93·6) in Beijing to 48·0 (43·4–53·2) in Tibet (a 43·5-point difference), while India saw a 30·8-point disparity, from 64·8 (59·6–68·8) in Goa to 34·0 (30·3–38·1) in Assam. Japan recorded the smallest range in subnational HAQ performance in 2016 (a 4·8-point difference), whereas differences between subnational locations with the highest and lowest HAQ Index values were more than two times as high for the USA and three times as high for England. State-level gaps in the HAQ Index in Mexico somewhat narrowed from 1990 to 2016 (from a 20·9-point to 17·0-point difference), whereas in Brazil, disparities slightly increased across states during this time (a 17·2-point to 20·4-point difference). Performance on the HAQ Index showed strong linkages to overall development, with high and high-middle SDI countries generally having higher scores and faster gains for non-communicable diseases. Nonetheless, countries across the development spectrum saw substantial gains in some key health service areas from 2000 to 2016, most notably vaccine-preventable diseases. Overall, national performance on the HAQ Index was positively associated with higher levels of total health spending per capita, as well as health systems inputs, but these relationships were quite heterogeneous, particularly among low-to-middle SDI countries.Interpretation: GBD 2016 provides a more detailed understanding of past success and current challenges in improving personal health-care access and quality worldwide. Despite substantial gains since 2000, many low-SDI and middle-SDI countries face considerable challenges unless heightened policy action and investments focus on advancing access to and quality of health care across key health services, especially non-communicable diseases. Stagnating or minimal improvements experienced by several low-middle to high-middle SDI countries could reflect the complexities of re-orienting both primary and secondary health-care services beyond the more limited foci of the Millennium Development Goals. Alongside initiatives to strengthen public health programmes, the pursuit of universal health coverage hinges upon improving both access and quality worldwide, and thus requires adopting a more comprehensive view—and subsequent provision—of quality health care for all populations.

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150176Test
https://doi.org/10.1016/S0140-6736Test(18)30994-2
https://umu.diva-portal.org/smash/get/diva2:1233527/FULLTEXT01.pdfTest

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المصدر: The Lancet. 392(10159):1923-1994

الوصف: Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk- outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017.

وصف الملف: electronic

الوصول الحر: https://research.chalmers.se/publication/509609Test
https://research.chalmers.se/publication/509609/file/509609_Fulltext.pdfTest