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1دورية أكاديمية
المؤلفون: Amare, AT, Thalamuthu, A, Schubert, KO, Fullerton, JM, Ahmed, M, Hartmann, S, Papiol, S, Heilbronner, U, Degenhardt, F, Tekola-Ayele, F, Hou, LP, Hsu, YH, Shekhtman, T, Adli, M, Akula, N, Akiyama, K, Ardau, R, Arias, B, Aubry, JM, Hasler, R, Richard-Lepouriel, H, Perroud, N, Backlund, L, Bhattacharjee, AK, Bellivier, F, Benabarre, A, Bengesser, S, Biernacka, JM, Birner, A, Marie-Claire, C, Cervantes, P, Chen, HC, Chillotti, C, Cichon, S, Cruceanu, C, Czerski, PM, Dalkner, N, Del Zompo, M, DePaulo, JR, Etain, B, Jamain, S, Falkai, P, Forstner, AJ, Frisen, L, Frye, MA, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Fallgatter, AJ, Stegmaier, S, Ethofer, T, Biere, S, Petrova, K, Schuster, C, Adorjan, K, Budde, M, Heilbronner, M, Kalman, JL, Kohshour, MO, Reich-Erkelenz, D, Schaupp, SK, Schulte, EC, Senner, F, Vogl, T, Anghelescu, IG, Arolt, V, Dannlowski, U, Dietrich, D, Figge, C, Jager, M, Lang, FB, Juckel, G, Konrad, C, Reimer, J, Schmauss, M, Schmitt, A, Spitzer, C, von Hagen, M, Wiltfang, J, Zimmermann, J, Andlauer, TFM, Fischer, A, Bermpohl, F, Ritter, P, Matura, S, Gryaznova, A, Falkenberg, I, Yildiz, C, Kircher, T, Schmidt, J, Koch, M, Gade, K, Trost, S, Haussleiter, IS, Lambert, M, Rohenkohl, AC, Kraft, V, Grof, P, Hashimoto, R, Hauser, J, Herms, S, Hoffmann, P, Jimenez, E, Kahn, JP, Kassem, L, Kuo, PH, Kato, T, Kelsoe, J, Kittel-Schneider, S, Ferensztajn-Rochowiak, E, Konig, B, Kusumi, I, Laje, G, Landen, M, Lavebratt, C, Leboyer, M, Leckband, SG, Tortorella, A, Manchia, M, Martinsson, L, McCarthy, MJ, McElroy, S, Colom, F, Millischer, V, Mitjans, M, Mondimore, FM, Monteleone, P, Nievergelt, CM, Nothen, MM, Novak, T, O'Donovan, C, Ozaki, N, Pfennig, A, Pisanu, C, Potash, JB, Reif, A, Reininghaus, E, Rouleau, GA, Rybakowski, JK, Schalling, M, Schofield, PR, Schweizer, BW, Severino, G, Shilling, PD, Shimoda, K, Simhandl, C, Slaney, CM, Squassina, A, Stamm, T, Stopkova, P, Maj, M, Turecki, G, Vieta, E, Veeh, J, Witt, SH, Wright, A, Zandi, PP, Mitchell, PB, Bauer, M, Alda, M, Rietschel, M, McMahon, FJ, Schulze, TG, Clark, SR, Baune, BT
المصدر: Molecular psychiatry. 28(12):5251-5261
مصطلحات موضوعية: Medicin och hälsovetenskap
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2دورية أكاديمية
المؤلفون: Amare, A, Thalamuthu, A, Schubert, KO, Fullerton, J, Ahmed, M, Hartmann, S, Papiol, S, Heilbronner, U, Degenhardt, F, Tekola-Ayele, F, Hou, L, Hsu, YH, Shekhtman, T, Adli, M, Akula, N, Akiyama, K, Ardau, R, Arias, B, Aubry, JM, Backlund, L, Bhattacharjee, AK, Bellivier, F, Benabarre, A, Bengesser, S, Biernacka, J, Birner, A, Marie-Claire, C, Cervantes, P, Chen, HC, Chillotti, C, Cichon, S, Cruceanu, C, Czerski, P, Dalkner, N, Del Zompo, M, DePaulo, JR, Etain, B, Jamain, S, Falkai, P, Forstner, AJ, Frisén, L, Frye, M, Gard, S, Garnham, J, Goes, F, Grigoroiu-Serbanescu, M, Fallgatter, A, Stegmaier, S, Ethofer, T, Biere, S, Petrova, K, Schuster, C, Adorjan, K, Budde, M, Heilbronner, M, Kalman, J, Oraki Kohshour, M, Reich-Erkelenz, D, Schaupp, S, Schulte, E, Senner, F, Vogl, T, Anghelescu, IG, Arolt, V, Dannlowski, U, Dietrich, DE, Figge, C, Jäger, M, Lang, F, Juckel, G, Spitzer, C, Reimer, J, Schmauß, M, Schmitt, A, Konrad, C, von Hagen, M, Wiltfang, J, Zimmermann, J, Andlauer, T, Fischer, A, Bermpohl, F, Kraft, V, Matura, S, Gryaznova, A, Falkenberg, I, Yildiz, C, Kircher, T, Schmidt, J, Koch, M, Gade, K, Trost, S, Haußleiter, I, Lambert, M, Rohenkohl, AC, Grof, P, Hashimoto, R, Hauser, J, Herms, S, Hoffmann, P, Jiménez, E, Kahn, JP, Kassem, L, Kuo, PH, Kato, T, Kelsoe, J, Kittel-Schneider, S, Ferensztajn-Rochowiak, E, König, B, Kusumi, I, Laje, G, Landén, M, Lavebratt, C, Leboyer, M, Leckband, SG, Tortorella, A, Manchia, M, Martinsson, L, McCarthy, M, McElroy, SL, Colom, F, Mitjans, M, Mondimore, F, Monteleone, P, Nievergelt, C, Nöthen, M, Novak, T, O'Donovan, C, Ozaki, N, Pfennig, A, Pisanu, C, Potash, J, Reif, A, Reininghaus, E, Rouleau, G, Rybakowski, JK, Schalling, M, Schofield, P, Schweizer, BW, Severino, G, Shilling, PD, Shimoda, K, Simhandl, C, Slaney, C, Squassina, A, Stamm, T, Stopkova, P, Maj, M, Turecki, G, Vieta, E, Veeh, J, Witt, S, Wright, A, Zandi, P, Mitchell, P, Bauer, M, Alda, M, Rietschel, M, McMahon, F, Schulze, TG, Millischer, V, Clark, S, Baune, B
المصدر: Research square.
مصطلحات موضوعية: Medicin och hälsovetenskap
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3دورية أكاديمية
المؤلفون: Kalman, JL, Papiol, S, Forstner, AJ, Heilbronner, U, Degenhardt, F, Strohmaier, J, Adli, M, Adorjan, K, Akula, N, Alda, M, Anderson-Schmidt, H, Andlauer, TFM, Anghelescu, IG, Ardau, R, Arias, B, Arolt, V, Aubry, JM, Backlund, L, Bartholdi, K, Bauer, M, Baune, BT, Becker, T, Bellivier, F, Benabarre, A, Bengesser, S, Bhattacharjee, AK, Biernacka, JM, Birner, A, Brichant-Petitjean, C, Budde, M, Cervantes, P, Chillotti, C, Cichon, S, Clark, SR, Colom, F, Comes, AL, Cruceanu, C, Czerski, PM, Dannlowski, U, Dayer, A, Del Zompo, M, DePaulo, JR, Dietrich, DE, Etain, B, Ethofer, T, Falkai, P, Fallgatter, A, Figge, C, Flatau, L, Folkerts, H, Frisen, L, Frye, MA, Fullerton, JM, Gade, K, Gard, S, Garnham, JS, Goes, FS, Grigoroiu-Serbanescu, M, Gryaznova, A, Hake, M, Hauser, J, Herms, S, Hoffmann, P, Hou, LP, Jager, M, Jamain, S, Jimenez, E, Juckel, G, Kahn, JP, Kassem, L, Kelsoe, J, Kittel-Schneider, S, Kliwicki, S, Klohn-Sagatholislam, F, Koller, M, Konig, B, Konrad, C, Lackner, N, Laje, G, Landen, M, Lang, FU, Lavebratt, C, Leboyer, M, Leckband, SG, Maj, M, Manchia, M, Martinsson, L, McCarthy, MJ, McElroy, SL, McMahon, FJ, Mitchell, PB, Mitjans, M, Mondimore, FM, Monteleone, P, Nieratschker, V, Nievergelt, CM, Novak, T, Osby, U, Pfennig, A, Potash, JB, Reich-Erkelenz, D, Reif, A, Reimer, J, Reininghaus, E, Reitt, M, Ripke, S, Rouleau, GA, Rybakowski, JK, Schalling, M, Scherk, H, Schmauss, M, Schofield, PR, Schubert, KO, Schulte, EC, Schulz, S, Senner, F, Severino, G, Shekhtman, T, Shilling, PD, Simhandl, C, Slaney, CM, Spitzer, C, Squassina, A, Stamm, T, Stegmaier, S, Stierl, S, Stopkova, P, Thiel, A, Tighe, SK, Tortorella, A, Turecki, G, Vieta, E, Veeh, J, von Hagen, M, Wigand, ME, Wiltfang, J, Witt, S, Wright, A, Zandi, PP, Zimmermann, J, Nothen, M, Rietschel, M, Schulze, TG
المصدر: Bipolar disorders. 21(1):68-75
مصطلحات موضوعية: Medicin och hälsovetenskap
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4دورية أكاديمية
المؤلفون: Wendel, B, Papiol, S, Andlauer, TFM, Zimmermann, J, Wiltfang, J, Spitzer, C, Senner, F, Schulte, EC, Schmauss, M, Schaupp, SK, Repple, J, Reininghaus, E, Reimer, J, Reich-Erkelenz, D, Opel, N, Meinert, S, Konrad, C, Kloehn-Saghatolislam, F, Kircher, T, Kalman, JL, Juckel, G, Jansen, A, Jaeger, M, Heilbronner, M, von Hagen, M, Gade, K, Figge, C, Fallgatter, AJ, Dietrich, DE, Dannlowski, U, Comes, AL, Budde, M, Baune, BT, Arolt, V, Anghelescu, I-G, Anderson-Schmidt, H, Adorjan, K, Falkai, P, Schulze, TG, Bickeboeller, H, Heilbronner, U
الوصف: Executive functions are metacognitive capabilities that control and coordinate mental processes. In the transdiagnostic PsyCourse Study, comprising patients of the affective-to-psychotic spectrum and controls, we investigated the genetic basis of the time course of two core executive subfunctions: set-shifting (Trail Making Test, part B (TMT-B)) and updating (Verbal Digit Span backwards) in 1338 genotyped individuals. Time course was assessed with four measurement points, each 6 months apart. Compared to the initial assessment, executive performance improved across diagnostic groups. We performed a genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with performance change over time by testing for SNP-by-time interactions using linear mixed models. We identified nine genome-wide significant SNPs for TMT-B in strong linkage disequilibrium with each other on chromosome 5. These were associated with decreased performance on the continuous TMT-B score across time. Variant rs150547358 had the lowest P value = 7.2 × 10-10 with effect estimate beta = 1.16 (95% c.i.: 1.11, 1.22). Implementing data of the FOR2107 consortium (1795 individuals), we replicated these findings for the SNP rs150547358 (P value = 0.015), analyzing the difference of the two available measurement points two years apart. In the replication study, rs150547358 exhibited a similar effect estimate beta = 0.85 (95% c.i.: 0.74, 0.97). Our study demonstrates that longitudinally measured phenotypes have the potential to unmask novel associations, adding time as a dimension to the effects of genomics.
العلاقة: pii: 10.1038/s41398-021-01510-8; Wendel, B., Papiol, S., Andlauer, T. F. M., Zimmermann, J., Wiltfang, J., Spitzer, C., Senner, F., Schulte, E. C., Schmauss, M., Schaupp, S. K., Repple, J., Reininghaus, E., Reimer, J., Reich-Erkelenz, D., Opel, N., Meinert, S., Konrad, C., Kloehn-Saghatolislam, F., Kircher, T. ,. Heilbronner, U. (2021). A genome-wide association study of the longitudinal course of executive functions. TRANSLATIONAL PSYCHIATRY, 11 (1), https://doi.org/10.1038/s41398-021-01510-8Test.; http://hdl.handle.net/11343/304952Test
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5دورية أكاديمية
المؤلفون: Smigielski, L, Papiol, S, Theodoridou, A, Heekeren, K, Gerstenberg, M, Wotruba, D, Buechler, R, Hoffmann, P, Herms, S, Adorjan, K, Anderson-Schmidt, H, Budde, M, Comes, AL, Gade, K, Heilbronner, M, Heilbronner, U, Kalman, JL, Kloehn-Saghatolislam, F, Reich-Erkelenz, D, Schaupp, SK, Schulte, EC, Senner, F, Anghelescu, I-G, Arolt, V, Baune, BT, Dannlowski, U, Dietrich, DE, Fallgatter, AJ, Figge, C, Jaeger, M, Juckel, G, Konrad, C, Nieratschker, V, Reimer, J, Reininghaus, E, Schmauss, M, Spitzer, C, von Hagen, M, Wiltfang, J, Zimmermann, J, Gryaznova, A, Flatau-Nagel, L, Reitt, M, Meyers, M, Emons, B, Haussleiter, IS, Lang, FU, Becker, T, Wigand, ME, Witt, SH, Degenhardt, F, Forstner, AJ, Rietschel, M, Nothen, MM, Andlauer, TFM, Roessler, W, Walitza, S, Falkai, P, Schulze, TG, Gruenblatt, E
الوصف: As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing the probabilistic susceptibility of developing a disorder could guide mitigation measures and clinical intervention. In this context, polygenic risk scores (PRSs) quantifying the additive effects of multiple common genetic variants hold the potential to predict complex diseases and index severity gradients. PRSs for schizophrenia (SZ) and bipolar disorder (BD) were computed using Bayesian regression and continuous shrinkage priors based on the latest SZ and BD genome-wide association studies (Psychiatric Genomics Consortium, third release). Eight well-phenotyped groups (n = 1580; 56% males) were assessed: control (n = 305), lower (n = 117) and higher (n = 113) schizotypy (both groups of healthy individuals), at-risk for psychosis (n = 120), BD type-I (n = 359), BD type-II (n = 96), schizoaffective disorder (n = 86), and SZ groups (n = 384). PRS differences were investigated for binary traits and the quantitative Positive and Negative Syndrome Scale. Both BD-PRS and SZ-PRS significantly differentiated controls from at-risk and clinical groups (Nagelkerke's pseudo-R2: 1.3-7.7%), except for BD type-II for SZ-PRS. Out of 28 pairwise comparisons for SZ-PRS and BD-PRS, 9 and 12, respectively, reached the Bonferroni-corrected significance. BD-PRS differed between control and at-risk groups, but not between at-risk and BD type-I groups. There was no difference between controls and schizotypy. SZ-PRSs, but not BD-PRSs, were positively associated with transdiagnostic symptomology. Overall, PRSs support the continuum model across the psychosis spectrum at the genomic level with possible irregularities for schizotypy. The at-risk state demands heightened clinical attention and research addressing symptom course specifiers. Continued efforts are needed to refine the diagnostic and prognostic accuracy of PRSs in mental healthcare.
العلاقة: pii: 10.1038/s41398-021-01720-0; Smigielski, L., Papiol, S., Theodoridou, A., Heekeren, K., Gerstenberg, M., Wotruba, D., Buechler, R., Hoffmann, P., Herms, S., Adorjan, K., Anderson-Schmidt, H., Budde, M., Comes, A. L., Gade, K., Heilbronner, M., Heilbronner, U., Kalman, J. L., Kloehn-Saghatolislam, F., Reich-Erkelenz, D. ,. Gruenblatt, E. (2021). Polygenic risk scores across the extended psychosis spectrum. TRANSLATIONAL PSYCHIATRY, 11 (1), https://doi.org/10.1038/s41398-021-01720-0Test.; http://hdl.handle.net/11343/296244Test
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6دورية أكاديمية
المؤلفون: Heilbronner, U., Streit, F., Vogl, T., Senner, F., Schaupp, S.K., Reich-Erkelenz, D., Papiol, S., Oraki Kohshour, M., Klöhn-Saghatolislam, F., Kalman, J.L., Heilbronner, M., Gade, K., Comes, A.L., Budde, M., Andlauer, T.F.M., Anderson-Schmidt, H., Adorjan, K., Stürmer, T., Loerbroks, A., Amelang, M., Poisel, E., Foo, J.C., Heilmann-Heimbach, S., Forstner, A.J., Degenhardt, F., Zimmermann, J., Wiltfang, J., von Hagen, M., Spitzer, C., Schmauss, M., Reininghaus, E., Reimer, J., Konrad, C., Juckel, G., Lang, F.U., Jäger, M., Figge, C., Fallgatter, A.J., Dietrich, D.E., Dannlowski, U., Baune, B.T., Arolt, V., Anghelescu, I.G., Nöthen, M.M., Witt, S.H., Andreassen, O.A., Chen, C.H., Falkai, P., Rietschel, M., Schulze, T.G., Schulte, E.C.
المصدر: BJPsych Open 7:e188 (2021)
مصطلحات موضوعية: Covid-19, Extraversion, Genetics, Personality Traits, Severe Mental Disorders
الوصف: Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, with its impact on our way of life, is affecting our experiences and mental health. Notably, individuals with mental disorders have been reported to have a higher risk of contracting SARS-CoV-2. Personality traits could represent an important determinant of preventative health behaviour and, therefore, the risk of contracting the virus. Aims: We examined overlapping genetic underpinnings between major psychiatric disorders, personality traits and susceptibility to SARS-CoV-2 infection. Method: Linkage disequilibrium score regression was used to explore the genetic correlations of coronavirus disease 2019 (COVID-19) susceptibility with psychiatric disorders and personality traits based on data from the largest available respective genome-wide association studies (GWAS). In two cohorts (the PsyCourse (n = 1346) and the HeiDE (n = 3266) study), polygenic risk scores were used to analyse if a genetic association between, psychiatric disorders, personality traits and COVID-19 susceptibility exists in individual-level data. Results: We observed no significant genetic correlations of COVID-19 susceptibility with psychiatric disorders. For personality traits, there was a significant genetic correlation for COVID-19 susceptibility with extraversion (P = 1.47 × 10-5; genetic correlation 0.284). Yet, this was not reflected in individual-level data from the PsyCourse and HeiDE studies. Conclusions: We identified no significant correlation between genetic risk factors for severe psychiatric disorders and genetic risk for COVID-19 susceptibility. Among the personality traits, extraversion showed evidence for a positive genetic association with COVID-19 susceptibility, in one but not in another setting. Overall, these findings highlight a complex contribution of genetic and non-genetic components in the interaction between COVID-19 susceptibility and personality traits or mental disorders.
وصف الملف: application/pdf
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34659794; info:eu-repo/semantics/altIdentifier/wos/WOS:000721235000001; info:eu-repo/semantics/altIdentifier/isbn/2056-4724; info:eu-repo/semantics/altI; https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63465Test; urn:isbn:2056-4724; urn:issn:2056-4724
الإتاحة: https://doi.org/10.1192/bjo.2021.1030Test
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63465Test -
7دورية أكاديمية
المؤلفون: Abel A, Glaznieks A, Müller-Spitzer C, Storrer A
الوصف: Das Kommunizieren in Sozialen Medien und der Umgang mit Hypertexten ist im Jahr 2020 kein Randphänomen mehr. Es gibt also durchaus Anlass, das Nachdenken über Textqualität auf digitale Schreibprodukte auszuweiten und bisherige Ansätze konzeptionell und methodisch weiterzuentwickeln. An diesem Desiderat setzte das Projekt „Wie misst man Textqualität im digitalen Zeitalter“ (MIT.Qualität) an, das von 2017-2019 von der Volkswagenstiftung gefördert wurde und dessen Ergebnisse in diesem Themenheft vorgestellt werden. Die Einführung erläutert die Ziele des Projekts und ordnet die Beiträge in den übergreifenden Projektrahmen ein. ; open
وصف الملف: application/pdf
العلاقة: http://dx.doi.org/10.37307/j.1868-775X.2020.02.02Test; https://bia.unibz.it/handle/10863/14721Test
الإتاحة: https://doi.org/10.37307/j.1868-775X.2020.02.02Test
https://bia.unibz.it/handle/10863/14721Test -
8دورية أكاديمية
المؤلفون: Budde, M, Anderson-Schmidt, H, Gade, K, Reich-Erkelenz, D, Adorjan, K, Kalman, JL, Senner, F, Papiol, S, Andlauer, TFM, Comes, AL, Schulte, EC, Kloehn-Saghatolislam, F, Gryaznova, A, Hake, M, Bartholdi, K, Flatau, L, Reitt, M, Quast, S, Stegmaier, S, Meyers, M, Emons, B, Haussleiter, IS, Juckel, G, Nieratschker, V, Dannlowski, U, Schaupp, SK, Schmauss, M, Zimmermann, J, Reimer, J, Schulz, S, Wiltfang, J, Reininghaus, E, Anghelescu, I-G, Arolt, V, Baune, BT, Konrad, C, Thiel, A, Fallgatter, AJ, Figge, C, von Hagen, M, Koller, M, Lang, FU, Wigand, ME, Becker, T, Jaeger, M, Dietrich, DE, Stierl, S, Scherk, H, Spitzer, C, Folkerts, H, Witt, SH, Degenhardt, F, Forstner, AJ, Rietschel, M, Noethen, MM, Falkai, P, Schulze, TG, Heilbronner, U
الوصف: In current diagnostic systems, schizophrenia and bipolar disorder are still conceptualized as distinct categorical entities. Recently, both clinical and genomic evidence have challenged this Kraepelinian dichotomy. There are only few longitudinal studies addressing potential overlaps between these conditions. Here, we present design and first results of the PsyCourse study (N = 891 individuals at baseline), an ongoing transdiagnostic study of the affective-to-psychotic continuum that combines longitudinal deep phenotyping and dimensional assessment of psychopathology with an extensive collection of biomaterial. To provide an initial characterization of the PsyCourse study sample, we compare two broad diagnostic groups defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) classification system, that is, predominantly affective (n = 367 individuals) versus predominantly psychotic disorders (n = 524 individuals). Depressive, manic, and psychotic symptoms as well as global functioning over time were contrasted using linear mixed models. Furthermore, we explored the effects of polygenic risk scores for schizophrenia on diagnostic group membership and addressed their effects on nonparticipation in follow-up visits. While phenotypic results confirmed expected differences in current psychotic symptoms and global functioning, both manic and depressive symptoms did not vary between both groups after correction for multiple testing. Polygenic risk scores for schizophrenia significantly explained part of the variability of diagnostic group. The PsyCourse study presents a unique resource to research the complex relationships of psychopathology and biology in severe mental disorders not confined to traditional diagnostic boundaries and is open for collaborations.
العلاقة: Budde, M., Anderson-Schmidt, H., Gade, K., Reich-Erkelenz, D., Adorjan, K., Kalman, J. L., Senner, F., Papiol, S., Andlauer, T. F. M., Comes, A. L., Schulte, E. C., Kloehn-Saghatolislam, F., Gryaznova, A., Hake, M., Bartholdi, K., Flatau, L., Reitt, M., Quast, S., Stegmaier, S. ,. Heilbronner, U. (2019). A longitudinal approach to biological psychiatric research: The PsyCourse study. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 180 (2), pp.89-102. https://doi.org/10.1002/ajmg.b.32639Test.; http://hdl.handle.net/11343/248153Test
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9دورية أكاديمية
المؤلفون: Comes, AL, Senner, F, Budde, M, Adorjan, K, Anderson-Schmidt, H, Andlauer, TFM, Gade, K, Hake, M, Heilbronner, U, Kalman, JL, Reich-Erkelenz, D, Kloehn-Saghatolislam, F, Schaupp, SK, Schulte, EC, Juckel, G, Dannlowski, U, Schmauss, M, Zimmermann, J, Reimer, J, Reininghaus, E, Anghelescu, I-G, Arolt, V, Baune, BT, Konrad, C, Thiel, A, Fallgatter, AJ, Nieratschker, V, Figge, C, von Hagen, M, Koller, M, Becker, T, Wigand, ME, Jaeger, M, Dietrich, DE, Stierl, S, Scherk, H, Spitzer, C, Folkerts, H, Witt, SH, Degenhardt, F, Forstner, AJ, Rietschel, M, Noethen, MM, Wiltfang, J, Falkai, P, Schulze, TG, Papiol, S
الوصف: Cognitive deficits are a core feature of psychiatric disorders like schizophrenia and bipolar disorder. Evidence supports a genome-wide polygenic score (GPS) for educational attainment (GPSEDU) can be used to explain variability in cognitive performance. We aimed to identify different cognitive domains associated with GPSEDU in a transdiagnostic clinical cohort of chronic psychiatric patients with known cognitive deficits. Bipolar and schizophrenia patients from the PsyCourse cohort (N = 730; 43% female) were used. Likewise, we tested whether GPSs for schizophrenia (GPSSZ) and bipolar disorder (GPSBD) were associated with cognitive outcomes. GPSEDU explained 1.5% of variance in the backward verbal digit span, 1.9% in the number of correctly recalled words of the Verbal Learning and Memory Test, and 1.1% in crystallized intelligence. These effects were robust to the influences of treatment and diagnosis. No significant associations between GPSSZ or GPSBD with cognitive outcomes were found. Furthermore, these risk scores did not confound the effect of GPSEDU on cognitive outcomes. GPSEDU explains a small fraction of cognitive performance in adults with psychiatric disorders, specifically for domains related to linguistic learning and working memory. Investigating such a proxy-phenotype longitudinally, could give intriguing insight into the disease course, highlighting at what time genes play a more influential role on cognitive performance. Better understanding the origin of these deficits might help identify those patients at risk for lower levels of functioning and poor social outcomes. Polygenic estimates may in the future be part of predictive models for more personalized interventions.
العلاقة: pii: 10.1038/s41398-019-0547-x; Comes, A. L., Senner, F., Budde, M., Adorjan, K., Anderson-Schmidt, H., Andlauer, T. F. M., Gade, K., Hake, M., Heilbronner, U., Kalman, J. L., Reich-Erkelenz, D., Kloehn-Saghatolislam, F., Schaupp, S. K., Schulte, E. C., Juckel, G., Dannlowski, U., Schmauss, M., Zimmermann, J., Reimer, J. ,. Papiol, S. (2019). The genetic relationship between educational attainment and cognitive performance in major psychiatric disorders. TRANSLATIONAL PSYCHIATRY, 9 (1), https://doi.org/10.1038/s41398-019-0547-xTest.; http://hdl.handle.net/11343/246596Test
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10دورية أكاديمية
المؤلفون: Leichsenring, F, Abbass, A, Beutel, M, Gündel, H, Heuft, G, Hoffman, SO, Kächele, H, Kruse, J, Rüger, U, Rudolf, G, Spitzer, C, Salzer, S, Luyten, P, Wampold, B, Steinert, C
المصدر: Zeitschrift für Psychosomatische Medizin und Psychotherapie , 65 (4) pp. 321-340. (2019)
مصطلحات موضوعية: Psychotherapeutische Verfahren, Richtlinientherapie, evidenz-basierte Methoden, Therapieausbildung
الوصف: Fragestellung: In Deutschland sind die geltenden Psychotherapierichtlinien für die ambulanten Behandlungen verfahrensorientiert ausgerichtet und auch die psychotherapeutische Aus- und Weiterbildung erfolgt im deutschen Gesundheitssystem verfahrensbezogen. In letzter Zeit werden jedoch Stimmen laut, die sich gegen die Beibehaltung des Verfahrensbegriffs in der Psychotherapie aussprechen und damit auch die Richtlinien-Psychotherapie in Frage stellen. Ziel: Die vorgebrachten Argumente (z.B. die Heterogenität der Verfahren) sowie die vorgetragenen Alternativen (z.B. ein verfahrens-übergreifendes „integratives“ Störungs- und Therapiemodell nach dem Baukasten-Prinzip) werden kritisch diskutiert. Ergebnisse: Die vorgebrachten Argumente gegen das Konzept der Verfahren und die präsentierten Alternativen erweisen sich unter wissenschaftlichen und psychotherapeutischen Gesichtspunkten als wenig überzeugend. Zum einen wird gezeigt, dass Psychotherapie nach dem Baukasten-Prinzip anhand von störungsspezifischen Methoden oder Modulen „verfahrens-übergreifend“ weder gelernt noch gelehrt oder ausgeübt werden kann. Zum anderen gibt es für eine „allgemeine“ oder „integrative“ Psychotherapie bisher keinerlei Evidenz – im Unterschied zu den Richtlinien-Verfahren. Schlussfolgerungen: Das Konzept der Psychotherapie-Verfahren erweist sich als ein unverzichtbares Orientierungsprinzip sowohl für Therapeuten als auch für Patienten.
وصف الملف: text
العلاقة: https://discovery.ucl.ac.uk/id/eprint/10075399/7/Luyten_zptm.2019.65.4.oa1.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10075399Test/
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