المؤلفون: Hoyos-López, Richard, Soto, Sandra Uribe, Rúa-Uribe, Guillermo, Gallego-Gómez, Juan Carlos

المصدر: Memórias do Instituto Oswaldo Cruz. September 2015 110(6)

مصطلحات موضوعية: Saint Louis encephalitis virus, flavivirus, genotype, Colombia

الوصف: Saint Louis encephalitis virus (SLEV) is a member of the Japanese-encephalitis virus serocomplex of the genus Flavivirus. SLEV is broadly distributed in the Americas and the Caribbean Islands, where it is usually transmitted by mosquitoes of the genus Culex and primarily to birds and mammalian-hosts. Humans are occasionally infected by the virus and are dead-end hosts. SLEV causes encephalitis in temperate regions, while in tropical regions of the Americas, several human cases and a wide biological diversity of SLEV-strains have been reported. The phylogenetic analysis of the envelope (E) protein genes indicated eight-genotypes of SLEV with geographic overlap. The present paper describes the genotyping of two SLEV viruses detected in mosquito-pools collected in northern Colombia (department of Cordoba). We used reverse transcription-polymerase chain reaction to amplify a fragment of theE-gene to confirm the virus identity and completeE-gene sequencing for phylogenetic analysis and genotyping of the two-SLEV viruses found circulating in Córdoba. This is the first report of SLEV genotype IV in Colombia (Córdoba) in mosquitoes from a region of human inhabitation, implicating the risk of human disease due to SLEV infection. Physicians should consider SLEV as a possible aetiology for undiagnosed febrile and neurologic syndromes among their patients who report exposure to mosquito-bites.

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000600719Test

المؤلفون: Messier, Stephen P., Callahan, Leigh F., Losina, Elena, Mihalko, Shannon L., Guermazi, Ali, Ip, Edward, Miller, Gary D., Katz, Jeffrey N., Loeser, Richard F., Pietrosimone, Brian G., Soto, Sandra, Cook, James L., Newman, Jovita J., DeVita, Paul, Spindler, Kurt P., Runhaar, Jos, Armitano-Lago, Cortney, Duong, Vicky, Selzer, Faith, Hill, Ryan, Love, Monica, Beavers, Daniel P., Saldana, Santiago, Stoker, Aaron M., Rice, Paige E., Hunter, David J.

المصدر: Messier , S P , Callahan , L F , Losina , E , Mihalko , S L , Guermazi , A , Ip , E , Miller , G D , Katz , J N , Loeser , R F , Pietrosimone , B G , Soto , S , Cook , J L , Newman , J J , DeVita , P , Spindler , K P , Runhaar , J , Armitano-Lago , C , Duong , V , Selzer , F , Hill , R , Love , M , Beavers , D P , ....

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الوصف: Background: Osteoarthritis (OA), the leading cause of disability among adults, has no cure and is associated with significant comorbidities. The premise of this randomized clinical trial is that, in a population at risk, a 48-month program of dietary weight loss and exercise will result in less incident structural knee OA compared to control. Methods/design: The Osteoarthritis Prevention Study (TOPS) is a Phase III, assessor-blinded, 48-month, parallel 2 arm, multicenter randomized clinical trial designed to reduce the incidence of structural knee OA. The study objective is to assess the effects of a dietary weight loss, exercise, and weight-loss maintenance program in preventing the development of structural knee OA in females at risk for the disease. TOPS will recruit 1230 ambulatory, community dwelling females with obesity (Body Mass Index (BMI) ≥ 30 kg/m 2 ) and aged ≥50 years with no radiographic (Kellgren-Lawrence grade ≤1) and no magnetic resonance imaging (MRI) evidence of OA in the eligible knee, with no or infrequent knee pain. Incident structural knee OA (defined as tibiofemoral and/or patellofemoral OA on MRI) assessed at 48-months from intervention initiation using the MRI Osteoarthritis Knee Score (MOAKS) is the primary outcome. Secondary outcomes include knee pain, 6-min walk distance, health-related quality of life, knee joint loading during gait, inflammatory biomarkers, and self-efficacy. Cost effectiveness and budgetary impact analyses will determine the value and affordability of this intervention. Discussion: This study will assess the efficacy and cost effectiveness of a dietary weight loss, exercise, and weight-loss maintenance program designed to reduce incident knee OA. Trial registration: ClinicalTrials.gov Identifier: NCT05946044.

وصف الملف: application/pdf

العلاقة: https://pure.eur.nl/en/publications/4f47dedb-a38f-4ef4-8b6f-9146d78ba487Test

الإتاحة: https://doi.org/10.1016/j.ocarto.2023.100418Test
https://pure.eur.nl/en/publications/4f47dedb-a38f-4ef4-8b6f-9146d78ba487Test
https://pure.eur.nl/ws/files/124162103/The_osteoarthritis_prevention_study_TOPS_-_A_randomized_controlled_trial_of_diet_and_exercise_to_prevent_Knee_Osteoarthritis.pdfTest
http://www.scopus.com/inward/record.url?scp=85179044965&partnerID=8YFLogxKTest

المؤلفون: Morse, Rachel M., Brown, Joanna, Gage, Julia C., Prieto, Bryn A., Jurczuk, Magdalena, Matos, Andrea, Vásquez Vásquez, Javier, Reátegui, Reyles Ríos, Meza-Sanchez, Graciela, Córdova, Luis Antonio Díaz, Gravitt, Patti E., Tracy, J. Kathleen, Paz-Soldan, Valerie A., Carhuaza, Iris, Carrillo Jara, Lita E., del Carmen Caruhapoma, María, Del Carpio-Morgan, Meda, Daza Grandez, Henrry, Figueredo Escudero, Magaly, Garcia Satalay, Esther Y., Gilman, Sarah D., Gonzales Díaz, Karina, Jerónimo, José, Jorges, Alcedo, Kohler-Smith, Anna, Kosek, Margaret, Ladrón de Guevarra, Gabriela, Lenin de Cuadro, Daniel, Lopez Liñán, Renso, Matos Orbegozo, Andrea, Marín, Jaime, Meza, Graciela, Noble, Helen E., Palacios, Victor A., Ríos López, E. Jennifer, Rivas, Patricia, Román, Karina, Rositch, Anne F., Santos-Ortiz, Carlos, Silva Delgado, Hermann F., Soto, Sandra, Tangoa, Nolberto, Vásquez del Aguila, Giannina, Zevallos, Karen

المساهمون: The National Institute of Health/National Cancer Institute

المصدر: BMC Public Health ; volume 23, issue 1 ; ISSN 1471-2458

مصطلحات موضوعية: Public Health, Environmental and Occupational Health

الوصف: Background Cervical cancer is preventable with vaccination and early detection and treatment programs. However, for these programs to work as intended, stigma related to HPV and cervical cancer must be understood and addressed. We explored pre-existing stigma associated with HPV and cervical cancer in the public healthcare system and community of a low-resource setting prior to implementation of an HPV screen-and-treat program. Methods This study conducted thematic analysis of data collected during implementation of a novel HPV screen-and-treat system for cervical cancer early detection and treatment in Iquitos, Peru. We included 35 semi-structured interviews (19 health professionals, 16 women with cervical precancer or cancer), eight focus groups (70 community women), one workshop (14 health professionals), 210 counseling observations (with 20 nurse-midwives), and a document review. We used the Socio-Ecological Model to organize the analysis. Results We identified three main themes: 1. the implication that women are to blame for their HPV infection through characterizations of being easy or promiscuous, 2. the implication that men are to blame for women’s HPV infections through being considered careless or unfaithful, 3. HPV is shameful, embarrassing, and something that should be hidden from others. Consequently, in some cases, women refrained from getting screened for HPV. These themes were seen at the individual level among women, relationship level among women, men, and family members, community level among healthcare staff, and societal level within components of cervical cancer guidelines and male chauvinism. Conclusions Cervical cancer early detection and treatment programs in limited resource settings must address stigma entrenched throughout the entire healthcare system and community in order to sustainably and successfully implement and scale-up new programs. Interventions to tackle this stigma can incorporate messages about HPV infections and latency to lessen the focus on the influence of ...

الإتاحة: https://doi.org/10.1186/s12889-023-17324-wTest

المؤلفون: Garreta-Catala, Iago, Planas-Balagué, Rosa, Abouzari, Reza, Carnaval, Thiago, Nolla, Joan M., Videla, Sebastián, Agulló-Ferré, José-Luis, Calvis-Garcia, Paula, Carmezim, João, Company-Llimona, Anna, Fernandez-Mariscal, Esmeralda, Fernandez-Solana, Coral, Figuerola-Batista, Montserrat, Gerique-Fornas, Neus, Grifell-Martín, Encarna, Gutierrez-Jimenez, Nuria, Mariano-Martin, Nuria, Mas-Garriga, Xavier, Otero-Gonzalez, Aurema, Soler-Soto, Sandra, Tebé, Cristian, Vázquez-Ventura, Teresa, Vázquez-Vera, Carlota, Vicent-Porquet, Ramón

المصدر: BMC Musculoskeletal Disorders ; volume 24, issue 1 ; ISSN 1471-2474

مصطلحات موضوعية: Orthopedics and Sports Medicine, Rheumatology

الوصف: Background Low back pain is a common condition that becomes even more prevalent with aging. A non-pharmacological multidisciplinary approach for chronic non-specific low back pain (CNSLBP) has been recommended, but integrating different healthcare professionals is challenging. A multidisciplinary group videoconferencing approach (MGVA) can be helpful. Our aim was to provide evidence on MGVA's feasibility in managing CNSLBP and its impact on clinical practice. Methods We conducted an open-label, randomized, controlled, parallel-group pilot clinical trial with CNSLBP patients irresponsive to conservative treatment. Patients between 18 and 67 years of age were randomly assigned (1:1) to either Standard-of-Care + MGVA (experimental group) or Standard-of-Care alone (control group). MGVA consisted of integrated sessions for physical rehabilitation/physiotherapy, psychology, and social work treatments. The control group received standard clinical practice treatment. The feasibility was assessed by the number of study procedures completed to at least 80% as planned. The impact on clinical practice was evaluated by the number of patients who changed their status from "candidate" to "non-candidate" to low back surgery as the treatment of choice for CNSLBP. The SF–36, Oswestry Disability Index, and TMMS–24 questionnaires were used. We performed a whole population-based descriptive analysis. Results We included 20 patients, but only 18 were randomized (2 withdrew consent before randomization). The mean (SD) age was 53.1 (5.9) years, and mostly women (13/18); 7 were actively employed. In the experimental group, 6/9 (67%, 95%CI:35–88%) patients attended at least 80% of the scheduled procedures, while in the control group, 8/9 (89%, 95%CI:57–98%) did. Additionally, 1 out of 4 (25%) patients in the experimental group changed their status from "candidate" for low back surgery to "non-candidate". None of the 2 patients in the control group did so. We found differences between groups in the SF-36 mental health component ( ...

الإتاحة: https://doi.org/10.1186/s12891-023-06763-6Test

المؤلفون: Morse, Rachel M., Jurczuk, Magdalena, Brown, Joanna, Jara, Lita E. Carrillo, Meza, Graciela, López, E. Jennifer Ríos, Tracy, J. Kathleen, Gravitt, Patti E., Paz-Soldan, Valerie A., Del Carpio-Morgan, Meda, Grandez, Henrry Daza, Escudero, Magaly Figueredo, Garcia Satalay, Esther Y., Gilman, Sarah D., Díaz, Karina Gonzales, Jerónimo, José, Jorges, Alcedo, Kohler-Smith, Anna, Kosek, Margaret, de Guevarra, Gabriela Ladrón, de Cuadro, Daniel Lenin, Liñán, Renso Lopez, Orbegozo, Andrea Matos, Marín, Jaime, Noble, Helen E., Palacios, Victor A., Reátegui, Reyles Ríos, Román, Karina, Rositch, Anne F., Santos-Ortiz, Carlos, Silva Delgado, Hermann F., Soto, Sandra, Tangoa, Nolberto, Vásquez, Javier Vásquez, del Aguila, Giannina Vásquez, Zevallos, Karen

المصدر: BMC Women's Health ; volume 23, issue 1 ; ISSN 1472-6874

مصطلحات موضوعية: Obstetrics and Gynecology, Reproductive Medicine, General Medicine

الوصف: Background The study’s objective was to explore the factors associated with loss to follow-up among women with abnormal cervical cancer screening results in Iquitos, Peru from women’s perspectives. Methods In-depth interviews were conducted with 20 screen-positive women who were referred for follow-up care but for whom evidence of follow-up was not found. Interview transcripts were thematically analyzed inductively, and the codes were then categorized using the Health Care Access Barriers Model for presentation of results. Results All interviewed women were highly motivated to complete the continuum of care but faced numerous barriers along the way, including cognitive barriers such as a lack of knowledge about cervical cancer and poor communication from health professionals regarding the process, structural barriers such as challenges with scheduling appointments and unavailability of providers, and financial barriers including out-of-pocket payments and costs related to travel or missing days of work. With no information system tracking the continuum of care, we found fragmentation between primary and hospital-level care, and often, registration of women’s follow-up care was missing altogether, preventing women from being able to receive proper care and providers from ensuring that women receive care and treatment as needed. Conclusions The challenges elucidated demonstrate the complexity of implementing a successful cervical cancer prevention program and indicate a need for any such program to consider the perspectives of women to improve follow-up after a positive screening test.

الإتاحة: https://doi.org/10.1186/s12905-023-02414-zTest

المؤلفون: Baena-Bejarano, Nathalie, Reina, Catalina, Martínez-Revelo, Diego Esteban, Medina, Claudia A., Tovar, Eduardo, Uribe-Soto, Sandra, Neita-Moreno, Jhon Cesar, Gonzalez, Mailyn A.

المساهمون: ZHANG, Feng, Minciencias, Colombia BIO Agreement, Santander BIO inter-agency Agreement

المصدر: PLOS ONE ; volume 18, issue 4, page e0277379 ; ISSN 1932-6203

الوصف: Recent declines of insect populations at high rates have resulted in the need to develop a quick method to determine their diversity and to process massive data for the identification of species of highly diverse groups. A short sequence of DNA from COI is widely used for insect identification by comparing it against sequences of known species. Repositories of sequences are available online with tools that facilitate matching of the sequences of interest to a known individual. However, the performance of these tools can differ. Here we aim to assess the accuracy in identification of insect taxonomic categories from two repositories, BOLD Systems and GenBank. This was done by comparing the sequence matches between the taxonomist identification and the suggested identification from the platforms. We used 1,160 COI sequences representing eight orders of insects from Colombia. After the comparison, we reanalyzed the results from a representative subset of the data from the subfamily Scarabaeinae (Coleoptera). Overall, BOLD systems outperformed GenBank, and the performance of both engines differed by orders and other taxonomic categories (species, genus and family). Higher rates of accurate identification were obtained at family and genus levels. The accuracy was higher in BOLD for the order Coleoptera at family level, for Coleoptera and Lepidoptera at genus and species level. Other orders performed similarly in both repositories. Moreover, the Scarabaeinae subset showed that species were correctly identified only when BOLD match percentage was above 93.4% and a total of 85% of the samples were correctly assigned to a taxonomic category. These results accentuate the great potential of the identification engines to place insects accurately into their respective taxonomic categories based on DNA barcodes and highlight the reliability of BOLD Systems for insect identification in the absence of a large reference database for a highly diverse country.

الإتاحة: https://doi.org/10.1371/journal.pone.0277379Test

المؤلفون: Alvarado-Esquivel, Cosme, Estrada-Martínez, Sergio, Ramos-Nevarez, Agar, Alvarado-Félix, Ángel Osvaldo, Cerrillo-Soto, Sandra Margarita, Alvarado-Félix, Gustavo Alexis, Guido-Arreola, Carlos Alberto, Saenz-Soto, Leandro

المصدر: European Journal of Microbiology & Immunology; Jun2024, Vol. 14 Issue 2, p180-184, 5p

مصطلحات موضوعية: TOXOPLASMA gondii, ABDOMINAL pain, SEROPREVALENCE, AGE factors in disease, IMMUNOGLOBULIN G

مستخلص: Abdominal pain has been rarely reported in individuals infected with Toxoplasma gondii (T. gondii). The aim of this study was to determine the association between T. gondii infection and abdominal pain. Two hundred and ninety-nine patients with abdominal pain (cases) and 299 age- and gender-matched people without abdominal pain (controls) were tested for anti- T. gondii IgG and IgM antibodies. Twenty-four (8.0%) of the 299 cases and 12 (4.0%) of the 299 controls were positive for anti- T. gondii IgG antibodies (OR: 2.08; 95% CI: 1.02–4.25; P = 0.03). The seroprevalence of T. gondii infection was significantly higher in women with frequent abdominal pain than in women without this clinical feature (OR: 2.30; 95% CI: 1.06–4.96; P = 0.02). Twelve (4.0%) of the 299 cases and 7 (2.3%) of the 299 controls had high (>150 IU mL⁻¹) anti- T. gondii IgG antibody levels (OR: 1.74; 95% CI: 0.67–4.49; P = 0.24). Seven (29.2%) of the 24 cases with anti- T. gondii IgG antibodies and 3 (25.0%) of the 12 controls with anti- T. gondii IgG antibodies were positive to anti- T. gondii IgM antibodies (OR: 1.23; 95% CI: 0.25–5.97; P = 1.00). Results suggest an association between T. gondii infection and frequent abdominal pain. Further research to confirm this association should be conducted. [ABSTRACT FROM AUTHOR]

: Copyright of European Journal of Microbiology & Immunology is the property of Akademiai Kiado Zrt and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Torrez-Ruiz, Marisa S., Soto, Sandra, Lopez, Nanette V., Arredondo, Elva M.

المصدر: Advancing the Science of Cancer in Latinos ; page 177-188 ; ISBN 9783031144356 9783031144363

الوصف: As Latinxs become exposed to US culture, their risk for many chronic diseases increases, including the risk of cancer. On average, less acculturated Latinxs consume more nutrient-dense foods including fruits, vegetables, and whole grains; they are also more active than their US counterparts because they use active transportation. Cultural and behavioral patterns of recent immigrants may prove to be protective; these patterns are based on the Latinx values of collectivism, familismo , and personalismo . As generational status in the United States increases, positive health behaviors related to dietary intake and activity diminish. Interventions that reinforce these practices may mitigate the negative effects of the acculturation process by capitalizing on behaviors that are protective against the risk of cancer. Traditional Latinx cultural values can be integrated into public health practice and intervention, preserving traditional Latinx practices that are protective and promote positive health outcomes. The integration of cultural beliefs and values into research studies will increase relevancy for Latinx participants and contribute to compliance and long-term participation for improved population health.

الإتاحة: https://doi.org/10.1007/978-3-031-14436-3_15Test

المؤلفون: Pérez-Álamos, Alma Rosa, Aguilar-Durán, Marisela, Martínez, Sergio Estrada, Ramos-Nevárez, Agar, Guido-Arreola, Carlos Alberto, Sifuentes-Álvarez, Antonio, Cerrillo-Soto, Sandra Margarita, Ibarra, Raúl Graciano, Alvarado-Esquivel, Cosme

المصدر: European Journal of Microbiology & Immunology; Mar2024, Vol. 14 Issue 1, p44-49, 6p

مصطلحات موضوعية: ABO blood group system, TOXOPLASMA gondii, RH factor, IMMUNOGLOBULINS, SEROLOGY

مستخلص: We aimed to determine the association between the seropositivity to Toxoplasma gondii and the ABO and Rh blood groups in 2,053 people. ABO and Rhesus blood groups and anti-T. gondii IgG and IgM antibodies were determined using commercially available assays. Of the 2,053 people studied, 171 (8.3%) were positive for anti-T. gondii IgG antibodies. Sixty-five (38.0%) and 36 (21.1%) of these 171 individuals had high anti-T. gondii IgG antibody levels (=150 IU mL^-1) and anti-T. gondii IgM antibodies, respectively. We found the following prevalences of T. gondii infection among the ABO groups: 8.5% in group A, 4.3% in group B, 4.7% in group AB, and 8.9% in group O (P 5 0.19). The prevalences of T. gondii infection among Rh groups were: 8.4% in the Rh-positive group and 7.1% in the Rh-negative group (P 5 0.58). Logistic regression analysis showed that the frequencies of ABO and Rh blood groups were similar (P > 0.05) among people with positive and negative serology for anti-T. gondii IgG antibodies, with high (=150 IU mL^-1) and lower (<150 IU mL^-1) levels of anti-T. gondii IgG antibodies, and with positive and negative serology for anti-T. gondii IgM antibodies. Results does not support an association between T. gondii infection and ABO and Rh blood groups. [ABSTRACT FROM AUTHOR]

: Copyright of European Journal of Microbiology & Immunology is the property of Akademiai Kiado Zrt and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Morse, Rachel M, Brown, Joanna, Noble, Helen E, Ríos López, E Jennifer, Kohler-Smith, Anna, Soto, Sandra, Del Cuadro, Daniel Lenin, Gonzales Díaz, Karina, Figueredo Escudero, Magaly, Vásquez Del Aguila, Giannina, Carrillo Jara, Lita E, Silva Delgado, Hermann F, Palacios, Victor A, Santos-Ortiz, Carlos, Gravitt, Patti E, Paz-Soldan, Valerie A

المصدر: BMC women's health ; 22 ; 1 ; 414 ; England

مصطلحات موضوعية: Ablative therapy, Acceptability, Cervical cancer, Screen-and-treat, Thermal ablation

الوصف: BACKGROUND: The objective of this study was to explore women's experiences of a screen-and-treat approach with ablative therapy (referred to by the Spanish acronym TVT-TA) as a method of treatment following a positive HPV test in Iquitos, Peru. METHODS: A total of 111 in-depth interviews were conducted with 47 HPV positive women who attended the TVT-TA procedure at a primary-level healthcare facility. Interviews were conducted immediately before, immediately after, and six-weeks after TVT-TA. RESULTS: Most interviewed women reported experiencing moderate pain during ablative therapy and minimal pain immediately after and six weeks after ablative therapy. Women also stated that the pain was less intense than they had expected. The most common physical after-effects of treatment were bleeding and vaginal odor. Women experienced oscillating emotions with fear upon receiving a positive HPV result, calming after hearing about ablative therapy treatment, worry about pain from the treatment itself, relaxation with counseling about the procedure, and relief following treatment. CONCLUSIONS: Nearly all participants emphasized that they were pleased with the TVT-TA process even if they had experienced pain during TVT-TA, recommended that TVT-TA be expanded and available to more women, and stated that TVT-TA was faster and easier than expected. This study found that TVT-TA is a feasible and acceptable means of treating HPV according to the women receiving the treatment. © 2022. The Author(s). ; https://doi.org/10.1186/s12905-022-01943-3Test

العلاقة: BMC women's health; http://hdl.handle.net/10713/20019Test

الإتاحة: https://doi.org/10.1186/s12905-022-01943-3Test
http://hdl.handle.net/10713/20019Test