المؤلفون: Lezaic L., Erba P. A., Decristoforo C., Zaletel K., Mikolajczak R., Maecke H., Maina T., Konijnenberg M., Kolenc P., Trofimiuk-Muldner M., Przybylik-Mazurek E., Virgolini I., de Jong M., Froberg A. C., Rangger C., Di Santo G., Skorkiewicz K., Garnuszek P., Solnica B., Nock B. A., Fedak D., Gaweda P., Hubalewska-Dydejczyk A.

المساهمون: Lezaic, L, Erba, P, Decristoforo, C, Zaletel, K, Mikolajczak, R, Maecke, H, Maina, T, Konijnenberg, M, Kolenc, P, Trofimiuk-Muldner, M, Przybylik-Mazurek, E, Virgolini, I, de Jong, M, Froberg, A, Rangger, C, Di Santo, G, Skorkiewicz, K, Garnuszek, P, Solnica, B, Nock, B, Fedak, D, Gaweda, P, Hubalewska-Dydejczyk, A

مصطلحات موضوعية: CCK2/gastrin receptor targeting, Medullary thyroid cancer, Molecular imaging, Theranostic, Therapy

الوصف: Introduction: Medullary thyroid cancer (MTC) is a rare malignant tumour of the parafollicular C-cells with an unpredictable clinical course and currently suboptimal diagnostic and therapeutic options, in particular in advanced disease. Overexpression of cholecystokinin-2 receptors (CCK2R) represents a promising avenue to diagnostic imaging and targeted therapy, ideally through a theranostic approach. Materials and methods: A translational study (GRAN-T-MTC) conducted through a Phase I multicentre clinical trial of the indium-111 labelled CP04 ([111In]In-CP04), a CCK2R-seeking ligand was initiated with the goal of developing a theranostic compound. Patients with proven advanced/metastatic MTC or short calcitonin doubling time were enrolled. A two-step concept was developed through the use of low- and high-peptide mass (10 and 50 μg, respectively) for safety assessment, with the higher peptide mass considered appropriate for therapeutic application. Gelofusine was co-infused in a randomized fashion in the second step for the evaluation of potential reduction of the absorbed dose to the kidneys. Imaging for the purpose of biodistribution, dosimetry evaluation, and diagnostic assessment were performed as well as pre-, peri-, and postprocedural clinical and biochemical assessment. Results: Sixteen patients were enrolled. No serious adverse events after application of the compound at both peptide amounts were witnessed; transient tachycardia and flushing were observed in two patients. No changes in biochemistry and clinical status were observed on follow-up. Preliminary dosimetry assessment revealed the highest dose to urinary bladder, followed by the kidneys and stomach wall. The effective dose for 200 MBq of [111In]In-CP04 was estimated at 7±3 mSv and 7±1 mSv for 10 μg and 50 μg CP04, respectively. Administration of Gelofusine reduced the dose to the kidneys by 53%, resulting in the organ absorbed dose of 0.044±0.019 mSv/MBq. Projected absorbed dose to the kidneys with the use of [177Lu]Lu-CP04 was estimated at ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36334104; info:eu-repo/semantics/altIdentifier/wos/WOS:000879156200001; volume:50; issue:3; firstpage:892; lastpage:907; numberofpages:16; journal:EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING; https://hdl.handle.net/10281/419258Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85141434161

الإتاحة: https://doi.org/10.1007/s00259-022-05992-6Test
https://hdl.handle.net/10281/419258Test

المؤلفون: Peeters S. A., Engelen L., Buijs J., Chaturvedi N., Fuller J. H., Schalkwijk C. G., Stehouwer C. D., Karamanos B., Kofinis A., Petrou K., Giorgino F., Picca G., Angarano A., de Pergola. G., Laviola L., Giorgino R., Ionescu-Tirgoviste C., Coszma A., Guja C., Songini M., Casu A., Pedron M., Pintus S., Fossarello M., Ferriss J. B., Grealy G., O'Keefe D., Toeller M., Arden C., Rottiers R., Tuyttens C., Priem H., Ebeling P., Kylliainen M., Koivisto V. A., Idzior-Walus B., Sieradzki J., Cyganek K., Solnica B., Lemkes H. H. P. J., Lemkes-Stuffken J. C., Nunes-Correa J., Rogado M. C., Gardete-Correia L., Cardoso M. C., Silva A., Boavida J., Machado Sa Marques M., Michel G., Wirion R., Cardillo S., Pozza G., Mangili R., Asnaghi V., Standl E., Schaffler B., Brand H., Harms A., Ben Soussan M., Verier-Mine O., Fallas P., Fallas M. C., Holloway J., Asbury L., Betteridge D. J., Cathelineau G., Bouallouche A., Villatte Cathelineau B., Santeusanio F., Rosi G., D'Alessandro V., Cagini C., Bottini P., Reboldi G. P., Navalesi R., Penno G., Bandinelli S., Miccoli R., Nannipieri M., Ghirlanda G., Saponara C., Cotroneo P., Manto A., Minnella A., Ward J. D., Tesfaye S., Eaton S., Mody C., Borra M., Cavallo Perin P., Giunti S., Grassi G., Pagano G. F., Porta M., Sivieri R., Vitelli F., Veglio M., Papazoglou N., Manes G., Muggeo M., Iagulli M., Cacciatori V., Cattedra di Malattie del Metabolismo V., Irsigler K., Abrahamian H., Walford S., Sinclair J., Hughes S., McLelland V., Ward J., Roglic G., Metelko Z., Pepeonik Z. R.

المساهمون: Peeters, S. A., Engelen, L., Buijs, J., Chaturvedi, N., Fuller, J. H., Schalkwijk, C. G., Stehouwer, C. D., Karamanos, B., Kofinis, A., Petrou, K., Giorgino, F., Picca, G., Angarano, A., Pergola. G., De, Laviola, L., Giorgino, R., Ionescu-Tirgoviste, C., Coszma, A., Guja, C., Songini, M., Casu, A., Pedron, M., Pintus, S., Fossarello, M., Ferriss, J. B., Grealy, G., O'Keefe, D., Toeller, M., Arden, C., Rottiers, R., Tuyttens, C., Priem, H., Ebeling, P., Kylliainen, M., Koivisto, V. A., Idzior-Walus, B., Sieradzki, J., Cyganek, K., Solnica, B., Lemkes, H. H. P. J., Lemkes-Stuffken, J. C., Nunes-Correa, J., Rogado, M. C., Gardete-Correia, L., Cardoso, M. C., Silva, A., Boavida, J., Machado Sa Marques, M., Michel, G., Wirion, R., Cardillo, S., Pozza, G., Mangili, R., Asnaghi, V., Standl, E., Schaffler, B., Brand, H., Harms, A., Ben Soussan, M., Verier-Mine, O., Fallas, P., Fallas, M. C., Holloway, J., Asbury, L., Betteridge, D. J., Cathelineau, G., Bouallouche, A., Villatte Cathelineau, B., Santeusanio, F., Rosi, G., D'Alessandro, V., Cagini, C., Bottini, P., Reboldi, G. P., Navalesi, R., Penno, G., Bandinelli, S., Miccoli, R., Nannipieri, M., Ghirlanda, G., Saponara, C., Cotroneo, P., Manto, A., Minnella, A., Ward, J. D., Tesfaye, S., Eaton, S., Mody, C., Borra, M., Cavallo Perin, P., Giunti, S., Grassi, G., Pagano, G. F., Porta, M., Sivieri, R., Vitelli, F., Veglio, M., Papazoglou, N., Manes, G.

مصطلحات موضوعية: Albuminuria, Cardiovascular disease, Matrix metalloproteinase, Retinopathy, Tissue inhibitor of metalloproteinase, Type 1 diabete, Adult, Biomarker, Cohort Studie, Cross-Sectional Studie, Diabetes Complication, Diabetes Mellitus, Type 1, Europe, Female, Human, Male, Matrix Metalloproteinase 10, Matrix Metalloproteinase 2, Matrix Metalloproteinase 3, Middle Aged, Prospective Studie, Tissue Inhibitor of Metalloproteinase-1, Vascular Diseases

الوصف: Impaired regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to vascular complications in patients with type 1 diabetes. We investigated associations between plasma MMP-1, -2, -3, -9, -10 and TIMP-1, and cardiovascular disease (CVD) or microvascular complications in type 1 diabetic patients. We also evaluated to which extent these associations could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). Methods: 493 type 1 diabetes patients (39.5 ± 9.9 years old, 51% men) from the EURODIAB Prospective Complications Study were included. Linear regression analysis was applied to investigate differences in plasma levels of MMP-1, -2, -3, -9, -10, and TIMP-1 between patients with and without CVD, albuminuria or retinopathy. All analyses were adjusted for age, sex, duration of diabetes, Hba1c and additionally for other cardiovascular risk factors including LGI and ED. Results: Patients with CVD (n = 118) showed significantly higher levels of TIMP-1 [β = 0.32 SD (95%CI: 0.12; 0.52)], but not of MMPs, than patients without CVD (n = 375). Higher plasma levels of MMP-2, MMP-3, MMP-10 and TIMP-1 were associated with higher levels of albuminuria (p-trends were 0.028, 0.004, 0.005 and 0.001, respectively). Severity of retinopathy was significantly associated with higher levels of MMP-2 (p-trend = 0.017). These associations remained significant after further adjustment for markers of LGI and ED. Conclusions: These data support the hypothesis that impaired regulation of matrix remodeling by actions of MMP-2, -3 and-10 and TIMP-1 contributes to the pathogenesis of vascular complications in type 1 diabetes.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25848912; info:eu-repo/semantics/altIdentifier/wos/WOS:000350726000001; volume:14; issue:1; firstpage:31; journal:CARDIOVASCULAR DIABETOLOGY; http://hdl.handle.net/11586/353539Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84925234995

الإتاحة: https://doi.org/10.1186/s12933-015-0195-2Test
http://hdl.handle.net/11586/353539Test

المؤلفون: Zapala, B., Dziechciowski, M., Piwowar, M., Chmura, O., Duda-Wiewiorka, M., Skotniczny, K., Pitynski, K., Solnica, B.

المصدر: Clinica Chimica Acta ; volume 530, page S59 ; ISSN 0009-8981

مصطلحات موضوعية: Biochemistry (medical), Clinical Biochemistry, Biochemistry, General Medicine

الإتاحة: https://doi.org/10.1016/j.cca.2022.04.260Test
https://api.elsevier.com/content/article/PII:S0009898122003898?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0009898122003898?httpAccept=text/plainTest

المؤلفون: Kaczynski, L., Solnica, B.

المصدر: Value in Health ; volume 17, issue 7, page A731-A732 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2014.08.085Test
https://api.elsevier.com/content/article/PII:S1098301514020154?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1098301514020154?httpAccept=text/plainTest

المؤلفون: Kaczynski, L., Solnica, B.

المصدر: Value in Health ; volume 15, issue 7, page A488-A489 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2012.08.1618Test
https://api.elsevier.com/content/article/PII:S1098301512033311?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1098301512033311?httpAccept=text/plainTest

المؤلفون: Giorgino, F., Laviola, L., Cavallo Perin, P., Solnica, B., Fuller, J., Chaturvedi, N.

المصدر: Diabetologia ; volume 47, issue 6 ; ISSN 0012-186X 1432-0428

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism, Internal Medicine

الإتاحة: https://doi.org/10.1007/s00125-004-1413-8Test

المؤلفون: Góralska, J, Raźny, U, Polus, A, Stancel-Możwiłło, J, Chojnacka, M, Gruca, A, Zdzienicka, A, Dembińska-Kieć, A, Kieć-Wilk, B, Solnica, B, Malczewska-Malec, M

المصدر: International Journal of Obesity ; volume 42, issue 4, page 826-834 ; ISSN 0307-0565 1476-5497

مصطلحات موضوعية: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous)

الإتاحة: https://doi.org/10.1038/ijo.2017.305Test
http://www.nature.com/articles/ijo2017305.pdfTest
http://www.nature.com/articles/ijo2017305Test

المؤلفون: Malczewska-Malec, M., Polus, A., Goralska, J., Razny, U., Dembinska-Kiec, A., Solnica, B.

المصدر: Atherosclerosis ; volume 252, page e177 ; ISSN 0021-9150

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.atherosclerosis.2016.07.831Test
https://api.elsevier.com/content/article/PII:S0021915016311327?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021915016311327?httpAccept=text/plainTest

المؤلفون: Góralska, J., Malczewska-Malec, M., Razny, U., Zdzienicka, A., Gruca, A., Chabowski, A., Sanak, M., Dembinska-Kiec, A., Solnica, B.

المصدر: Atherosclerosis ; volume 252, page e59 ; ISSN 0021-9150

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.atherosclerosis.2016.07.424Test
https://api.elsevier.com/content/article/PII:S0021915016307250?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021915016307250?httpAccept=text/plainTest

المؤلفون: Soedamah Muthu SS, Chaturvedi N, Fuller JH, Toeller M, Karamanos B, Kofinis A, Petrou K, Giorgino F, Picca G, Angarano A, De Pergola G, Laviola L, Giorgino R, Ionescu Tirgoviste C, Coszma A, Guja C, Songini M, Casu A, Pedron M, Pintus S, FOSSARELLO, MAURIZIO, Ferriss J, O'Keefe D, Grealy G, Arden C, Rottiers R, Tuyttens C, Priem H, Ebeling P, Kyllia M, Koivisto V, Idzior Walus B, Sieradzki J, Cyganek K, Solnica B, Lemkes H, Lemkes Stuffken J, Rogado M, Gardete Correia L, Cardoso M, Silva A, Boavida J, Machado Sa Marques M, Michel G, Wirion R, Cardillo S, Pozza G, Mangili R, Asnaghi V, Standl E, Schaffler B, Brand H, Soussan D, Verier O, Fallas P, Fallas M, Fuller J, Holloway J, Asbury L, Betteridge D, Cathelineau G, Bouallouche A, Cathelineau B, Santeusanio F, Rosi G, D'Alessandro V, Cagini C, Bottini P, Reboldi G, Navalesi R, Penno G, Bandinelli S, Miccoli R, Nannipieri M, Ghirlanda G, Saponara C, Cotroneo P, Manto A, Ward J, Tesfaye S, Eaton S, Mody C, Borra M, Perin PC, Giunti S, Grassi G, Pagano G, Porta M, Sivieri R, Vitelli F, Veglio M, Papazoglou N, Manes G, Muggeo M, Iagulli M, Cacciatori V, Cattedra V, Irsigler K, Abrahamian H, Walford S, Sinclair J, Hughes S, McLelland V, Roglic G, Metelko Z, Pepeonik Z, Ferriss B, Webb D, Viberti GC, Swaminathan R, Lumb P, Collins A, Sankaralingham S, Crook MA, Aldington S, Mortemore T, Lipinski H, Scherbaum WA, Gries F.A.

المساهمون: Soedamah Muthu, S, Chaturvedi, N, Fuller, Jh, Toeller, M, Karamanos, B, Kofinis, A, Petrou, K, Giorgino, F, Picca, G, Angarano, A, De Pergola, G, Laviola, L, Giorgino, R, Ionescu Tirgoviste, C, Coszma, A, Guja, C, Songini, M, Casu, A, Pedron, M, Pintus, S, Fossarello, Maurizio, Ferriss, J, O'Keefe, D, Grealy, G, Arden, C, Rottiers, R, Tuyttens, C, Priem, H, Ebeling, P, Kyllia, M, Koivisto, V, Idzior Walus, B, Sieradzki, J, Cyganek, K, Solnica, B, Lemkes, H, Lemkes Stuffken, J, Rogado, M, Gardete Correia, L, Cardoso, M, Silva, A, Boavida, J, Machado Sa Marques, M, Michel, G, Wirion, R, Cardillo, S, Pozza, G, Mangili, R, Asnaghi, V, Standl, E, Schaffler, B, Brand, H, Soussan, D, Verier, O, Fallas, P, Fallas, M, Fuller, J, Holloway, J, Asbury, L, Betteridge, D, Cathelineau, G, Bouallouche, A, Cathelineau, B, Santeusanio, F, Rosi, G, D'Alessandro, V, Cagini, C, Bottini, P, Reboldi, G, Navalesi, R, Penno, G, Bandinelli, S, Miccoli, R, Nannipieri, M, Ghirlanda, G, Saponara, C, Cotroneo, P, Manto, A, Ward, J, Tesfaye, S, Eaton, S, Mody, C, Borra, M, Perin, Pc, Giunti, S, Grassi, G, Pagano, G, Porta, M, Sivieri, R, Vitelli, F, Veglio, M, Papazoglou, N, Manes, G, Muggeo, M, Iagulli, M, Cacciatori, V, Cattedra, V, Irsigler, K, Abrahamian, H

الوصف: BACKGROUND/OBJECTIVES: Individuals with type 1 diabetes have a high risk of developing cardiovascular diseases, and it has been reported that they consume a high atherogenic diet. We examined how nutrient intake and adherence to current European nutritional recommendations evolved in a large cohort of European individuals with type 1 diabetes over a period of 7 years. SUBJECTS/METHODS: We analysed data from the EURODIAB Prospective Complications Study, a European multicentre prospective cohort study. Standardized 3-day dietary records were employed in individuals with type 1 diabetes. One thousand one hundred and two patients (553 men, 549 women, baseline age 33 ± 10 years, duration 15 ± 9 years) had complete nutritional data available at baseline and after 7 years. We calculated mean differences in reported nutrients over time and adjusted these for age, gender, HbA1c and BMI with ANOVA models. RESULTS: Compared to baseline, there were minor changes in nutrients. Reported protein (-0.35% energy (en), fat (-1.07% en), saturated fat (-0.25% en) and cholesterol (-7.42 mg/1000 kcal) intakes were lower, whereas carbohydrate (+1.23% en) and fibre (+0.46 g/1000 kcal) intakes were higher at the 7-year follow-up. European recommendations for adequate nutrient intakes were followed in individuals with type 1 diabetes for protein (76% at baseline and 78% at follow-up), moderately for fat (34, 40%), carbohydrate (34, 41%) and cholesterol (39, 47%), but poorly for fibre (1.4, 2.4%) and saturated fat (11, 13%). CONCLUSION: European individuals with type 1 diabetes consume a high atherogenic diet as few patients met recommendations for dietary fibre and saturated fat. This study showed minor changes in dietary nutrients and energy intakes over a period of 7 years. Nutrition education needs particular focus on strategies to increase dietary fibre and reduce saturated fat to exploit their potential benefit

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/23224030; info:eu-repo/semantics/altIdentifier/wos/WOS:000324833000002; volume:52; issue:7; firstpage:1701; lastpage:1710; numberofpages:10; journal:EUROPEAN JOURNAL OF NUTRITION; http://hdl.handle.net/11584/59760Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84885471550

الإتاحة: https://doi.org/10.1007/s00394-012-0473-7Test
http://hdl.handle.net/11584/59760Test