المؤلفون: Hariri, Zahra, Yari, Zahra, Hoseini, Sedighe, Abhari, Khadijeh, Sohrab, Golbon

المصدر: BMC Women's Health ; volume 24, issue 1 ; ISSN 1472-6874

مصطلحات موضوعية: Obstetrics and Gynecology, Reproductive Medicine, General Medicine

الوصف: Background There are complicated mechanisms that link the disruption of the gut microbiome to the symptoms and complications of polycystic ovary syndrome (PCOS). In this study, an attempt was made to assess the effects of synbiotics on the health-related quality of life (HRQoL) in women with PCOS . Methods Fifty-six women with PCOS were enrolled in a triple-blind controlled trial for 12 weeks. They were randomly assigned to receive a daily 2-gram synbiotic sachets (containing Bacillus coagulans (GBI-30), Lactobacillus rhamnosus, Lactobacillus helveticus, and fructooligosaccharide) (n = 28) or placebo (n = 28). To evaluate the impact on the HRQoL, participants were required to fill 26-Item Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire (PCOSQ-26), 12-Item Short-Form Health Survey (SF-12) and Perceived Stress Scale (PSS-10) pre and post the intervention. Results Finally, statistical analyses were performed on 52 participants who finished the trial. Synbiotic supplementation improved the scores of emotional ( P = 0.044), body hair ( P = 0.016), weight ( P = 0.033) and infertility domains ( P = 0.027) of PCOSQ-26 compared to placebo group. The physical score within SF-12 also had a significant enhancement ( P = 0.035). No significant improvement was seen in the PSS-10 score at the end of the trial. Conclusion This study illustrated the advantageous effects of synbiotics on the health-related quality of life in women with PCOS. Further studies are required to confirm our findings. Trial registration http://www.irct.irTest : IRCT20211108053007N1; date of registration: 14/02/2023.

الإتاحة: https://doi.org/10.1186/s12905-023-02868-1Test

المؤلفون: Hariri, Zahra, Afzalzade, Fatemeh, Sohrab, Golbon, Saadati, Saeede, Yari, Zahra

المصدر: Systematic Reviews ; volume 12, issue 1 ; ISSN 2046-4053

مصطلحات موضوعية: Medicine (miscellaneous)

الوصف: Background We aimed to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to investigate the effects of rice bran supplementation on serum lipid profile levels. Methods We searched PubMed/Medline, Scopus, ISI Web of Science, and Google Scholar using related keywords. Published RCTs exploring the effects of rice bran consumption on lipid profile were searched up to June 2022. Evidence certainty was assessed on the basis of the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. The data were pooled using a random-effects model and reported as weighted mean difference (WMD) and 95% confidence interval (CI) for each outcome. Results Meta-analysis of eight RCTs (with 11 effect sizes) showed no significant effect of rice bran supplementation on serum levels of triglyceride (WMD: -11.38 mg/dl; 95% CI: -27.73, 4.96; P = 0.17), total cholesterol (WMD: -0.68 mg/dl; 95% CI: -7.25, 5.88; P = 0.834), low-density lipoprotein cholesterol (WMD: -1.68 mg/dl; 95% CI: -8.46, 5.09; P = 0.627) and high-density lipoprotein cholesterol (WMD: 0.16 mg/dl; 95% CI: -1.52, 1.85; P = 0.848) compared to control group. Conclusion Our meta-analysis suggests that rice bran supplementation has no significant effects on serum levels of lipid profile components. However, larger studies with longer durations and improved methodological quality are needed before firm conclusions can be reached.

الإتاحة: https://doi.org/10.1186/s13643-023-02228-yTest

المؤلفون: Nikpayam, Omid, Jafari, Ali, Safaei, Ehsan, Naghshi, Niayesh, Najafi, Marziyeh, Sohrab, Golbon

المساهمون: Golestan University of Medical Sciences

المصدر: Journal of Functional Foods ; volume 110, page 105867 ; ISSN 1756-4646

مصطلحات موضوعية: Nutrition and Dietetics, Medicine (miscellaneous), Food Science

الإتاحة: https://doi.org/10.1016/j.jff.2023.105867Test
https://api.elsevier.com/content/article/PII:S175646462300467X?httpAccept=text/xmlTest
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المؤلفون: Ahmadzadeh, Mina, Sohrab, Golbon, Alaei, Mohammadreza, Eini-Zinab, Hassan, mohammadpour-Ahranjani, Behzad, Rastgoo, Samira, Namkhah, Zahra

المساهمون: The National Nutrition & Food Technology Research Institute’s Research Ethics Committees

المصدر: BMC Pediatrics ; volume 22, issue 1 ; ISSN 1471-2431

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الوصف: Background The goal of this study was to assess the anthropometric and biochemical parameters of children and adolescents with phenylketonuria (PKU). Methods The participants in this cross-sectional study ranged in age from four to 18 years old. Biochemical markers such as vitamin B12, folic acid, iron, ferritin, calcium, 25-hydroxy vitamin D3, zinc, plasma phenylalanine (Phe) and tyrosine (Tyr) levels in blood were evaluated, as well as demographics and anthropometric measurements. A three-day dietary recall questionnaire was completed by all individuals. Results 80% (64) of the 80 patients (42 females, 52.5%) had typical PKU. Consanguineous marriages were found in 57.5% (46) of the patients’ parents. According to the height for age index, 17.5% of the study group (n = 14) were short or very short. According to age-related weight and body mass index (BMI), 37.5% (n = 30) and 43.8% (n = 35) of people are obese or overweight, respectively. Biochemical tests revealed increased vitamin B12 levels and 25-hydroxy vitamin D3 deficiency in 35% (n = 28) of the patients, insufficient folic acid in 12.5% (n = 10), and elevated phenylalanine levels in 70.3% (n = 45) of children under 12 years old, and adolescents 62.5% (n = 10). A high Phe intake (OR = 4.44, CI %95 = 1.27–15.57) is a risk factor for obesity and overweight. Conclusion Patients with PKU had a high rate of overweight and obesity. PKU patients who are overweight or obese do not differ from normal-weight patients in terms of dietary intake or laboratory findings (except for serum iron levels). One-third of patients with phenylketonuria were vitamin D deficient and had a BMI/A index of overweight/obese. It is recommended to use special medical food to help solve energy and nutrient deficiencies.

الإتاحة: https://doi.org/10.1186/s12887-022-03715-2Test

المؤلفون: Velayati, Aynaz, Kareem, Iman, Sedaghat, Meghdad, Sohrab, Golbon, Nikpayam, Omid, Hedayati, Mehdi, Abhari, Khadijeh, Hejazi, Ehsan

المصدر: Archives of Physiology & Biochemistry; 2023, Vol. 129 Issue 6, p1211-1218, 8p

مصطلحات موضوعية: LACTOBACILLUS acidophilus, TYPE 2 diabetes, LACTOBACILLUS rhamnosus, BACILLUS (Bacteria), PEOPLE with diabetes, GLYCEMIC index

مستخلص: This study aimed to determine the effect of Bacillus Coagulans symbiotic supplementation on metabolic factors and inflammation in patients with type-2 diabetes. In this clinical trial, 50 patients with type-2 diabetes were randomly assigned to the symbiotic (containing Bacillus Coagulans + Lactobacillus rhamnosus + Lactobacillus acidophilus and fructooligosaccharide) or placebo groups to receive one sachet daily for 12 weeks. Glycaemic Index, lipid profile, and hs-CRP were measured at the beginning and end of the study. Analysis of covariance demonstrated that fasting blood glucose (FBG), insulin, homeostatic Model Assessment for Insulin Resistance (HOMA-IR), β-cell function (HOMA-β) (p <.05) and hs-CRP (p <.05) significantly declined in the treatment group compared with the placebo group. So, the current study indicated that Bacillus Coagulans symbiotic supplementation could improve metabolic factors and inflammation in patients with type-2 diabetes. [ABSTRACT FROM AUTHOR]

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المؤلفون: Behrouz, Vahideh, Dastkhosh, Ali, Hedayati, Mehdi, Sedaghat, Meghdad, Sharafkhah, Maryam, Sohrab, Golbon

المساهمون: Shahid Beheshti University of Medical Sciences

المصدر: Diabetology & Metabolic Syndrome ; volume 12, issue 1 ; ISSN 1758-5996

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism, Internal Medicine

الوصف: Background Crocin as a carotenoid exerts anti-oxidant, anti-inflammatory, anti-cancer, neuroprotective and cardioprotective effects. Besides, the increasing prevalence of diabetes mellitus and its allied complications, and also patients' desire to use natural products for treating their diseases, led to the design of this study to evaluate the efficacy of crocin on glycemic control, insulin resistance and active adenosine monophosphate-activated protein kinase (AMPK) levels in patients with type-2 diabetes (T2D). Methods In this clinical trial with a parallel-group design, 50 patients with T2D received either 15-mg crocin or placebo, twice daily, for 12 weeks. Anthropometric measurements, dietary intake, physical activity, blood pressure, glucose homeostasis parameters, active form of AMPK were assessed at the beginning and at the end of the study. Results Compared with the placebo group, crocin improved fasting glucose level ( P = 0.015), hemoglobin A1c ( P = 0.045), plasma insulin level ( P = 0.046), insulin resistance ( P = 0.001), and insulin sensitivity ( P = 0.001). Based on the within group analysis, crocin led to significant improvement in plasma levels of glucose, insulin, hemoglobin A1c, systolic blood pressure, insulin resistance and insulin sensitivity. The active form of AMPK did not change within and between groups after intervention. Conclusions The findings indicate that crocin supplementation can improve glycemic control and insulin resistance in patients with T2D. Further studies are needed to confirm these findings. Trial Registration This study has been registered at Clinicaltrial.gov with registration number NCT04163757

الإتاحة: https://doi.org/10.1186/s13098-020-00568-6Test

المؤلفون: Hariri, Zahra, Yari, Zahra, Hoseini, Sedighe, Mehrnami, Afsaneh, Abhari, Khadijeh, Sohrab, Golbon

المصدر: Clinical Therapeutics ; volume 45, issue 10, page e193-e199 ; ISSN 0149-2918

مصطلحات موضوعية: Pharmacology (medical), Pharmacology

الإتاحة: https://doi.org/10.1016/j.clinthera.2023.07.024Test
https://api.elsevier.com/content/article/PII:S0149291823002990?httpAccept=text/xmlTest
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المؤلفون: Hodaei, Homa, Adibian, Mahsa, Nikpayam, Omid, Hedayati, Mehdi, Sohrab, Golbon

المساهمون: National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences

المصدر: Diabetology & Metabolic Syndrome ; volume 11, issue 1 ; ISSN 1758-5996

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism, Internal Medicine

الوصف: Background Diabetes mellitus is a common metabolic disorders in human and affect a lot of people around the world. Curcumin is a component of turmeric and in many studies therapeutic effects such as anti-hypertensive, anti-hyperlipidemia, anti-hyperglycemia for this substance are shown. Aim The aim of this study was to investigate the effect of curcumin supplementation on anthropometric indices glycemic control and oxidative stress in overweight patients with type 2 diabetes. Materials and methods In this randomized, double-blind, placebo-controlled trial, 53 participants with type 2 diabetes were divided randomly into the experimental and control groups to receive either 1500 mg curcumin or placebo capsule three times in a day for 10 weeks. Result Supplementation with curcumin in type 2 diabetes compare to placebo causes a significant changes in mean weight (− 0.64 ± 0.22 vs. 0.19 ± 0.37 p < 0.05), body mass index (BMI) (0.3 ± 0.03 vs. 0.1 ± 0 p < 0.05), waist circumference (WC) (− 1.2 ± 0.4 vs. − 0.43 ± 0.11 p < 0.05) and fasting blood sugar (FBS) (− 7 ± 2 vs. 3 ± 0.2 p < 0.05) but did not show any difference for hemoglobin A1c (HbA1c), insulin, malondialdehyde (MDA), total antioxidant capacity (TAC), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and pancreatic B cell function (HOMA-B) at end of study. Conclusion This study indicated that daily administration of 1500 mg curcumin has positive effects in reducing fasting blood glucose and weight in patients with type 2 diabetes. Trial registration NCT02529982. Registered 19 August 2015, http://www.clinicaltrial.govTest

الإتاحة: https://doi.org/10.1186/s13098-019-0437-7Test

المؤلفون: Nikpayam, Omid, Najafi, Marziyeh, Ghaffari, Samad, Jafarabadi, Mohammad Asghari, Sohrab, Golbon, Roshanravan, Neda

المصدر: Diabetology & Metabolic Syndrome ; volume 11, issue 1 ; ISSN 1758-5996

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism, Internal Medicine

الوصف: Many studies have investigated the relationship between coffee and diabetes. Evaluation of the current evidence on the effect of coffee intake on diabetes is critical. Therefore, we aimed to investigate the potential association between green coffee extract (GCE) and fasting blood glucose (FBG), insulin and homeostatic model assessment of insulin resistance (HOMA-IR) by pooling together the results from clinical trials. PubMed, Scopus and Google Scholar were searched for experimental studies which have been published up to December 2018. Randomized controlled trials (RCTs) that investigated the effect of GCE supplementation on FBG, insulin and HOMA-IR in adults were included for final analysis. A total of six articles were included in the meta-analysis. Results revealed that GCE supplementation reduced FBG level (SMD: −0.32, 95% CI − 0.59 to − 0.05, P = 0.02) but had no effect on insulin levels (SMD: −0.22, 95% CI −0.53 to 0.09, P = 0.159). Although analysis showed that GCE supplementation cannot change the HOMA-IR status (SMD: −0.30, 95% CI −0.73 to 0.13, P = 0.172), after stratified studies by GCE dosage (< 400 mg/day versus > 400 mg/day) there was a significant decrease in HOMA-IR status in a dose greater than 400 mg. These findings suggest that GCE intake might be associated with FBG improvement.

الإتاحة: https://doi.org/10.1186/s13098-019-0489-8Test

المؤلفون: Hariri, Zahra, Afzalzade, Fatemeh, Sohrab, Golbon, Saadati, Saeede, Yari, Zahra

الوصف: Additional file 1: Table S1. Risk of bias assessment. Table S2. GRADE profile of rice bran supplementation for lipid profile. Figure S2.A. Forest plot detailing weighted mean difference and 95% confidence intervals (CIs) for the effect of rice bran supplementation on triglycerides (TG). Figure S2.B. Forest plot detailing weighted mean difference and 95% confidence intervals (CIs) for the effect of rice bran supplementation on total cholesterol (TC). Figure S2.C. Forest plot detailing weighted mean difference and 95% confidence intervals (CIs) for the effect of rice bran supplementation on low density lipoprotein cholesterol (LDL-C). Figure S2.D. Forest plot detailing weighted mean difference and 95% confidence intervals (CIs) for the effect of rice bran supplementation on high density lipoprotein cholesterol (HDL-C). Figure S3. Funnel plot for the effect of rice bran supplementation on A) TG; B) TC; C) LDL-C and D) HDL-C. Abbreviations: TG: triglycerides; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol. Figure S4. Non-linear dose-response relations between dose of rice bran supplementation (g/day) and absolute mean differences in A) TG; B) TC; C) LDL-C and D) HDL-C. Abbreviations: TG: triglycerides; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol. Figure S5. Non-linear dose-response relations between duration of intervention (week) and absolute mean differences in A) TG; B) TC C) LDL-C and D) HDL-C. Abbreviations: TG: triglycerides; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol. Figure S6. Bubble plots of the association between dose of rice bran (g/day) and weighted mean difference of A) TG; B) TC; C) LDL-C and D) HDL-C. The size of the bubbles is proportional to the accuracy of the estimate. Abbreviations: TG: triglycerides; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol. Figure S7. Bubble plots of the association between duration of intervention and weighted mean difference of A) TG; B) TC C) LDL-C and B) HDL-C. The size of the bubbles is proportional to the accuracy of the estimate. Abbreviations: TG: triglycerides; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol. Search strategy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072f23000c3b2b185b5655f933ec20b7Test