المؤلفون: Dombrowska-Pali, Agnieszka, Wiktorczyk-Kapischke, Natalia, Chrustek, Agnieszka, Olszewska-Słonina, Dorota, Gospodarek-Komkowska, Eugenia, Socha, Maciej W.

المصدر: Nutrients; May2024, Vol. 16 Issue 10, p1420, 36p

مستخلص: One of the most important bioactive components of breast milk are free breast milk oligosaccharides, which are a source of energy for commensal intestinal microorganisms, stimulating the growth of Bifidobacterium, Lactobacillus, and Bacteroides in a child's digestive tract. There is some evidence that maternal, perinatal, and environmental-cultural factors influence the modulation of the breast milk microbiome. This review summarizes research that has examined the composition of the breast milk microbiome and the factors that may influence it. The manuscript highlights the potential importance of the breast milk microbiome for the future development and health of children. The origin of bacteria in breast milk is thought to include the mother's digestive tract (entero-mammary tract), bacterial exposure to the breast during breastfeeding, and the retrograde flow of breast milk from the infant's mouth to the woman's milk ducts. Unfortunately, despite increasingly more precise methods for assessing microorganisms in human milk, the topic of the human milk microbiome is still quite limited and requires scientific research that takes into account various conditions. [ABSTRACT FROM AUTHOR]

: Copyright of Nutrients is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Flis, Wojciech^1,2 (AUTHOR) wflis@copernicus.gda.pl, Socha, Maciej W.^1,2 (AUTHOR) msocha@copernicus.gda.pl

المصدر: Cells (2073-4409). Apr2024, Vol. 13 Issue 7, p600. 22p.

مصطلحات موضوعية: *FRUIT ripening, *NLRP3 protein, *CHILDBIRTH, *INFLAMMASOMES, *PREMATURE labor, *CERVIX uteri, *INFLAMMATORY mediators

مستخلص: The uterine cervix is one of the key factors involved in ensuring a proper track of gestation and labor. At the end of the gestational period, the cervix undergoes extensive changes, which can be summarized as a transformation from a non-favorable cervix to one that is soft and prone to dilation. During a process called cervical ripening, fundamental remodeling of the cervical extracellular matrix (ECM) occurs. The cervical ripening process is a derivative of many interlocking and mutually driving biochemical and molecular pathways under the strict control of mediators such as inflammatory cytokines, nitric oxide, prostaglandins, and reactive oxygen species. A thorough understanding of all these pathways and learning about possible triggering factors will allow us to develop new, better treatment algorithms and therapeutic goals that could protect women from both dysfunctional childbirth and premature birth. This review aims to present the possible role of the NLRP3 inflammasome in the cervical ripening process, emphasizing possible mechanisms of action and regulatory factors. [ABSTRACT FROM AUTHOR]

المؤلفون: Socha, Maciej W., Flis, Wojciech, Wartęga, Mateusz

المصدر: Nutrients; Mar2024, Vol. 16 Issue 5, p678, 22p

مستخلص: Pregnancy is an extremely stressful period in a pregnant woman's life. Currently, women's awareness of the proper course of pregnancy and its possible complications is constantly growing. Therefore, a significant percentage of women increasingly reach for various dietary supplements during gestation. Some of the most popular substances included in multi-ingredient supplements are folic acid and choline. Those substances are associated with positive effects on fetal intrauterine development and fewer possible pregnancy-associated complications. Recently, more and more attention has been paid to the impacts of specific environmental factors, such as diet, stress, physical activity, etc., on epigenetic modifications, understood as changes occurring in gene expression without the direct alteration of DNA sequences. Substances such as folic acid and choline may participate in epigenetic modifications by acting via a one-carbon cycle, leading to the methyl-group donor formation. Those nutrients may indirectly impact genome phenotype by influencing the process of DNA methylation. This review article presents the current state of knowledge on the use of folic acid and choline supplementation during pregnancy, taking into account their impacts on the maternal–fetal unit and possible pregnancy outcomes, and determining possible mechanisms of action, with particular emphasis on their possible impacts on epigenetic modifications. [ABSTRACT FROM AUTHOR]

: Copyright of Nutrients is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Socha, Maciej W., Malinowski, Bartosz, Puk, Oskar, Wartęga, Mateusz, Bernard, Piotr, Nowaczyk, Monika, Wolski, Bartłomiej, Wiciński, Michał

المصدر: Critical Reviews in Oncology/Hematology ; volume 164, page 103419 ; ISSN 1040-8428

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.critrevonc.2021.103419Test
https://api.elsevier.com/content/article/PII:S1040842821002079?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1040842821002079?httpAccept=text/plainTest

المؤلفون: Socha, Maciej W.^1,2 (AUTHOR) msocha@copernicus.gda.pl, Chmielewski, Jakub² (AUTHOR), Pietrus, Miłosz³ (AUTHOR), Wartęga, Mateusz⁴ (AUTHOR)

المصدر: International Journal of Molecular Sciences. Aug2023, Vol. 24 Issue 16, p12743. 19p.

مصطلحات موضوعية: *PREECLAMPSIA, *PATHOLOGICAL physiology, *CHRONIC kidney failure, *CONGESTIVE heart failure, *HYPERTENSION, *CARDIOVASCULAR diseases

مستخلص: Preeclampsia (PE), the most severe presentation of hypertensive disorders of pregnancy, is the major cause of morbidity and mortality linked to pregnancy, affecting both mother and fetus. Despite advances in prophylaxis and managing PE, delivery of the fetus remains the only causative treatment available. Focus on complex pathophysiology brought the potential for new treatment options, and more conservative options allowing reduction of feto-maternal complications and sequelae are being investigated. Endogenous digitalis-like factors, which have been linked to the pathogenesis of preeclampsia since the mid-1980s, have been shown to play a role in the pathogenesis of various cardiovascular diseases, including congestive heart failure and chronic renal disease. Elevated levels of EDLF have been described in pregnancy complicated by hypertensive disorders and are currently being investigated as a therapeutic target in the context of a possible breakthrough in managing preeclampsia. This review summarizes mechanisms implicating EDLFs in the pathogenesis of preeclampsia and evidence for their potential role in treating this doubly life-threatening disease. [ABSTRACT FROM AUTHOR]

المؤلفون: Socha, Maciej W., Flis, Wojciech, Pietrus, Miłosz, Wartęga, Mateusz

المصدر: Biomedicines; Aug2023, Vol. 11 Issue 8, p2125, 10p

مصطلحات موضوعية: INDUCED labor (Obstetrics), VAGINAL birth after cesarean, FETAL heart rate, CESAREAN section, URINARY catheters, PROSTAGLANDINS

مستخلص: (1) Background: Induction of labor is currently the most frequently performed procedure in modern obstetrics, referring to more than one in five women, and it is postulated that the percentage of labor induction will increase. (2) Methods: In total, 2935 patients in uncomplicated full-term pregnancy fulfilled the study inclusion criteria and underwent induction of labor. Pregnant women were divided into three groups: IOL with Dinoprostone, Misoprostol vaginal suppositories, and Foley catheter. Outcomes, including cesarean section rates, time to delivery, and cesarean section indications, were analyzed. (3) Results: There was statistically significantly more cesarean sections within 24 h in the Misoprostol group in comparison with the Dinoprostone and Foley catheter groups (p < 0.0001). The percentage of patients who had a cesarean section due to clinically diagnosed threatened fetal asphyxia was 63% in the Dinoprostone group, 81.3% in the Misoprostol group, and 55.3% in the Foley catheter group. There were statistically significantly more cesarean deliveries due to nonreassuring fetal heart rate patterns within 24 h in the Misoprostol group in comparison with the Dinoprostone and Foley catheter groups (p = 0.0031 and p = 0.0363). (4) Conclusions: Misoprostol may cause a more turbulent and violent course of labor, with a higher rate of increased incidence of nonreassuring fetal heart rate patterns and cesarean deliveries. The use of a Dinoprostone vaginal insert or Foley catheter may provide longer labor, although still within 48 h, with a lower risk of cesarean section caused by nonreassuring fetal heart rate patterns. [ABSTRACT FROM AUTHOR]

: Copyright of Biomedicines is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Socha, Maciej W., Flis, Wojciech, Pietrus, Miłosz, Wartęga, Mateusz

العلاقة: Pharmaceuticals, T. 16, nr 7; https://ruj.uj.edu.pl/xmlui/handle/item/317701Test; https://www.mdpi.com/1424-8247/16/7/982Test

الإتاحة: https://doi.org/10.3390/ph16070982Test
https://ruj.uj.edu.pl/xmlui/handle/item/317701Test
https://www.mdpi.com/1424-8247/16/7/982Test

المؤلفون: Socha, Maciej W., Flis, Wojciech, Pietrus, Miłosz, Wartęga, Mateusz, Szambelan, Monika

العلاقة: Journal of Clinical Medicine, T. 12, nr 14; https://ruj.uj.edu.pl/xmlui/handle/item/317472Test; https://www.mdpi.com/2077-0383/12/14/4839Test

الإتاحة: https://doi.org/10.3390/jcm12144839Test
https://ruj.uj.edu.pl/xmlui/handle/item/317472Test
https://www.mdpi.com/2077-0383/12/14/4839Test

المؤلفون: Pietrus, Miłosz, Pityński, Kazimierz, Waligóra, Marcin, Milian-Ciesielska, Katarzyna, Ludwin, Artur, Socha, Maciej W., Skrzypek, Klaudia

العلاقة: International Journal of Molecular Sciences, T. 24, nr 9; https://ruj.uj.edu.pl/xmlui/handle/item/311358Test; https://www.mdpi.com/1422-0067/24/9/8342Test

الإتاحة: https://doi.org/10.3390/ijms24098342Test
https://ruj.uj.edu.pl/xmlui/handle/item/311358Test
https://www.mdpi.com/1422-0067/24/9/8342Test

المؤلفون: Socha, Maciej W., Flis, Wojciech, Wartęga, Mateusz, Szambelan, Monika, Pietrus, Miłosz, Kazdepka-Ziemińska, Anita

المصدر: Nutrients; Jul2023, Vol. 15 Issue 14, p3206, 17p

مستخلص: The gestational period is an incredibly stressful time for a pregnant woman. Pregnant patients constantly seek effective and reliable compounds in order to achieve a healthy labor. Nowadays, increasing numbers of women use herbal preparations and supplements during pregnancy. One of the most popular and most frequently chosen herbs during pregnancy is the raspberry leaf (Rubus idaeus). Raspberry extracts are allegedly associated with a positive effect on childbirth through the induction of uterine contractions, acceleration of the cervical ripening, and shortening of childbirth. The history of the consumption of raspberry leaves throughout pregnancy is vast. This review shows the current status of the use of raspberry leaves in pregnancy, emphasizing the effect on the cervix, and the safety profile of this herb. The majority of women apply raspberry leaves during pregnancy to induce and ease labor. However, it has not been possible to determine the exact effect of using raspberry extracts on the course of childbirth and the perinatal period. Additionally, it is unclear whether this herb has only positive effects. The currently available data indicate a weak effect of raspberry leaf extracts on labor induction and, at the same time, their possible negative impact on cervical ripening. [ABSTRACT FROM AUTHOR]

: Copyright of Nutrients is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)