المؤلفون: Hardcastle, Nicholas, Josipovic, Mirjana, Clementel, Enrico, Hernandez, Victor, Smyth, Gregory, Gober, Manuela, Wilke, Lotte, Eaton, David, Josset, Stéphanie, Lazarakis, Smaro, Saez, Jordi, Vieillevigne, Laure, Jornet, Núria, Mancosu, Pietro

المصدر: Radiotherapy and Oncology ; volume 190, page 110042 ; ISSN 0167-8140

الإتاحة: https://doi.org/10.1016/j.radonc.2023.110042Test
https://api.elsevier.com/content/article/PII:S0167814023093490?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0167814023093490?httpAccept=text/plainTest

المؤلفون: Mowat, Sarah, Smyth, Gregory, Mandeville, Henry, Blasiak-Wal, Irena, Warren-Oseni, Karole, Welsh, Liam

المصدر: Radiography ; volume 26, page S26-S27 ; ISSN 1078-8174

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging

الإتاحة: https://doi.org/10.1016/j.radi.2019.11.065Test
https://api.elsevier.com/content/article/PII:S1078817419302275?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1078817419302275?httpAccept=text/plainTest

المؤلفون: Smyth, Gregory, Evans, Philip M., Bamber, Jeffrey C., Bedford, James L.

الوصف: This paper gives an overview of recent developments in non-coplanar intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT). Modern linear accelerators are capable of automating motion around multiple axes, allowing efficient delivery of highly non-coplanar radiotherapy techniques. Novel techniques developed for C-arm and non-standard linac geometries, methods of optimization, and clinical applications are reviewed. The additional degrees of freedom are shown to increase the therapeutic ratio, either through dose escalation to the target or dose reduction to functionally important organs at risk, by multiple research groups. Although significant work is still needed to translate these new non-coplanar radiotherapy techniques into the clinic, clinical implementation should be prioritized. Recent developments in non-coplanar radiotherapy demonstrate that it continues to have a place in modern cancer treatment.

وصف الملف: text

العلاقة: http://epubs.surrey.ac.uk/858481Test/; http://dx.doi.org/10.1259/bjr.20180908Test; http://epubs.surrey.ac.uk/858481/1/bjr.20180908.pdfTest; Smyth, Gregory, Evans, Philip M., Bamber, Jeffrey C. and Bedford, James L. (2019) Recent developments in non-coplanar radiotherapy The British Journal of Radiology, 92 (1097), 20180908.

الإتاحة: https://doi.org/10.1259/bjr.20180908Test
http://epubs.surrey.ac.uk/858481/1/bjr.20180908.pdfTest

المؤلفون: Smyth, Gregory, Evans, Philip M., Bamber, Jeffrey C, Mandeville, Henry C, Rollo Moore, A, Welsh, Liam C, Saran, Frank H, Bedford, James L

الوصف: Radiotherapy treatment plans using dynamic couch rotation during volumetric modulated arc therapy (DCR-VMAT) reduce the dose to organs at risk (OARs) compared to coplanar VMAT, while maintaining the dose to the planning target volume (PTV). This paper seeks to validate this finding with measurements. DCR-VMAT treatment plans were produced for five patients with primary brain tumours and delivered using a commercial linear accelerator (linac). Dosimetric accuracy was assessed using point dose and radiochromic film measurements. Linac-recorded mechanical errors were assessed by extracting deviations from log files for multi-leaf collimator (MLC), couch, and gantry positions every 20 ms. Dose distributions, reconstructed from every fifth log file sample, were calculated and used to determine deviations from the treatment plans. Median (range) treatment delivery times were 125 s (123–133 s) for DCR-VMAT, compared to 78 s (64–130 s) for coplanar VMAT. Absolute point doses were 0.8% (0.6%–1.7%) higher than prediction. For coronal and sagittal films, respectively, 99.2% (96.7%–100%) and 98.1% (92.9%–99.0%) of pixels above a 20% low dose threshold reported gamma <1 for 3% and 3 mm criteria. Log file analysis showed similar gantry rotation root-mean-square error (RMSE) for VMAT and DCR-VMAT. Couch rotation RMSE for DCR-VMAT was 0.091° (0.086–0.102°). For delivered dose reconstructions, 100% of pixels above a 5% low dose threshold reported gamma <1 for 2% and 2 mm criteria in all cases. DCR-VMAT, for the primary brain tumour cases studied, can be delivered accurately using a commercial linac.

وصف الملف: text

العلاقة: http://epubs.surrey.ac.uk/858480Test/; http://dx.doi.org/10.1088/1361-6560/ab0a8eTest; http://epubs.surrey.ac.uk/858480/1/Smyth_2019_Phys._Med._Biol._64_08NT01.pdfTest; Smyth, Gregory, Evans, Philip M., Bamber, Jeffrey C, Mandeville, Henry C, Rollo Moore, A, Welsh, Liam C, Saran, Frank H and Bedford, James L (2019) Dosimetric accuracy of dynamic couch rotation during volumetric modulated arc therapy (DCR-VMAT) for primary brain tumours Physics in Medicine & Biology, 64 (8), 08NT01.

الإتاحة: https://doi.org/10.1088/1361-6560/ab0a8eTest
http://epubs.surrey.ac.uk/858480/1/Smyth_2019_Phys._Med._Biol._64_08NT01.pdfTest

المؤلفون: Seravalli, Enrica, Bosman, Mirjam, Lassen-Ramshad, Yasmin, Vestergaard, Anne, Oldenburger, Foppe, Visser, Jorrit, Koutsouveli, Efi, Paraskevopoulou, Chryssa, Horan, Gail, Ajithkumar, Thankamma, Timmermann, Beate, Fuentes, Carolina Sofia, Whitfield, Gillian, Marchant, Thomas, Padovani, Laetitia, Garnier, Eloise, Gandola, Lorenza, Meroni, Silvia, Hoeben, Bianca A.W., Kusters, Martijn, Alapetite, Claire, Losa, Sandra, Goudjil, Farid, Magelssen, Henriette, Evensen, Morten Egeberg, Saran, Frank, Smyth, Gregory, Rombi, Barbara, Righetto, Roberto, Kortmann, Rolf Dieter, Janssens, Geert O.

المصدر: Seravalli , E , Bosman , M , Lassen-Ramshad , Y , Vestergaard , A , Oldenburger , F , Visser , J , Koutsouveli , E , Paraskevopoulou , C , Horan , G , Ajithkumar , T , Timmermann , B , Fuentes , C S , Whitfield , G , Marchant , T , Padovani , L , Garnier , E , Gandola , L , Meroni , S , Hoeben , B A W , Kusters , M , Alapetite , C , Losa , S , Goudjil , F , Magelssen , H , ....

مصطلحات موضوعية: ResearchInstitutes_Networks_Beacons/mcrc, Manchester Cancer Research Centre

الوصف: Purpose: Conventional techniques (3D-CRT) for craniospinal irradiation (CSI) are still widely used. Modern techniques (IMRT, VMAT, TomoTherapy ® , proton pencil beam scanning [PBS]) are applied in a limited number of centers. For a 14-year-old patient, we aimed to compare dose distributions of five CSI techniques applied across Europe and generated according to the participating institute protocols, therefore representing daily practice. Material and methods: A multicenter (n = 15) dosimetric analysis of five different techniques for CSI (3D-CRT, IMRT, VMAT, TomoTherapy ® , PBS; 3 centers per technique) was performed using the same patient data, set of delineations and dose prescription (36.0/1.8 Gy). Different treatment plans were optimized based on the same planning target volume margin. All participating institutes returned their best treatment plan applicable in clinic. Results: The modern radiotherapy techniques investigated resulted in superior conformity/homogeneity-indices (CI/HI), particularly in the spinal part of the target (CI: 3D-CRT:0.3 vs. modern:0.6; HI: 3D-CRT:0.2 vs. modern:0.1), and demonstrated a decreased dose to the thyroid, heart, esophagus and pancreas. Dose reductions of >10.0 Gy were observed with PBS compared to modern photon techniques for parotid glands, thyroid and pancreas. Following this technique, a wide range in dosimetry among centers using the same technique was observed (e.g., thyroid mean dose: VMAT: 5.6–24.6 Gy; PBS: 0.3–10.1 Gy). Conclusions: The investigated modern radiotherapy techniques demonstrate superior dosimetric results compared to 3D-CRT. The lowest mean dose for organs at risk is obtained with proton therapy. However, for a large number of organs ranges in mean doses were wide and overlapping between techniques making it difficult to recommend one radiotherapy technique over another.

الإتاحة: https://doi.org/10.1080/0284186X.2018.1465588Test
https://research.manchester.ac.uk/en/publications/e571810a-1bec-45de-bd3e-e2099c37f927Test
http://www.scopus.com/inward/record.url?scp=85046034560&partnerID=8YFLogxKTest

المؤلفون: Lehmann, Joerg, Hussein, Mohammad, Claridge Mackonis, Elizabeth, Meehan, Carole, Patel, Rushil, Ray, Xenia, Shaw, Maddison, Shepherd, Justin, Smyth, Gregory, Standen, Therese S., Subramanian, Brindha, Greer, Peter B., Barry, Miriam A., Clark, Catharine H., Siva, Shankar, Moore, Alisha, Chu, Michael, Díez, Patricia, Eaton, David J., Harwood, Jeffrey, Lonski, Peta

المساهمون: The University of Newcastle. College of Engineering, Science & Environment, School of Information and Physical Sciences

مصطلحات موضوعية: quality assurance, clinical trials, dosimetry audits, sensitivity, patient specific quality assurance, intensity modulated radiotherapy

الوصف: Background: The quality of radiotherapy delivery has been shown to significantly impact clinical outcomes including patient survival. To identify errors, institutions perform Patient Specific Quality Assurance (PSQA) assessing each individual radiotherapy plan prior to starting patient treatments. Externally administered Dosimetry Audits have found problems despite institutions passing their own PSQA. Hence a new audit concept which assesses the institution’s ability to detect errors with their routine PSQA is needed. Methods: Purposefully introduced edits which simulated treatment delivery errors were embedded into radiation treatment plans of participating institutions. These were designed to produce clinically significant changes yet were mostly within treatment delivery specifications. Actual impact was centrally assessed for each plan. Institutions performed PSQA on each plan, without knowing which contained errors. Results: Seventeen institutions using six radiation treatment planning systems and two delivery systems performed PSQA on twelve plans each. Seventeen erroneous plans (across seven institutions) passed PSQA despite causing >5% increase in spinal cord dose relative to the original plans. Six plans (from four institutions) passed despite a >10% increase. Conclusions: This novel audit concept evolves beyond testing an institution’s ability to deliver a single test case, to increasing the number of errors caught by institutions themselves, thus increasing quality of radiation therapy and impacting every patient treated. Administered remotely this audit also provides advantages in cost, environmental impact, and logistics.

العلاقة: Radiotherapy and Oncology Vol. 171, p. 121-128; http://hdl.handle.net/1959.13/1487641Test; uon:52206

الإتاحة: http://hdl.handle.net/1959.13/1487641Test

المؤلفون: Lehmann, Joerg, Hussein, Mohammad, Barry, Miriam A., Siva, Shankar, Moore, Alisha, Chu, Michael, Díez, Patricia, Eaton, David J., Harwood, Jeffrey, Lonski, Peta, Claridge Mackonis, Elizabeth, Meehan, Carole, Patel, Rushil, Ray, Xenia, Shaw, Maddison, Shepherd, Justin, Smyth, Gregory, Standen, Therese S., Subramanian, Brindha, Greer, Peter B., Clark, Catharine H.

المصدر: Radiotherapy and Oncology ; volume 171, page 121-128 ; ISSN 0167-8140

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.radonc.2022.04.019Test
https://api.elsevier.com/content/article/PII:S0167814022002250?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0167814022002250?httpAccept=text/plainTest

المؤلفون: Smyth, Gregory, Evans, Philip M., Bamber, Jeffrey C., Mandeville, Henry C., Welsh, Liam C., Saran, Frank H., Bedford, James L.

المساهمون: NHS

المصدر: Radiotherapy and Oncology ; volume 121, issue 1, page 124-131 ; ISSN 0167-8140

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.radonc.2016.07.014Test
https://api.elsevier.com/content/article/PII:S0167814016312063?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0167814016312063?httpAccept=text/plainTest

المؤلفون: Bedford, James L., Smyth, Gregory, Hanson, Ian M., Tree, Alison C., Dearnaley, David P., Hansen, Vibeke N.

المساهمون: NHS

المصدر: Radiotherapy and Oncology ; volume 120, issue 2, page 320-326 ; ISSN 0167-8140

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.radonc.2016.07.004Test
https://api.elsevier.com/content/article/PII:S0167814016311963?httpAccept=text/plainTest
https://api.elsevier.com/content/article/PII:S0167814016311963?httpAccept=text/xmlTest

مستخلص: An enclosure is provided for a device comprising one or more electronic assemblies where the enclosure deforms under a shock in one or more selected manners to dissipate the shock energy. The deformation, which is elastic deformation, occurs at selected parts of the enclosure and/or in selected translations and/or rotations where those selections are made by the designer of the enclosure. By being able to define where and how the deformations will occur, the electronic assemblies can be located, mounted and interconnect within the enclosure such that the deformation does not adversely affect the assemblies or device.